Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1xjn | DTP | Vitamin B12-dependent ribonucleotide reductase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1xjn | DTP | Vitamin B12-dependent ribonucleotide reductase | / | 1.000 | |
| 1xjg | DTP | Vitamin B12-dependent ribonucleotide reductase | / | 0.526 | |
| 3o0q | TTP | Vitamin B12-dependent ribonucleotide reductase | / | 0.521 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.504 | |
| 5im3 | DTP | Ribonucleoside-diphosphate reductase | / | 0.502 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.501 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.496 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.496 | |
| 2wgh | DTP | Ribonucleoside-diphosphate reductase large subunit | 1.17.4.1 | 0.494 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.492 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.491 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.491 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.489 | |
| 2bun | FAD | AppA protein | / | 0.488 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.486 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.486 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.485 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.482 | |
| 2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.481 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.481 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.480 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.479 | |
| 1xjk | DGT | Vitamin B12-dependent ribonucleotide reductase | / | 0.478 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.478 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.478 | |
| 3w0p | ADP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.476 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.475 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.474 | |
| 4o1p | ANP | Ribonuclease L | / | 0.474 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.473 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.472 | |
| 1m51 | TSX | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.471 | |
| 1q4t | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.471 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.470 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.470 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.469 | |
| 2c6d | ANP | Aurora kinase A | 2.7.11.1 | 0.468 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.468 | |
| 1jm6 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.467 | |
| 2izu | P01 | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.467 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.466 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.466 | |
| 2b9j | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.466 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.466 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
| 4f4p | 0SB | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.466 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.466 | |
| 3ef6 | FAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.465 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.465 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.465 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.464 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.464 | |
| 4fz7 | 0VH | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.464 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.464 | |
| 4rph | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.464 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.463 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.463 | |
| 2z6i | FMN | 2-nitropropane dioxygenase | / | 0.463 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.463 | |
| 3v0t | ATR | Perakine reductase | 1.1.1.317 | 0.463 | |
| 3zon | IK1 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.463 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.462 | |
| 1kvt | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.462 | |
| 1xje | TTP | Vitamin B12-dependent ribonucleotide reductase | / | 0.462 | |
| 2ceo | T44 | Thyroxine-binding globulin | / | 0.462 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.462 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.462 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.462 | |
| 5f1c | ATP | Uncharacterized protein | / | 0.462 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.461 | |
| 1ie4 | T44 | Transthyretin | / | 0.461 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.461 | |
| 1zao | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.461 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.461 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 1mru | AGS | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.460 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 2hfo | FMN | Activator of photopigment and puc expression | / | 0.460 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.460 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.460 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.460 | |
| 4fl3 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.460 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.460 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.460 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.459 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.459 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.459 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.459 | |
| 3v5j | 0F2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.459 | |
| 1i44 | ACP | Insulin receptor | 2.7.10.1 | 0.458 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.458 | |
| 2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.458 | |
| 3rep | ATP | Integrin-linked protein kinase | 2.7.11.1 | 0.458 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.458 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.458 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4xlv | ACP | Insulin receptor | 2.7.10.1 | 0.458 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.458 | |
| 5c03 | AGS | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.458 | |
| 5ce3 | ADP | Protein kinase YopO | / | 0.458 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.457 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.457 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.457 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.456 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.456 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.456 | |
| 4die | C5P | Cytidylate kinase | / | 0.456 | |
| 4iqk | IQK | Kelch-like ECH-associated protein 1 | / | 0.456 | |
| 5dt3 | ATP | Aurora kinase A | 2.7.11.1 | 0.456 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.455 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.455 | |
| 2r1r | TTP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.455 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.455 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.455 | |
| 2zfa | FMN | Lactate oxidase | / | 0.455 | |
| 3cr3 | ADP | PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.455 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.455 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.455 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 1qr0 | COA | 4'-phosphopantetheinyl transferase sfp | 2.7.8 | 0.454 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.454 | |
| 2cmw | OLP | Casein kinase I isoform gamma-1 | 2.7.11.1 | 0.454 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.454 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.454 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.453 | |
| 2x7b | COA | N-alpha-acetyltransferase | 2.3.1 | 0.453 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.453 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.453 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 1ol7 | ADP | Aurora kinase A | 2.7.11.1 | 0.452 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3pxv | FMN | Nitroreductase | / | 0.452 | |
| 4gub | 0Y4 | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4ifn | 12O | Kelch-like ECH-associated protein 1 | / | 0.452 | |
| 4jrn | ANP | Rhoptry kinase family protein | / | 0.452 | |
| 4krc | AGS | Cyclin-dependent protein kinase PHO85 | 2.7.11.22 | 0.452 | |
| 4r3k | COA | N-alpha-acetyltransferase | 2.3.1 | 0.452 | |
| 1sn5 | T3 | Transthyretin | / | 0.451 | |
| 1v0o | INR | Cell division control protein 2 homolog | 2.7.11.22 | 0.451 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.451 | |
| 2l84 | J28 | CREB-binding protein | / | 0.451 | |
| 2nli | FMN | Lactate oxidase | / | 0.451 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.451 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4f7l | 0SO | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.451 | |
| 4utd | ACP | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.451 | |
| 1d7y | FAD | Ferredoxin reductase | / | 0.450 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.450 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.450 | |
| 2e2q | ADP | ATP-dependent hexokinase | / | 0.450 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.450 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.450 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4n9w | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.450 | |
| 4ndn | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.450 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.450 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1ja1 | NAP | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.449 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.449 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 2e9z | UTP | Genome polyprotein | / | 0.449 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2pkn | ACP | Adenosine kinase | 2.7.1.20 | 0.449 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.449 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.449 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.449 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.449 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.449 | |
| 4rqv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1g67 | TZP | Thiamine-phosphate synthase | / | 0.448 | |
| 1jst | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.448 | |
| 3a8t | ATP | Adenylate isopentenyltransferase | / | 0.448 | |
| 3c4z | ADP | Rhodopsin kinase | / | 0.448 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 3my5 | RFZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3nnx | EDD | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3owl | 19E | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.448 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.447 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.447 | |
| 1mf0 | GDP | Adenylosuccinate synthetase isozyme 1 | / | 0.447 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 2cea | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.447 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.447 | |
| 2r3o | 2SC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2xuu | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.447 | |
| 3cis | ATP | Universal stress protein Rv2623 | / | 0.447 | |
| 3f5u | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.447 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.447 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 5l8k | ADP | Aurora kinase A | 2.7.11.1 | 0.447 | |
| 2c6e | HPM | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2xgo | ZKD | Uncharacterized protein | / | 0.446 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.446 | |
| 3bpz | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.446 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 3rps | 4B0 | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.446 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.446 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.446 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.446 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.446 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.446 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1ol5 | ADP | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.445 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.445 | |
| 2oby | NAP | Quinone oxidoreductase PIG3 | 1 | 0.445 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.445 | |
| 2yvf | NAD | Ferredoxin reductase | / | 0.445 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.445 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.445 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 4g0k | 0VS | Glutathionyl-hydroquinone reductase YqjG | 1.8 | 0.445 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.445 | |
| 5auw | QUE | Death-associated protein kinase 1 | 2.7.11.1 | 0.445 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.444 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 1xjj | DGT | Vitamin B12-dependent ribonucleotide reductase | / | 0.444 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 2v1a | FMN | NPH1-1 | / | 0.444 | |
| 2wpw | ACO | Orf14 | / | 0.444 | |
| 3av7 | KYA | Uncharacterized protein | / | 0.444 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3ibe | L64 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.444 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.444 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.444 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.444 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.444 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.444 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.444 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.443 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.443 | |
| 2p9e | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.443 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.443 | |
| 2vqs | BVD | Deoxynucleoside kinase | / | 0.443 | |
| 3o0o | TTP | Vitamin B12-dependent ribonucleotide reductase | / | 0.443 | |
| 3zvv | XAZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4c59 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.443 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4hyu | 1BK | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.443 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.443 | |
| 4lb2 | DM5 | Serum albumin | / | 0.443 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.443 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.442 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.442 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.442 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 2byc | FMN | Blue-light receptor of the BLUF-family | / | 0.442 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.442 | |
| 2pc9 | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.442 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2uyi | ADP | Kinesin-like protein KIF11 | / | 0.442 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.442 | |
| 4acd | GR9 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.442 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4nu6 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.442 | |
| 4oau | ADP | 2-5A-dependent ribonuclease | 3.1.26 | 0.442 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.442 | |
| 1agw | SU2 | Fibroblast growth factor receptor 1 | / | 0.441 | |
| 1g69 | TZP | Thiamine-phosphate synthase | / | 0.441 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.441 | |
| 1q8y | ADP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.441 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.441 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 1y7u | COA | Acyl-CoA hydrolase | / | 0.441 | |
| 2bmc | MPY | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 2c4g | 514 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2pyw | ADP | Methylthioribose kinase | 2.7.1.100 | 0.441 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.441 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.441 | |
| 3gu5 | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3t54 | ATP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.441 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.441 | |
| 3w55 | 1FM | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4asy | N5Y | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 5a3b | APR | SIR2 family protein | / | 0.441 | |
| 5dby | NPS | Serum albumin | / | 0.441 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 1b39 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.440 | |
| 1g6c | IFP | Thiamine-phosphate synthase | / | 0.440 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.440 | |
| 1n9l | FMN | Putative blue light receptor | / | 0.440 | |
| 1y8q | ATP | SUMO-activating enzyme subunit 2 | 6.3.2 | 0.440 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.440 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2oji | 33A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 2p5f | SAH | Diphthine synthase | / | 0.440 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 2qtv | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.440 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.440 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.440 | |
| 3rvg | 17P | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 3up5 | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.440 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.440 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.440 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.440 | |
| 4lsm | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.440 |