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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qtzX42Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qtzX42Cyclin-dependent kinase 22.7.11.221.000
3qu0X40Cyclin-dependent kinase 22.7.11.220.664
3unj0BXCyclin-dependent kinase 22.7.11.220.659
4fko20KCyclin-dependent kinase 22.7.11.220.651
3r9oZ71Cyclin-dependent kinase 22.7.11.220.649
1ckpPVBCyclin-dependent kinase 22.7.11.220.641
2r64740Cyclin-dependent kinase 22.7.11.220.639
3rpv26ZCyclin-dependent kinase 22.7.11.220.632
3r9dX6BCyclin-dependent kinase 22.7.11.220.628
3sqq99ZCyclin-dependent kinase 22.7.11.220.627
3qxoX65Cyclin-dependent kinase 22.7.11.220.622
4fkr45KCyclin-dependent kinase 22.7.11.220.622
3rmf20ZCyclin-dependent kinase 22.7.11.220.621
3rjc06ZCyclin-dependent kinase 22.7.11.220.619
1urwI1PCyclin-dependent kinase 22.7.11.220.616
3ti1B49Cyclin-dependent kinase 22.7.11.220.613
3r7vZ02Cyclin-dependent kinase 22.7.11.220.612
4fkv61KCyclin-dependent kinase 22.7.11.220.612
1ke9LS5Cyclin-dependent kinase 22.7.11.220.611
3rni21ZCyclin-dependent kinase 22.7.11.220.611
3s1h56ZCyclin-dependent kinase 22.7.11.220.611
3r8lZ30Cyclin-dependent kinase 22.7.11.220.610
3s2pPMUCyclin-dependent kinase 22.7.11.220.610
3rak03ZCyclin-dependent kinase 22.7.11.220.609
2btsU32Cyclin-dependent kinase 22.7.11.220.608
2w06FRVCyclin-dependent kinase 22.7.11.220.608
3qtuX44Cyclin-dependent kinase 22.7.11.220.604
2c6o4SPCyclin-dependent kinase 22.7.11.220.602
3qzhX69Cyclin-dependent kinase 22.7.11.220.601
3ral04ZCyclin-dependent kinase 22.7.11.220.601
4fkq42KCyclin-dependent kinase 22.7.11.220.596
1ke6LS2Cyclin-dependent kinase 22.7.11.220.593
1pxmCK5Cyclin-dependent kinase 22.7.11.220.593
2iw94SPCyclin-dependent kinase 22.7.11.220.593
3r6xX84Cyclin-dependent kinase 22.7.11.220.592
2b52D42Cyclin-dependent kinase 22.7.11.220.591
3sw418KCyclin-dependent kinase 22.7.11.220.591
1v1k3FPCyclin-dependent kinase 22.7.11.220.590
3r1sX73Cyclin-dependent kinase 22.7.11.220.590
1gih1PUCyclin-dependent kinase 22.7.11.220.589
1p2a5BNCyclin-dependent kinase 22.7.11.220.589
4ek610KCyclin-dependent kinase 22.7.11.220.589
3lfsA07Cyclin-dependent kinase 22.7.11.220.588
4fkw62KCyclin-dependent kinase 22.7.11.220.588
4acm7YGCyclin-dependent kinase 22.7.11.220.587
4fkpLS5Cyclin-dependent kinase 22.7.11.220.586
3roy22ZCyclin-dependent kinase 22.7.11.220.584
3unk0BYCyclin-dependent kinase 22.7.11.220.584
1vyzN5BCyclin-dependent kinase 22.7.11.220.583
4erwSTUCyclin-dependent kinase 22.7.11.220.583
3s0o50ZCyclin-dependent kinase 22.7.11.220.582
2r3lSCWCyclin-dependent kinase 22.7.11.220.581
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.581
3qqkX02Cyclin-dependent kinase 22.7.11.220.581
2w05FRTCyclin-dependent kinase 22.7.11.220.580
3qwkX62Cyclin-dependent kinase 22.7.11.220.579
1di8DTQCyclin-dependent kinase 22.7.11.220.578
2xmyCDKCyclin-dependent kinase 22.7.11.220.578
1oi9N20Cyclin-dependent kinase 22.7.11.220.577
2b55D31Cyclin-dependent kinase 22.7.11.220.577
4fkt48KCyclin-dependent kinase 22.7.11.220.575
1ke8LS4Cyclin-dependent kinase 22.7.11.220.574
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.574
3lfnA27Cyclin-dependent kinase 22.7.11.220.574
4bgh3I6Cyclin-dependent kinase 22.7.11.220.574
3rk507ZCyclin-dependent kinase 22.7.11.220.573
4fki09KCyclin-dependent kinase 22.7.11.220.573
1oitHDTCyclin-dependent kinase 22.7.11.220.572
3qxpX64Cyclin-dependent kinase 22.7.11.220.572
1h1s4SPCyclin-dependent kinase 22.7.11.220.571
3rm719ZCyclin-dependent kinase 22.7.11.220.571
1h1r6CPCyclin-dependent kinase 22.7.11.220.569
2iw84SPCyclin-dependent kinase 22.7.11.220.569
3r9hZ67Cyclin-dependent kinase 22.7.11.220.567
3qqfX07Cyclin-dependent kinase 22.7.11.220.566
3qtrX36Cyclin-dependent kinase 22.7.11.220.564
2btrU73Cyclin-dependent kinase 22.7.11.220.563
2duv371Cyclin-dependent kinase 22.7.11.220.563
4ek816KCyclin-dependent kinase 22.7.11.220.563
1ke7LS3Cyclin-dependent kinase 22.7.11.220.562
3iggEFQCyclin-dependent kinase 22.7.11.220.562
1g5sI17Cyclin-dependent kinase 22.7.11.220.561
1w0xOLOCyclin-dependent kinase 22.7.11.220.561
3rpy27ZCyclin-dependent kinase 22.7.11.220.560
3sw719KCyclin-dependent kinase 22.7.11.220.560
3py0SU9Cyclin-dependent kinase 22.7.11.220.559
4fkg4CKCyclin-dependent kinase 22.7.11.220.559
4fkj11KCyclin-dependent kinase 22.7.11.220.559
4ez30S0Cyclin-dependent kinase 22.7.11.220.558
3ddqRRCCyclin-dependent kinase 22.7.11.220.557
3qzgX67Cyclin-dependent kinase 22.7.11.220.557
3r7yZ04Cyclin-dependent kinase 22.7.11.220.557
2a0cCK9Cyclin-dependent kinase 22.7.11.220.556
2w1hL0FCyclin-dependent kinase 22.7.11.220.556
3ezvEZVCyclin-dependent kinase 22.7.11.220.556
3ddpRC8Cyclin-dependent kinase 22.7.11.220.555
3rk708ZCyclin-dependent kinase 22.7.11.220.555
1ke5LS1Cyclin-dependent kinase 22.7.11.220.554
1pxoCK7Cyclin-dependent kinase 22.7.11.220.554
1oiyN41Cyclin-dependent kinase 22.7.11.220.553
1y91CT9Cyclin-dependent kinase 22.7.11.220.552
3r8zZ63Cyclin-dependent kinase 22.7.11.220.552
1oguST8Cyclin-dependent kinase 22.7.11.220.550
3r1yX76Cyclin-dependent kinase 22.7.11.220.550
3qruX19Cyclin-dependent kinase 22.7.11.220.549
3qtxX43Cyclin-dependent kinase 22.7.11.220.549
3qwjX6ACyclin-dependent kinase 22.7.11.220.549
3raiX85Cyclin-dependent kinase 22.7.11.220.549
3uli1N3Cyclin-dependent kinase 22.7.11.220.549
3fz1B98Cyclin-dependent kinase 22.7.11.220.548
3qziX72Cyclin-dependent kinase 22.7.11.220.548
1oiuN76Cyclin-dependent kinase 22.7.11.220.547
2j9mPY8Cyclin-dependent kinase 22.7.11.220.547
4fks46KCyclin-dependent kinase 22.7.11.220.547
4fx360KCyclin-dependent kinase 22.7.11.220.547
3r7uX96Cyclin-dependent kinase 22.7.11.220.546
1h0w207Cyclin-dependent kinase 22.7.11.220.545
2fvdLIACyclin-dependent kinase 22.7.11.220.544
2vv9IM9Cyclin-dependent kinase 22.7.11.220.544
1dm2HMDCyclin-dependent kinase 22.7.11.220.543
2xnbY8LCyclin-dependent kinase 22.7.11.220.543
3ql8X01Cyclin-dependent kinase 22.7.11.220.543
3r83Z14Cyclin-dependent kinase 22.7.11.220.543
1oiqHDUCyclin-dependent kinase 22.7.11.220.542
3rk909ZCyclin-dependent kinase 22.7.11.220.542
2bhhRYUCyclin-dependent kinase 22.7.11.220.541
2uzoC62Cyclin-dependent kinase 22.7.11.220.541
3ig7EFPCyclin-dependent kinase 22.7.11.220.541
3r1qX75Cyclin-dependent kinase 22.7.11.220.541
3r7eX88Cyclin-dependent kinase 22.7.11.220.541
1vyw292Cyclin-dependent kinase 22.7.11.220.540
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.540
3r71X86Cyclin-dependent kinase 22.7.11.220.540
3ezrEZRCyclin-dependent kinase 22.7.11.220.539
4eor4SPCyclin-dependent kinase 22.7.11.220.539
4nj32KDCyclin-dependent kinase 22.7.11.220.539
3r73X87Cyclin-dependent kinase 22.7.11.220.538
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.536
2vthLZ2Cyclin-dependent kinase 22.7.11.220.535
3rm618ZCyclin-dependent kinase 22.7.11.220.535
1r78FMDCyclin-dependent kinase 22.7.11.220.534
3pj8404Cyclin-dependent kinase 22.7.11.220.533
1aq1STUCyclin-dependent kinase 22.7.11.220.532
4eos1ROCyclin-dependent kinase 22.7.11.220.531
1oirHDYCyclin-dependent kinase 22.7.11.220.530
2c6iDT1Cyclin-dependent kinase 22.7.11.220.530
3r8vZ62Cyclin-dependent kinase 22.7.11.220.529
4eok4SPCyclin-dependent kinase 22.7.11.220.529
1fvt106Cyclin-dependent kinase 22.7.11.220.528
2exmZIPCyclin-dependent kinase 22.7.11.220.527
2x1nX1NCyclin-dependent kinase 22.7.11.220.527
2uznC96Cyclin-dependent kinase 22.7.11.220.526
3r7iX9ICyclin-dependent kinase 22.7.11.220.526
1h0vUN4Cyclin-dependent kinase 22.7.11.220.525
1b38ATPCyclin-dependent kinase 22.7.11.220.524
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.524
3r28XA0Cyclin-dependent kinase 22.7.11.220.524
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.523
4bcpT3CCyclin-dependent kinase 22.7.11.220.522
1gij2PUCyclin-dependent kinase 22.7.11.220.520
1pxkCK3Cyclin-dependent kinase 22.7.11.220.520
2r3iSCFCyclin-dependent kinase 22.7.11.220.520
1e1xNW1Cyclin-dependent kinase 22.7.11.220.518
2r3p3SCCyclin-dependent kinase 22.7.11.220.518
1gii1PUCyclin-dependent kinase 22.7.11.220.517
3qqhX0ACyclin-dependent kinase 22.7.11.220.517
4bcnT9NCyclin-dependent kinase 22.7.11.220.517
1e9hINRCyclin-dependent kinase 22.7.11.220.516
2r3kSCQCyclin-dependent kinase 22.7.11.220.516
1pyePM1Cyclin-dependent kinase 22.7.11.220.515
4eol1ROCyclin-dependent kinase 22.7.11.220.515
4eon1ROCyclin-dependent kinase 22.7.11.220.514
1b39ATPCyclin-dependent kinase 22.7.11.220.513
2bheBRYCyclin-dependent kinase 22.7.11.220.512
3rpo24ZCyclin-dependent kinase 22.7.11.220.512
4bcoT6QCyclin-dependent kinase 22.7.11.220.512
3pxyJWSCyclin-dependent kinase 22.7.11.220.511
2wpa889Cyclin-dependent kinase 22.7.11.220.510
4eop1ROCyclin-dependent kinase 22.7.11.220.510
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.510
1pxpCK8Cyclin-dependent kinase 22.7.11.220.508
2a4lRRCCyclin-dependent kinase 22.7.11.220.508
3qqlX03Cyclin-dependent kinase 22.7.11.220.508
2c5nCK8Cyclin-dependent kinase 22.7.11.220.507
4lyn1YGCyclin-dependent kinase 22.7.11.220.507
1w8cN69Cyclin-dependent kinase 22.7.11.220.506
2r3jSCJCyclin-dependent kinase 22.7.11.220.506
2r3r6SCCyclin-dependent kinase 22.7.11.220.506
4qmpDKISerine/threonine-protein kinase 242.7.11.10.506
1fvv107Cyclin-dependent kinase 22.7.11.220.505
2r3gSC9Cyclin-dependent kinase 22.7.11.220.505
1unlRRCCyclin-dependent-like kinase 52.7.11.10.504
1ykr628Cyclin-dependent kinase 22.7.11.220.504
2wxvWXVCyclin-dependent kinase 22.7.11.220.504
2vtqLZACyclin-dependent kinase 22.7.11.220.502
2vu3LZECyclin-dependent kinase 22.7.11.220.501
3be9P04Casein kinase II subunit alpha2.7.11.10.501
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.501
1h1q2A6Cyclin-dependent kinase 22.7.11.220.500
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.500
2wihP48Cyclin-dependent kinase 22.7.11.220.500
3qx2X63Cyclin-dependent kinase 22.7.11.220.500
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.499
3axwTIDCasein kinase II subunit alpha2.7.11.10.499
3qrtX14Cyclin-dependent kinase 22.7.11.220.499
3tiz3TICyclin-dependent kinase 22.7.11.220.499
2eufLQQCyclin-dependent kinase 62.7.11.220.498
2r3mSCXCyclin-dependent kinase 22.7.11.220.498
2uzeC95Cyclin-dependent kinase 22.7.11.220.497
1h1pCMGCyclin-dependent kinase 22.7.11.220.496
3rkb12ZCyclin-dependent kinase 22.7.11.220.496
4bcmT7ZCyclin-dependent kinase 22.7.11.220.496
5aniES4Cyclin-dependent kinase 22.7.11.220.495
2c5yMTWCyclin-dependent kinase 22.7.11.220.494
3bhtMFRCyclin-dependent kinase 22.7.11.220.494
2pvnP63Casein kinase II subunit alpha2.7.11.10.492
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.492
4dgo0JWCasein kinase II subunit alpha2.7.11.10.492
3qx4X4BCyclin-dependent kinase 22.7.11.220.491
2vtsLZCCyclin-dependent kinase 22.7.11.220.490
2vttLZDCyclin-dependent kinase 22.7.11.220.490
4fklCK2Cyclin-dependent kinase 22.7.11.220.490
2c6kDT2Cyclin-dependent kinase 22.7.11.220.489
2r3o2SCCyclin-dependent kinase 22.7.11.220.489
3r8pZ46Cyclin-dependent kinase 22.7.11.220.488
3qtqX35Cyclin-dependent kinase 22.7.11.220.487
4eoi1ROCyclin-dependent kinase 22.7.11.220.487
4eomATPCyclin-dependent kinase 22.7.11.220.487
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.487
1pkdUCNCyclin-dependent kinase 22.7.11.220.486
2uzbC75Cyclin-dependent kinase 22.7.11.220.486
3qtwX3ACyclin-dependent kinase 22.7.11.220.486
3tnwF18Cyclin-dependent kinase 22.7.11.220.485
3lfqA28Cyclin-dependent kinase 22.7.11.220.483
2c6tDT5Cyclin-dependent kinase 22.7.11.220.482
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.482
1qmzATPCyclin-dependent kinase 22.7.11.220.481
3dogNNNCyclin-dependent kinase 22.7.11.220.481
4cfnJYMCyclin-dependent kinase 22.7.11.220.481
1pxlCK4Cyclin-dependent kinase 22.7.11.220.480
2b53D23Cyclin-dependent kinase 22.7.11.220.479
2pvlP55Casein kinase II subunit alpha2.7.11.10.478
3rzb02ZCyclin-dependent kinase 22.7.11.220.478
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.478
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.476
4dgnLU2Casein kinase II subunit alpha2.7.11.10.476
1xjdSTUProtein kinase C theta type2.7.11.130.475
3gxlQIGTGF-beta receptor type-12.7.11.300.475
3rahO1ZCyclin-dependent kinase 22.7.11.220.475
3s00Z60Cyclin-dependent kinase 22.7.11.220.475
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.475
2cchATPCyclin-dependent kinase 22.7.11.220.474
2i40BLZCyclin-dependent kinase 22.7.11.220.474
2uzdC85Cyclin-dependent kinase 22.7.11.220.473
3my5RFZCyclin-dependent kinase 22.7.11.220.473
3wblPDYCyclin-dependent kinase 22.7.11.220.473
3qzfX66Cyclin-dependent kinase 22.7.11.220.472
4bcqTJFCyclin-dependent kinase 22.7.11.220.472
2c6lDT4Cyclin-dependent kinase 22.7.11.220.471
3ggfGVDSerine/threonine-protein kinase 26/0.470
4aua4AUCyclin-dependent kinase 62.7.11.220.470
4gub0Y4Casein kinase II subunit alpha2.7.11.10.470
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.469
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.469
2wotZZGTGF-beta receptor type-12.7.11.300.467
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.467
4kd11QKCyclin-dependent kinase 22.7.11.220.467
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.467
4anmWULCasein kinase II subunit alpha2.7.11.10.466
2c6mDT5Cyclin-dependent kinase 22.7.11.220.465
2uzlC94Cyclin-dependent kinase 22.7.11.220.464
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.464
1y8yCT7Cyclin-dependent kinase 22.7.11.220.463
3sheI85MAP kinase-activated protein kinase 32.7.11.10.462
4jqeANPCasein kinase II subunit alpha2.7.11.10.462
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.462
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.461
1v0pPVBCell division control protein 2 homolog2.7.11.220.460
2c4g514Cyclin-dependent kinase 22.7.11.220.460
2c69CT8Cyclin-dependent kinase 22.7.11.220.460
4ii5ADPCyclin-dependent kinase 22.7.11.220.459
1eh4IC1Casein kinase I homolog 12.7.11.10.458
1finATPCyclin-dependent kinase 22.7.11.220.458
2r3fSC8Cyclin-dependent kinase 22.7.11.220.458
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.456
1unhIXMCyclin-dependent-like kinase 52.7.11.10.455
3lq5SLQCyclin-dependent kinase 92.7.11.220.454
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.454
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
3bheBZNGag-Pol polyprotein3.4.23.160.453
1lp4ANPCasein kinase II subunit alpha2.7.11.10.452
2b54D05Cyclin-dependent kinase 22.7.11.220.452
3r9nZ68Cyclin-dependent kinase 22.7.11.220.452
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.452
3nga3NGCasein kinase II subunit alpha2.7.11.10.451
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.451
1xo2FSECyclin-dependent kinase 62.7.11.220.449
3nux3NVCyclin-dependent kinase 62.7.11.220.449
2bkzSBCCyclin-dependent kinase 22.7.11.220.448
2zjwREFCasein kinase II subunit alpha2.7.11.10.448
3mtfA3FActivin receptor type-12.7.11.300.448
3q43D66M1 family aminopeptidase3.4.110.448
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
1vjy460TGF-beta receptor type-12.7.11.300.447
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.447
5cshATPCasein kinase II subunit alpha2.7.11.10.447
2pmlANPUncharacterized protein/0.446
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.446
2wipP49Cyclin-dependent kinase 22.7.11.220.446
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.446
4bgg844Activin receptor type-12.7.11.300.446
4c61LMMTyrosine-protein kinase JAK2/0.446
4dgmAGICasein kinase II subunit alpha2.7.11.10.446
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.445
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.445
1dawANPCasein kinase II subunit alpha2.7.11.10.443
1om1IQACasein kinase II subunit alpha2.7.11.10.443
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.443
5dr6SKEAurora kinase A2.7.11.10.443
1v0oINRCell division control protein 2 homolog2.7.11.220.442
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.442
3u4uLNHCasein kinase II subunit alpha2.7.11.10.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
1e1vCMGCyclin-dependent kinase 22.7.11.220.441
3at3ATKCasein kinase II subunit alpha2.7.11.10.441
3at4CCKCasein kinase II subunit alpha2.7.11.10.441
3fwgCAMCamphor 5-monooxygenase1.14.15.10.441
3uzp0CKCasein kinase I isoform delta2.7.11.10.441
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.441
1m2qMNXCasein kinase II subunit alpha2.7.11.10.440
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
4i22IREEpidermal growth factor receptor2.7.10.10.440