sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2iyi | FMN | AppA, antirepressor of ppsR, sensor of blue light |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2iyi | FMN | AppA, antirepressor of ppsR, sensor of blue light | / | 1.000 | |
| 4hh0 | FMN | AppA protein | / | 0.609 | |
| 1yrx | FMN | AppA protein | / | 0.605 | |
| 2iyg | FMN | AppA, antirepressor of ppsR, sensor of blue light | / | 0.529 | |
| 1x0p | FAD | Tll0078 protein | / | 0.523 | |
| 4yus | FMN | Family 3 adenylate cyclase | / | 0.515 | |
| 3gfx | FMN | Uncharacterized protein | / | 0.497 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.495 | |
| 2byc | FMN | Blue-light receptor of the BLUF-family | / | 0.495 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.492 | |
| 3gfz | FMN | Uncharacterized protein | / | 0.491 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.491 | |
| 3eyh | IZA | Tyrosine-protein kinase JAK1 | / | 0.489 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.485 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.484 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.484 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.483 | |
| 3gg0 | FMN | Uncharacterized protein | / | 0.482 | |
| 2pv7 | NAD | T-protein | 1.3.1.12 | 0.481 | |
| 2wti | WTI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.480 | |
| 2ycr | HCW | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.480 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 4aw1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.479 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.479 | |
| 4yut | FMN | Family 3 adenylate cyclase | / | 0.479 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.479 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.477 | |
| 4a9r | RU5 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.477 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 2euf | LQQ | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.476 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.476 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.476 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.475 | |
| 3gfy | FMN | Uncharacterized protein | / | 0.475 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.474 | |
| 2yex | YEX | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.474 | |
| 3qcy | 3Q3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.474 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.473 | |
| 3gg1 | FMN | Uncharacterized protein | / | 0.473 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.473 | |
| 3w55 | 1FM | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.473 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.472 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2wmr | ZYR | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.470 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3r6x | X84 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.470 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.470 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.470 | |
| 4ek8 | 16K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 3qih | FG7 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.468 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.468 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.468 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.467 | |
| 1yqy | 915 | Lethal factor | 3.4.24.83 | 0.467 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.466 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.466 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.466 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.465 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.465 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.465 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.464 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.464 | |
| 4fsy | HK7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 1pxl | CK4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4iva | 1J5 | Tyrosine-protein kinase JAK2 | / | 0.463 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.463 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.463 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.462 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.462 | |
| 3t4s | H35 | Histidine kinase 4 | 2.7.13.3 | 0.462 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.462 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.462 | |
| 1b38 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 1u30 | GOX | Pancreatic alpha-amylase | / | 0.461 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.461 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.461 | |
| 4bdg | P3J | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.461 | |
| 5f0a | 1FB | cGMP-dependent protein kinase, putative | / | 0.461 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.460 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.459 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 2vtp | LZ9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.459 | |
| 3nbw | TR4 | Ketohexokinase | / | 0.459 | |
| 3nlb | 5BE | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 4bdd | Z0O | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.459 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.459 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 4fyo | 0VF | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.459 | |
| 4u7w | NDP | MxaA | / | 0.459 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2c5y | MTW | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.457 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.457 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.457 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.457 | |
| 2wmt | ZYT | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3r1y | X76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.457 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.457 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.457 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1y7u | COA | Acyl-CoA hydrolase | / | 0.456 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.456 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3r8v | Z62 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4fto | 3HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 1ydr | IQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.455 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.455 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 3qqh | X0A | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4a9u | A9U | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.455 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.455 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 1s4e | ADP | Galactokinase | / | 0.454 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.454 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 3amf | FMN | FMN-binding protein | / | 0.454 | |
| 3nta | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.454 | |
| 3qih | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.454 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.454 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 2pe0 | 39Z | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 3qqg | X06 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.453 | |
| 4ft3 | H1K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2ojf | 4PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2xmy | CDK | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4a9s | RU9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.452 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.452 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.452 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.452 | |
| 1nf7 | RVP | Inosine-5'-monophosphate dehydrogenase 2 | / | 0.451 | |
| 2a0c | CK9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.451 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.451 | |
| 4fkj | 11K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4fst | HK4 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4l4x | NDP | AmphI | / | 0.451 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.450 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.450 | |
| 2nnp | ROC | Protease | / | 0.450 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3evb | SAH | Genome polyprotein | 2.1.1.56 | 0.450 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.450 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 1mrx | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.449 | |
| 2r5t | ANP | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.449 | |
| 3bv3 | P39 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3pvu | QRW | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.449 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4fks | 46K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.449 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.449 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.449 | |
| 2ahc | VNL | Chorismate pyruvate-lyase | / | 0.448 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.448 | |
| 2v8p | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
| 2vti | LZ3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.448 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.448 | |
| 3p0h | FSE | Putative tyrosyl-tRNA synthetase | / | 0.448 | |
| 3qcq | 3Q0 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.448 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.448 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.448 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.448 | |
| 4fx3 | 60K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1unh | IXM | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.447 | |
| 1wlk | FMN | FMN-binding protein | / | 0.447 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.447 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3rk1 | ATP | N-type ATP pyrophosphatase superfamily | / | 0.447 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3unk | 0BY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 4xhg | ADP | Uncharacterized protein | / | 0.447 | |
| 5ca0 | ACP | Tubulin tyrosine ligase | / | 0.447 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.446 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.446 | |
| 2c6t | DT5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.446 | |
| 2pml | ANP | Uncharacterized protein | / | 0.446 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2ydk | YDK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.446 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.446 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.446 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.446 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.446 | |
| 4k77 | 1Q4 | Tyrosine-protein kinase JAK1 | / | 0.446 | |
| 4ozn | ATP | Ammonium transporter | / | 0.446 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.446 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1c70 | L75 | Protease | / | 0.445 | |
| 1efp | FAD | Electron transfer flavoprotein subunit alpha | / | 0.445 | |
| 1k2c | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.445 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.445 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.445 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.445 | |
| 3py0 | SU9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3spt | UD1 | Bifunctional protein GlmU | / | 0.445 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.445 | |
| 4eok | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.445 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.445 | |
| 5ani | ES4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.444 | |
| 1u26 | IHS | Myo-inositol hexaphosphate phosphohydrolase | / | 0.444 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.444 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.444 | |
| 2p9k | ATP | Actin-related protein 2 | / | 0.444 | |
| 2vgo | AD5 | Aurora kinase B-A | 2.7.11.1 | 0.444 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.444 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.444 | |
| 4ewh | T77 | Activated CDC42 kinase 1 | / | 0.444 | |
| 4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.444 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 5h86 | BCO | Histone acetyltransferase KAT2A | 2.3.1.48 | 0.444 | |
| 1cm0 | COA | Histone acetyltransferase KAT2B | 2.3.1.48 | 0.443 | |
| 1u3w | FXY | Alcohol dehydrogenase 1C | 1.1.1.1 | 0.443 | |
| 1z5m | LI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 3krw | BA1 | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.443 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.443 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.443 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.443 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.443 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.443 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1oit | HDT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1pxp | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1yp4 | ADQ | Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic | 2.7.7.27 | 0.442 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2c4g | 514 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.442 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 2vtr | LZB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2wtj | WTJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 2zxu | DST | tRNA dimethylallyltransferase | 2.5.1.75 | 0.442 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.442 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.442 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 4bdi | HAU | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.442 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.441 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.441 | |
| 1lol | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.441 | |
| 1me7 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.441 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1oir | HDY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.441 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.441 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.441 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3liv | E16 | Protease | / | 0.441 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.441 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.441 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.441 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.441 | |
| 5cb4 | ACP | Tubulin tyrosine ligase | / | 0.441 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1g41 | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.440 | |
| 1phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.440 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2biy | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 2buf | ADP | Acetylglutamate kinase | / | 0.440 | |
| 2j7p | GNP | Signal recognition particle protein | / | 0.440 | |
| 2j7p | GNP | Signal recognition particle receptor FtsY | / | 0.440 | |
| 2vtl | LZ5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2wmv | ZYV | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.440 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.440 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.440 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.440 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3tif | ADP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.440 | |
| 4die | C5P | Cytidylate kinase | / | 0.440 | |
| 4ei4 | 0Q2 | Tyrosine-protein kinase JAK1 | / | 0.440 | |
| 4fln | UNK_UNK_TRP_UNK | Protease Do-like 2, chloroplastic | 3.4.21 | 0.440 | |
| 4ftj | H8K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4h0y | LAR | Actin, alpha skeletal muscle | / | 0.440 | |
| 4i9n | 1E6 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.440 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.440 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.440 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.440 |