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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a9hTVPBromodomain-containing protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a9hTVPBromodomain-containing protein 2/1.000
4a9e3PFBromodomain-containing protein 2/0.642
4a9iP9IBromodomain-containing protein 2/0.613
4a9mP9MBromodomain-containing protein 2/0.606
4uyf73BBromodomain-containing protein 2/0.606
2yekEAMBromodomain-containing protein 2/0.605
4alhA9PBromodomain-containing protein 2/0.571
2ydwWSHBromodomain-containing protein 2/0.570
4o761M3Bromodomain-containing protein 4/0.570
4o701QKBromodomain-containing protein 4/0.546
4o71CPBBromodomain-containing protein 4/0.514
4py6R78Bromodomain protein, putative/0.511
4a9nA9NBromodomain-containing protein 2/0.510
4c67L5SBromodomain-containing protein 4/0.507
4jx1CAHCamphor 5-monooxygenase1.14.15.10.505
4a9oA9OBromodomain-containing protein 2/0.494
4aknS5BBromodomain-containing protein 2/0.494
4uyg73BBromodomain-containing protein 2/0.494
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.481
1xddAAYIntegrin alpha-L/0.475
1uyhPU0Heat shock protein HSP 90-alpha/0.472
2po7CHDFerrochelatase, mitochondrial4.99.1.10.472
3mdmFJZCholesterol 24-hydroxylase/0.472
4mr61K0Bromodomain-containing protein 2/0.472
4e960NSBromodomain-containing protein 4/0.471
3ddpRC8Cyclin-dependent kinase 22.7.11.220.470
4iteTEYVitamin D3 receptor/0.470
4j1p1K0Bromodomain-containing protein 2/0.470
4nyv15ECREB-binding protein/0.470
1fm4DXCMajor pollen allergen Bet v 1-L/0.469
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
2x7hPFNProstaglandin reductase 310.469
4yaoFMNNADPH--cytochrome P450 reductase/0.469
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
5bt52LOBromodomain-containing protein 2/0.468
5ii2LU2Protein polybromo-1/0.468
3aqaBYHBromodomain-containing protein 2/0.467
3s1h56ZCyclin-dependent kinase 22.7.11.220.467
4nr82LLBromodomain-containing protein 4/0.467
4bw1S5BBromodomain-containing protein 4/0.466
1eioGCHGastrotropin/0.465
2cchATPCyclin-dependent kinase 22.7.11.220.464
3a9wNADNDP-sugar epimerase/0.464
3k4nFADPyranose 2-oxidase/0.464
3rk507ZCyclin-dependent kinase 22.7.11.220.464
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.463
1ppjANYCytochrome b/0.462
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.462
4j0s1H3Bromodomain-containing protein 4/0.462
2hamC33Vitamin D3 receptor/0.461
2wipP49Cyclin-dependent kinase 22.7.11.220.461
3hvcGG5Mitogen-activated protein kinase 14/0.461
1s19MC9Vitamin D3 receptor/0.460
2g5cNADPrephenate dehydrogenase/0.460
3tk3CPZCytochrome P450 2B41.14.14.10.460
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3zuyTCHTransporter/0.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
1dz4CAMCamphor 5-monooxygenase1.14.15.10.458
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.458
1kzjCB3Thymidylate synthase/0.457
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.457
3nx4NAPPutative oxidoreductase/0.457
1h1s4SPCyclin-dependent kinase 22.7.11.220.456
1kvkATPMevalonate kinase2.7.1.360.456
2hb8MVDVitamin D3 receptor/0.456
3rak03ZCyclin-dependent kinase 22.7.11.220.456
3zk5Z18Cytochrome P450 monooxygenase PikC/0.456
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.455
2xa4AZ5Tyrosine-protein kinase JAK2/0.455
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.455
3gggNADPrephenate dehydrogenase/0.455
3w5rLOAVitamin D3 receptor/0.455
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4bcqTJFCyclin-dependent kinase 22.7.11.220.455
4eh60ONMitogen-activated protein kinase 14/0.455
4qmzB49Serine/threonine-protein kinase 242.7.11.10.455
1y0s331Peroxisome proliferator-activated receptor delta/0.454
3a783EVVitamin D3 receptor/0.454
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3hz5Z64Heat shock protein HSP 90-alpha/0.454
3qtzX42Cyclin-dependent kinase 22.7.11.220.454
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.454
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.454
1v1k3FPCyclin-dependent kinase 22.7.11.220.453
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.453
2i40BLZCyclin-dependent kinase 22.7.11.220.453
2vkeTACTetracycline repressor protein class D/0.453
3mg3ECHOrange carotenoid-binding protein/0.453
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.453
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
5a3cNADSIR2 family protein/0.453
1di8DTQCyclin-dependent kinase 22.7.11.220.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2y4gTIRTamL/0.452
2yelWSHBromodomain-containing protein 4/0.452
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3w0aDS5Vitamin D3 receptor/0.452
3w0yDS4Vitamin D3 receptor/0.452
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.452
4q71FADBifunctional protein PutA/0.452
1rk3VDXVitamin D3 receptor/0.451
2wxvWXVCyclin-dependent kinase 22.7.11.220.451
2y3rTRKTamL/0.451
3ddqRRCCyclin-dependent kinase 22.7.11.220.451
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.451
3vt45YIVitamin D3 receptor/0.451
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.451
4k2xFADPolyketide oxygenase/hydroxylase/0.451
4kko1REGag-Pol polyprotein2.7.7.490.451
1xjdSTUProtein kinase C theta type2.7.11.130.450
2aclREARetinoic acid receptor RXR-alpha/0.450
2hb7O1CVitamin D3 receptor/0.450
3e5aVX6Aurora kinase A2.7.11.10.450
3tnlNADShikimate dehydrogenase (NADP(+))/0.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4fhi0S4Vitamin D3 receptor A/0.450
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.450
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.450
4ia7BIVVitamin D3 receptor A/0.450
4lrg1XBBromodomain-containing protein 4/0.450
4mr51K0Bromodomain-containing protein 2/0.450
1phePIYCamphor 5-monooxygenase1.14.15.10.449
2c3qGTXGlutathione S-transferase theta-12.5.1.180.449
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
2p33J07Mitogen-activated protein kinase 102.7.11.240.449
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.449
2xpuTDCTetracycline repressor protein class D/0.449
3fwjCAMCamphor 5-monooxygenase1.14.15.10.449
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3lqfNADGalactitol dehydrogenase/0.449
3r9oZ71Cyclin-dependent kinase 22.7.11.220.449
3t2yFADSulfide-quinone reductase/0.449
3vrwYS5Vitamin D3 receptor/0.449
4g47TZFMycocyclosin synthase1.14.21.90.449
4y8wSTRSteroid 21-hydroxylase/0.449
1bygSTUTyrosine-protein kinase CSK/0.448
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.448
1rfvADPPyridoxal kinase2.7.1.350.448
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.448
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2m56CAMCamphor 5-monooxygenase1.14.15.10.448
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.448
3a4pDFQHepatocyte growth factor receptor2.7.10.10.448
3jynNDPQuinone oxidoreductase/0.448
3own3OWRenin3.4.23.150.448
3poz03PEpidermal growth factor receptor2.7.10.10.448
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.448
3stuDK3Methylketone synthase I/0.448
3w0gW07Vitamin D3 receptor/0.448
4ead0NPThymidine phosphorylase2.4.2.40.448
4g1z0VPVitamin D3 receptor A/0.448
4gmy0X5Tyrosine-protein kinase JAK2/0.448
4itfTFYVitamin D3 receptor/0.448
4lyw21QBromodomain-containing protein 4/0.448
4men25KBromodomain-containing protein 4/0.448
1ia3TQ5Dihydrofolate reductase1.5.1.30.447
1uy7PU4Heat shock protein HSP 90-alpha/0.447
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3a1nNADNDP-sugar epimerase/0.447
3nr4PYVAbscisic acid receptor PYL2/0.447
3stv3HOMethylketone synthase I/0.447
4gk4L90Ephrin type-A receptor 32.7.10.10.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
3sn6P0GBeta-2 adrenergic receptor/0.447
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.446
3gstGPRGlutathione S-transferase Mu 12.5.1.180.446
3kpkFADSulfide-quinone reductase/0.446
3mdvCL6Cholesterol 24-hydroxylase/0.446
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4bcmT7ZCyclin-dependent kinase 22.7.11.220.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.446
4o2bLOCTubulin beta-2B chain/0.446
1fmlRTLRetinol dehydratase/0.445
1kl2FONSerine hydroxymethyltransferase/0.445
1rw8580TGF-beta receptor type-12.7.11.300.445
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.445
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.445
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.445
2ykbYKBHeat shock protein HSP 90-alpha/0.445
2ykjYKJHeat shock protein HSP 90-alpha/0.445
3fwiCAMCamphor 5-monooxygenase1.14.15.10.445
3ibdCPZCytochrome P450 2B61.14.130.445
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4cd0AWJALK tyrosine kinase receptor2.7.10.10.445
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.445
4yntFDAGlucose oxidase, putative/0.445
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.445
1g4sTPSThiamine-phosphate synthase/0.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1yvj4STTyrosine-protein kinase JAK32.7.10.20.444
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3fi4FI4Mitogen-activated protein kinase 14/0.444
3ix9MTXDihydrofolate reductase1.5.1.30.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3l8p0CEAngiopoietin-1 receptor2.7.10.10.444
3r1sX73Cyclin-dependent kinase 22.7.11.220.444
3wv9FEGHmd co-occurring protein HcgE/0.444
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.444
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.444
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.444
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4i8vBHFCytochrome P450 1A11.14.14.10.444
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.444
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.444
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.443
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3flzFLZMitogen-activated protein kinase 14/0.443
3qziX72Cyclin-dependent kinase 22.7.11.220.443
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
3uli1N3Cyclin-dependent kinase 22.7.11.220.443
3w0c6DSVitamin D3 receptor/0.443
4aacAAVMitogen-activated protein kinase 14/0.443
4dx9SER_ALA_VAL_THRIntegrin beta-1/0.443
4dx9SER_ALA_VAL_THRIntegrin beta-1-binding protein 1/0.443
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
1b4vFADCholesterol oxidase1.1.3.60.442
1uy6PU3Heat shock protein HSP 90-alpha/0.442
2b52D42Cyclin-dependent kinase 22.7.11.220.442
2d52COA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.442
2hcdBIVVitamin D3 receptor A/0.442
2vzmNRBCytochrome P450 monooxygenase PikC/0.442
2w06FRVCyclin-dependent kinase 22.7.11.220.442
3a7hATPSerine/threonine-protein kinase 242.7.11.10.442
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3fln3FNMitogen-activated protein kinase 14/0.442
3flwFLWMitogen-activated protein kinase 14/0.442
3s7a684Dihydrofolate reductase1.5.1.30.442
4a6nFADTetX family tetracycline inactivation enzyme/0.442
4acm7YGCyclin-dependent kinase 22.7.11.220.442
4b7sQLECytochrome P450 monooxygenase PikC/0.442
4ips1G4Mycocyclosin synthase1.14.21.90.442
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.442
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.442
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1cf3FADGlucose oxidase1.1.3.40.441
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1n83CLRNuclear receptor ROR-alpha/0.441
1ndiCOACarnitine O-acetyltransferase2.3.1.70.441
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2f2uM77Rho-associated protein kinase 22.7.11.10.441
2nnhREACytochrome P450 2C8/0.441
2nq8ZIDEnoyl-ACP reductase/0.441
2on6IMHPurine nucleoside phosphorylase2.4.2.10.441
2w05FRTCyclin-dependent kinase 22.7.11.220.441
2z97CAMCamphor 5-monooxygenase1.14.15.10.441
3p3zP3ZPutative cytochrome P450/0.441
3q5kD1UHeat shock protein 83-1/0.441
3t3r9PLCytochrome P450 2A61.14.130.441
3vt5YI2Vitamin D3 receptor/0.441
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4e5yNDPGDP-L-fucose synthase1.1.1.2710.441
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
1ikwEFZGag-Pol polyprotein2.7.7.490.440
1t87CAMCamphor 5-monooxygenase1.14.15.10.440
1t88CAMCamphor 5-monooxygenase1.14.15.10.440
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.440
2ca0PXICytochrome P450 monooxygenase PikC/0.440
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.440
3lkhLT6Genome polyprotein2.7.7.480.440
3lpbNVBTyrosine-protein kinase JAK2/0.440
3pj8404Cyclin-dependent kinase 22.7.11.220.440
3wrjCAMCamphor 5-monooxygenase1.14.15.10.440
4b1rITCTetracycline repressor protein class D/0.440
4bw39BMBromodomain-containing protein 4/0.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4fhh0U3Vitamin D3 receptor A/0.440
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4ia3BIVVitamin D3 receptor A/0.440
4jx1CAMCamphor 5-monooxygenase1.14.15.10.440
4nqmY1ZBromodomain-containing protein 4/0.440
4tuvCPZCytochrome P450 1191.140.440
4ure1PSCyclohexanol dehydrogenase/0.440
4xwrFADCholesterol oxidase1.1.3.60.440
5hs1VORLanosterol 14-alpha demethylase/0.440
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.440