sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1av5 | AP2 | Histidine triad nucleotide-binding protein 1 | 3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1av5 | AP2 | Histidine triad nucleotide-binding protein 1 | 3 | 1.000 | |
| 1rzy | 5AS | Histidine triad nucleotide-binding protein 1 | 3 | 0.614 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.569 | |
| 5i2f | BS5 | Histidine triad nucleotide-binding protein 1 | 3 | 0.567 | |
| 3oxk | 5GP | Histidine triad nucleotide-binding protein | 3 | 0.557 | |
| 3qgz | ADN | Histidine triad nucleotide-binding protein 1 | 3 | 0.552 | |
| 4eqe | KAA | Histidine triad nucleotide-binding protein 1 | 3 | 0.538 | |
| 5fit | AP2 | Bis(5'-adenosyl)-triphosphatase | 3.6.1.29 | 0.514 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.498 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.496 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.495 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.492 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.486 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.486 | |
| 3n1t | 5GP | Purine nucleoside phosphoramidase | / | 0.484 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.483 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.483 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.483 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.482 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.481 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.480 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.479 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.479 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.477 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 4az0 | S61 | Lysosomal protective protein | 3.4.16.5 | 0.476 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.474 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.473 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.472 | |
| 4egu | 5GP | Putative histidine triad (HIT) protein | / | 0.472 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.471 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.471 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.470 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.470 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4h5c | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.468 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.468 | |
| 2gd0 | MRS | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.467 | |
| 3n1s | 5GP | Purine nucleoside phosphoramidase | / | 0.467 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.467 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.466 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.466 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.465 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.464 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.463 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.463 | |
| 3ou7 | SAM | SAM-dependent methyltransferase | / | 0.463 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.462 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.462 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.462 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.462 | |
| 1it7 | GUN | tRNA-guanine(15) transglycosylase | 2.4.2.48 | 0.461 | |
| 2i4t | UA2 | Purine nucleoside phosphorylase, putative | / | 0.461 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.461 | |
| 4h5e | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.461 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.460 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.460 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.459 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.459 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.458 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.457 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.457 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.456 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.456 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.456 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4ap0 | ADP | Kinesin-like protein KIF11 | / | 0.456 | |
| 1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.455 | |
| 2bp1 | NDP | Aflatoxin B1 aldehyde reductase member 2 | / | 0.455 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.455 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.455 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.455 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1v2h | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.454 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 4phl | PIL | Phosphodiesterase | / | 0.454 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3gki | CLR | Niemann-Pick C1 protein | / | 0.453 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.453 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.453 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.453 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.453 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.453 | |
| 4ykl | GMP | Aprataxin-like protein | 3 | 0.453 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.452 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.452 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.452 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.452 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.452 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.451 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.451 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.451 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.451 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.450 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.450 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.450 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.450 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.450 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.450 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.450 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.450 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.450 | |
| 4dem | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.450 | |
| 4i5v | B4P | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 | / | 0.450 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.450 | |
| 4v2g | CTC | Tetracycline repressor protein class D | / | 0.450 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.450 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.449 | |
| 2ohh | FMN | Type A flavoprotein FprA | 1 | 0.449 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.449 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.449 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.449 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.449 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.449 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.448 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.448 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.448 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.448 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.448 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.448 | |
| 4ydq | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.448 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.448 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.447 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.447 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.447 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.447 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.447 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.446 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.446 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4ivr | N50 | Thymidine kinase | / | 0.446 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.446 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.446 | |
| 1khr | COA | Streptogramin A acetyltransferase | 2.3.1 | 0.445 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 2wn6 | NDP | ADP-ribosyltransferase enzymatic component | / | 0.445 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.445 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.445 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.445 | |
| 3up0 | D7S | aceDAF-12 | / | 0.445 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.445 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.445 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.444 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.444 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.444 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.444 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.444 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.444 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2isc | 223 | Purine nucleoside phosphorylase, putative | / | 0.444 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.444 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3up3 | XCA | aceDAF-12 | / | 0.444 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.444 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.443 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.443 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 2ay8 | 4TB | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.443 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.443 | |
| 3my5 | RFZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 3u3o | 3QV | Sulfotransferase 1A1 | 2.8.2.1 | 0.443 | |
| 4f6x | ZYL | Dehydrosqualene synthase | / | 0.443 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.443 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 4onq | SFG | DNA methyltransferase | / | 0.443 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.443 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.443 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1e2j | THM | Thymidine kinase | / | 0.442 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.442 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.442 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.442 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.442 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.442 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.442 | |
| 3ei8 | PL5 | LL-diaminopimelate aminotransferase, chloroplastic | / | 0.442 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.442 | |
| 3upy | FOM | Oxidoreductase, putative | / | 0.442 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.442 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 4ckc | SAH | mRNA-capping enzyme catalytic subunit | 2.1.1.56 | 0.442 | |
| 4d2d | ALA_ALA_ALA | Di-or tripeptide:H+ symporter | / | 0.442 | |
| 4pkh | ADP | Actin, alpha skeletal muscle | / | 0.442 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.441 | |
| 1kf6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.441 | |
| 1kgj | FL8 | Transthyretin | / | 0.441 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.441 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.441 | |
| 2bgj | FAD | NADPH:ferredoxin reductase | / | 0.441 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.441 | |
| 2uw0 | GVK | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3vaq | ADN | Putative adenosine kinase | / | 0.441 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.441 | |
| 4lb2 | DM5 | Serum albumin | / | 0.441 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.440 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 1pyd | TDP | Pyruvate decarboxylase isozyme 1 | / | 0.440 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.440 | |
| 2ejz | SAH | Diphthine synthase | / | 0.440 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.440 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.440 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4jvj | 1MV | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.440 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.440 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.440 |