sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ypi | PGH | Triosephosphate isomerase | 5.3.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ypi | PGH | Triosephosphate isomerase | 5.3.1.1 | 1.000 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.505 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.484 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.480 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.480 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.480 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.479 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.477 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.477 | |
| 2mwg | FMN | Blue-light photoreceptor | / | 0.477 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.477 | |
| 5a3c | NAD | SIR2 family protein | / | 0.475 | |
| 1tf7 | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.474 | |
| 1u9i | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.474 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.474 | |
| 2vww | 7X2 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.474 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.474 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.473 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.473 | |
| 3pww | ROC | Endothiapepsin | 3.4.23.22 | 0.473 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.473 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.471 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.471 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.471 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.471 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.471 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.470 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.470 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.469 | |
| 2zdu | 446 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.469 | |
| 3ics | FAD | Coenzyme A disulfide reductase | / | 0.469 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.469 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.468 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.468 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 1ppm | 0P1 | Penicillopepsin-1 | 3.4.23.20 | 0.466 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.466 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.466 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.465 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.465 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.465 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.465 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.465 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.464 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.464 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.464 | |
| 4aic | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.464 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.464 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.462 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.462 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
| 2yr5 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.461 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.461 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.461 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.461 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.461 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 4ho9 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.461 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.460 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.460 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4mgi | CMP | Rap guanine nucleotide exchange factor 4 | / | 0.460 | |
| 4u7w | NDP | MxaA | / | 0.460 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 2qd9 | LGF | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.459 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.459 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.458 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.458 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.458 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.458 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.458 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3pvu | QRW | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.457 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.457 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.457 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.456 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.456 | |
| 1nqo | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.456 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.456 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.456 | |
| 3r9i | ADP | Septum site-determining protein MinD | / | 0.456 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.456 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.456 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.456 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.455 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.455 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.455 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.455 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.455 | |
| 3bkb | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.455 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 1c70 | L75 | Protease | / | 0.454 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.454 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.454 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.454 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.454 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 5a3b | APR | SIR2 family protein | / | 0.454 | |
| 2hut | SAH | Diphthine synthase | / | 0.453 | |
| 2owv | SAH | Diphthine synthase | / | 0.453 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 3lu8 | IQX | Serum albumin | / | 0.453 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.453 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.453 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.452 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.452 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3lcd | BDY | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.452 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.452 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.452 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.451 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.451 | |
| 3qai | XNN | Ketohexokinase | / | 0.451 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 4pk4 | ADP | Unconventional myosin-VI | / | 0.451 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.451 | |
| 1c6x | 3IN | Protease | / | 0.450 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.450 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.450 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.450 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.450 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 4r3a | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.450 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.450 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.449 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.449 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.449 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.449 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.449 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.449 | |
| 2yww | ATP | Aspartate carbamoyltransferase regulatory chain | / | 0.449 | |
| 3a6q | FMN | FMN-binding protein | / | 0.449 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.449 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.449 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.449 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.449 | |
| 3vi2 | HMZ | Orotidine 5'-monophosphate decarboxylase | / | 0.449 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.449 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.448 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.448 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.448 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.448 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 1jgt | APC | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.447 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.447 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.447 | |
| 2bxm | IMN | Serum albumin | / | 0.447 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.447 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.447 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.447 | |
| 3kf7 | L9G | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.447 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.447 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.447 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4o3m | ADP | Bloom syndrome protein | 3.6.4.12 | 0.447 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.447 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.446 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.446 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.446 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.446 | |
| 4okx | 198 | Androgen receptor | / | 0.446 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.446 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.446 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1f3p | NAD | Ferredoxin reductase | / | 0.445 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.445 | |
| 1um0 | FMN | Chorismate synthase | / | 0.445 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.445 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.445 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.445 | |
| 4k5s | PM0 | Oxygenase | / | 0.445 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.445 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4yd7 | F5N | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.444 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2e08 | SAH | Diphthine synthase | / | 0.444 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.444 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 4h0y | LAR | Actin, alpha skeletal muscle | / | 0.444 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.444 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.444 | |
| 4o6m | C5P | Uncharacterized protein | / | 0.444 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.444 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.444 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.444 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.443 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.443 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.443 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.443 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.443 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.443 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.443 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.443 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.443 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.443 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.442 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.442 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.442 | |
| 1fnn | ADP | ORC1-type DNA replication protein | / | 0.442 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.442 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.442 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.442 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.442 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.442 | |
| 2j0j | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.442 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.442 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2q5o | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.442 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2vuu | NAP | Nitrogen metabolite repression protein nmrA | / | 0.442 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.442 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3ibe | L64 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.442 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.442 | |
| 3k0f | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.442 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 3uxj | NAP | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.442 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.442 | |
| 4mcc | 21X | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.442 | |
| 4pd6 | URI | Nucleoside permease | / | 0.442 | |
| 4wuc | ANP | DNA gyrase subunit B | / | 0.442 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.442 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.441 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.441 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.441 | |
| 3a1e | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.441 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.441 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.441 | |
| 3umw | 596 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.441 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4bdg | P3J | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 4ckj | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.441 | |
| 4dja | FAD | (6-4) photolyase | / | 0.441 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.441 | |
| 4i0r | 1B4 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.441 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1e80 | 0GQ | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 1gqt | ACP | Ribokinase | / | 0.440 | |
| 1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1r2j | FAD | FkbI | / | 0.440 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.440 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2czf | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2p6i | SAH | Diphthine synthase | / | 0.440 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.440 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.440 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.440 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.440 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.440 | |
| 3nbw | TR4 | Ketohexokinase | / | 0.440 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.440 | |
| 4aqk | ADP | Inositol-pentakisphosphate 2-kinase | 2.7.1.158 | 0.440 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.440 | |
| 4u0i | 0LI | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.440 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.440 |