sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3f68 | 91U | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 1.000 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.716 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.712 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.699 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.688 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.685 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.683 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.683 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.662 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.661 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.660 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.652 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.646 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.637 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.634 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.632 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.630 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.623 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.621 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.619 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.617 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.613 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.610 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.609 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.606 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.605 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.599 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.593 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.592 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.591 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.591 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.590 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.590 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.583 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.581 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.581 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.580 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.579 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.578 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.578 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.576 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.575 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.571 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.569 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.569 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.569 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.566 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.565 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.565 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.563 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.562 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.560 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.559 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.555 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.553 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.551 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.550 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.549 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.549 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.548 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.547 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.547 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.545 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.542 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.542 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.541 | |
| 4fuf | 8UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.541 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.540 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.540 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.539 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.538 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.538 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.537 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.536 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.535 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.535 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.534 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.533 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.528 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.527 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.526 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.525 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.525 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.524 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.523 | |
| 1nt1 | T76 | Prothrombin | 3.4.21.5 | 0.522 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.522 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.515 | |
| 2e1m | FAD | L-glutamate oxidase | / | 0.510 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.508 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.508 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.508 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.506 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.506 | |
| 1owk | 303 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.503 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.503 | |
| 1sl3 | 170 | Prothrombin | 3.4.21.5 | 0.501 | |
| 4fub | 4UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.501 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.497 | |
| 2c4f | GIL | Coagulation factor VII | 3.4.21.21 | 0.493 | |
| 4l7v | SAH | Protein-L-isoaspartate O-methyltransferase | / | 0.493 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.491 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.490 | |
| 1owd | 497 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.487 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.487 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.487 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.486 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.485 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.484 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.484 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.483 | |
| 3lbn | GNP | GTPase HRas | / | 0.483 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.483 | |
| 1owi | 426 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.482 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.481 | |
| 3a6q | FMN | FMN-binding protein | / | 0.481 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.481 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.481 | |
| 2j08 | IRF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.479 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.479 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.478 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.478 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.476 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.475 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.475 | |
| 4fui | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.475 | |
| 2y5h | Y5H | Coagulation factor X | 3.4.21.6 | 0.474 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.474 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.474 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.473 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.473 | |
| 1f92 | UKP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.472 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.472 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.472 | |
| 2avi | BTN | Avidin | / | 0.471 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.471 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.471 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.471 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.470 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.470 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 | 0.470 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.469 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.469 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.469 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.468 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.468 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.467 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.467 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.467 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.466 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.466 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.465 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.465 | |
| 4e2d | FMN | Dehydrogenase | / | 0.465 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.464 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.464 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.464 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.463 | |
| 4btt | VYR | Coagulation factor X | 3.4.21.6 | 0.463 | |
| 4e32 | DWN | Methyltransferase | / | 0.463 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.462 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.462 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.462 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.462 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.462 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.462 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.461 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.460 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.460 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.460 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.460 | |
| 3v2u | ATP | Protein GAL3 | / | 0.460 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2zp0 | PI0 | Coagulation factor VII | 3.4.21.21 | 0.459 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.458 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.458 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.458 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.458 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2cji | GSK | Coagulation factor X | 3.4.21.6 | 0.457 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.457 | |
| 3sor | O58 | Coagulation factor XI | 3.4.21.27 | 0.457 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.457 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.456 | |
| 1k8c | NAP | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.456 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.456 | |
| 1wqv | PSM | Coagulation factor VII | 3.4.21.21 | 0.456 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.456 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.455 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 1u6q | 745 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.454 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.454 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.454 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.454 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.454 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.454 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.454 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3ppr | 4CS | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.454 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.454 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.454 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.454 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.454 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.454 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.453 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.453 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.453 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.453 | |
| 4h6p | FMN | Chromate reductase | / | 0.453 | |
| 4jic | FMN | GTN Reductase | / | 0.453 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.453 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.452 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.452 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.452 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.452 | |
| 3kqb | LGJ | Coagulation factor X | 3.4.21.6 | 0.452 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.451 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.451 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.451 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.451 | |
| 3wag | TYD | Glycosyltransferase | / | 0.451 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.451 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.450 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.450 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.450 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.450 | |
| 2vo0 | M03 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3e8x | NAP | BH1520 protein | / | 0.450 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.450 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.450 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.450 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.450 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.450 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.450 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.449 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.449 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.449 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.449 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.449 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.449 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.449 | |
| 4blr | UTP | NTPase P4 | / | 0.449 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4fud | 6UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.449 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.448 | |
| 1iqh | XMF | Coagulation factor X | 3.4.21.6 | 0.448 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.448 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.448 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2i9k | SAH | Modification methylase HhaI | 2.1.1.37 | 0.448 | |
| 2xjc | 5GP | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.448 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.448 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.448 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.447 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.447 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.447 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.446 | |
| 1wtg | 3BP | Coagulation factor VII | 3.4.21.21 | 0.446 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.446 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.446 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.446 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.446 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 2ydx | STL | Methionine adenosyltransferase 2 subunit beta | / | 0.446 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.446 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.446 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.446 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.446 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.446 | |
| 4bti | 7R9 | Coagulation factor X | 3.4.21.6 | 0.446 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.446 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2bbw | GP5 | Adenylate kinase 4, mitochondrial | / | 0.445 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.445 | |
| 2y5g | FJD | Coagulation factor X | 3.4.21.6 | 0.445 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.445 | |
| 3pld | F90 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 3ppo | DCK | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.445 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.445 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.445 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.445 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.444 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.444 | |
| 2x96 | RX3 | Angiotensin-converting enzyme | 3.4.15.1 | 0.444 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.444 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.444 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.444 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4l4x | NDP | AmphI | / | 0.444 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.443 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.443 | |
| 1iqe | XMB | Coagulation factor X | 3.4.21.6 | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.443 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.443 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.443 | |
| 2y82 | 930 | Coagulation factor X | 3.4.21.6 | 0.443 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.443 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.443 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.443 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 4hyv | PEP | Pyruvate kinase 1 | 2.7.1.40 | 0.443 | |
| 5c4c | UPG | Histo-blood group ABO system transferase | / | 0.443 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.443 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.442 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.442 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.442 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.442 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.442 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.442 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3gf4 | U5P | UDP-galactopyranose mutase | 5.4.99.9 | 0.442 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.442 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.442 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.442 | |
| 4ys2 | 2BA | Uncharacterized protein | / | 0.442 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.441 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.441 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.441 | |
| 3f8w | ADN | Purine nucleoside phosphorylase | / | 0.441 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.441 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.441 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.441 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.441 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.441 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1q6i | FK5 | FKBP-type peptidyl-prolyl cis-trans isomerase FkpA | 5.2.1.8 | 0.440 | |
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.440 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.440 | |
| 2cwf | NDP | Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase | / | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.440 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2xbx | RR8 | Coagulation factor X | 3.4.21.6 | 0.440 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.440 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.440 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.440 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.440 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.440 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 4rel | KMP | Glycosyltransferase | / | 0.440 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.440 |