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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hv3R49Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hv3R49Mitogen-activated protein kinase 14/1.000
3gcq1BUMitogen-activated protein kinase 14/0.644
3lfeZ84Mitogen-activated protein kinase 14/0.612
2bakAQZMitogen-activated protein kinase 14/0.593
4a9yAQZMitogen-activated protein kinase 14/0.593
3l8sBFFMitogen-activated protein kinase 14/0.546
2ewaSB2Mitogen-activated protein kinase 14/0.538
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.521
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.517
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.505
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.501
4b2gV1NUncharacterized protein/0.498
1crbRTLRetinol-binding protein 1/0.497
3iw8HIZMitogen-activated protein kinase 14/0.497
2zb1GK4Mitogen-activated protein kinase 14/0.495
3itzP66Mitogen-activated protein kinase 14/0.489
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.489
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.488
3pg3DG7Mitogen-activated protein kinase 14/0.488
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.486
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.485
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.482
1pqc444Oxysterols receptor LXR-beta/0.481
1w83L11Mitogen-activated protein kinase 14/0.481
3ds6A17Mitogen-activated protein kinase 14/0.481
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.481
2z2w770Wee1-like protein kinase2.7.10.20.480
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.479
3cv9VDXVitamin D3 dihydroxylase/0.478
4jlj1NMDeoxycytidine kinase2.7.1.740.478
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.477
4aa4QC0Mitogen-activated protein kinase 14/0.473
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.472
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.471
4rh10TTSpore photoproduct lyase/0.471
1pkfEPDEpothilone C/D epoxidase1.140.470
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
3c34KAIGlutamate receptor ionotropic, kainate 1/0.470
4l8u9AZSerum albumin/0.470
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
3rthRTHBeta-secretase 13.4.23.460.469
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.469
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.468
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
1hfqMOTDihydrofolate reductase1.5.1.30.467
1obnASVIsopenicillin N synthase1.21.3.10.467
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.467
3fskRO6Mitogen-activated protein kinase 14/0.467
3zkuHCVIsopenicillin N synthase1.21.3.10.467
4eyjN61Mitogen-activated protein kinase 132.7.11.240.467
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.467
3rtnRTNBeta-secretase 13.4.23.460.466
4twnB96Ephrin type-A receptor 32.7.10.10.466
1eqbFFOSerine hydroxymethyltransferase2.1.2.10.465
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3eta351Insulin receptor2.7.10.10.465
3hucG97Mitogen-activated protein kinase 14/0.465
5dp2NAPCurF/0.465
1w7h3IPMitogen-activated protein kinase 14/0.464
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.464
5bt42LOBromodomain-containing protein 4/0.464
3njoPYVAbscisic acid receptor PYR1/0.463
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.463
2ejzSAHDiphthine synthase/0.462
3ctj320Hepatocyte growth factor receptor2.7.10.10.462
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.462
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.462
1s3uTQDDihydrofolate reductase1.5.1.30.461
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.461
3h3sH15Collagen type IV alpha-3-binding protein/0.461
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3vrvYSDVitamin D3 receptor/0.461
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.461
4plpNADHomospermidine synthase2.5.1.440.461
2bktRPFRenin3.4.23.150.460
3n87N873-dehydroquinate dehydratase4.2.1.100.460
3nxvD2FDihydrofolate reductase1.5.1.30.460
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.460
4fhd0TTSpore photoproduct lyase/0.460
1hb1OCVIsopenicillin N synthase1.21.3.10.459
1p0pBCHCholinesterase3.1.1.80.459
2iviACWIsopenicillin N synthase1.21.3.10.459
3p3zP3ZPutative cytochrome P450/0.459
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
3ufl508Beta-secretase 13.4.23.460.459
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.459
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.459
2gfsPQBMitogen-activated protein kinase 14/0.458
2tscCB3Thymidylate synthase/0.458
3tdaPN0Cytochrome P450 2D6/0.458
3zoiM2WIsopenicillin N synthase1.21.3.10.458
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3bi6396Wee1-like protein kinase2.7.10.20.457
3nxoD2BDihydrofolate reductase1.5.1.30.457
1dgfNDPCatalase1.11.1.60.456
1sezFADProtoporphyrinogen oxidase, mitochondrial1.3.3.40.456
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.456
3ihgVAKAklavinone 12-hydroxylase RdmE/0.456
1bk0ACVIsopenicillin N synthase1.21.3.10.455
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.455
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.455
3d74NBBPheromone-binding protein ASP1/0.455
3zkyWT4Isopenicillin N synthase1.21.3.10.455
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.455
4i3vNADAldehyde dehydrogenase (NAD+)/0.455
5jy1NADPutative short-chain dehydrogenase/reductase/0.455
1hb3SCVIsopenicillin N synthase1.21.3.10.454
1hfrMOTDihydrofolate reductase1.5.1.30.454
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.454
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.454
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.454
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.454
3q2mCKISpectinomycin phosphotransferase/0.454
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.454
1mczRMNBenzoylformate decarboxylase4.1.1.70.453
1ohkCOPDihydrofolate reductase1.5.1.30.453
3fklFKLMitogen-activated protein kinase 14/0.453
3p9tTCLRepressor/0.453
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.453
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.453
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.453
1dr3HBIDihydrofolate reductase1.5.1.30.452
1w06W05Isopenicillin N synthase1.21.3.10.452
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.452
4jln18VDeoxycytidine kinase2.7.1.740.452
1nceCB3Thymidylate synthase/0.451
2gvcFADThiol-specific monooxygenase1.14.130.451
2io6330Wee1-like protein kinase2.7.10.20.451
2jb4A14Isopenicillin N synthase1.21.3.10.451
2jizANPATP synthase subunit beta, mitochondrial3.6.3.140.451
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.451
2yac937Serine/threonine-protein kinase PLK12.7.11.210.451
3acy702Dehydrosqualene synthase/0.451
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
3biz61EWee1-like protein kinase2.7.10.20.451
3zc3FADFerredoxin--NADP reductase1.18.1.20.451
5c1mCLRMu-type opioid receptor/0.451
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.450
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1pd9CO4Dihydrofolate reductase1.5.1.30.450
1rd4L08Integrin alpha-L/0.450
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.450
2vcmM11Isopenicillin N synthase1.21.3.10.450
3arvSAUChitinase A/0.450
3d5wADPSerine/threonine-protein kinase PLK/0.450
4at0FADPossible succinate dehydrogenase/0.450
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.450
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
1blzACVIsopenicillin N synthase1.21.3.10.449
1hfpMOTDihydrofolate reductase1.5.1.30.449
2uxhQUEHTH-type transcriptional regulator TtgR/0.449
2vbdV10Isopenicillin N synthase1.21.3.10.449
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.449
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.449
2zazGK1Mitogen-activated protein kinase 14/0.449
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.449
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.449
4m6kFOLDihydrofolate reductase1.5.1.30.449
1bozPRDDihydrofolate reductase1.5.1.30.448
1drfFOLDihydrofolate reductase1.5.1.30.448
1mvtDTMDihydrofolate reductase1.5.1.30.448
1oc1ASVIsopenicillin N synthase1.21.3.10.448
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2bf7HBIPteridine reductase 11.5.1.330.448
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.448
2jedLG8Protein kinase C theta type2.7.11.130.448
2pl0STITyrosine-protein kinase Lck2.7.10.20.448
2ydoADNAdenosine receptor A2a/0.448
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
1dr4HBIDihydrofolate reductase1.5.1.30.447
1rkhVD2Vitamin D3 receptor/0.447
2in6839Wee1-like protein kinase2.7.10.20.447
2vbpVB1Isopenicillin N synthase1.21.3.10.447
3d7zGK5Mitogen-activated protein kinase 14/0.447
3dgeADPSensor histidine kinase/0.447
3er93ATPoly(A) polymerase catalytic subunit2.7.7.190.447
3nxyD2HDihydrofolate reductase1.5.1.30.447
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.447
4jx1CAHCamphor 5-monooxygenase1.14.15.10.447
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.447
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1lbbKAIGlutamate receptor 2/0.446
1x8b824Wee1-like protein kinase2.7.10.20.446
2hamC33Vitamin D3 receptor/0.446
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.446
3ft8MOJHeat shock protein HSP 90-alpha/0.446
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3qm4PN0Cytochrome P450 2D6/0.446
3v94WYQPhosphodiesterase/0.446
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.446
4eh60ONMitogen-activated protein kinase 14/0.446
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
2ph5NADHomospermidine synthase/0.445
2pnuENMAndrogen receptor/0.445
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
2vnhFADNADPH:ferredoxin reductase/0.445
2w6oOA3Biotin carboxylase6.3.4.140.445
3e92G6AMitogen-activated protein kinase 14/0.445
3hz5Z64Heat shock protein HSP 90-alpha/0.445
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
3tk3CPZCytochrome P450 2B41.14.14.10.445
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.445
4bfxZVXPantothenate kinase2.7.1.330.445
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.445
5dozNDPJamJ/0.445
1dgbNDPCatalase1.11.1.60.444
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2w3mFOLDihydrofolate reductase1.5.1.30.444
2xviFADPutative flavin-containing monooxygenase/0.444
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.444
3iphG11Mitogen-activated protein kinase 14/0.444
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3p99LNPLanosterol 14-alpha-demethylase/0.444
4e37NDPCatalase1.11.1.60.444
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.444
4iarERM5-hydroxytryptamine receptor 1B/0.444
4orkGDPBifunctional AAC/APH2.3.10.444
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.444
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.443
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.443
3flyFLYMitogen-activated protein kinase 14/0.443
3ghvGHCDihydrofolate reductase1.5.1.30.443
3lfcZ86Mitogen-activated protein kinase 14/0.443
3nmpPYVAbscisic acid receptor PYL2/0.443
3p6nDSOCamphor 5-monooxygenase1.14.15.10.443
3uibSB2Putative mitogen-activated protein kinase/0.443
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.443
3znqSS8D-amino-acid oxidase1.4.3.30.443
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.443
4g1nNZTPyruvate kinase PKM2.7.1.400.443
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.443
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4s1iPLPPyridoxal kinase, putative/0.443
4wa9AXITyrosine-protein kinase ABL12.7.10.20.443
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1z6tADPApoptotic protease-activating factor 1/0.442
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.442
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
2hb8MVDVitamin D3 receptor/0.442
2w4qCBWProstaglandin reductase 21.3.1.480.442
3bx5304Mitogen-activated protein kinase 14/0.442
3nu03TUDihydrofolate reductase1.5.1.30.442
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.442
4aacAAVMitogen-activated protein kinase 14/0.442
4ddrMMVDihydrofolate reductase1.5.1.30.442
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3reyXACAdenosine receptor A2a/0.442
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.441
1opbRETRetinol-binding protein 2/0.441
1pq944BOxysterols receptor LXR-beta/0.441
1qiqACCIsopenicillin N synthase1.21.3.10.441
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
3c36KAIGlutamate receptor ionotropic, kainate 1/0.441
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.441
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.441
4dlj6RGMitogen-activated protein kinase 14/0.441
4ea2RWZDehydrosqualene synthase/0.441
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4j6cSTRCytochrome P450 monooxygenase/0.441
4jpg1OXPyruvate kinase PKM2.7.1.400.441
4xbfFADLysine-specific histone demethylase 1A10.441
1d3pBT3Prothrombin3.4.21.50.440
1q5dEPBEpothilone C/D epoxidase1.140.440
1s3wTQTDihydrofolate reductase1.5.1.30.440
1uzwCDHIsopenicillin N synthase1.21.3.10.440
1x8lOXRRetinol dehydratase/0.440
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.440
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3bhrTHGThymidylate synthase/0.440
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3tfn2CJDehydrosqualene synthase/0.440
4b4vL34Bifunctional protein FolD/0.440
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.440
4hfp15UProthrombin3.4.21.50.440
4iaq2GM5-hydroxytryptamine receptor 1B/0.440
4jqh1MFAlr2278 protein/0.440
4phlPILPhosphodiesterase/0.440
5jtbZMAAdenosine receptor A2a/0.440