Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t50FMNBlue-light-activated histidine kinase2.7.13.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3t50FMNBlue-light-activated histidine kinase2.7.13.31.000
2pr5FMNBlue-light photoreceptor/0.621
4eetFMNPhototropin-22.7.11.10.600
2z6dFMNPhototropin-22.7.11.10.589
3ue6FMNAureochrome1/0.579
2pdtFADVivid PAS protein VVD/0.568
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.568
5dkkFMNPredicted protein/0.565
3is2FADVivid PAS protein VVD/0.557
3p7nFMNLight-activated DNA-binding protein EL222/0.556
3sw1FMNSensory box protein/0.532
1n9nFMNPutative blue light receptor/0.526
4eeuFMNPhototropin-22.7.11.10.524
5djtFMNNPH1-2/0.519
4hhdFMNPhototropin-12.7.11.10.508
2z6cFMNPhototropin-12.7.11.10.506
3d72FADVivid PAS protein VVD/0.501
4eepFMNPhototropin-22.7.11.10.495
2pd8FADVivid PAS protein VVD/0.492
4eerFMNPhototropin-22.7.11.10.490
4hiaFMNLOV protein/0.489
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.489
5j4eFMNSensory box protein/0.488
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.484
1n9lFMNPutative blue light receptor/0.480
2znnS44Peroxisome proliferator-activated receptor alpha/0.480
2po7CHDFerrochelatase, mitochondrial4.99.1.10.478
2e2qADPATP-dependent hexokinase/0.476
4i02CMPcAMP-activated global transcriptional regulator CRP/0.475
2pd7FADVivid PAS protein VVD/0.474
1nvtNAPShikimate dehydrogenase (NADP(+))/0.473
2znpK55Peroxisome proliferator-activated receptor delta/0.473
4m10ICDProstaglandin G/H synthase 21.14.99.10.473
4xiwAZMCarbonic anhydrase, alpha type/0.472
5j3wFMNSensory box protein/0.472
2uyiADPKinesin-like protein KIF11/0.471
4kukRBFPutative blue-light photoreceptor/0.471
2npaMMBPeroxisome proliferator-activated receptor alpha/0.470
3b9lAZZSerum albumin/0.470
1nzdUPGDNA beta-glucosyltransferase/0.469
3hjkFADVivid PAS protein VVD/0.469
3s79ASDAromatase1.14.14.140.469
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
2qblCAMCamphor 5-monooxygenase1.14.15.10.468
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.468
4lxhC1EAlpha/beta hydrolase fold/0.468
1qvrANPChaperone protein ClpB/0.467
1jpaANPEphrin type-B receptor 22.7.10.10.466
2gjlFMNNitronate monooxygenase1.13.12.160.466
2j14GNIPeroxisome proliferator-activated receptor delta/0.466
1g1aNADdTDP-glucose 4,6-dehydratase/0.465
2p4yC03Peroxisome proliferator-activated receptor gamma/0.465
4k28NADShikimate dehydrogenase family protein/0.465
1i3mUD1UDP-glucose 4-epimerase/0.464
1t88CAMCamphor 5-monooxygenase1.14.15.10.464
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.464
4ienCOAPutative acyl-CoA hydrolase/0.464
5efwFMNNPH1-1/0.464
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.463
1dg8NDPDihydrofolate reductase1.5.1.30.462
1udaUFGUDP-glucose 4-epimerase5.1.3.20.462
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.462
4hj6FMNLOV protein/0.462
2panTDPGlyoxylate carboligase4.1.1.470.461
1t86CAMCamphor 5-monooxygenase1.14.15.10.460
3hx4ANPCalmodulin-domain protein kinase 1/0.460
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.460
4iawLIZNeutrophil gelatinase-associated lipocalin/0.460
1b6kPI5Gag-Pol polyprotein3.4.23.160.459
3tjsD0RCytochrome P450 3A4/0.459
2dvlFADAcyl-CoA dehydrogenase/0.458
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.458
2g78REACellular retinoic acid-binding protein 2/0.458
3ajrNADNDP-sugar epimerase/0.458
4eesFMNPhototropin-22.7.11.10.458
1lbcCYZGlutamate receptor 2/0.457
1xddAAYIntegrin alpha-L/0.457
2j8zNAPQuinone oxidoreductase PIG310.457
3c212BADNA integrity scanning protein DisA/0.457
4xqcNADHomospermidine synthase2.5.1.440.457
1lf3EH5Plasmepsin-23.4.23.390.456
3p2oNADBifunctional protein FolD/0.456
3qlrNDPDihydrofolate reductase1.5.1.30.456
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.456
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.456
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2znq401Peroxisome proliferator-activated receptor delta/0.455
3d4pNADL-lactate dehydrogenase 11.1.1.270.455
3uu114BAnthranilate phosphoribosyltransferase/0.455
3wrmCAMCamphor 5-monooxygenase1.14.15.10.455
2briANPUridylate kinase2.7.4.220.454
2cig1DGDihydrofolate reductase1.5.1.30.454
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.454
5cnoANPEpidermal growth factor receptor2.7.10.10.454
1t87CAMCamphor 5-monooxygenase1.14.15.10.453
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.453
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.453
3tz3B36Acetyl-CoA carboxylase/0.453
3wrjCAMCamphor 5-monooxygenase1.14.15.10.453
4l4cCAMCamphor 5-monooxygenase1.14.15.10.453
6cp4CAMCamphor 5-monooxygenase1.14.15.10.453
1jipKTN6-deoxyerythronolide B hydroxylase/0.452
2a1mCAMCamphor 5-monooxygenase1.14.15.10.452
2ft9CHDFatty acid-binding protein 2, liver/0.452
2xvv9DNSerum albumin/0.452
4jldADPAdenylate kinase/0.452
4xyeNADFormate dehydrogenase/0.452
4zohFADPutative oxidoreductase FAD-binding subunit/0.452
1tl7ONMAdenylate cyclase type 2/0.451
1tl7ONMAdenylate cyclase type 5/0.451
2bxmIMNSerum albumin/0.451
2gjnFMNNitronate monooxygenase1.13.12.160.451
2iviACWIsopenicillin N synthase1.21.3.10.451
2qbnCAMCamphor 5-monooxygenase1.14.15.10.451
2y9qANPMitogen-activated protein kinase 12.7.11.240.451
3asjXYMHomoisocitrate dehydrogenase/0.451
3t2zFADSulfide-quinone reductase/0.451
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.451
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4ek1CAMCamphor 5-monooxygenase1.14.15.10.451
5jscFADPutative acyl-CoA dehydrogenase/0.451
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.450
2obyNAPQuinone oxidoreductase PIG310.450
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.450
5cmsAPRO-acetyl-ADP-ribose deacetylase/0.450
1phgMYTCamphor 5-monooxygenase1.14.15.10.449
1yrdCAMCamphor 5-monooxygenase1.14.15.10.449
2qboCAMCamphor 5-monooxygenase1.14.15.10.449
2ql6ADPNicotinamide riboside kinase 1/0.449
3kpkFADSulfide-quinone reductase/0.449
3nbvANPKetohexokinase/0.449
3tqhNDPQuinone oxidoreductase/0.449
3vt9YI4Vitamin D3 receptor/0.449
3vvpBNUUncharacterized protein/0.449
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
4oaeCLMUncharacterized protein/0.449
4zrnUPGUDP-glucose 4-epimerase, putative/0.449
2a94AP0L-lactate dehydrogenase1.1.1.270.448
2g8yNADHydroxycarboxylate dehydrogenase B/0.448
2h94FADLysine-specific histone demethylase 1A10.448
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.448
2qenADPWalker-Type ATPase/0.448
2xvw9NRSerum albumin/0.448
2z97CAMCamphor 5-monooxygenase1.14.15.10.448
2zaxCAMCamphor 5-monooxygenase1.14.15.10.448
3cppCAMCamphor 5-monooxygenase1.14.15.10.448
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.448
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.448
4ocgCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.448
4plpNADHomospermidine synthase2.5.1.440.448
4yryFADGlutamate synthase, beta subunit/0.448
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.448
1dz4CAMCamphor 5-monooxygenase1.14.15.10.447
1dz6CAMCamphor 5-monooxygenase1.14.15.10.447
1qmfKEFPenicillin-binding protein 2x/0.447
2yy7NADL-threonine dehydrogenase/0.447
3qaaG04Gag-Pol polyprotein3.4.23.160.447
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.447
4ryvZEAProtein LlR18A/0.447
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.446
2ozuACOHistone acetyltransferase KAT6A/0.446
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.446
4h3j10WBeta-secretase 13.4.23.460.446
4ocvANPAminoglycoside phosphotransferase/0.446
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.445
1bdlIM1Gag-Pol polyprotein3.4.23.160.445
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.445
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.445
2bpw1INGag-Pol polyprotein3.4.23.160.445
3oetNADErythronate-4-phosphate dehydrogenase/0.445
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.445
4em9TCEPeroxisome proliferator-activated receptor gamma/0.445
4g47TZFMycocyclosin synthase1.14.21.90.445
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.445
4q71FADBifunctional protein PutA/0.445
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.444
1iwjCAMCamphor 5-monooxygenase1.14.15.10.444
1kkq471Peroxisome proliferator-activated receptor alpha/0.444
1me6IVSPlasmepsin-23.4.23.390.444
1meiXMPInosine-5'-monophosphate dehydrogenase/0.444
1meiMOAInosine-5'-monophosphate dehydrogenase/0.444
1ot7IU5Bile acid receptor/0.444
2ejvNADL-threonine 3-dehydrogenase/0.444
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.444
2qbmCAMCamphor 5-monooxygenase1.14.15.10.444
3adaNADSubunit alpha of sarocosine oxidase/0.444
3fwjCAMCamphor 5-monooxygenase1.14.15.10.444
3l63CAMCamphor 5-monooxygenase1.14.15.10.444
4g2gTDHMycocyclosin synthase1.14.21.90.444
4iae1DXAlr2278 protein/0.444
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.444
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.444
5eoxADPType 4 fimbrial biogenesis protein PilM/0.444
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1osvCHCBile acid receptor/0.443
2a1nCAMCamphor 5-monooxygenase1.14.15.10.443
2ev9NAPShikimate dehydrogenase (NADP(+))/0.443
2hk9NAPShikimate dehydrogenase (NADP(+))/0.443
2q4bNAPUncharacterized protein At5g02240/0.443
2udpUPPUDP-glucose 4-epimerase5.1.3.20.443
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3otwCOAPhosphopantetheine adenylyltransferase/0.443
3pgqGY3Acetyl-CoA carboxylase/0.443
4a8v2ANMajor pollen allergen Bet v 1-J/0.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
5lc1NADL-threonine 3-dehydrogenase/0.443
1idb0DOGag-Pol polyprotein/0.442
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.442
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.442
2yxuATPPyridoxal kinase2.7.1.350.442
3oqfS51Renin3.4.23.150.442
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.442
4g48PZBMycocyclosin synthase1.14.21.90.442
4gxs0YSGlutamate receptor 2/0.442
4iaxLIZNeutrophil gelatinase-associated lipocalin/0.442
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
4xrgNADHomospermidine synthase2.5.1.440.442
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.441
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1draMTXDihydrofolate reductase1.5.1.30.441
1jioDEB6-deoxyerythronolide B hydroxylase/0.441
1kvrNADUDP-glucose 4-epimerase5.1.3.20.441
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.441
2g37FADProline dehydrogenase/0.441
2vhtATPNTPase P4/0.441
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.441
2y60M8FIsopenicillin N synthase1.21.3.10.441
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3qsaTA7Anthranilate phosphoribosyltransferase/0.441
3t9aANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.441
3tnlNADShikimate dehydrogenase (NADP(+))/0.441
4cbqNDPThioredoxin reductase/0.441
4l4fCAMCamphor 5-monooxygenase1.14.15.10.441
4l4xNDPAmphI/0.441
4m4922YL-lactate dehydrogenase A chain1.1.1.270.441
4wudANPDNA gyrase subunit B/0.441
4xx0COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.441
5bsgNAPPyrroline-5-carboxylate reductase/0.441
1k6pXN3Gag-Pol polyprotein3.4.23.160.440
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1nahNADUDP-glucose 4-epimerase5.1.3.20.440
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.440
1xelUPGUDP-glucose 4-epimerase5.1.3.20.440
2bhiSFTCytotoxin 3/0.440
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.440
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2y3sTIRTamL/0.440
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.440
3bfa9ODOdorant binding protein ASP1/0.440
3fwfCAMCamphor 5-monooxygenase1.14.15.10.440
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3s1dZIRCytokinin dehydrogenase 11.5.99.120.440
4dpmCOAMalonyl-CoA reductase1.2.1.750.440
4iah1DXAlr2278 protein/0.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440