sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 1.000 | |
| 2fbw | CBE | Succinate dehydrogenase cytochrome b, large subunit | / | 1.000 | |
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.585 | |
| 1zoy | UQ1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.585 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.495 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.495 | |
| 4ku2 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.495 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.493 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.492 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.492 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.490 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.489 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.487 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.486 | |
| 3nzp | PLP | Arginine decarboxylase | / | 0.485 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.484 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.480 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.477 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.474 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.474 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.474 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.474 | |
| 4ytn | FD8 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.474 | |
| 4ytn | FD8 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | / | 0.474 | |
| 4ytn | FD8 | Succinate dehydrogenase cytochrome b560 | / | 0.474 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.473 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.473 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.473 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.472 | |
| 2wdq | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.472 | |
| 2wdq | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.472 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.472 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.471 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.471 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.470 | |
| 2xls | NAP | Putative flavin-containing monooxygenase | / | 0.470 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.469 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.469 | |
| 2wu5 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.468 | |
| 2wu5 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.468 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.468 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.466 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.466 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.465 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.464 | |
| 3e39 | FMN | Nitroreductase | / | 0.464 | |
| 3v2b | AR6 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.464 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.464 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.464 | |
| 1e1c | DCA | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.463 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.463 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.463 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.463 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.463 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.462 | |
| 3sud | SUE | Polyprotein | / | 0.462 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.462 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4e31 | JHZ | Methyltransferase | / | 0.462 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.462 | |
| 2v0u | FMN | NPH1-1 | / | 0.461 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.461 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.461 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.461 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.460 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 1o6z | NAD | Malate dehydrogenase | / | 0.459 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.459 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.459 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.459 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4h4w | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.459 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.458 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.458 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.458 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.458 | |
| 4h4u | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.458 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.458 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.457 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.457 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.457 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.457 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.457 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.457 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.457 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.457 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.456 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.456 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.456 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.456 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.456 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.456 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.456 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.455 | |
| 1sre | HAB | Streptavidin | / | 0.455 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.455 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.455 | |
| 3wag | TYD | Glycosyltransferase | / | 0.455 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.455 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.454 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.454 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 2uyw | BTN | Avd protein | / | 0.453 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.453 | |
| 3kai | 4FI | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 5.2.1.8 | 0.453 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.453 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.453 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.452 | |
| 2izf | BTN | Streptavidin | / | 0.452 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.452 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.452 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.452 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4d03 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.452 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.452 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.452 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.451 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.451 | |
| 3koq | FMN | Putative nitroreductase | / | 0.451 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.451 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.451 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4l8u | 9AZ | Serum albumin | / | 0.451 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.451 | |
| 4p13 | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 1n2g | APC | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.450 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.450 | |
| 5gpb | GPM | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.450 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.449 | |
| 1s07 | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.449 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.449 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.449 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.449 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.449 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.449 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.449 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.448 | |
| 2po3 | T4K | 4-dehydrase | / | 0.448 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.448 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.448 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.448 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.448 | |
| 4boe | CLR | Japanin | / | 0.448 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.448 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.447 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.447 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.447 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.447 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.447 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.446 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.446 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.446 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.446 | |
| 2xlr | NAP | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.446 | |
| 3b9l | AZZ | Serum albumin | / | 0.446 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 3znq | SS8 | D-amino-acid oxidase | 1.4.3.3 | 0.446 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.446 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 4xw5 | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.446 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.445 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.445 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 2uyy | NA7 | Putative oxidoreductase GLYR1 | 1 | 0.445 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.445 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.445 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.445 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.444 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.444 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.444 | |
| 2izh | BTN | Streptavidin | / | 0.444 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.444 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.444 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.444 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.444 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.444 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.444 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.443 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.443 | |
| 2bxq | IMN | Serum albumin | / | 0.443 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.443 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.443 | |
| 2vig | COS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.443 | |
| 3nh8 | DC2 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | 3.5.1.114 | 0.443 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4ap3 | NAP | Steroid monooxygenase | / | 0.443 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.443 | |
| 4f5d | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 4hkk | AGI | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.443 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.443 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.442 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.442 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.442 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.442 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.442 | |
| 2p6k | SAH | Diphthine synthase | / | 0.442 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.442 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.442 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.442 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.442 | |
| 4ozn | ATP | Ammonium transporter | / | 0.442 | |
| 4rnv | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 5eyu | NAD | Betaine-aldehyde dehydrogenase | / | 0.442 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.442 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.441 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2bxm | IMN | Serum albumin | / | 0.441 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.441 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.441 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3b4p | 3B4 | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 3eku | CY9 | Actin-5C | / | 0.441 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.441 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.441 | |
| 4e2d | FMN | Dehydrogenase | / | 0.441 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4qnw | FMN | Chanoclavine-I aldehyde reductase easA | / | 0.441 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.440 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.440 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.440 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1vfr | FMN | Major NAD(P)H-flavin oxidoreductase | 1.6.99 | 0.440 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.440 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.440 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.440 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.440 | |
| 3zid | GDP | Tubulin-like protein CetZ | / | 0.440 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.440 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.440 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.440 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |