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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pvmP29Casein kinase II subunit alpha2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pvmP29Casein kinase II subunit alpha2.7.11.11.000
2pvnP63Casein kinase II subunit alpha2.7.11.10.710
2pvlP55Casein kinase II subunit alpha2.7.11.10.622
3be9P04Casein kinase II subunit alpha2.7.11.10.622
2pvjP44Casein kinase II subunit alpha2.7.11.10.593
4anmWULCasein kinase II subunit alpha2.7.11.10.586
2pvhP19Casein kinase II subunit alpha2.7.11.10.568
3q9xEMOCasein kinase II subunit alpha2.7.11.10.554
4aqc88ATyrosine-protein kinase JAK2/0.543
4hge15VTyrosine-protein kinase JAK2/0.538
1dawANPCasein kinase II subunit alpha2.7.11.10.536
1lp4ANPCasein kinase II subunit alpha2.7.11.10.534
1m2pHNACasein kinase II subunit alpha2.7.11.10.532
3at4CCKCasein kinase II subunit alpha2.7.11.10.532
3iok1P6Tyrosine-protein kinase JAK2/0.532
3lpbNVBTyrosine-protein kinase JAK2/0.532
4dgnLU2Casein kinase II subunit alpha2.7.11.10.531
1dayGNPCasein kinase II subunit alpha2.7.11.10.530
4fv6E57Mitogen-activated protein kinase 12.7.11.240.528
4gub0Y4Casein kinase II subunit alpha2.7.11.10.528
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.520
4dgmAGICasein kinase II subunit alpha2.7.11.10.519
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.517
5cvfATPCasein kinase II subunit alpha2.7.11.10.510
4btjADPTau-tubulin kinase 12.7.11.10.509
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.508
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.506
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.505
5e8ySTUTGF-beta receptor type-22.7.11.300.502
4jqeANPCasein kinase II subunit alpha2.7.11.10.501
1g5sI17Cyclin-dependent kinase 22.7.11.220.500
4grb0XGCasein kinase II subunit alpha2.7.11.10.500
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.499
4dgo0JWCasein kinase II subunit alpha2.7.11.10.499
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.497
4ji91M3Tyrosine-protein kinase JAK2/0.497
5cvhADPCasein kinase II subunit alpha2.7.11.10.497
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.492
3pe2E1BCasein kinase II subunit alpha2.7.11.10.492
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.492
2vv9IM9Cyclin-dependent kinase 22.7.11.220.491
3u4uLNHCasein kinase II subunit alpha2.7.11.10.490
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.489
4lfiGNPCasein kinase II subunit alpha2.7.11.10.489
3rak03ZCyclin-dependent kinase 22.7.11.220.488
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.488
4hvi19STyrosine-protein kinase JAK32.7.10.20.488
4btjATPTau-tubulin kinase 12.7.11.10.487
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.487
2vttLZDCyclin-dependent kinase 22.7.11.220.486
2w05FRTCyclin-dependent kinase 22.7.11.220.486
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.486
1gii1PUCyclin-dependent kinase 22.7.11.220.485
4ix6ADPUncharacterized protein/0.484
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.484
1eh4IC1Casein kinase I homolog 12.7.11.10.482
2c6lDT4Cyclin-dependent kinase 22.7.11.220.482
3gubGUBDeath-associated protein kinase 12.7.11.10.482
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.482
4jr7GNPCasein kinase II subunit alpha2.7.11.10.482
1m2rMNYCasein kinase II subunit alpha2.7.11.10.481
3at3ATKCasein kinase II subunit alpha2.7.11.10.481
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.480
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.479
3zewSTUEphrin type-B receptor 42.7.10.10.479
4h3qANPMitogen-activated protein kinase 12.7.11.240.478
2j0m4STFocal adhesion kinase 12.7.10.20.477
3rvg17PTyrosine-protein kinase JAK2/0.477
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.477
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.476
2pvkP45Casein kinase II subunit alpha2.7.11.10.476
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.476
3s1h56ZCyclin-dependent kinase 22.7.11.220.476
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.476
3zh8C58Protein kinase C iota type2.7.11.130.476
4jia1K3Tyrosine-protein kinase JAK2/0.476
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3i60E86Mitogen-activated protein kinase 12.7.11.240.475
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.475
5av2KMPDeath-associated protein kinase 12.7.11.10.475
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.474
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.474
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.474
5cnoANPEpidermal growth factor receptor2.7.10.10.474
3ormAGSSerine/threonine protein kinase/0.473
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
2uzbC75Cyclin-dependent kinase 22.7.11.220.472
4f081RSTyrosine-protein kinase JAK2/0.472
5cnnANPEpidermal growth factor receptor2.7.10.10.472
1pjkANPCasein kinase II subunit alpha2.7.11.10.471
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.471
3nux3NVCyclin-dependent kinase 62.7.11.220.471
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.470
4ez50RSCyclin-dependent kinase 62.7.11.220.470
4kbk1QGCasein kinase I isoform delta2.7.11.10.470
4q5hANPProtein kinase OspG2.70.470
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.469
1pyePM1Cyclin-dependent kinase 22.7.11.220.469
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.469
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.469
4e6d0NUTyrosine-protein kinase JAK2/0.469
4qmlANPSerine/threonine-protein kinase 242.7.11.10.469
4qnyANPMitogen activated protein kinase, putative/0.469
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.468
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.467
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.467
1aq1STUCyclin-dependent kinase 22.7.11.220.466
2fvdLIACyclin-dependent kinase 22.7.11.220.466
3nga3NGCasein kinase II subunit alpha2.7.11.10.466
4btmF8ETau-tubulin kinase 12.7.11.10.466
4c61LMMTyrosine-protein kinase JAK2/0.466
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
4o0wADNAurora kinase A2.7.11.10.466
1pxmCK5Cyclin-dependent kinase 22.7.11.220.465
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.465
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2vu3LZECyclin-dependent kinase 22.7.11.220.465
2w17I19Cyclin-dependent kinase 22.7.11.220.465
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.465
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.465
3bqr4RBDeath-associated protein kinase 3/0.464
3juhANPCasein kinase II subunit alpha2.7.11.10.464
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.464
3sheI85MAP kinase-activated protein kinase 32.7.11.10.464
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.464
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.464
2vtqLZACyclin-dependent kinase 22.7.11.220.463
3gu7ADPDeath-associated protein kinase 12.7.11.10.463
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.463
2b7aIZATyrosine-protein kinase JAK2/0.462
2c6iDT1Cyclin-dependent kinase 22.7.11.220.462
3dfcANPDeath-associated protein kinase 12.7.11.10.462
3ncz3NCRho-associated protein kinase 12.7.11.10.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.462
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2yn8STUEphrin type-B receptor 42.7.10.10.461
4aguD15Cyclin-dependent kinase-like 1/0.461
5e92ANPTGF-beta receptor type-22.7.11.300.461
1m2qMNXCasein kinase II subunit alpha2.7.11.10.460
3lltANPProtein serine/threonine kinase-1/0.460
4j99ACPFibroblast growth factor receptor 2/0.460
5av3KMPDeath-associated protein kinase 12.7.11.10.460
2qo7ANPEphrin type-A receptor 32.7.10.10.459
2zjwREFCasein kinase II subunit alpha2.7.11.10.459
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
1h1s4SPCyclin-dependent kinase 22.7.11.220.458
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.458
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
2yaaATPDeath-associated protein kinase 2/0.458
4k33ACPFibroblast growth factor receptor 32.7.10.10.458
4bcmT7ZCyclin-dependent kinase 22.7.11.220.457
4fv9E71Mitogen-activated protein kinase 12.7.11.240.457
4i5cC5ITyrosine-protein kinase JAK1/0.457
2j0lANPFocal adhesion kinase 12.7.10.20.456
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.456
3rkb12ZCyclin-dependent kinase 22.7.11.220.456
4dtaADNAPH(2'')-Id/0.456
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.456
4ux9ANPMitogen-activated protein kinase 82.7.11.240.456
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3gxlQIGTGF-beta receptor type-12.7.11.300.455
3pxkPXKFocal adhesion kinase 12.7.10.20.455
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.455
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.455
4j95ACPFibroblast growth factor receptor 2/0.455
5cu6ATPCasein kinase II subunit alpha2.7.11.10.455
1bygSTUTyrosine-protein kinase CSK/0.454
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1w8cN69Cyclin-dependent kinase 22.7.11.220.454
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.454
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3t8oATPRhodopsin kinase/0.454
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.454
1pmn984Mitogen-activated protein kinase 102.7.11.240.453
4lrjANPUncharacterized protein/0.453
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.453
1yvj4STTyrosine-protein kinase JAK32.7.10.20.452
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.452
4nifANPMitogen-activated protein kinase 12.7.11.240.452
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.451
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.451
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4eooATPCyclin-dependent kinase 22.7.11.220.451
4fkv61KCyclin-dependent kinase 22.7.11.220.451
4y93746Tyrosine-protein kinase/0.451
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2in6839Wee1-like protein kinase2.7.10.20.450
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2x1nX1NCyclin-dependent kinase 22.7.11.220.450
4ix5ANPUncharacterized protein/0.450
4wsqKSAAP2-associated protein kinase 12.7.11.10.450
1p2a5BNCyclin-dependent kinase 22.7.11.220.449
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.449
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.449
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3kvxFMYMitogen-activated protein kinase 102.7.11.240.449
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.449
1e9hINRCyclin-dependent kinase 22.7.11.220.448
1fvv107Cyclin-dependent kinase 22.7.11.220.448
1om1IQACasein kinase II subunit alpha2.7.11.10.448
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.448
2xa4AZ5Tyrosine-protein kinase JAK2/0.448
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.448
3lqfNADGalactitol dehydrogenase/0.448
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.448
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
1oitHDTCyclin-dependent kinase 22.7.11.220.447
2xngA0HAurora kinase A2.7.11.10.447
2xs0ANPMitogen-activated protein kinase 82.7.11.240.447
3rmf20ZCyclin-dependent kinase 22.7.11.220.447
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.447
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.447
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.447
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4ocvANPAminoglycoside phosphotransferase/0.446
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.446
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.445
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
2ijmADPFocal adhesion kinase 12.7.10.20.444
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.444
4fko20KCyclin-dependent kinase 22.7.11.220.444
1pxpCK8Cyclin-dependent kinase 22.7.11.220.443
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.443
1ykr628Cyclin-dependent kinase 22.7.11.220.443
2henADPEphrin type-B receptor 22.7.10.10.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.443
2xb7GUIALK tyrosine kinase receptor2.7.10.10.443
2y9qANPMitogen-activated protein kinase 12.7.11.240.443
3nieANPMitogen-activated protein kinase/0.443
3orkAGSSerine/threonine protein kinase/0.443
3wblPDYCyclin-dependent kinase 22.7.11.220.443
3zmmF9JTyrosine-protein kinase JAK2/0.443
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bcoT6QCyclin-dependent kinase 22.7.11.220.443
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.443
4o4fATPKinase/0.443
1xjdSTUProtein kinase C theta type2.7.11.130.442
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2qoqANPEphrin type-A receptor 32.7.10.10.442
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.442
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.442
3cgfJNFMitogen-activated protein kinase 102.7.11.240.442
3eljGS7Mitogen-activated protein kinase 82.7.11.240.442
3hmm855TGF-beta receptor type-12.7.11.300.442
3igoANPCalmodulin-domain protein kinase 1, putative/0.442
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.442
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.442
4e730NRMitogen-activated protein kinase 82.7.11.240.442
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.442
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.442
4ii5ADPCyclin-dependent kinase 22.7.11.220.442
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.442
4iwd1JCHepatocyte growth factor receptor2.7.10.10.442
1pxoCK7Cyclin-dependent kinase 22.7.11.220.441
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.441
2b52D42Cyclin-dependent kinase 22.7.11.220.441
2ckeIQUDeath-associated protein kinase 2/0.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.441
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.441
3bheBZNGag-Pol polyprotein3.4.23.160.441
3gu6ADPDeath-associated protein kinase 12.7.11.10.441
3le62BZCyclin-dependent kinase 22.7.11.220.441
3ortAGSSerine/threonine protein kinase/0.441
4bbfO19Tyrosine-protein kinase JAK2/0.441
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.441
4gmy0X5Tyrosine-protein kinase JAK2/0.441
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.440
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.440
2ijmATPFocal adhesion kinase 12.7.10.20.440
2izuP01Casein kinase I isoform gamma-32.7.11.10.440
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3a62STURibosomal protein S6 kinase beta-12.7.11.10.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.440
4y95746Tyrosine-protein kinase/0.440