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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ue4DB8Tyrosine-protein kinase ABL12.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ue4DB8Tyrosine-protein kinase ABL12.7.10.21.000
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.551
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.550
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.549
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.547
2hk51BMTyrosine-protein kinase HCK2.7.10.20.546
4gk4L90Ephrin type-A receptor 32.7.10.10.544
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.540
2of4979Tyrosine-protein kinase Lck2.7.10.20.540
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.539
2vwx7X4Ephrin type-B receptor 42.7.10.10.538
1bygSTUTyrosine-protein kinase CSK/0.537
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.536
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.536
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.533
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.532
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.529
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.528
3zewSTUEphrin type-B receptor 42.7.10.10.528
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.527
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.527
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.526
4jia1K3Tyrosine-protein kinase JAK2/0.525
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.522
2xvdAS6Ephrin type-B receptor 42.7.10.10.522
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.522
4gk3L87Ephrin type-A receptor 32.7.10.10.521
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.521
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.521
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.521
2of2547Tyrosine-protein kinase Lck2.7.10.20.520
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.519
3vs3VSETyrosine-protein kinase HCK2.7.10.20.519
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.517
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.517
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.517
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.516
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.515
4gmy0X5Tyrosine-protein kinase JAK2/0.515
4id71G0Activated CDC42 kinase 1/0.514
4gk2L66Ephrin type-A receptor 32.7.10.10.513
2vwu7X1Ephrin type-B receptor 42.7.10.10.512
2vx07X7Ephrin type-B receptor 42.7.10.10.511
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.510
2vwz7X6Ephrin type-B receptor 42.7.10.10.508
2xyuQ9GEphrin type-A receptor 42.7.10.10.508
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.508
4g2fC07Ephrin type-A receptor 32.7.10.10.508
1jpaANPEphrin type-B receptor 22.7.10.10.506
2itqITQEpidermal growth factor receptor2.7.10.10.506
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.505
2vx17X8Ephrin type-B receptor 42.7.10.10.505
2yn8STUEphrin type-B receptor 42.7.10.10.505
5aaaVGHALK tyrosine kinase receptor2.7.10.10.505
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.504
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.504
2itnANPEpidermal growth factor receptor2.7.10.10.503
2itvANPEpidermal growth factor receptor2.7.10.10.502
2vwy7X5Ephrin type-B receptor 42.7.10.10.502
3vs1VSATyrosine-protein kinase HCK2.7.10.20.502
4fob0USALK tyrosine kinase receptor2.7.10.10.502
4nka2K7Fibroblast growth factor receptor 1/0.502
5e8wSTUTGF-beta receptor type-12.7.11.300.502
2xp2VGHALK tyrosine kinase receptor2.7.10.10.501
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.501
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.501
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.500
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.499
2ittAEEEpidermal growth factor receptor2.7.10.10.498
2qo9ANPEphrin type-A receptor 32.7.10.10.498
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.498
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.498
4bb432WEphrin type-B receptor 42.7.10.10.498
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.498
3ac2KSETyrosine-protein kinase Lck2.7.10.20.496
3vjoANPEpidermal growth factor receptor2.7.10.10.496
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.496
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.495
2pwlACPFibroblast growth factor receptor 2/0.493
2y6o1N1Ephrin type-A receptor 42.7.10.10.492
3vryB43Tyrosine-protein kinase HCK2.7.10.20.492
4j97ACPFibroblast growth factor receptor 2/0.492
5e8ySTUTGF-beta receptor type-22.7.11.300.492
3oom507Activin receptor type-12.7.11.300.490
4nks2M2Fibroblast growth factor receptor 1/0.490
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.490
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.489
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.489
2itzIREEpidermal growth factor receptor2.7.10.10.489
4i22IREEpidermal growth factor receptor2.7.10.10.489
1vjy460TGF-beta receptor type-12.7.11.300.488
4c62XWWTyrosine-protein kinase JAK2/0.488
1u54ACPActivated CDC42 kinase 1/0.487
2j0j4STFocal adhesion kinase 12.7.10.20.487
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.487
2pz5ACPFibroblast growth factor receptor 2/0.487
2pzpACPFibroblast growth factor receptor 2/0.487
2itpAEEEpidermal growth factor receptor2.7.10.10.486
2qoqANPEphrin type-A receptor 32.7.10.10.486
4j98ACPFibroblast growth factor receptor 2/0.486
3gc9B45Mitogen-activated protein kinase 112.7.11.240.485
4y95746Tyrosine-protein kinase/0.485
2zybKSLTyrosine-protein kinase Lck2.7.10.20.484
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
1m17AQ4Epidermal growth factor receptor2.7.10.10.483
1pmn984Mitogen-activated protein kinase 102.7.11.240.482
1y6bAAXVascular endothelial growth factor receptor 22.7.10.10.482
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.482
1u4dDBQActivated CDC42 kinase 1/0.481
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.481
2x9fX9FEphrin type-B receptor 42.7.10.10.480
4jrvKJVEpidermal growth factor receptor2.7.10.10.480
4riyADPEpidermal growth factor receptor2.7.10.10.480
1m52P17Tyrosine-protein kinase ABL12.7.10.20.479
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.479
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.479
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
2hcdBIVVitamin D3 receptor A/0.478
2py3ACPFibroblast growth factor receptor 2/0.478
3ac1KZITyrosine-protein kinase Lck2.7.10.20.478
3w2sW2REpidermal growth factor receptor2.7.10.10.478
4jlj1NMDeoxycytidine kinase2.7.1.740.478
4jq8KJ8Epidermal growth factor receptor2.7.10.10.478
2fgiPD1Fibroblast growth factor receptor 1/0.477
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
4c57FEFCyclin-G-associated kinase2.7.11.10.477
4f640S8Fibroblast growth factor receptor 1/0.477
4nk92K5Fibroblast growth factor receptor 1/0.477
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
2bujSTUSerine/threonine-protein kinase 16/0.476
2j0k4STFocal adhesion kinase 12.7.10.20.476
4bcmT7ZCyclin-dependent kinase 22.7.11.220.476
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.476
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.476
5aabVGHALK tyrosine kinase receptor2.7.10.10.476
5e8xSTUTGF-beta receptor type-12.7.11.300.476
1fmlRTLRetinol dehydratase/0.475
2ghmLICMitogen-activated protein kinase 14/0.475
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
4ia7BIVVitamin D3 receptor A/0.475
4wkqIREEpidermal growth factor receptor2.7.10.10.475
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.474
2v7a627Tyrosine-protein kinase ABL12.7.10.20.474
3qly55VUncharacterized protein/0.474
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.474
4f630S7Fibroblast growth factor receptor 1/0.474
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.474
4k33ACPFibroblast growth factor receptor 32.7.10.10.474
4wa9AXITyrosine-protein kinase ABL12.7.10.20.474
4y93746Tyrosine-protein kinase/0.474
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.473
2eb3ANPEpidermal growth factor receptor2.7.10.10.473
4i231C9Epidermal growth factor receptor2.7.10.10.473
4ia3BIVVitamin D3 receptor A/0.473
4j99ACPFibroblast growth factor receptor 2/0.473
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.473
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.473
2wqeADPAurora kinase A2.7.11.10.472
3t8oATPRhodopsin kinase/0.472
4bgg844Activin receptor type-12.7.11.300.472
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.472
4hni16WCasein kinase I isoform epsilon2.7.11.10.472
1py5PY1TGF-beta receptor type-12.7.11.300.471
2j7t274Serine/threonine-protein kinase 102.7.11.10.471
4bcqTJFCyclin-dependent kinase 22.7.11.220.471
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.471
1ia3TQ5Dihydrofolate reductase1.5.1.30.470
2henADPEphrin type-B receptor 22.7.10.10.470
3mtfA3FActivin receptor type-12.7.11.300.470
3vrwYS5Vitamin D3 receptor/0.470
4af3VX6Aurora kinase B2.7.11.10.470
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.470
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.470
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.470
2vww7X2Ephrin type-B receptor 42.7.10.10.469
2yfxVGHALK tyrosine kinase receptor2.7.10.10.469
3ttjJBIMitogen-activated protein kinase 102.7.11.240.469
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.469
4bbe3O4Tyrosine-protein kinase JAK2/0.469
1synF89Thymidylate synthase/0.468
1y6aAAZVascular endothelial growth factor receptor 22.7.10.10.468
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.468
4b99R4LMitogen-activated protein kinase 72.7.11.240.468
4cd0AWJALK tyrosine kinase receptor2.7.10.10.468
2jedLG8Protein kinase C theta type2.7.11.130.467
2lbaCHOFatty acid binding protein 6/0.467
2p33J07Mitogen-activated protein kinase 102.7.11.240.467
2qocANPEphrin type-A receptor 32.7.10.10.467
2wotZZGTGF-beta receptor type-12.7.11.300.467
3a60STURibosomal protein S6 kinase beta-12.7.11.10.467
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.467
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.467
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
3a7hATPSerine/threonine-protein kinase 242.7.11.10.466
3irxUDRGag-Pol polyprotein2.7.7.490.466
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.464
4ansVGHALK tyrosine kinase receptor2.7.10.10.464
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.464
4iui1GQEstrogen receptor/0.464
4jbtASDCytochrome P450 monooxygenase/0.464
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.464
5l8lADPAurora kinase A2.7.11.10.464
1gy3ATPCyclin-dependent kinase 22.7.11.220.463
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.463
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.463
3gxlQIGTGF-beta receptor type-12.7.11.300.463
4ia1BIVVitamin D3 receptor A/0.463
4j6cSTRCytochrome P450 monooxygenase/0.463
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.463
1fmjRTLRetinol dehydratase/0.462
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
1mqbANPEphrin type-A receptor 22.7.10.10.462
1nq7ARLNuclear receptor ROR-beta/0.462
2hw2RFPRifampin ADP-ribosyl transferase/0.462
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.462
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.462
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.462
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.462
4qmlANPSerine/threonine-protein kinase 242.7.11.10.462
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.461
2i0ePDSProtein kinase C beta type2.7.11.130.461
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.461
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.461
3t2zFADSulfide-quinone reductase/0.461
4g1z0VPVitamin D3 receptor A/0.461
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.460
2qo7ANPEphrin type-A receptor 32.7.10.10.460
3iw4LW4Protein kinase C alpha type2.7.11.130.460
3l8p0CEAngiopoietin-1 receptor2.7.10.10.460
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.460
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.460
4enhFVXCholesterol 24-hydroxylase/0.460
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.460
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.460
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.460
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.460
4rupH97Vitamin D3 receptor A/0.460
2nq8ZIDEnoyl-ACP reductase/0.459
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
4jq7KJQEpidermal growth factor receptor2.7.10.10.459
1phgMYTCamphor 5-monooxygenase1.14.15.10.458
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.458
2etm7PYFocal adhesion kinase 12.7.10.20.458
2j0lANPFocal adhesion kinase 12.7.10.20.458
3e5aVX6Aurora kinase A2.7.11.10.458
3ezpB3NHistone deacetylase 83.5.1.980.458
4dymIYZActivin receptor type-12.7.11.300.458
4e37NDPCatalase1.11.1.60.458
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.458
4jbqVX6Aurora kinase A2.7.11.10.458
4wboANWRhodopsin kinase/0.458
1x8lOXRRetinol dehydratase/0.457
1xjdSTUProtein kinase C theta type2.7.11.130.457
2itwITQEpidermal growth factor receptor2.7.10.10.457
2jn3JN3Fatty acid-binding protein, liver/0.457
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.457
3acjKSSTyrosine-protein kinase Lck2.7.10.20.457
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.457
3d7tSTUTyrosine-protein kinase CSK/0.457
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.457
3t2yFADSulfide-quinone reductase/0.457
4jr3KJREpidermal growth factor receptor2.7.10.10.457
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2cig1DGDihydrofolate reductase1.5.1.30.456
2fzhDH1Dihydrofolate reductase1.5.1.30.456
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.456
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4fod0UVALK tyrosine kinase receptor2.7.10.10.456
4g1y0VOVitamin D3 receptor A/0.456
4nh82LCHeat shock protein HSP 90-alpha/0.456
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.455
2hog710Serine/threonine-protein kinase Chk12.7.11.10.455
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.455
4anqVGHALK tyrosine kinase receptor2.7.10.10.455
4c02TAKActivin receptor type-12.7.11.300.455
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1agwSU2Fibroblast growth factor receptor 1/0.454
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.454
2hziJINTyrosine-protein kinase ABL12.7.10.20.454
2i40BLZCyclin-dependent kinase 22.7.11.220.454
3nmpPYVAbscisic acid receptor PYL2/0.454
3uvqFS8Mitogen-activated protein kinase 14/0.454
3zk5Z18Cytochrome P450 monooxygenase PikC/0.454
4aotGW8Serine/threonine-protein kinase 102.7.11.10.454
1g5sI17Cyclin-dependent kinase 22.7.11.220.453
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1vrwNAIEnoyl-ACP reductase/0.453
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.453
2excJNKMitogen-activated protein kinase 102.7.11.240.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
3q5iANPProtein kinase, putative/0.453
3ttiKBIMitogen-activated protein kinase 102.7.11.240.453
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.453
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.453
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.453
1iyzNDPProbable quinone oxidoreductase/0.452
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.452
2vn0TDZCytochrome P450 2C8/0.452
3fzr3JZProtein-tyrosine kinase 2-beta2.7.10.20.452
3hmm855TGF-beta receptor type-12.7.11.300.452
4aw530KEphrin type-B receptor 42.7.10.10.452
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
5aacVGHALK tyrosine kinase receptor2.7.10.10.452
1dajMOTDihydrofolate reductase1.5.1.30.451
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.451
1yvj4STTyrosine-protein kinase JAK32.7.10.20.451
2c6eHPMAurora kinase A2.7.11.10.451
3s2pPMUCyclin-dependent kinase 22.7.11.220.451
3vtcTK3Vitamin D3 receptor/0.451
4hvg19QTyrosine-protein kinase JAK32.7.10.20.451
4jboWPHAurora kinase A2.7.11.10.451
4jlk1NODeoxycytidine kinase2.7.1.740.451
4qo9627Serine/threonine-protein kinase 242.7.11.10.451
1dhjMTXDihydrofolate reductase1.5.1.30.450
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.450
2hc4VDXVitamin D3 receptor A/0.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.450
3efwAK8Aurora kinase A2.7.11.10.450
3zze6XPHepatocyte growth factor receptor2.7.10.10.450
4c61LMMTyrosine-protein kinase JAK2/0.450
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.450
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.450
4r21STRCytochrome P450 family 17 polypeptide 2/0.450
1pkdUCNCyclin-dependent kinase 22.7.11.220.449
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.449
2bfyH1NAurora kinase B-A2.7.11.10.449
2hasC3OVitamin D3 receptor/0.449
2ijmATPFocal adhesion kinase 12.7.10.20.449
2ituITQEpidermal growth factor receptor2.7.10.10.449
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.449
2q0bACPFibroblast growth factor receptor 2/0.449
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.449
3uo50BXAurora kinase A2.7.11.10.449
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.449
4e4m0NHTyrosine-protein kinase JAK2/0.449
4fz60VGTyrosine-protein kinase SYK2.7.10.20.449
4hvh19RTyrosine-protein kinase JAK32.7.10.20.449
4ic7ANPMitogen-activated protein kinase 72.7.11.240.449
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.449
4r20AERCytochrome P450 family 17 polypeptide 2/0.449
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.449
1eupASD6-deoxyerythronolide B hydroxylase/0.448
1rkhVD2Vitamin D3 receptor/0.448
2b1pAIZMitogen-activated protein kinase 102.7.11.240.448
2vwv7X3Ephrin type-B receptor 42.7.10.10.448
2w1eL0EAurora kinase A2.7.11.10.448
2w2lNADD-mandelate dehydrogenase/0.448
2x6dX6DAurora kinase A2.7.11.10.448
3cv9VDXVitamin D3 dihydroxylase/0.448
3ddpRC8Cyclin-dependent kinase 22.7.11.220.448
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.448
3my5RFZCyclin-dependent kinase 22.7.11.220.448
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.448
4h9753SDihydrofolate reductase1.5.1.30.448
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
1drbMTXDihydrofolate reductase1.5.1.30.447
1txiTX5Vitamin D3 receptor/0.447
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.447
3kpzZNEVitamin D3 receptor/0.447
3p3e3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.447
3w5tLHPVitamin D3 receptor/0.447
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2itxANPEpidermal growth factor receptor2.7.10.10.446
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.446
2oyuIMSProstaglandin G/H synthase 11.14.99.10.446
2q59240Peroxisome proliferator-activated receptor gamma/0.446
3mdvCL6Cholesterol 24-hydroxylase/0.446
3sz0FADSulfide-quinone reductase/0.446
3t8xT8XT-cell surface glycoprotein CD1b/0.446
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
3vt5YI2Vitamin D3 receptor/0.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.446
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.446
4fv9E71Mitogen-activated protein kinase 12.7.11.240.446
4hvi19STyrosine-protein kinase JAK32.7.10.20.446
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.446
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.446
4qa0SHHHistone deacetylase 83.5.1.980.446
4ruoBIVVitamin D3 receptor A/0.446
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
1m13HYFNuclear receptor subfamily 1 group I member 2/0.445
1zrzBI1Protein kinase C iota type2.7.11.130.445
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.445
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3be9P04Casein kinase II subunit alpha2.7.11.10.445
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.445
3is9AC7Gag-Pol polyprotein2.7.7.490.445
3och2MXDihydrofolate reductase1.5.1.30.445
3w33W19Epidermal growth factor receptor2.7.10.10.445
3w5rLOAVitamin D3 receptor/0.445
4c58824Cyclin-G-associated kinase2.7.11.10.445
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.445
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
1nhz486Glucocorticoid receptor/0.444
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.444
2y30SM8Putative repressor SimReg2/0.444
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
3v2uATPProtein GAL3/0.444
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.444
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4h9506UDihydrofolate reductase1.5.1.30.444
1m7aMQUDihydrofolate reductase1.5.1.30.443
1oecAA2Fibroblast growth factor receptor 2/0.443
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.443
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.443
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.443
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.443
3cx5SMACytochrome b/0.443
3drcMTXDihydrofolate reductase1.5.1.30.443
3u4uLNHCasein kinase II subunit alpha2.7.11.10.443
4b7dQLECytochrome P450 monooxygenase PikC/0.443
4b8mVX6Aurora kinase B-A2.7.11.10.443
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4ia2BIVVitamin D3 receptor A/0.443
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.443
4ly91YYGlucokinase regulatory protein/0.443
4o0uADNAurora kinase A2.7.11.10.443
4ubsDIFPentalenic acid synthase1.14.15.110.443
2fvdLIACyclin-dependent kinase 22.7.11.220.442
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.442
2wihP48Cyclin-dependent kinase 22.7.11.220.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3lakKR1Gag-Pol polyprotein2.7.7.490.442
3vjnANPEpidermal growth factor receptor2.7.10.10.442
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.442
4bcnT9NCyclin-dependent kinase 22.7.11.220.442
4c4g7RODual specificity protein kinase TTK2.7.12.10.442
4f9wLM4Mitogen-activated protein kinase 14/0.442
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4yuqKS1Calmodulin-like domain protein kinase/0.442
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3pwhZMAAdenosine receptor A2a/0.442
1jioDEB6-deoxyerythronolide B hydroxylase/0.441
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.441
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3ddw055Glycogen phosphorylase, liver form2.4.1.10.441
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3vt65YIVitamin D3 receptor/0.441
3w18N13Aurora kinase A2.7.11.10.441
3w2o03PEpidermal growth factor receptor2.7.10.10.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4btkDTQTau-tubulin kinase 12.7.11.10.441
4cd2FOLDihydrofolate reductase1.5.1.30.441
4f650S9Fibroblast growth factor receptor 1/0.441
4i6gFADCryptochrome-2/0.441
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4oavACP2-5A-dependent ribonuclease3.1.260.441
4qmzB49Serine/threonine-protein kinase 242.7.11.10.441
4tuvCPZCytochrome P450 1191.140.441
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.441
1aq1STUCyclin-dependent kinase 22.7.11.220.440
1dkfBMSRetinoic acid receptor alpha/0.440
1klkPMDDihydrofolate reductase1.5.1.30.440
1l2jETCEstrogen receptor beta/0.440
2j4z626Aurora kinase A2.7.11.10.440
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.440
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.440
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.440
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.440
3uyt0CKCasein kinase I isoform delta2.7.11.10.440
3w0jT08Vitamin D3 receptor/0.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.440
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.440
5cvhADPCasein kinase II subunit alpha2.7.11.10.440