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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tif ADP Uncharacterized ABC transporter ATP-binding protein MJ0796

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3tif ADPUncharacterized ABC transporter ATP-binding protein MJ0796 / 0.918
2fgj ATPAlpha-hemolysin translocation ATP-binding protein HlyB / 0.780
2xau ADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 3.6.4.13 0.765
4bzq ADPBifunctional enzyme CysN/CysC 2.7.1.25 0.761
4tla ADPCircadian clock protein kinase KaiC 2.7.11.1 0.757
3tlx ADPAdenylate kinase 2 / 0.755
2jj2 ADPATP synthase subunit alpha, mitochondrial / 0.754
2jj2 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.754
1mma ADPMyosin-2 heavy chain / 0.753
3l1c ADPProtein claret segregational / 0.753
1ow3 GDPTransforming protein RhoA / 0.752
2dpx GDPGTP-binding protein RAD / 0.752
4gp6 ADPMetallophosphoesterase / 0.752
1xmv ADPProtein RecA / 0.751
1e1q ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.750
2fna ADPUncharacterized protein / 0.750
2y65 ADPKinesin heavy chain / 0.750
3ea5 GDPGTP-binding nuclear protein Ran / 0.750
3d8b ADPFidgetin-like protein 1 3.6.4 0.749
4ldj GDPGTPase KRas / 0.749
1x1r GDPRas-related protein M-Ras / 0.748
1xef ATPAlpha-hemolysin translocation ATP-binding protein HlyB / 0.748
1bof GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.747
2gm1 ADPKinesin-like protein KIF11 / 0.747
2ce7 ADPATP-dependent zinc metalloprotease FtsH / 0.746
2zfi ADPKinesin-like protein KIF1A / 0.746
3l9h ADPKinesin-like protein KIF11 / 0.746
5bn3 ADPV-type ATP synthase alpha chain / 0.746
5bn3 ADPNEQ263 / 0.746
1sdm ADPKinesin heavy chain-like protein / 0.745
2xae ADPKinesin-like protein KIF11 / 0.745
2zts ADPUncharacterized protein / 0.745
1in5 ADPHolliday junction ATP-dependent DNA helicase RuvB / 0.744
1njf ADPDNA polymerase III subunit tau 2.7.7.7 0.744
2pg2 ADPKinesin-like protein KIF11 / 0.744
2x2r ADPKinesin-like protein KIF11 / 0.744
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.744
4l8g GDPGTPase KRas / 0.744
1xnj ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.7.1.25 0.743
2uyi ADPKinesin-like protein KIF11 / 0.743
4b7b ADPKinesin-like protein KIF11 / 0.743
1jx2 ADPMyosin-2 heavy chain / 0.742
2gks ADPProbable bifunctional SAT/APS kinase 2.7.1.25 0.742
4obe GDPGTPase KRas / 0.742
4pjk ADPMyosin-2 heavy chain / 0.742
4luc GDPGTPase KRas / 0.741
1l8q ADPChromosomal replication initiator protein DnaA / 0.740
2qen ADPWalker-Type ATPase / 0.740
3cob ADPKinesin heavy chain-like protein / 0.740
5irn ADPNucleotide binding oligomerization domain containing 2 / 0.740
1sq5 ADPPantothenate kinase 2.7.1.33 0.738
1w0k ADPATP synthase subunit alpha, mitochondrial / 0.738
1w0k ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.738
1z0a GDPRas-related protein Rab-2A / 0.738
1z0f GDPRas-related protein Rab-14 / 0.738
2j0v GDPRac-like GTP-binding protein ARAC7 / 0.738
4ncl GDPEukaryotic translation initiation factor 5B / 0.738
4q03 GDPGTPase KRas / 0.738
3kuc GDPRas-related protein Rap-1A / 0.737
3kud GDPGTPase HRas / 0.737
3tqc ADPPantothenate kinase / 0.737
3x1w GDPRas-related protein Rap-1b / 0.737
4pfp ADPUnconventional myosin-VI / 0.737
4tl9 AGSCircadian clock protein kinase KaiC 2.7.11.1 0.737
4ymu ATPABC-type polar amino acid transport system, ATPase component / 0.737
3cph GDPRas-related protein SEC4 / 0.736
4yer ADPAntibiotic ABC transporter, ATP-binding protein, putative / 0.736
1wbb ADPDNA mismatch repair protein MutS / 0.735
4o2r GDPGTP-binding protein Rheb / 0.735
3k1j ADPATP-dependent protease Lon / 0.734
3t1t GDPProbable gliding protein mglA / 0.734
4dzz ADPPlasmid partitioning protein ParF / 0.733
5ftc ADPTPR domain protein / 0.733
2dr3 ADPUPF0273 protein PH0284 / 0.732
4jl5 ADPAdenylate kinase / 0.732
4tl8 AGSCircadian clock protein kinase KaiC 2.7.11.1 0.732
1h8h ADPATP synthase subunit alpha, mitochondrial / 0.731
1h8h ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.731
1q3h ANPCystic fibrosis transmembrane conductance regulator / 0.731
3mle ADPATP-dependent dethiobiotin synthetase BioD 6.3.3.3 0.731
3qpv ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.731
2o8b ADPDNA mismatch repair protein Msh2 / 0.730
2axn ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 / 0.729
2i1v ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.729
1cxz GSPTransforming protein RhoA / 0.728
2v7q ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.728
4y0v GDPADP-ribosylation factor 1, putative / 0.728
2ql6 ADPNicotinamide riboside kinase 1 / 0.727
4r43 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.727
5cyo GDPSeptin-9 / 0.727
1rrg GDPADP-ribosylation factor 1 / 0.726
1yra GDPGPN-loop GTPase PAB0955 / 0.726
2p2l GDPRas-related C3 botulinum toxin substrate 1 / 0.726
1mmg AGSMyosin-2 heavy chain / 0.725
1zcb GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.724
5fl3 ADPPili retraction protein PilT / 0.723
2eck ADPAdenylate kinase / 0.722
5aun ADPIron-sulfur cluster carrier protein / 0.722
2fl2 ADPKinesin-like protein KIF11 / 0.721
3cx6 GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.721
1b7t ADPMyosin heavy chain, striated muscle / 0.720
2j5x GSPADP-ribosylation factor 6 / 0.720
2jiz ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.720
4hse ADPChaperone protein ClpB / 0.720
4qbi AP5Adenylate kinase / 0.720
4tl7 ATPCircadian clock protein kinase KaiC 2.7.11.1 0.720
4ihq ADPConserved Archaeal protein / 0.719
4r9u ANPVitamin B12 import ATP-binding protein BtuD / 0.719
4tlc AGSCircadian clock protein kinase KaiC 2.7.11.1 0.719
4tld AGSCircadian clock protein kinase KaiC 2.7.11.1 0.719
1z0d GDPRas-related protein Rab-5C / 0.718
2jj1 ADPATP synthase subunit alpha, mitochondrial / 0.718
2jj1 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.718
1ii6 ADPKinesin-like protein KIF11 / 0.717
2gcp GSPRho-related GTP-binding protein RhoC / 0.717
3ieu GDPGTPase Era / 0.716
4dxa GSPRas-related protein Rap-1b / 0.716
4jlo ADPAdenylate kinase / 0.716
4tle AGSCircadian clock protein kinase KaiC 2.7.11.1 0.716
1e79 ADPATP synthase subunit alpha, mitochondrial / 0.715
1e79 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.715
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.715
1m7b GTPRho-related GTP-binding protein RhoE / 0.715
1svl ADPLarge T antigen 3.6.4 0.715
4pk4 ADPUnconventional myosin-VI / 0.715
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.714
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.714
3qbv GDPCell division control protein 42 homolog / 0.714
4asu ADPATP synthase subunit alpha, mitochondrial / 0.714
4ylg GDPADP-ribosylation factor 1, putative / 0.714
4qos ADPPsp operon transcriptional activator / 0.713
4tlb AGSCircadian clock protein kinase KaiC 2.7.11.1 0.713
1gia GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.712
2zrj AGSProtein RecA / 0.712
3mjh GTPRas-related protein Rab-5A / 0.712
4dso GSPGTPase KRas / 0.712
1e96 GTPRas-related C3 botulinum toxin substrate 1 / 0.711
1yrs ADPKinesin-like protein KIF11 / 0.711
1z6t ADPApoptotic protease-activating factor 1 / 0.711
2gvd GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.711
2xtz GSPGuanine nucleotide-binding protein alpha-1 subunit / 0.711
3kz1 GSPTransforming protein RhoA / 0.711
4d81 ADPAAA ATPase, central domain protein / 0.711
4mkf AP5Adenylate kinase / 0.711
4tyq AP5Adenylate kinase / 0.711
2fju GSPRas-related C3 botulinum toxin substrate 1 / 0.710
2vos ADPFolylpolyglutamate synthase / 0.710
3zia ATPATP synthase subunit alpha, mitochondrial / 0.710
4itr GDPCell division control protein 42 homolog / 0.710
4ap0 ADPKinesin-like protein KIF11 / 0.709
4xsg GSPTransforming protein RhoA / 0.709
1q12 ATPMaltose/maltodextrin import ATP-binding protein MalK / 0.708
3cx8 GSPGuanine nucleotide-binding protein subunit alpha-13 / 0.708
4cf7 ADPAdenylate kinase / 0.708
1gil GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.706
3pfi ADPHolliday junction ATP-dependent DNA helicase RuvB / 0.706
4ki0 ANPMaltose/maltodextrin import ATP-binding protein MalK / 0.706
4pjj ADPUnconventional myosin-VI / 0.706
4z54 GDPNeuronal-specific septin-3 / 0.706
1g6o ADPCag alpha / 0.705
3zvm ADPBifunctional polynucleotide phosphatase/kinase 2.7.1.78 0.705
4a51 ADPKinesin-like protein KIF11 / 0.705
2c9o ADPRuvB-like 1 3.6.4.12 0.704
4x8o AP5Adenylate kinase / 0.703
1wdt GTPElongation factor G (EF-G-2) / 0.702
2ax4 ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 2.7.1.25 0.702
4a28 ADPKinesin-like protein KIF11 / 0.702
4hi0 GDPUrease accessory protein UreG / 0.702
1um8 ADPATP-dependent Clp protease ATP-binding subunit ClpX / 0.701
4a1z ADPKinesin-like protein KIF11 / 0.700
4ww0 ADPATP-dependent zinc metalloprotease FtsH / 0.700
1g16 GDPRas-related protein SEC4 / 0.699
2g1q ADPKinesin-like protein KIF11 / 0.699
3kkq GDPRas-related protein M-Ras / 0.699
4jky ADPAdenylate kinase / 0.699
4tq9 GDPGTPase KRas / 0.699
1e79 ATPATP synthase subunit alpha, mitochondrial / 0.698
1e79 ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.698
2vcz VC3Hematopoietic prostaglandin D synthase / 0.698
3c41 ANPAmino acid ABC transporter / 0.698
3cf0 ADPTransitional endoplasmic reticulum ATPase 3.6.4.6 0.698
3r9i ADPSeptum site-determining protein MinD / 0.698
4epx GDPGTPase KRas / 0.698
4lv6 GDPGTPase KRas / 0.698
4q02 GDPGTPase KRas / 0.698
4ma4 ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.697
1mez GDPAdenylosuccinate synthetase isozyme 1 / 0.696
3qi2 GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.696
4jld ADPAdenylate kinase / 0.696
1oix GDPRas-related protein Rab-11A / 0.695
4ike ADPAdenylate kinase / 0.695
4jl6 ADPAdenylate kinase / 0.695
2zro ADPProtein RecA / 0.694
2l0x GDPGTP-binding protein Rheb / 0.693
4wou GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.693
1cul GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.692
1gp2 GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.692
3hu3 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.692
4cvm ANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.691
4qm6 GTPMetallophosphoesterase / 0.691
4xvq GNPGTPase HRas / 0.691
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.689
2x7e ADPKinesin-like protein KIF11 / 0.689
3bb3 GDPTranslocase of chloroplast 33, chloroplastic 3.6.5 0.689
3oee ANPATP synthase subunit alpha, mitochondrial / 0.689
3oee ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.689
4iok ADPFormate--tetrahydrofolate ligase / 0.689
2vor ACPFolylpolyglutamate synthase / 0.688
1p3d ANPUDP-N-acetylmuramate--L-alanine ligase 6.3.2.8 0.687
2c96 ATPPsp operon transcriptional activator / 0.687
2hld ANPATP synthase subunit alpha, mitochondrial / 0.687
2hld ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.687
4m0l GDPTranslation initiation factor 2 subunit gamma / 0.687
5ftf ADPTPR domain protein / 0.687
1ny5 ADPTranscriptional regulator (NtrC family) / 0.686
1sxj ADPReplication factor C subunit 5 / 0.686
2fe4 GDPRas-related protein Rab-6B / 0.686
3kji ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.686
1e32 ADPTransitional endoplasmic reticulum ATPase 3.6.4.6 0.684
1e4v AP5Adenylate kinase / 0.684
1n6m ADPProtein claret segregational / 0.684
2ck3 ANPATP synthase subunit alpha, mitochondrial / 0.684
2ck3 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.684
3ref GDPRho family GTPase / 0.684
4zca ADPKinesin-like protein KIF11 / 0.684
1nly AGSCag alpha / 0.682
2q2z ADPKinesin-like protein KIF11 / 0.682
3pcr GTPADP-ribosylation factor 6 / 0.682
2gil GTPRas-related protein Rab-6A / 0.681
2ic5 GNPRas-related C3 botulinum toxin substrate 3 / 0.681
2rgb GNPGTPase HRas / 0.681
2rge GNPGTPase HRas / 0.681
3ddc GNPGTPase HRas / 0.681
2ce2 GDPGTPase HRas / 0.680
3a4l ANPL-seryl-tRNA(Sec) kinase 2.7.1.164 0.680
3i3s GNPGTPase HRas / 0.680
3oiu GNPGTPase HRas / 0.680
3x1z GNPRas-related protein Rap-1b / 0.680
1a2b GSPTransforming protein RhoA / 0.679
2rgc GNPGTPase HRas / 0.679
3oiw GNPGTPase HRas / 0.679
3rs0 GNPGTPase HRas / 0.679
3rsl GNPGTPase HRas / 0.679
1lfd GNPGTPase HRas / 0.678
1s3s ADPTransitional endoplasmic reticulum ATPase 3.6.4.6 0.678
2bme GNPRas-related protein Rab-4A / 0.678
2xsz ATPRuvB-like 2 3.6.4.12 0.678
3kko GNPRas-related protein M-Ras / 0.678
3qcz ANPDihydrofolate synthase/folylpolyglutamate synthase / 0.678
4dlz GNPGTPase HRas / 0.678
2bku GTPGTP-binding nuclear protein Ran / 0.677
3q9l ATPSeptum site-determining protein MinD / 0.677
3uk6 ADPRuvB-like 2 3.6.4.12 0.677
4ko8 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.677
4mfe BTNPyruvate carboxylase / 0.677
4rz3 ADPSite-determining protein / 0.677
1v8k ANPKinesin-like protein KIF2C / 0.676
2iut AGSDNA translocase FtsK / 0.676
3bos CDPRegulatory inactivation of DnaA Hda protein / 0.676
3zia ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.676
3zl8 ADPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.676
4cvl ACPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.676
4cym GCPRas-related protein Rab-32 / 0.676
5i67 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.676
1xp8 AGSProtein RecA / 0.675
2fah GDPPhosphoenolpyruvate carboxykinase [GTP], mitochondrial 4.1.1.32 0.675
4cei ANPATP-dependent helicase/deoxyribonuclease subunit B 3.1 0.675
4goj GNPADP-ribosylation factor-like protein 3 / 0.675
1fnn ADPORC1-type DNA replication protein / 0.674
3moh GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.674
2cea ADPATP-dependent zinc metalloprotease FtsH / 0.673
3tso GNPRas-related protein Rab-25 / 0.672
4yqf GDPSeptin-9 / 0.672
2bif ANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 2.7.1.105 0.671
3fwy ADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein / 0.671
4uj3 GNPRas-related protein Rab-11A / 0.671
1e4y AP5Adenylate kinase / 0.670
1f5n GNPGuanylate-binding protein 1 / 0.670
4nh0 ATPESX secretion system protein EccC / 0.670
1rj9 GCPSignal recognition particle receptor FtsY / 0.669
3k3b ADPKinesin-like protein KIF11 / 0.669
3thy ADPDNA mismatch repair protein Msh2 / 0.669
4idn GNPAtlastin-1 3.6.5 0.669
4kvg GTPRas-related protein Rap-1A / 0.669
4l9s GDPGTPase HRas / 0.668
2v7q ATPATP synthase subunit alpha, mitochondrial / 0.667
2v7q ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.667
2zsa ADPPantothenate kinase 2.7.1.33 0.667
4ql3 GDPGTPase KRas / 0.667
1d5c GDPGTPase (Rab6) / 0.666
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.666
4epw GDPGTPase KRas / 0.666
2zw9 SAMtRNA wybutosine-synthesizing protein 4 2.1.1.290 0.665
3ftq GNPSeptin-2 / 0.665
2q2y ADPKinesin-like protein KIF11 / 0.664
3nbx ADPATPase RavA 3.6.3 0.664
3sbd GNPRas-related C3 botulinum toxin substrate 1 / 0.664
4wa7 GDPGTPase KRas / 0.664
1k6m AGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 2.7.1.105 0.663
2dft ADPShikimate kinase 2.7.1.71 0.663
3adc ANPL-seryl-tRNA(Sec) kinase 2.7.1.164 0.663
5c46 GSPRas-related protein Rab-11A / 0.663
1m2o GNPSmall COPII coat GTPase SAR1 3.6.5 0.662
1mh1 GNPRas-related C3 botulinum toxin substrate 1 / 0.662
2pc9 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.662
4v02 ATPSite-determining protein / 0.662
4xvr GNPGTPase HRas / 0.662
1g17 GNPRas-related protein SEC4 / 0.661
2uz3 TTPThymidine kinase / 0.661
4dsu GDPGTPase KRas / 0.661
4o25 GTPGTP-binding protein Rheb / 0.660
1z2a GDPRas-related protein Rab-23 / 0.659
1zd9 GDPADP-ribosylation factor-like protein 8A / 0.659
2whq HI6Acetylcholinesterase 3.1.1.7 0.659
2qf2 GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.658
3bxz ADPProtein translocase subunit SecA / 0.658
3oes GNPGTPase RhebL1 / 0.658
4jjz ADPFormate--tetrahydrofolate ligase / 0.658
4oi2 ADPProtein clpf-1 / 0.657
1azt GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.656
3r9x GNPGTPase Era / 0.656
1zc4 GNPRas-related protein Ral-A / 0.655
2dwp ACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.655
3l8y GNPGTPase HRas / 0.655
3oiv GNPGTPase HRas / 0.655
4lrw GDPGTPase KRas / 0.655
1xms ANPProtein RecA / 0.654
3lbh GNPGTPase HRas / 0.654
4dlt GNPGTPase HRas / 0.654
4dlv GNPGTPase HRas / 0.654
4dlx GNPGTPase HRas / 0.654
4hdo GNPRas-related protein Rap-1b / 0.654
3q5d GDPAtlastin-1 3.6.5 0.653
4mkh AP5Adenylate kinase / 0.653
1p9w ANPType II secretion system protein E / 0.652
3lbi GNPGTPase HRas / 0.652
4loc BTNPyruvate carboxylase / 0.652
4qxa GTPRas-related protein Rab-9A / 0.652
4yaw 2AMNADPH--cytochrome P450 reductase / 0.652
5k5z ANPUncharacterized protein / 0.652
1n6l GTPRas-related protein Rab-5A / 0.651
3rab GNPRas-related protein Rab-3A / 0.651
4yaf 2AMNADPH--cytochrome P450 reductase / 0.651
1xtr GNPGTP-binding protein Rheb / 0.650
2d4h 5GPGuanylate-binding protein 1 / 0.650
3tjz GNPADP-ribosylation factor 1 / 0.650
5di3 GNPADP-ribosylation factor-like protein 3 / 0.650