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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.11.000
5dnrATPAurora kinase A2.7.11.10.553
1dawANPCasein kinase II subunit alpha2.7.11.10.539
4deeADPAurora kinase A2.7.11.10.536
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.536
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.531
5dn3ATPAurora kinase A2.7.11.10.523
4o0wADNAurora kinase A2.7.11.10.517
5dosATPAurora kinase A2.7.11.10.517
3gu7ADPDeath-associated protein kinase 12.7.11.10.515
4ysjADPCalmodulin-like domain protein kinase/0.511
2w4jADPDeath-associated protein kinase 12.7.11.10.509
4jbpYPHAurora kinase A2.7.11.10.508
3c4zADPRhodopsin kinase/0.507
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.507
5drdATPAurora kinase A2.7.11.10.507
3bu5ATPInsulin receptor2.7.10.10.506
4lfiGNPCasein kinase II subunit alpha2.7.11.10.506
4k33ACPFibroblast growth factor receptor 32.7.10.10.504
4jboWPHAurora kinase A2.7.11.10.498
2w1fL0FAurora kinase A2.7.11.10.495
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.495
1ig1ANPDeath-associated protein kinase 12.7.11.10.493
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.493
3c4wATPRhodopsin kinase/0.492
3orpAGSSerine/threonine protein kinase/0.491
4lrjANPUncharacterized protein/0.490
5dt3ATPAurora kinase A2.7.11.10.490
5av3KMPDeath-associated protein kinase 12.7.11.10.489
3k5uPFQAurora kinase A2.7.11.10.488
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.488
1dayGNPCasein kinase II subunit alpha2.7.11.10.487
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.487
5dt4ATPAurora kinase A2.7.11.10.487
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.486
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.486
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.484
3ttjJBIMitogen-activated protein kinase 102.7.11.240.483
4anmWULCasein kinase II subunit alpha2.7.11.10.483
4o0uADNAurora kinase A2.7.11.10.482
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.481
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.480
2wqeADPAurora kinase A2.7.11.10.479
3lltANPProtein serine/threonine kinase-1/0.479
3oriAGSSerine/threonine protein kinase/0.479
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.478
5av2KMPDeath-associated protein kinase 12.7.11.10.478
2yaaATPDeath-associated protein kinase 2/0.477
4btjATPTau-tubulin kinase 12.7.11.10.477
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.477
1jnkANPMitogen-activated protein kinase 102.7.11.240.476
2dwbANPAurora kinase A2.7.11.10.476
3be9P04Casein kinase II subunit alpha2.7.11.10.476
3kvxFMYMitogen-activated protein kinase 102.7.11.240.475
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.475
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.474
3ormAGSSerine/threonine protein kinase/0.474
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4btjADPTau-tubulin kinase 12.7.11.10.474
4ux9ANPMitogen-activated protein kinase 82.7.11.240.474
1ol5ADPAurora kinase A2.7.11.10.473
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.473
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.472
2ijmATPFocal adhesion kinase 12.7.10.20.472
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.471
4qnyANPMitogen activated protein kinase, putative/0.471
2p33J07Mitogen-activated protein kinase 102.7.11.240.469
4o1pANPRibonuclease L/0.469
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.468
4hvi19STyrosine-protein kinase JAK32.7.10.20.468
4l9i8PRRhodopsin kinase/0.467
1m2pHNACasein kinase II subunit alpha2.7.11.10.466
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.466
5e92ANPTGF-beta receptor type-22.7.11.300.466
1ol7ADPAurora kinase A2.7.11.10.465
1pmn984Mitogen-activated protein kinase 102.7.11.240.465
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.465
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4h3qANPMitogen-activated protein kinase 12.7.11.240.465
3r9dX6BCyclin-dependent kinase 22.7.11.220.464
2j0lANPFocal adhesion kinase 12.7.10.20.463
3ortAGSSerine/threonine protein kinase/0.463
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.463
1jklANPDeath-associated protein kinase 12.7.11.10.462
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.462
3cgfJNFMitogen-activated protein kinase 102.7.11.240.462
3i60E86Mitogen-activated protein kinase 12.7.11.240.462
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.461
4aqc88ATyrosine-protein kinase JAK2/0.461
2henADPEphrin type-B receptor 22.7.10.10.460
3qc9ADPRhodopsin kinase/0.460
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.460
5dr2ATPAurora kinase A2.7.11.10.460
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.459
4jr7GNPCasein kinase II subunit alpha2.7.11.10.459
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.458
2zdt46CMitogen-activated protein kinase 102.7.11.240.458
3c4xATPRhodopsin kinase/0.458
4j99ACPFibroblast growth factor receptor 2/0.458
1bygSTUTyrosine-protein kinase CSK/0.457
2v7a627Tyrosine-protein kinase ABL12.7.10.20.457
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.457
4wsqKSAAP2-associated protein kinase 12.7.11.10.457
3iok1P6Tyrosine-protein kinase JAK2/0.456
3wfjNAD2-dehydropantoate 2-reductase/0.456
4hge15VTyrosine-protein kinase JAK2/0.456
3dfcANPDeath-associated protein kinase 12.7.11.10.455
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
2ckeIQUDeath-associated protein kinase 2/0.454
3t8oATPRhodopsin kinase/0.454
4c3rACPAurora kinase A2.7.11.10.454
4qmlANPSerine/threonine-protein kinase 242.7.11.10.454
4xlvACPInsulin receptor2.7.10.10.454
2w1gL0GAurora kinase A2.7.11.10.453
2xneASHAurora kinase A2.7.11.10.453
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.453
3orkAGSSerine/threonine protein kinase/0.453
3ttiKBIMitogen-activated protein kinase 102.7.11.240.453
4fv6E57Mitogen-activated protein kinase 12.7.11.240.453
4n57ADPAPH(2'')-Id/0.453
5cnnANPEpidermal growth factor receptor2.7.10.10.453
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.452
4j95ACPFibroblast growth factor receptor 2/0.452
4jbqVX6Aurora kinase A2.7.11.10.452
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.451
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.451
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.451
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.451
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.451
4ix5ANPUncharacterized protein/0.451
5e8ySTUTGF-beta receptor type-22.7.11.300.451
1b38ATPCyclin-dependent kinase 22.7.11.220.450
1ir3ANPInsulin receptor2.7.10.10.450
2etm7PYFocal adhesion kinase 12.7.10.20.450
2j0m4STFocal adhesion kinase 12.7.10.20.450
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
4c3pACPAurora kinase A2.7.11.10.450
4jqeANPCasein kinase II subunit alpha2.7.11.10.450
2xrwANPMitogen-activated protein kinase 82.7.11.240.449
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.449
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.449
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
5dr9SKEAurora kinase A2.7.11.10.448
1jkkANPDeath-associated protein kinase 12.7.11.10.447
1lp4ANPCasein kinase II subunit alpha2.7.11.10.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2x1nX1NCyclin-dependent kinase 22.7.11.220.447
3gxlQIGTGF-beta receptor type-12.7.11.300.447
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.447
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.446
2xvdAS6Ephrin type-B receptor 42.7.10.10.446
3c50ADPRhodopsin kinase/0.446
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3tdvGDPGentamicin resistance protein/0.446
3uo50BXAurora kinase A2.7.11.10.446
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.446
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4utdACPAurora kinase A2.7.11.10.446
2vu3LZECyclin-dependent kinase 22.7.11.220.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
1u54ACPActivated CDC42 kinase 1/0.444
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.444
3gubGUBDeath-associated protein kinase 12.7.11.10.444
3sheI85MAP kinase-activated protein kinase 32.7.11.10.444
4fmqANPMitogen-activated protein kinase 12.7.11.240.444
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3cgoJNOMitogen-activated protein kinase 102.7.11.240.443
3oroAGSSerine/threonine protein kinase/0.443
3r9hZ67Cyclin-dependent kinase 22.7.11.220.443
3w16P9JAurora kinase A2.7.11.10.443
4b0gVEKAurora kinase A2.7.11.10.443
5cvhADPCasein kinase II subunit alpha2.7.11.10.443
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.442
3gu5ANPDeath-associated protein kinase 12.7.11.10.442
3tqhNDPQuinone oxidoreductase/0.442
3w2sW2REpidermal growth factor receptor2.7.10.10.442
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.442
4eooATPCyclin-dependent kinase 22.7.11.220.442
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1p4fDRGDeath-associated protein kinase 12.7.11.10.441
2bfyH1NAurora kinase B-A2.7.11.10.441
2excJNKMitogen-activated protein kinase 102.7.11.240.441
2np8CC3Aurora kinase A2.7.11.10.441
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.441
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.441
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.441
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.440
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
2xyoFADTetX family tetracycline inactivation enzyme/0.440
3pxkPXKFocal adhesion kinase 12.7.10.20.440
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
5dpvSKEAurora kinase A2.7.11.10.440