sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 1.000 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.667 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.637 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.635 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.546 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.540 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.523 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.518 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.517 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.515 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.512 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.511 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.509 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.508 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.506 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.502 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.501 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.499 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.497 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.497 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.497 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.496 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.496 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.496 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.496 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.492 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.492 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.492 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.490 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.490 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.489 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.488 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.487 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.487 | |
| 2y3r | TRK | TamL | / | 0.485 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.485 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.485 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.484 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.484 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.483 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.483 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.483 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.482 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.482 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.481 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.480 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.480 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.480 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.480 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.478 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.478 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.478 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.477 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.477 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.476 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta | / | 0.476 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta' | / | 0.476 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.475 | |
| 4o3m | ADP | Bloom syndrome protein | 3.6.4.12 | 0.475 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.474 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.474 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.474 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.473 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.472 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.471 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.471 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.470 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.470 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.470 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.470 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.469 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.469 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.469 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.469 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.469 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.468 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.468 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.467 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.467 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.467 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.466 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.466 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.466 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.466 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.465 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.465 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.465 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.464 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.464 | |
| 4aic | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.464 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.464 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.464 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.463 | |
| 2y3s | TIR | TamL | / | 0.463 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.463 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.463 | |
| 1eio | GCH | Gastrotropin | / | 0.462 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.462 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.462 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.462 | |
| 3tba | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.462 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.462 | |
| 3zuy | TCH | Transporter | / | 0.462 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.462 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.461 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.461 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.461 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.461 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.460 | |
| 1yon | A2R | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.460 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.460 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.460 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.460 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.460 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.460 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.459 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.459 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.459 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.458 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.458 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.458 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.458 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.457 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.457 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.457 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2y4g | TIR | TamL | / | 0.457 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.457 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.457 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.457 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.457 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.455 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.455 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.455 | |
| 2ves | GVR | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.455 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.455 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.455 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.455 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.455 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.454 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.454 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.454 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.454 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.454 | |
| 4c9w | VGH | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.454 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.454 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.454 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.453 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.453 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.453 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.453 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 3u9e | COA | Lmo1369 protein | / | 0.453 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.453 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.453 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.453 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.452 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.452 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.452 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.452 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.452 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.452 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.451 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.451 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.451 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.451 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.451 | |
| 4l8u | 9AZ | Serum albumin | / | 0.451 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.451 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.450 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2bxm | IMN | Serum albumin | / | 0.450 | |
| 2cx8 | SAH | Ribosomal RNA small subunit methyltransferase E | / | 0.450 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.449 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.449 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.449 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.449 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.448 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.448 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.448 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.448 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.448 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.448 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.447 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.447 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.447 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.447 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2ejz | SAH | Diphthine synthase | / | 0.447 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.447 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.447 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.446 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.446 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.446 | |
| 3ieu | GDP | GTPase Era | / | 0.446 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.446 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.446 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.446 | |
| 4xr9 | NAD | CalS8 | / | 0.446 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.446 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.445 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.445 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.445 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.445 | |
| 3h3c | P1E | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.445 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.445 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.445 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4dja | FAD | (6-4) photolyase | / | 0.445 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.445 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.445 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.444 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.444 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.444 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.444 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.444 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.444 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.444 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.444 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.444 | |
| 4uun | NAI | L-lactate dehydrogenase | / | 0.444 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.443 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.443 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.443 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 2fy5 | SOP | Choline O-acetyltransferase | 2.3.1.6 | 0.443 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.443 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.443 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3gob | HXX | DdmC | / | 0.443 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.443 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.443 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.443 | |
| 1aj8 | COA | Citrate synthase | / | 0.442 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.442 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.442 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.442 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.442 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.442 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3uf6 | COD | Lmo1369 protein | / | 0.442 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.442 | |
| 4cdg | ADP | Bloom syndrome protein | 3.6.4.12 | 0.442 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.441 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.441 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.441 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.441 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.441 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.441 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.441 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.441 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.441 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.441 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.441 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1ep3 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.440 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.440 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.440 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.440 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.440 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.440 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4ig0 | 1FG | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4l9k | EHF | Serum albumin | / | 0.440 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.440 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 |