sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3evj | NTO | Antithrombin-III |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3evj | NTO | Antithrombin-III | / | 1.000 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.507 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.500 | |
| 4apu | A2K | Progesterone receptor | / | 0.499 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.495 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.494 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.490 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.486 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.483 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.482 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.480 | |
| 2fr3 | REA | Cellular retinoic acid-binding protein 2 | / | 0.480 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.480 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.480 | |
| 3eku | CY9 | Actin-5C | / | 0.480 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.479 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.479 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.479 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.479 | |
| 5efw | FMN | NPH1-1 | / | 0.479 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.476 | |
| 2pnu | ENM | Androgen receptor | / | 0.476 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.474 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.474 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.471 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.471 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.471 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.471 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.470 | |
| 3u2l | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.470 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.470 | |
| 4fvr | ATP | Tyrosine-protein kinase JAK2 | / | 0.470 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.470 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.469 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.469 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.469 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.468 | |
| 3dsr | ADP | V-type ATP synthase beta chain | / | 0.468 | |
| 1swt | BTN | Streptavidin | / | 0.467 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.467 | |
| 4o8j | ADN | RNA 3'-terminal phosphate cyclase | 6.5.1.4 | 0.467 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.466 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.466 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.466 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.466 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.466 | |
| 4y9x | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.466 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.465 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.465 | |
| 2pda | TPP | Pyruvate synthase | / | 0.465 | |
| 3f10 | 8HG | 8-oxoguanine-DNA-glycosylase | / | 0.465 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 3g1l | RF2 | HTH-type transcriptional regulator EthR | / | 0.464 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.464 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.464 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.464 | |
| 1g28 | FMN | PHY3 | / | 0.463 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.463 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.463 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.463 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.463 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.462 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.462 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.462 | |
| 4e0h | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.462 | |
| 4egn | TWO | Cytochrome P450 | / | 0.462 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.461 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.461 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.461 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.461 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.461 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.461 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.460 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.460 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.460 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.460 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.460 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.460 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.460 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.460 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.460 | |
| 1zdw | FLV | Prenyltransferase | / | 0.459 | |
| 3da1 | FAD | Glycerol-3-phosphate dehydrogenase | / | 0.459 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.459 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.459 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.458 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.458 | |
| 1req | DCA | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.458 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.458 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.458 | |
| 2vos | ADP | Folylpolyglutamate synthase | / | 0.458 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.458 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.458 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.458 | |
| 3qvw | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.458 | |
| 4cer | VL4 | Integrase | / | 0.458 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.458 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.458 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.457 | |
| 1e7a | PFL | Serum albumin | / | 0.457 | |
| 1g7v | PAI | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.457 | |
| 1z0f | GDP | Ras-related protein Rab-14 | / | 0.457 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.457 | |
| 5dp2 | NAP | CurF | / | 0.457 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.457 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.456 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ced | 9NS | Integrase | / | 0.456 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.456 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.456 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.456 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.456 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.455 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.455 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2wpw | ACO | Orf14 | / | 0.455 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.455 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.454 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.454 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.454 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3b1j | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.454 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.454 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.454 | |
| 4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.454 | |
| 1b4p | GPS | Glutathione S-transferase Mu 2 | / | 0.453 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.453 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.453 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.453 | |
| 1p4a | PCP | Pur operon repressor | / | 0.453 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.453 | |
| 3kvx | FMY | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.453 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.453 | |
| 3tk0 | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.453 | |
| 4co4 | ATP | Nitrogen regulatory protein P-II 1 | / | 0.453 | |
| 4ok1 | 198 | Androgen receptor | / | 0.453 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.453 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.452 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.452 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.452 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.452 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.452 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.452 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.452 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.452 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.452 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4ldk | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.452 | |
| 4n1g | CEI | Obelin | / | 0.452 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.452 | |
| 1cjw | COT | Serotonin N-acetyltransferase | / | 0.451 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 3g1o | RF1 | HTH-type transcriptional regulator EthR | / | 0.451 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3t19 | 5MA | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4ceq | QCH | Integrase | / | 0.451 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.451 | |
| 5agy | GTB | Tau class glutathione S-transferase | / | 0.451 | |
| 5i4n | ATP | Tyrosine-protein kinase JAK2 | / | 0.451 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.450 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.450 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.450 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.450 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.450 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.450 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.450 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.450 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.450 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.450 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.450 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.450 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.450 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.450 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.450 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.449 | |
| 2ejz | SAH | Diphthine synthase | / | 0.449 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.449 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 3hpq | AP5 | Adenylate kinase | / | 0.449 | |
| 3nhy | A7B | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.449 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.448 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.448 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 2e82 | IM3 | D-amino-acid oxidase | 1.4.3.3 | 0.448 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.448 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2z6i | FMN | 2-nitropropane dioxygenase | / | 0.448 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.448 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 4ees | FMN | Phototropin-2 | 2.7.11.1 | 0.448 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.448 | |
| 5il1 | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.448 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.447 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.447 | |
| 1efp | FAD | Electron transfer flavoprotein subunit alpha | / | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qay | MEV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.447 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4ag5 | ADP | Type IV secretory pathway VirB4 components-like protein | / | 0.447 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 4mfp | COA | Uncharacterized protein | / | 0.447 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.447 | |
| 4xoo | FMN | Coenzyme F420:L-glutamate ligase | / | 0.447 | |
| 5djt | FMN | NPH1-2 | / | 0.447 | |
| 5xra | CLR | Cannabinoid receptor 1 | / | 0.447 | |
| 1njc | DCM | Thymidylate synthase | / | 0.446 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.446 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.446 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.446 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.446 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.446 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.446 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.446 | |
| 4h0y | LAR | Actin, alpha skeletal muscle | / | 0.446 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 4xvu | ATP | ATPase GET3 | / | 0.446 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.445 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.445 | |
| 1e79 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 1e79 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.445 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.445 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.445 | |
| 3d2m | COA | Amino-acid acetyltransferase | / | 0.445 | |
| 3d45 | GDP | Poly(A)-specific ribonuclease PARN | 3.1.13.4 | 0.445 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.445 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.445 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.445 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4hxy | NDP | Plm1 | / | 0.445 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.445 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 5ans | RX8 | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.445 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 1g7u | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.444 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.444 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.444 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2gj3 | FAD | Nitrogen fixation regulatory protein | 2.7.13.3 | 0.444 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.444 | |
| 2owv | SAH | Diphthine synthase | / | 0.444 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3f88 | 3HT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.444 | |
| 3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 3rw9 | DSH | Spermidine synthase | 2.5.1.16 | 0.444 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.444 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.444 | |
| 4nyw | 2O3 | CREB-binding protein | / | 0.444 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.444 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.444 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.444 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.443 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.443 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.443 | |
| 2a8s | GTP | U8 snoRNA-decapping enzyme | / | 0.443 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.443 | |
| 2q5q | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.443 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 3b9l | AZZ | Serum albumin | / | 0.443 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.443 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.443 | |
| 3gag | FMN | Putative NADH dehydrogenase NAD(P)H nitroreductase | / | 0.443 | |
| 3gob | HXX | DdmC | / | 0.443 | |
| 3hav | ATP | Aminoglycoside phosphotransferase | / | 0.443 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.443 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.443 | |
| 4a2b | AGS | Cell division protein FtsA | / | 0.443 | |
| 4cfb | OM3 | Integrase | / | 0.443 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.443 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4nu0 | AP5 | Adenylate kinase | / | 0.443 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.443 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.443 | |
| 5hgc | HCY | Uncharacterized protein | / | 0.443 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.443 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.442 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2v1a | FMN | NPH1-1 | / | 0.442 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.442 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 3anm | SYD | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.442 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.442 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3znp | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.442 | |
| 4a0z | MLC | Transcription factor FapR | / | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4kwh | NAP | Reductase homolog | / | 0.442 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.442 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.441 | |
| 1tys | DHF | Thymidylate synthase | / | 0.441 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.441 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 2bxm | IMN | Serum albumin | / | 0.441 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.441 | |
| 2fto | TMP | Thymidylate synthase | / | 0.441 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2ozr | GG1 | Collagenase 3 | 3.4.24 | 0.441 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 2wge | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.441 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.441 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.441 | |
| 3bnk | FMN | Flavoredoxin | / | 0.441 | |
| 3g51 | ANP | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.441 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.441 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.441 | |
| 3q9z | TXQ | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.441 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4h80 | 04T | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.441 | |
| 4s34 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.441 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.441 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.441 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.440 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.440 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.440 | |
| 2nnl | ERD | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.440 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.440 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2z2d | HSI | Macrophage metalloelastase | 3.4.24.65 | 0.440 | |
| 3r4b | 74T | Gag-Pol polyprotein | / | 0.440 | |
| 3rsr | N5P | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.440 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.440 | |
| 3up3 | XCA | aceDAF-12 | / | 0.440 | |
| 3zqt | TES | Androgen receptor | / | 0.440 | |
| 4cj3 | E4F | Integrase | / | 0.440 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.440 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 4ovi | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.440 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.440 |