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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.11.000
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.600
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.597
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.588
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.584
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.583
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.575
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.574
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.573
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.569
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.564
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.557
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.557
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.552
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.552
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.549
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.547
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.543
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.539
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.537
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.536
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.533
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.532
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.530
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.528
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.526
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.525
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.524
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.523
3umw596Serine/threonine-protein kinase pim-12.7.11.10.522
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.521
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.519
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.519
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.517
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.517
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.516
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.516
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.515
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.515
5av2KMPDeath-associated protein kinase 12.7.11.10.515
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.512
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.511
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.510
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.510
2ckeIQUDeath-associated protein kinase 2/0.508
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.508
3q9xEMOCasein kinase II subunit alpha2.7.11.10.507
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.506
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.506
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.502
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.502
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.502
3bqr4RBDeath-associated protein kinase 3/0.500
2pvlP55Casein kinase II subunit alpha2.7.11.10.499
4i22IREEpidermal growth factor receptor2.7.10.10.499
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.499
5av3KMPDeath-associated protein kinase 12.7.11.10.499
1jklANPDeath-associated protein kinase 12.7.11.10.498
3at4CCKCasein kinase II subunit alpha2.7.11.10.498
3mtfA3FActivin receptor type-12.7.11.300.495
3u4uLNHCasein kinase II subunit alpha2.7.11.10.495
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.493
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.492
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.492
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.491
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.489
2yaaATPDeath-associated protein kinase 2/0.489
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.489
4bgg844Activin receptor type-12.7.11.300.489
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.488
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.487
4dymIYZActivin receptor type-12.7.11.300.487
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.486
5cvfATPCasein kinase II subunit alpha2.7.11.10.485
1xjdSTUProtein kinase C theta type2.7.11.130.484
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.484
3lltANPProtein serine/threonine kinase-1/0.484
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.484
4grb0XGCasein kinase II subunit alpha2.7.11.10.484
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.483
2vu3LZECyclin-dependent kinase 22.7.11.220.483
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.483
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.483
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.482
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.481
3w2sW2REpidermal growth factor receptor2.7.10.10.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.481
1wvxBD4Death-associated protein kinase 12.7.11.10.480
3be9P04Casein kinase II subunit alpha2.7.11.10.480
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.479
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.479
4kbk1QGCasein kinase I isoform delta2.7.11.10.479
4dgnLU2Casein kinase II subunit alpha2.7.11.10.477
4anmWULCasein kinase II subunit alpha2.7.11.10.476
2pvhP19Casein kinase II subunit alpha2.7.11.10.475
4o0wADNAurora kinase A2.7.11.10.475
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.474
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.474
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.474
3uyt0CKCasein kinase I isoform delta2.7.11.10.474
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.474
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.474
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.473
4xlvACPInsulin receptor2.7.10.10.473
2wihP48Cyclin-dependent kinase 22.7.11.220.472
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.472
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4j95ACPFibroblast growth factor receptor 2/0.472
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.471
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.471
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
5auwQUEDeath-associated protein kinase 12.7.11.10.471
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.470
3i60E86Mitogen-activated protein kinase 12.7.11.240.469
3w33W19Epidermal growth factor receptor2.7.10.10.469
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.468
2uzbC75Cyclin-dependent kinase 22.7.11.220.468
2hog710Serine/threonine-protein kinase Chk12.7.11.10.467
3nux3NVCyclin-dependent kinase 62.7.11.220.467
4bbe3O4Tyrosine-protein kinase JAK2/0.467
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.467
4erwSTUCyclin-dependent kinase 22.7.11.220.467
3sheI85MAP kinase-activated protein kinase 32.7.11.10.466
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.466
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.465
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.465
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.465
4j99ACPFibroblast growth factor receptor 2/0.465
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.464
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.463
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
1aq1STUCyclin-dependent kinase 22.7.11.220.462
2ijmADPFocal adhesion kinase 12.7.10.20.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.462
4ix6ADPUncharacterized protein/0.462
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.461
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.461
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.461
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.461
3axwTIDCasein kinase II subunit alpha2.7.11.10.461
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
3js2VM1Fibroblast growth factor receptor 1/0.461
1h1s4SPCyclin-dependent kinase 22.7.11.220.460
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.460
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.460
4fv9E71Mitogen-activated protein kinase 12.7.11.240.460
4jia1K3Tyrosine-protein kinase JAK2/0.460
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.460
1fvv107Cyclin-dependent kinase 22.7.11.220.459
2vv9IM9Cyclin-dependent kinase 22.7.11.220.459
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.459
3gubGUBDeath-associated protein kinase 12.7.11.10.459
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.459
4dtaADNAPH(2'')-Id/0.459
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2w17I19Cyclin-dependent kinase 22.7.11.220.458
3pe2E1BCasein kinase II subunit alpha2.7.11.10.458
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.457
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.457
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.456
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.456
2iw84SPCyclin-dependent kinase 22.7.11.220.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.456
2h96893Mitogen-activated protein kinase 82.7.11.240.455
3emg685Tyrosine-protein kinase SYK2.7.10.20.455
4btjATPTau-tubulin kinase 12.7.11.10.455
4e730NRMitogen-activated protein kinase 82.7.11.240.455
2cchATPCyclin-dependent kinase 22.7.11.220.454
3iw4LW4Protein kinase C alpha type2.7.11.130.454
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.454
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.454
1eh4IC1Casein kinase I homolog 12.7.11.10.453
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.453
3bu5ATPInsulin receptor2.7.10.10.453
3my5RFZCyclin-dependent kinase 22.7.11.220.453
3rak03ZCyclin-dependent kinase 22.7.11.220.453
4dgmAGICasein kinase II subunit alpha2.7.11.10.453
4fob0USALK tyrosine kinase receptor2.7.10.10.453
4hvh19RTyrosine-protein kinase JAK32.7.10.20.453
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.452
2c5nCK8Cyclin-dependent kinase 22.7.11.220.452
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.452
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.452
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.452
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.452
4hni16WCasein kinase I isoform epsilon2.7.11.10.452
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.451
2fvdLIACyclin-dependent kinase 22.7.11.220.451
2itpAEEEpidermal growth factor receptor2.7.10.10.451
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.451
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.451
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.451
1om1IQACasein kinase II subunit alpha2.7.11.10.450
2pvnP63Casein kinase II subunit alpha2.7.11.10.450
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.450
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.450
4qmzB49Serine/threonine-protein kinase 242.7.11.10.450
1oirHDYCyclin-dependent kinase 22.7.11.220.449
1zys199Serine/threonine-protein kinase Chk12.7.11.10.449
2j0m4STFocal adhesion kinase 12.7.10.20.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.449
4b99R4LMitogen-activated protein kinase 72.7.11.240.449
4c02TAKActivin receptor type-12.7.11.300.449
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.449
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.449
4ii5ADPCyclin-dependent kinase 22.7.11.220.449
4jboWPHAurora kinase A2.7.11.10.449
5auvAGIDeath-associated protein kinase 12.7.11.10.449
2pvmP29Casein kinase II subunit alpha2.7.11.10.448
2w05FRTCyclin-dependent kinase 22.7.11.220.448
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.448
3gu83GUDeath-associated protein kinase 12.7.11.10.448
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.448
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.448
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.447
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.447
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3s2pPMUCyclin-dependent kinase 22.7.11.220.447
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.447
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.447
4hge15VTyrosine-protein kinase JAK2/0.447
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.447
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.446
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.446
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.446
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.446
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.446
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.446
4g1wG1WMitogen-activated protein kinase 82.7.11.240.446
4hvi19STyrosine-protein kinase JAK32.7.10.20.446
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.446
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.446
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.446
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.445
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.445
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.445
2xvdAS6Ephrin type-B receptor 42.7.10.10.445
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3igoANPCalmodulin-domain protein kinase 1, putative/0.445
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.445
3qxpX64Cyclin-dependent kinase 22.7.11.220.445
4fv6E57Mitogen-activated protein kinase 12.7.11.240.445
5f0a1FBcGMP-dependent protein kinase, putative/0.445
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.444
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.444
3ormAGSSerine/threonine protein kinase/0.444
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.444
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.444
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.444
4eooATPCyclin-dependent kinase 22.7.11.220.444
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.444
4jrvKJVEpidermal growth factor receptor2.7.10.10.444
1u54ACPActivated CDC42 kinase 1/0.443
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.443
4f650S9Fibroblast growth factor receptor 1/0.443
4gmy0X5Tyrosine-protein kinase JAK2/0.443
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.443
5auuLU2Death-associated protein kinase 12.7.11.10.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.442
3ezvEZVCyclin-dependent kinase 22.7.11.220.442
3fskRO6Mitogen-activated protein kinase 14/0.442
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3s1h56ZCyclin-dependent kinase 22.7.11.220.442
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.442
4c4f7CEDual specificity protein kinase TTK2.7.12.10.442
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.442
4j98ACPFibroblast growth factor receptor 2/0.442
4q5hANPProtein kinase OspG2.70.442
1e9hINRCyclin-dependent kinase 22.7.11.220.441
1m17AQ4Epidermal growth factor receptor2.7.10.10.441
2bujSTUSerine/threonine-protein kinase 16/0.441
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.441
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3du8553Glycogen synthase kinase-3 beta2.7.11.260.441
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.441
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.441
4eok4SPCyclin-dependent kinase 22.7.11.220.441
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.440
4qmySTUSerine/threonine-protein kinase 242.7.11.10.440