Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1t36ADPCarbamoyl-phosphate synthase large chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1t36ADPCarbamoyl-phosphate synthase large chain/1.000
1jdbADPCarbamoyl-phosphate synthase large chain/0.593
3wo1ADPAlanine--anticapsin ligase/0.514
3g8dADPBiotin carboxylase6.3.4.140.511
5ifyUMPGlucose-1-phosphate thymidylyltransferase/0.485
4l9q9TPSerum albumin/0.483
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.480
4ma628EAra h 8 allergen/0.480
1ivhCOSIsovaleryl-CoA dehydrogenase, mitochondrial1.3.8.40.479
1j21ATPArgininosuccinate synthase/0.479
3ix9MTXDihydrofolate reductase1.5.1.30.479
2zshGA3Gibberellin receptor GID1A30.478
3wo0ADPAlanine--anticapsin ligase/0.478
1pk8ATPSynapsin-1/0.477
4mv3ACPBiotin carboxylase6.3.4.140.476
4nr42LKCREB-binding protein/0.476
4mv4ACPBiotin carboxylase6.3.4.140.474
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.472
2bxiAZQSerum albumin/0.472
3zc3NAPFerredoxin--NADP reductase1.18.1.20.472
1g4sTPSThiamine-phosphate synthase/0.471
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.471
2yx6ADPUncharacterized protein/0.471
3hz142CHeat shock protein HSP 90-alpha/0.471
4kq21S3Glycogen [starch] synthase isoform 22.4.1.110.470
1tezHDFDeoxyribodipyrimidine photo-lyase4.1.99.30.469
1uy7PU4Heat shock protein HSP 90-alpha/0.469
5bpfADPD-alanine--D-alanine ligase/0.469
1nd52BFProstatic acid phosphatase3.1.3.20.468
3lu8IQXSerum albumin/0.468
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.467
3d0bSNXHeat shock protein HSP 90-alpha/0.467
1g4pFQPThiamine-phosphate synthase/0.466
4z17PEPEnolase/0.466
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.465
1g69TZPThiamine-phosphate synthase/0.464
1lhwESMSex hormone-binding globulin/0.464
1suoCPZCytochrome P450 2B41.14.14.10.464
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4bqg50QHeat shock protein HSP 90-alpha/0.464
1esvLARActin, alpha skeletal muscle/0.463
2cvyTTPRibonucleoside-diphosphate reductase large chain 11.17.4.10.462
3vmmP0DAlanine--anticapsin ligase/0.462
3wnzADPAlanine--anticapsin ligase/0.462
4mv1ADPBiotin carboxylase6.3.4.140.462
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.461
2ydfIO3Serum albumin/0.461
3r336MEDihydrofolate reductase1.5.1.30.461
4f5dC2EStimulator of interferon genes protein/0.461
4qbhAP5Adenylate kinase/0.461
5kgpACOPredicted acetyltransferase/0.461
1eyn2ANUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.460
1taeNADDNA ligase/0.460
2cvuANPRibonucleoside-diphosphate reductase large chain 11.17.4.10.460
2wpwACOOrf14/0.460
2zpaADPtRNA(Met) cytidine acetyltransferase TmcA/0.460
3mjrAC2Deoxycytidine kinase2.7.1.740.460
4eftEFTHeat shock protein HSP 90-alpha/0.460
4iqkIQKKelch-like ECH-associated protein 1/0.460
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.459
1uyfPU1Heat shock protein HSP 90-alpha/0.459
2x60GTPMannose-1-phosphate guanylyltransferase/0.459
2xh9J01Uncharacterized protein/0.459
5ce3ADPProtein kinase YopO/0.459
1h9zRWFSerum albumin/0.458
2ijmATPFocal adhesion kinase 12.7.10.20.458
3av7KYNUncharacterized protein/0.458
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.458
4e37NDPCatalase1.11.1.60.458
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.458
4ho4THMGlucose-1-phosphate thymidylyltransferase/0.458
1g6cIFPThiamine-phosphate synthase/0.457
1g6cTZPThiamine-phosphate synthase/0.457
1xjnDTPVitamin B12-dependent ribonucleotide reductase/0.457
3sa0NRAMitogen-activated protein kinase 12.7.11.240.457
3to3ATPPetrobactin biosynthesis protein AsbB/0.457
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4kgmATPUncharacterized protein/0.457
1e8hADPVanillyl-alcohol oxidase1.1.3.380.456
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.456
2j7t274Serine/threonine-protein kinase 102.7.11.10.456
4iyg1HUStrictosidine synthase4.3.3.20.456
4jk4DIUSerum albumin/0.456
1ir3ANPInsulin receptor2.7.10.10.455
1w87NAPFerredoxin--NADP reductase1.18.1.20.455
3qdd94MHeat shock protein HSP 90-alpha/0.455
4yswNAIXanthine dehydrogenase/oxidase/0.455
1a9xADPCarbamoyl-phosphate synthase large chain/0.454
1uy6PU3Heat shock protein HSP 90-alpha/0.454
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.454
3ijwACOAminoglycoside N3-acetyltransferase/0.454
4o6mC5PUncharacterized protein/0.454
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1qaxHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.453
2ql6ADPNicotinamide riboside kinase 1/0.453
2w6oOA3Biotin carboxylase6.3.4.140.453
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.453
4u7wNDPMxaA/0.453
5c1oANPD-alanine--D-alanine ligase/0.453
1g0rTHMGlucose-1-phosphate thymidylyltransferase/0.452
1uy9PU6Heat shock protein HSP 90-alpha/0.452
2pmdGNPTranslation initiation factor 2 subunit gamma/0.452
2qocANPEphrin type-A receptor 32.7.10.10.452
2vpyMGDThiosulfate reductase/0.452
2vqdAP2Biotin carboxylase6.3.4.140.452
3eej53RUncharacterized protein/0.452
3zp4TSAChorismate mutase AroH5.4.99.50.452
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.452
5eypLOCTubulin beta chain/0.452
2w6qOA5Biotin carboxylase6.3.4.140.451
2x1eX1EAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form2.3.1.1640.451
4e5nNADPhosphonate dehydrogenase1.20.1.10.451
4m2xTMQDihydrofolate reductase1.5.1.30.451
4xr9TMPCalS8/0.451
1h6vNDPThioredoxin reductase 1, cytoplasmic1.8.1.90.450
1u71MXADihydrofolate reductase1.5.1.30.450
3f5uANPDeath-associated protein kinase 12.7.11.10.450
3mdmFJZCholesterol 24-hydroxylase/0.450
3nc9TR3Ketohexokinase/0.450
3zrrPXGSerine-pyruvate aminotransferase (AgxT)/0.450
4bewCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.450
4dieC5PCytidylate kinase/0.450
1llqNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.449
1orrCDPCDP-paratose 2-epimerase/0.449
1yreCOAUncharacterized protein/0.449
3bv2P38Mitogen-activated protein kinase 14/0.449
3jukUPGUTP--glucose-1-phosphate uridylyltransferase/0.449
3l63CAMCamphor 5-monooxygenase1.14.15.10.449
3lfcZ86Mitogen-activated protein kinase 14/0.449
4asyN5YGlucose-1-phosphate thymidylyltransferase/0.449
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.449
1z0zNADNAD kinase/0.448
2aazCB3Thymidylate synthase2.1.1.450.448
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.448
3b9lAZZSerum albumin/0.448
4becATPType I restriction enzyme EcoR124II R protein3.1.21.30.448
4jia1K3Tyrosine-protein kinase JAK2/0.448
5dn3ATPAurora kinase A2.7.11.10.448
1uyePU9Heat shock protein HSP 90-alpha/0.447
2acxANPG protein-coupled receptor kinase 62.7.11.160.447
2bpoNAPNADPH--cytochrome P450 reductase/0.447
2e2qADPATP-dependent hexokinase/0.447
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.447
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4o4iACPTubulin tyrosine ligase/0.447
4u0oMTALipoyl synthase 2/0.447
5kf9ACOPredicted acetyltransferase/0.447
1ouk084Mitogen-activated protein kinase 14/0.446
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.446
2w6zL21Biotin carboxylase6.3.4.140.446
3cvuFADRE11660p/0.446
3o15IFPThiamine-phosphate synthase/0.446
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3wb2YGPUncharacterized protein MJ0488/0.446
3wrjCAMCamphor 5-monooxygenase1.14.15.10.446
3wrlCAMCamphor 5-monooxygenase1.14.15.10.446
4dqwATPInosine-5'-monophosphate dehydrogenase/0.446
4hys1BJMitogen-activated protein kinase 82.7.11.240.446
4oi2ADPProtein clpf-1/0.446
4wzyATPMaltokinase2.7.1.1750.446
1v11TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.445
1xjeTTPVitamin B12-dependent ribonucleotide reductase/0.445
2tpsTPSThiamine-phosphate synthase/0.445
2wi4ZZ4Heat shock protein HSP 90-alpha/0.445
2y6pCTP3-deoxy-manno-octulosonate cytidylyltransferase2.7.7.380.445
3ft8MOJHeat shock protein HSP 90-alpha/0.445
3fwfCAMCamphor 5-monooxygenase1.14.15.10.445
3gg0FMNUncharacterized protein/0.445
3s87DGTRibonucleoside-diphosphate reductase large chain 11.17.4.10.445
4n49MGTCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 12.1.1.570.445
4n57ADPAPH(2'')-Id/0.445
4nh82LCHeat shock protein HSP 90-alpha/0.445
1dliUDXUDP-glucose 6-dehydrogenase/0.444
1i58ADPChemotaxis protein CheA2.7.13.30.444
1l8qADPChromosomal replication initiator protein DnaA/0.444
1pvoANPTranscription termination factor Rho3.6.40.444
1tllNAPNitric oxide synthase, brain1.14.13.390.444
1uykPUXHeat shock protein HSP 90-alpha/0.444
2vnjNAPNADPH:ferredoxin reductase/0.444
3a13CAPRibulose bisphosphate carboxylase/0.444
3akeC5PCytidylate kinase/0.444
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3dj4UD1Bifunctional protein GlmU/0.444
3eem53VUncharacterized protein/0.444
3t9dANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.444
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.444
4bfvZVVPantothenate kinase2.7.1.330.444
4g3sUD1Bifunctional protein GlmU/0.444
4jl5ADPAdenylate kinase/0.444
4l9kEHFSerum albumin/0.444
4z69DIFSerum albumin/0.444
1qnfHDFDeoxyribodipyrimidine photo-lyase4.1.99.30.443
2bunFADAppA protein/0.443
2fwzH71Heat shock protein HSP 90-alpha/0.443
2q7hYLYPyrrolysine--tRNA ligase/0.443
3e8xNAPBH1520 protein/0.443
3g8aSAHRibosomal RNA small subunit methyltransferase G/0.443
3nkt1HNGentisate 1,2-dioxygenase/0.443
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
4ag9COAGlucosamine 6-phosphate N-acetyltransferase/0.443
4fokC2EUncharacterized protein/0.443
4lrzADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.443
4mb2ATPUncharacterized protein/0.443
4xooFMNCoenzyme F420:L-glutamate ligase/0.443
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.443
5d3fFSC14-3-3 protein zeta/delta/0.443
5kghACOPredicted acetyltransferase/0.443
1fgxU5PBeta-1,4-galactosyltransferase 1/0.442
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.442
2b9wFADPutative aminooxidase/0.442
2gn9UPGUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.442
2j2pSC2Ficolin-2/0.442
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.442
3lf0ATPNitrogen regulatory protein P-II/0.442
3mn7ATPActin-5C/0.442
4eajATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4in44IDKelch-like ECH-associated protein 1/0.442
4l5b1UXDeoxycytidine kinase2.7.1.740.442
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.441
1oc1ASVIsopenicillin N synthase1.21.3.10.441
1rdwLARActin, alpha skeletal muscle/0.441
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.441
2cl6CAGGTPase HRas/0.441
2eckADPAdenylate kinase/0.441
2j9gADPBiotin carboxylase6.3.4.140.441
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.441
3o6o94MHeat shock protein 83/0.441
3ub5ATPActin, cytoplasmic 1/0.441
3wecAUICytochrome P450/0.441
4nt03DUOrotidine 5'-phosphate decarboxylase4.1.1.230.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
1eblCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.440
1egcCO8Medium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1hk2T44Serum albumin/0.440
1mb9ATPCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.440
1t88CAMCamphor 5-monooxygenase1.14.15.10.440
1uydPU8Heat shock protein HSP 90-alpha/0.440
1wzyF29Mitogen-activated protein kinase 12.7.11.240.440
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.440
2i14PCPNicotinate-nucleotide pyrophosphorylase/0.440
2wtkANPSTE20-related kinase adapter protein alpha/0.440
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
3evbSAHGenome polyprotein2.1.1.560.440
3h24B55Dihydropteroate synthase/0.440
3m31FADEndoplasmic oxidoreductin-11.8.40.440
3n8nN883-dehydroquinate dehydratase4.2.1.100.440
3tqhNDPQuinone oxidoreductase/0.440
3u5sFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.440
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.440
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4efuEFUHeat shock protein HSP 90-alpha/0.440
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.440
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.440
4i3p1CW3-hydroxyanthranilate 3,4-dioxygenase/0.440
4jlk1NODeoxycytidine kinase2.7.1.740.440
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.440
4o1pANPRibonuclease L/0.440
4ohvANPProtein clpf-1/0.440
4r87COASpermidine N(1)-acetyltransferase/0.440
5kf8ACOPredicted acetyltransferase/0.440