sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1u0z | RDC | Endoplasmin |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1u0z | RDC | Endoplasmin | / | 1.000 | |
| 1ysz | NEC | Endoplasmin | / | 0.661 | |
| 2exl | GDM | Endoplasmin | / | 0.649 | |
| 1qy8 | RDI | Endoplasmin | / | 0.639 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.638 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.636 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.636 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.635 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.633 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.632 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.632 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.629 | |
| 2gqp | PA7 | Endoplasmin | / | 0.626 | |
| 2hch | N5A | Endoplasmin | / | 0.623 | |
| 1u0y | PA7 | Endoplasmin | / | 0.620 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.618 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.618 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.618 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.615 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.614 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.613 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.613 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.613 | |
| 2gfd | RDA | Endoplasmin | / | 0.611 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.611 | |
| 2fyp | RDE | Endoplasmin | / | 0.610 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.610 | |
| 1u2o | NEC | Endoplasmin | / | 0.607 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.606 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.606 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.603 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.603 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.602 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.601 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.601 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.600 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.598 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.597 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.596 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.593 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.593 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.588 | |
| 1qy5 | NEC | Endoplasmin | / | 0.586 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.584 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.580 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.578 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.578 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.576 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.574 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.574 | |
| 3ied | AN2 | HSP90 | / | 0.572 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.572 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.568 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.567 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 2hg1 | N5O | Endoplasmin | / | 0.564 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.562 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.560 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.559 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.557 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.551 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.548 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.548 | |
| 1yt0 | ADP | Endoplasmin | / | 0.547 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.547 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.546 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.541 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.540 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 2o1u | ANP | Endoplasmin | / | 0.537 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.536 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.533 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.531 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.531 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.527 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.525 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.523 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.522 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.522 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.521 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.520 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.519 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.516 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.510 | |
| 2esa | GDM | Endoplasmin | / | 0.509 | |
| 2xx5 | 13N | ATP-dependent molecular chaperone HSP82 | / | 0.503 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.491 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.490 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.488 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.487 | |
| 2o1v | ADP | Endoplasmin | / | 0.486 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.486 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.486 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.484 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.484 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.484 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.483 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.482 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.482 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.482 | |
| 1z59 | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.480 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.479 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 2q8i | RDC | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | 2.7.11.2 | 0.477 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.475 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 2fde | 385 | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 2hkj | RDC | Type 2 DNA topoisomerase 6 subunit B | / | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.471 | |
| 3bva | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.470 | |
| 1hos | PHP | Gag-Pol polyprotein | / | 0.469 | |
| 3ggx | GGX | Gag-Pol polyprotein | / | 0.469 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 2qhc | AB1 | Protease | / | 0.468 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.468 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.468 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.467 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.467 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.467 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.466 | |
| 1fg6 | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3qrm | NK7 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.463 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.463 | |
| 2idw | 017 | Protease | / | 0.462 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.462 | |
| 3sa3 | 23X | Protease | / | 0.462 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.461 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3ekt | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.461 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.461 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.460 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.460 | |
| 3d1z | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 3dck | KVI | Protease | / | 0.459 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.459 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.459 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 1fej | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2xhx | T5M | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3kfn | 3TL | Gag-Pol polyprotein | / | 0.458 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.458 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.457 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3r4b | 74T | Gag-Pol polyprotein | / | 0.457 | |
| 1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 4hla | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.455 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.455 | |
| 1t3r | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.455 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.455 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.455 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.454 | |
| 2q5k | AB1 | Protease | / | 0.454 | |
| 2rkf | AB1 | Pol protein | / | 0.454 | |
| 3oxc | ROC | Protease | / | 0.454 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.453 | |
| 2avm | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.453 | |
| 2q54 | MU1 | Protease | / | 0.453 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.453 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.452 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.452 | |
| 2f3k | RO1 | Protease | / | 0.452 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 2p3c | 3TL | Protease | / | 0.452 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3a2o | KNJ | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.452 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1mui | AB1 | Protease | / | 0.451 | |
| 1nqo | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 2nmy | ROC | Protease | / | 0.451 | |
| 2p3a | 3TL | Pol protein | / | 0.451 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.451 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3m9v | TYD | FAD-dependent oxidoreductase | / | 0.451 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.451 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.451 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.450 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.450 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.450 | |
| 2qnp | QN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 3so9 | 017 | Pol protein | / | 0.450 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.449 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.449 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.449 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.449 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.449 | |
| 3oxw | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3vf7 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.449 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.449 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.449 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.448 | |
| 2a4f | AAU | V-1 protease | / | 0.448 | |
| 2f80 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2pk6 | O33 | V-1 protease | / | 0.448 | |
| 3ec0 | GRL | Gag-Pol polyprotein | 3.4.23.47 | 0.448 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.448 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3s85 | LK0 | Gag-Pol polyprotein | / | 0.448 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.448 | |
| 4dqe | 017 | Gag-Pol polyprotein | / | 0.448 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2b60 | RIT | Pol polyprotein | / | 0.447 | |
| 2hc0 | AB2 | Protease | / | 0.447 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 2hs2 | 017 | Protease | / | 0.447 | |
| 3gga | GGW | Gag-Pol polyprotein | / | 0.447 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3qih | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3qro | NK9 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3s56 | ROC | Protease | / | 0.447 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.447 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4njs | G08 | Protease | / | 0.447 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.447 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.447 | |
| 1hiv | 1ZK | Gag-Pol polyprotein | / | 0.446 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1vij | BAY | Gag-Pol polyprotein | / | 0.446 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.446 | |
| 3d20 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3kdc | JZP | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3lit | E15 | Protease | / | 0.446 | |
| 3liv | E16 | Protease | / | 0.446 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 3nu3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.446 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4dqb | 017 | Gag-Pol polyprotein | / | 0.446 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.446 | |
| 4mgi | CMP | Rap guanine nucleotide exchange factor 4 | / | 0.446 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.445 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2fdd | 385 | Pol protein | / | 0.445 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.445 | |
| 2i4u | DJR | Protease | / | 0.445 | |
| 2nnk | ROC | Protease | / | 0.445 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3i2l | 2NC | Protease | / | 0.445 | |
| 3qn8 | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3s54 | 017 | Protease | / | 0.445 | |
| 3ttp | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.445 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.445 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.444 | |
| 1k1u | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1pro | A88 | Gag-Pol polyprotein | / | 0.444 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.444 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.444 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2r3t | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.444 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3djk | G55 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 3vfa | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.444 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.444 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.444 | |
| 1b6m | PI6 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1ffi | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.443 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.443 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2avs | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.443 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 2nnp | ROC | Protease | / | 0.443 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.443 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 3ndu | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3sa5 | A69 | Protease | / | 0.443 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.443 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4hdf | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1hvr | XK2 | Gag-Pol polyprotein | / | 0.442 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.442 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2bu2 | ATP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.442 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 0.442 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.442 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3o9i | A61 | Gag-Pol polyprotein | / | 0.442 | |
| 3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.442 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.442 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.442 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.442 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.441 | |
| 1r2j | FAD | FkbI | / | 0.441 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 2q55 | MU0 | Protease | / | 0.441 | |
| 2qi6 | MZ8 | Gag-Pol polyprotein | / | 0.441 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3d1y | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3lix | E17 | Protease | / | 0.441 | |
| 3qbf | JHG | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4djq | M86 | Pol polyprotein | / | 0.441 | |
| 4dpm | COA | Malonyl-CoA reductase | 1.2.1.75 | 0.441 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.441 | |
| 4oae | CLM | Uncharacterized protein | / | 0.441 | |
| 1c6y | MK1 | Protease | / | 0.440 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.440 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.440 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.440 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.440 | |
| 2qi0 | MZ3 | Gag-Pol polyprotein | / | 0.440 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.440 | |
| 3bxr | DRR | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.440 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 3i81 | EBI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.440 | |
| 3mxe | K54 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.440 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.440 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.440 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.440 |