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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q1w FAD Putidaredoxin reductase 1.18.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1q1w FADPutidaredoxin reductase 1.18.1.5 1.402
1q1r FADPutidaredoxin reductase 1.18.1.5 1.251
3lb8 FADPutidaredoxin reductase 1.18.1.5 1.133
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.859
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.859
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.854
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.846
2gqw FADFerredoxin reductase / 0.839
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.839
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.838
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.838
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.832
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.830
4yry FADGlutamate synthase, beta subunit / 0.826
2yvf FADFerredoxin reductase / 0.820
2gr3 FADFerredoxin reductase / 0.819
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.819
1d7y FADFerredoxin reductase / 0.815
2gr1 FADFerredoxin reductase / 0.815
4eqx FADCoenzyme A disulfide reductase / 0.813
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.810
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.809
3fg2 FADPutative rubredoxin reductase / 0.808
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.805
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.804
2yvj FADFerredoxin reductase / 0.799
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.795
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.794
4em3 FADCoenzyme A disulfide reductase / 0.793
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.790
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.790
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.790
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.790
4eqs FADCoenzyme A disulfide reductase / 0.789
4em4 FADCoenzyme A disulfide reductase / 0.787
4eqw FADCoenzyme A disulfide reductase / 0.777
3atq FDAConserved Archaeal protein / 0.770
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.770
2gr0 FADFerredoxin reductase / 0.767
1yqz FADCoenzyme A disulfide reductase / 0.766
2q0k FADThioredoxin reductase 1.8.1.9 0.766
4nev FADTrypanothione reductase / 0.765
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.762
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.760
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.759
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.759
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.758
3f8d FADNADH oxidase/thioredoxin reductase / 0.756
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.755
3cge FADCoenzyme A disulfide reductase / 0.754
3ish FADThioredoxin reductase 1.8.1.9 0.752
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.749
3icr FADCoenzyme A disulfide reductase / 0.749
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.749
2wba FADTrypanothione reductase 1.8.1.12 0.748
3cgd FADCoenzyme A disulfide reductase / 0.748
2wp5 FADTrypanothione reductase / 0.747
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.747
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.747
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.746
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.745
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.744
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.742
4opl FDAConserved Archaeal protein / 0.742
1f3p FADFerredoxin reductase / 0.740
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.738
1rsg FADPolyamine oxidase FMS1 / 0.736
1zk7 FADMercuric reductase 1.16.1.1 0.736
3cgc FADCoenzyme A disulfide reductase / 0.734
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.734
1zx9 FADMercuric reductase 1.16.1.1 0.730
1joa FADNADH peroxidase 1.11.1.1 0.729
3cgb FADCoenzyme A disulfide reductase / 0.729
4wct FADFructosyl amine:oxygen oxidoreductase / 0.729
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.726
3cnd FADPolyamine oxidase FMS1 / 0.726
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.724
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.724
4eqr FADCoenzyme A disulfide reductase / 0.724
1fea FADTrypanothione reductase 1.8.1.12 0.723
1geu FADGlutathione reductase 1.8.1.7 0.723
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.722
1ges FADGlutathione reductase 1.8.1.7 0.721
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.721
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.720
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.720
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.720
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.719
4bjz FADProbable salicylate monooxygenase / 0.719
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.718
2ywl FADThioredoxin reductase related protein / 0.718
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.718
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.717
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.717
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.716
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.716
2tpr FADTrypanothione reductase 1.8.1.12 0.714
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.714
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.714
1feb FADTrypanothione reductase 1.8.1.12 0.713
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.712
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.712
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.711
1npx FADNADH peroxidase 1.11.1.1 0.711
2hqm FADGlutathione reductase 1.8.1.7 0.711
4rsl FADFructosyl peptide oxidase / 0.711
2jb2 FADL-amino acid oxidase / 0.710
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.709
2yqu FADDihydrolipoyl dehydrogenase / 0.709
2w0h FADTrypanothione reductase / 0.707
5l3d FADLysine-specific histone demethylase 1A 1 0.707
2whd FADThioredoxin reductase / 0.706
2qa1 FADPgaE / 0.705
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.705
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.704
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.704
2r9z FADGlutathione amide reductase / 0.704
4x4j FADPutative oxygenase / 0.704
4xbf FADLysine-specific histone demethylase 1A 1 0.704
2wow FADTrypanothione reductase / 0.702
1fec FADTrypanothione reductase 1.8.1.12 0.701
1get FADGlutathione reductase 1.8.1.7 0.700
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.700
4up3 FADThioredoxin reductase / 0.699
1kif FADD-amino-acid oxidase 1.4.3.3 0.698
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
2eq7 FADDihydrolipoyl dehydrogenase / 0.697
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.695
2jb1 FADL-amino acid oxidase / 0.694
1nhq FADNADH peroxidase 1.11.1.1 0.693
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.692
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
1nhs FADNADH peroxidase 1.11.1.1 0.691
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.691
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
1trb FADThioredoxin reductase 1.8.1.9 0.690
2xdo FADTetX family tetracycline inactivation enzyme / 0.690
4k2x FADPolyketide oxygenase/hydroxylase / 0.690
3fbs FADOxidoreductase / 0.689
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.688
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.688
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.688
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.687
4ynt FDAGlucose oxidase, putative / 0.687
4mih FADPyranose 2-oxidase 1.1.3.10 0.686
2b9w FADPutative aminooxidase / 0.685
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.685
3r9u FADThioredoxin reductase / 0.685
4j57 FADThioredoxin reductase 2 1.8.1.9 0.685
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.684
4b1b FADThioredoxin reductase 1.8.1.9 0.684
2b9y FADPutative aminooxidase / 0.683
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.682
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.682
1nhr FADNADH peroxidase 1.11.1.1 0.681
2a87 FADThioredoxin reductase 1.8.1.9 0.681
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.681
2x3n FADProbable FAD-dependent monooxygenase / 0.681
3ics FADCoenzyme A disulfide reductase / 0.681
1bzl FADTrypanothione reductase 1.8.1.12 0.679
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.679
2x8h FADThioredoxin glutathione reductase / 0.679
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.679
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.679
4jq9 FADDihydrolipoyl dehydrogenase / 0.679
2ba9 FADPutative aminooxidase / 0.678
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.678
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.677
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.677
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
1gxf FADTrypanothione reductase 1.8.1.12 0.676
2eq6 FADDihydrolipoyl dehydrogenase / 0.676
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.676
4ntc FADThioredoxin reductase gliT / 0.676
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.676
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.675
2x8g FADThioredoxin glutathione reductase / 0.675
4mo2 FADUDP-galactopyranose mutase / 0.675
2jk6 FADTrypanothione reductase / 0.674
3if9 FADGlycine oxidase 1.4.3.19 0.674
3kve FADL-amino-acid oxidase / 0.674
1nhp FADNADH peroxidase 1.11.1.1 0.673
1yy5 FADPolyamine oxidase FMS1 / 0.673
3bi5 FADPolyamine oxidase FMS1 / 0.673
3v76 FDAUncharacterized protein / 0.672
3qj4 FADRenalase / 0.671
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.671
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.670
2cdu FADNADH oxidase / 0.670
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.670
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.669
1tyt FADTrypanothione reductase 1.8.1.12 0.669
3atr FDAConserved Archaeal protein / 0.669
4a6n FADTetX family tetracycline inactivation enzyme / 0.669
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.669
3lad FADDihydrolipoyl dehydrogenase / 0.668
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.667
3he3 FADUDP-galactopyranose mutase / 0.667
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.667
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.666
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.666
3t2z FADSulfide-quinone reductase / 0.666
1ger FADGlutathione reductase 1.8.1.7 0.665
2eq8 FADDihydrolipoyl dehydrogenase / 0.665
4fwe FADLysine-specific histone demethylase 1B 1 0.665
4fwj FADLysine-specific histone demethylase 1B 1 0.665
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.664
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.664
1typ FADTrypanothione reductase 1.8.1.12 0.663
2wes FADTryptophan 5-halogenase / 0.663
3urh FADDihydrolipoyl dehydrogenase / 0.663
4opc FDAConserved Archaeal protein / 0.663
2vig FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.1 0.662
4la1 FADThioredoxin glutathione reductase / 0.662
2j6x FMNLactate oxidase / 0.661
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.661
4z44 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.660
3mkh FADNitroalkane oxidase / 0.659
3sz0 FADSulfide-quinone reductase / 0.659
4c3x FAD3-ketosteroid dehydrogenase / 0.659
4ccq FADThioredoxin reductase / 0.659
4opi FDAConserved Archaeal protein / 0.659
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.659
1d7l RFLp-hydroxybenzoate hydroxylase / 0.658
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.658
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.658
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.658
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.658
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.658
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.658
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.658
4opt FDAConserved Archaeal protein / 0.658
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.657
3gsi FADDimethylglycine oxidase 1.5.3.10 0.657
3we0 FADLysine 2-monooxygenase / 0.656
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
1knr FADL-aspartate oxidase 1.4.3.16 0.655
1ojt FADDihydrolipoyl dehydrogenase / 0.655
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.655
4k5r FADOxygenase / 0.655
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.654
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.654
3znp FADD-amino-acid oxidase 1.4.3.3 0.654
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.654
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.652
3nlc FADUncharacterized protein / 0.652
4fwf FADLysine-specific histone demethylase 1B 1 0.652
3gwf FADCyclohexanone monooxygenase / 0.651
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.651
3zdn FADMonoamine oxidase N 1.4.3.4 0.651
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.651
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.650
1jra FADFAD-linked sulfhydryl oxidase ERV2 1.8.3.2 0.650
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.650
2xyo FADTetX family tetracycline inactivation enzyme / 0.650
3bi2 FADPolyamine oxidase FMS1 / 0.650
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.650
3mzi FMNActivator of photopigment and puc expression / 0.650