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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1og4NAIT-cell ecto-ADP-ribosyltransferase 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1og4NAIT-cell ecto-ADP-ribosyltransferase 2/1.000
1og1TADT-cell ecto-ADP-ribosyltransferase 2/0.556
4q0kGA3Phytohormone-binding protein/0.503
3gncQQQGlutaryl-CoA dehydrogenase/0.497
3phjDHKShikimate dehydrogenase (NADP(+))/0.497
4xguADPPutative pachytene checkpoint protein 2/0.496
4bfzZVZPantothenate kinase2.7.1.330.495
3hl0NADMaleylacetate reductase/0.490
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.485
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.484
1rzuADPGlycogen synthase 12.4.1.210.483
2rlcCHDCholoylglycine hydrolase3.5.1.240.481
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.481
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.478
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.478
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.478
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.477
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.477
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.476
4dptAGSMevalonate diphosphate decarboxylase/0.474
2bjfDXCCholoylglycine hydrolase3.5.1.240.473
2xysSY9Soluble acetylcholine receptor/0.473
2x06NADL-sulfolactate dehydrogenase/0.472
2gv8NDPThiol-specific monooxygenase1.14.130.471
3qt62P0Mevalonate diphosphate decarboxylase/0.471
1nm6L86Prothrombin3.4.21.50.470
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.470
1a9cGTPGTP cyclohydrolase 13.5.4.160.469
1w6hTITPlasmepsin-23.4.23.390.469
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.469
2cftPLPPyridoxal phosphate phosphatase/0.469
3h3qH13Collagen type IV alpha-3-binding protein/0.469
3h3t16HCollagen type IV alpha-3-binding protein/0.469
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.468
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.468
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.468
2eh5SAHDiphthine synthase/0.466
4nv1TYDFormyl transferase/0.466
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1o97FADElectron transfer flavoprotein subunit alpha/0.465
2j3qTFLAcetylcholinesterase3.1.1.70.465
2yj4ATPCopper-transporting ATPase/0.465
3q43D66M1 family aminopeptidase3.4.110.465
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.465
1ypgUIRProthrombin3.4.21.50.464
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.464
2g1n1IGRenin3.4.23.150.464
2il2LIXRenin3.4.23.150.464
3c1kT15Prothrombin3.4.21.50.464
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3p62FMNPentaerythritol tetranitrate reductase/0.464
4bfwZVWPantothenate kinase2.7.1.330.464
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.464
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.463
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.463
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.463
4ey6GNTAcetylcholinesterase3.1.1.70.463
4lol1YEStimulator of interferon genes protein/0.463
4xmxBESAminopeptidase N3.4.11.20.463
1pl1ABYGlutathione S-transferase A12.5.1.180.462
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.462
3vsxR32Renin3.4.23.150.462
2ejzSAHDiphthine synthase/0.461
2uxoTACHTH-type transcriptional regulator TtgR/0.461
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.461
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.461
3s5wFADL-ornithine N(5)-monooxygenase/0.461
4kbyC2EStimulator of interferon genes protein/0.461
1g1aNADdTDP-glucose 4,6-dehydratase/0.460
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.460
4e2yJHZMethyltransferase/0.460
1d9i00PProthrombin3.4.21.50.459
1ma0NADAlcohol dehydrogenase class-31.1.1.10.459
1xe65FPPlasmepsin-23.4.23.390.459
2g247IGRenin3.4.23.150.459
2x0fTRHWsaF/0.459
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.459
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
4b7zQ4QAcetylcholinesterase3.1.1.70.459
4m0f1YKAcetylcholinesterase3.1.1.70.459
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.458
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.458
4b4vL34Bifunctional protein FolD/0.458
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.458
1rneC60Renin3.4.23.150.457
1x1aSAMC-20 methyltransferase/0.457
2r2mI50Prothrombin3.4.21.50.457
3cb2GDPTubulin gamma-1 chain/0.457
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.457
5kwvANPPantothenate synthetase/0.457
1ja0FADNADPH--cytochrome P450 reductase/0.456
1ja1FMNNADPH--cytochrome P450 reductase/0.456
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.456
2g1y5IGRenin3.4.23.150.456
2hk9NAPShikimate dehydrogenase (NADP(+))/0.456
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
4bb3KKAIsopenicillin N synthase1.21.3.10.456
4r81FMNPredicted NADH dehydrogenase/0.456
1w1wAGSStructural maintenance of chromosomes protein 1/0.455
1ypeUIPProthrombin3.4.21.50.455
1z41FMNNADPH dehydrogenase/0.455
3egkM18Prothrombin3.4.21.50.455
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.455
3gwfFADCyclohexanone monooxygenase/0.455
3ig6438Urokinase-type plasminogen activator3.4.21.730.455
4bfxZVXPantothenate kinase2.7.1.330.455
4egbNADdTDP-glucose 4,6-dehydratase/0.455
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.455
4yaoFMNNADPH--cytochrome P450 reductase/0.455
1eveE20Acetylcholinesterase3.1.1.70.454
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.454
2gjnFMNNitronate monooxygenase1.13.12.160.454
2qimZEAClass 10 plant pathogenesis-related protein/0.454
3jusBCDLanosterol 14-alpha demethylase1.14.13.700.454
3v2uATPProtein GAL3/0.454
4b4w9L9Bifunctional protein FolD/0.454
4wecNADShort chain dehydrogenase/0.454
3h3r14HCollagen type IV alpha-3-binding protein/0.453
4asuADPATP synthase subunit alpha, mitochondrial/0.453
4cdmFO1Deoxyribodipyrimidine photolyase/0.453
4lutDCSAlanine racemase/0.453
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.452
1b2lNDCAlcohol dehydrogenase1.1.1.10.452
1g63FMNEpidermin decarboxylase4.1.10.452
1mu6CDAProthrombin3.4.21.50.452
1tojHCIAspartate aminotransferase2.6.1.10.452
1x2hLPALipoate-protein ligase A6.3.1.200.452
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.452
2cekN8TAcetylcholinesterase3.1.1.70.452
3elePLPAminotransferase/0.452
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.452
3vyfVYFRenin3.4.23.150.452
4fsl0VBBeta-secretase 13.4.23.460.452
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.452
1ja1FADNADPH--cytochrome P450 reductase/0.451
1q84TZ4Acetylcholinesterase3.1.1.70.451
2ed3SAHDiphthine synthase/0.451
2g21L1BRenin3.4.23.150.451
2iyfERYOleandomycin glycosyltransferase2.4.10.451
2pj4414Carboxypeptidase B/0.451
3jzdNADMaleylacetate reductase/0.451
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.451
4b68FADL-ornithine N(5)-monooxygenase/0.451
4rn615UProthrombin3.4.21.50.451
5dp2NAPCurF/0.451
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.450
1nqw5YL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
1vbiNADMalate/L-lactate dehydrogenase family protein/0.450
1xe55FEPlasmepsin-23.4.23.390.450
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.450
2futH1SHeparin and heparin-sulfate lyase/0.450
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.450
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.450
2xlrFADPutative flavin-containing monooxygenase/0.450
3coy53HPantothenate synthetase6.3.2.10.450
1d3pBT3Prothrombin3.4.21.50.449
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1icsFMN12-oxophytodienoate reductase 11.3.1.420.449
1w0kADPATP synthase subunit alpha, mitochondrial/0.449
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.449
2bn4FMNNADPH--cytochrome P450 reductase/0.449
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.449
2gjlFMNNitronate monooxygenase1.13.12.160.449
2zi224UProthrombin3.4.21.50.449
2zsaADPPantothenate kinase2.7.1.330.449
3kxw1ZZSaframycin Mx1 synthetase B/0.449
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.449
4araC56Acetylcholinesterase3.1.1.70.449
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.448
2iypNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.448
2zevIPEGeranylgeranyl pyrophosphate synthase/0.448
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.448
3f03FMNPentaerythritol tetranitrate reductase/0.448
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.448
4a6nFADTetX family tetracycline inactivation enzyme/0.448
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.448
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.448
4esoNAPPutative oxidoreductase/0.448
4fse0VABeta-secretase 13.4.23.460.448
1c4vIH2Prothrombin3.4.21.50.447
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.447
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.447
1x1bSAHC-20 methyltransferase/0.447
2g1r3IGRenin3.4.23.150.447
2zr9DTPProtein RecA/0.447
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3fr5I4AFatty acid-binding protein, adipocyte/0.447
3lnc5GPGuanylate kinase/0.447
3nutSAHPrecorrin-3 methylase/0.447
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.447
4n1gCEIObelin/0.447
1c4uIH1Prothrombin3.4.21.50.446
1d3dBZTProthrombin3.4.21.50.446
1icqFMN12-oxophytodienoate reductase 11.3.1.420.446
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.446
1ut6A8NAcetylcholinesterase3.1.1.70.446
1zgcA2EAcetylcholinesterase3.1.1.70.446
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.446
2iko7IGRenin3.4.23.150.446
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.446
2qw034Z4-chlorobenzoyl CoA ligase/0.446
2w6zL21Biotin carboxylase6.3.4.140.446
3a0tADPSensor histidine kinase/0.446
3bk2U5PRibonuclease J/0.446
3g72A6TRenin3.4.23.150.446
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.446
3zeiAWHO-acetylserine sulfhydrylase/0.446
4j75TYMTryptophan--tRNA ligase/0.446
4k36SAMAnaerobic sulfatase-maturating enzyme1.8.980.446
4ycoFMNtRNA-dihydrouridine(16) synthase/0.446
1d4pBPPProthrombin3.4.21.50.445
1jedADPSulfate adenylyltransferase/0.445
1jil485Tyrosine--tRNA ligase/0.445
1jqdSAHHistamine N-methyltransferase2.1.1.80.445
1kp2ATPArgininosuccinate synthase6.3.4.50.445
1obbNADAlpha-glucosidase3.2.1.200.445
1z71L17Prothrombin3.4.21.50.445
2ek7SAHDiphthine synthase/0.445
2g1o2IGRenin3.4.23.150.445
2yoj8Y6Genome polyprotein2.7.7.480.445
3b7dCNIGlutamate receptor 2/0.445
3br3ETHTH-type transcriptional regulator QacR/0.445
3rykTYDdTDP-4-dehydrorhamnose 3,5-epimerase/0.445
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.445
4de2DN3Beta-lactamase/0.445
4f5yC2EStimulator of interferon genes protein/0.445
4mlp2CXCryptochrome-2/0.445
5a4vQUEGlutathione S-transferase F22.5.1.180.445
1bmfANPATP synthase subunit alpha, mitochondrial/0.444
1bmfANPATP synthase subunit beta, mitochondrial3.6.3.140.444
1xddAAYIntegrin alpha-L/0.444
2emrSAHDiphthine synthase/0.444
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.444
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.444
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.444
2xugTZ4Acetylcholinesterase3.1.1.70.444
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3apwDP0Alpha-1-acid glycoprotein 2/0.444
3au2DGTDNA polymerase beta family (X family)/0.444
3eksCY9Actin-5C/0.444
3hlwCE3Beta-lactamase/0.444
4e470N6Histone-lysine N-methyltransferase SETD72.1.1.430.444
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.444
4l0qNADAlcohol dehydrogenase class-3/0.444
4xbfFADLysine-specific histone demethylase 1A10.444
4xwtU5PRibonuclease J/0.444
5hg0SAMPantothenate synthetase/0.444
1n2hPAJPantothenate synthetase6.3.2.10.443
1tehNADAlcohol dehydrogenase class-31.1.1.10.443
1tllFMNNitric oxide synthase, brain1.14.13.390.443
2a92NAIL-lactate dehydrogenase/0.443
2e7rSAHDiphthine synthase/0.443
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.443
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.443
2zc922UProthrombin3.4.21.50.443
3ohh3HHBeta-secretase 13.4.23.460.443
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.443
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.443
3udn09BBeta-secretase 13.4.23.460.443
4eu4COASuccinyl-CoA:acetate CoA-transferase/0.443
4g7gVFVLanosterol 14-alpha-demethylase/0.443
4tlxFDAKtzI/0.443
1nmq160Caspase-33.4.22.560.442
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.442
1wuaAP8Actin, alpha skeletal muscle/0.442
2cf8ESHProthrombin3.4.21.50.442
2huxSAHDiphthine synthase/0.442
2xupTZ5Acetylcholinesterase3.1.1.70.442
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.442
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3g70A5TRenin3.4.23.150.442
3hyoADPPyridoxal kinase/0.442
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.442
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.442
4arbC57Acetylcholinesterase3.1.1.70.442
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.442
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4ey7E20Acetylcholinesterase3.1.1.70.442
4kbz1QAEgl nine homolog 1/0.442
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.442
1bil0IURenin3.4.23.150.441
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.441
1x1cSAHC-20 methyltransferase/0.441
1xm1GAHProthrombin3.4.21.50.441
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.441
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
2ehlSAHDiphthine synthase/0.441
2p6dSAHDiphthine synthase/0.441
3b1dPLSBetaC-S lyase/0.441
3bl7DD1m7GpppX diphosphatase3.6.1.590.441
3ekuCY9Actin-5C/0.441
3muoZPRProlyl endopeptidase/0.441
3q9bB3NAcetylpolyamine amidohydrolase/0.441
4b1rITCTetracycline repressor protein class D/0.441
4bftZVTPantothenate kinase2.7.1.330.441
4g8jTHMUridine phosphorylase/0.441
4ke11R6Beta-secretase 13.4.23.460.441
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.441
4qxr1YEStimulator of interferon genes protein/0.441
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.441
5ewkP34Putative secreted protein/0.441
5f8eSAHPossible transcriptional regulatory protein/0.441
5fmmMGTPolymerase basic protein 2/0.441
1kh3ANPArgininosuccinate synthase/0.440
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.440
1ppjANYCytochrome b/0.440
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.440
1vftDCSAlanine racemase/0.440
2a7r5GPGMP reductase 2/0.440
2hxzH7JCathepsin S3.4.22.270.440
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.440
2ifaFMNUncharacterized protein/0.440
3dt2GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.440
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3e23SAMUncharacterized protein/0.440
3gqvNAPEnoyl reductase LovC10.440
3h3sH15Collagen type IV alpha-3-binding protein/0.440
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.440
3nn6HNK6-hydroxy-L-nicotine oxidase/0.440
3ojxFADNADPH--cytochrome P450 reductase/0.440
3ukoNADAlcohol dehydrogenase class-3/0.440
3zv7NHGAcetylcholinesterase3.1.1.70.440
4jjiNADAlcohol dehydrogenase class-3/0.440
4m83ERYOleandomycin glycosyltransferase2.4.10.440
4nieNBHNuclear receptor ROR-gamma/0.440
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.440
4ycpFMNtRNA-dihydrouridine(16) synthase/0.440