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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5i39 FAD L-amino acid deaminase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
5i39 FADL-amino acid deaminase / 1.588
5hxw FADL-amino acid deaminase / 1.341
4ysh FADGlycine oxidase / 0.965
3axb FADPutative oxidoreductase / 0.947
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.938
3vqr FADPutative oxidoreductase / 0.928
3gsi FADDimethylglycine oxidase 1.5.3.10 0.911
3dme FADPutative conserved exported protein / 0.907
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.883
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.861
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.852
1ryi FADGlycine oxidase 1.4.3.19 0.849
1c0k FADD-amino-acid oxidase 1.4.3.3 0.848
1ng3 FADGlycine oxidase 1.4.3.19 0.848
2rgh FADAlpha-Glycerophosphate Oxidase / 0.848
4wct FADFructosyl amine:oxygen oxidoreductase / 0.846
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.844
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.843
3znp FADD-amino-acid oxidase 1.4.3.3 0.837
3ad9 FADSubunit beta of sarcosine oxidase / 0.836
4x9m FADUncharacterized protein MG039 homolog / 0.828
3cuk FADD-amino-acid oxidase 1.4.3.3 0.804
4x9n FADUncharacterized protein MG039 homolog / 0.801
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.797
3rp8 FADFAD-dependent urate hydroxylase / 0.793
1ng4 FADGlycine oxidase 1.4.3.19 0.789
1c0l FADD-amino-acid oxidase 1.4.3.3 0.786
2iid FADL-amino-acid oxidase 1.4.3.2 0.786
1kif FADD-amino-acid oxidase 1.4.3.3 0.777
2rgo FADAlpha-Glycerophosphate Oxidase / 0.774
4rsl FADFructosyl peptide oxidase / 0.774
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.770
1zk7 FADMercuric reductase 1.16.1.1 0.768
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.768
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.764
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.762
4tm4 FDAKtzI / 0.761
1rsg FADPolyamine oxidase FMS1 / 0.760
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.760
2jae FADL-amino acid oxidase / 0.760
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.759
1h83 FADPolyamine oxidase 1.5.3.14 0.757
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.754
1f8r FADL-amino-acid oxidase 1.4.3.2 0.751
3if9 FADGlycine oxidase 1.4.3.19 0.751
2jb1 FADL-amino acid oxidase / 0.750
3atq FDAConserved Archaeal protein / 0.749
3lov FADProtoporphyrinogen oxidase / 0.749
3cge FADCoenzyme A disulfide reductase / 0.747
3ka7 FADPutative oxidoreductase / 0.743
2du8 FADD-amino-acid oxidase 1.4.3.3 0.742
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.741
3we0 FADLysine 2-monooxygenase / 0.740
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.739
4gdp FADPolyamine oxidase FMS1 / 0.738
4cnk FADL-amino acid oxidase / 0.736
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.735
3cnt FADPolyamine oxidase FMS1 / 0.735
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.735
4yjd FADD-amino-acid oxidase 1.4.3.3 0.734
1zx9 FADMercuric reductase 1.16.1.1 0.733
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.732
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.732
4opd FDAConserved Archaeal protein / 0.729
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.728
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.723
4opl FDAConserved Archaeal protein / 0.723
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.722
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.721
1qo8 FADFumarate reductase flavoprotein subunit / 0.718
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.717
3cgd FADCoenzyme A disulfide reductase / 0.716
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.716
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.715
4c3y FAD3-ketosteroid dehydrogenase / 0.715
1knp FADL-aspartate oxidase 1.4.3.16 0.714
1tdk FADL-amino-acid oxidase 1.4.3.2 0.714
2jb2 FADL-amino acid oxidase / 0.714
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.714
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.713
4bk3 FADProbable salicylate monooxygenase / 0.713
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.712
4tlz FADKtzI / 0.711
3cgc FADCoenzyme A disulfide reductase / 0.710
3q9t FAYUncharacterized protein / 0.710
4jn9 FADDepH / 0.710
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.709
4rek FADCholesterol oxidase 1.1.3.6 0.709
4xwr FADCholesterol oxidase 1.1.3.6 0.709
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.708
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.708
1tdo FADL-amino-acid oxidase 1.4.3.2 0.707
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.707
1ojt FADDihydrolipoyl dehydrogenase / 0.706
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.706
1knr FADL-aspartate oxidase 1.4.3.16 0.705
3ish FADThioredoxin reductase 1.8.1.9 0.704
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.704
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.702
1tdn FADL-amino-acid oxidase 1.4.3.2 0.701
4opt FDAConserved Archaeal protein / 0.701
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.700
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.700
4bjz FADProbable salicylate monooxygenase / 0.699
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
2e1m FADL-glutamate oxidase / 0.697
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
1reo FADL-amino-acid oxidase 1.4.3.2 0.695
2cdu FADNADH oxidase / 0.695
4emw FADCoenzyme A disulfide reductase / 0.694
4eqx FADCoenzyme A disulfide reductase / 0.694
3kve FADL-amino-acid oxidase / 0.693
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.693
4opg FDAConserved Archaeal protein / 0.693
4xbf FADLysine-specific histone demethylase 1A 1 0.693
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.691
2eq6 FADDihydrolipoyl dehydrogenase / 0.691
4gut FADLysine-specific histone demethylase 1B 1 0.691
4opu FDAConserved Archaeal protein / 0.691
5a89 FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.691
3kkj FADRenalase / 0.690
4hb9 FADUncharacterized protein / 0.690
4opc FDAConserved Archaeal protein / 0.690
4ynt FDAGlucose oxidase, putative / 0.690
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.690
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.689
2npx FADNADH peroxidase 1.11.1.1 0.689
3bi2 FADPolyamine oxidase FMS1 / 0.688
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.688
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.688
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.687
2e48 FADD-amino-acid oxidase 1.4.3.3 0.687
2pr5 FMNBlue-light photoreceptor / 0.687
2q0k FADThioredoxin reductase 1.8.1.9 0.687
2q7v FADThioredoxin reductase / 0.687
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.687
4i58 FADCyclohexylamine Oxidase / 0.687
4opi FDAConserved Archaeal protein / 0.687
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.687
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.686
4yac NAIC alpha-dehydrogenase / 0.686
4z24 FADPutative GMC-type oxidoreductase R135 1 0.686
1gpe FADGlucose oxidase 1.1.3.4 0.685
2y48 FADLysine-specific histone demethylase 1A 1 0.685
3w5u FADFerredoxin / 0.685
4z44 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.685
3cgb FADCoenzyme A disulfide reductase / 0.684
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.684
1h51 FMNPentaerythritol tetranitrate reductase / 0.683
1n4u FAECholesterol oxidase 1.1.3.6 0.682
2yg6 FADPutrescine oxidase / 0.682
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.682
2r0c FADPutative FAD-monooxygenase / 0.681
4cnj FADL-amino acid oxidase / 0.681
4jq9 FADDihydrolipoyl dehydrogenase / 0.681
5j60 FADThioredoxin reductase / 0.681
2fzm FADBifunctional protein PutA 1.5.5.2 0.680
3qvr FADGlucose oxidase 1.1.3.4 0.680
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.679
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.679
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.679
3cnd FADPolyamine oxidase FMS1 / 0.679
4b68 FADL-ornithine N(5)-monooxygenase / 0.679
4uir FADOleate hydratase 4.2.1.53 0.679
1cf3 FADGlucose oxidase 1.1.3.4 0.678
1z6l FADPolyamine oxidase FMS1 / 0.678
3atr FDAConserved Archaeal protein / 0.678
3k30 ADPHistamine dehydrogenase / 0.678
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.678
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.677
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.677
3gg0 FMNUncharacterized protein / 0.677
3lsi FADPyranose 2-oxidase / 0.677
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.676
3gg1 FMNUncharacterized protein / 0.676
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.675
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.675
3k4n FADPyranose 2-oxidase / 0.675
5djt FMNNPH1-2 / 0.675
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.674
1yqz FADCoenzyme A disulfide reductase / 0.674
3cty FADProbable thioredoxin reductase / 0.674
3gwd FADCyclohexanone monooxygenase / 0.674
3qj4 FADRenalase / 0.674
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.673
2vvl FADMonoamine oxidase N 1.4.3.4 0.673
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.673
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.673
3gyi FADCholesterol oxidase 1.1.3.6 0.673
3gyj FADCholesterol oxidase 1.1.3.6 0.673
3lsh FADPyranose 2-oxidase / 0.673
4af6 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.673
4bk2 FADProbable salicylate monooxygenase / 0.673
4c3x FAD3-ketosteroid dehydrogenase / 0.673
4eqw FADCoenzyme A disulfide reductase / 0.673
1f8s FADL-amino-acid oxidase 1.4.3.2 0.672
1x0p FADTll0078 protein / 0.672
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.672
2bab FADPutative aminooxidase / 0.672
1nhs FADNADH peroxidase 1.11.1.1 0.671
3ict FADCoenzyme A disulfide reductase / 0.671
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.671
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.671
4eer FMNPhototropin-2 2.7.11.1 0.671
1qaq SFGrRNA adenine N-6-methyltransferase 2.1.1.184 0.670
1vhn FMNtRNA-dihydrouridine synthase / 0.670
2e0i FADDNA photolyase / 0.670
1cqx FADFlavohemoprotein / 0.669
1yy5 FADPolyamine oxidase FMS1 / 0.669
2b9x FADPutative aminooxidase / 0.669
2dw4 FADLysine-specific histone demethylase 1A 1 0.669
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.669
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.668
3r9u FADThioredoxin reductase / 0.668
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.668
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.667
2ign FADPyranose 2-oxidase / 0.667
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.666
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.666
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.665
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.665
2iyi FMNAppA, antirepressor of ppsR, sensor of blue light / 0.665
3gfx FMNUncharacterized protein / 0.665
4fwj FADLysine-specific histone demethylase 1B 1 0.665
2pg0 FADAcyl-CoA dehydrogenase / 0.664
2yg3 FADPutrescine oxidase / 0.664
3pl8 FADPyranose 2-oxidase / 0.664
4u8p FDAUDP-galactopyranose mutase / 0.664
5l3d FADLysine-specific histone demethylase 1A 1 0.664
1w34 FADFerredoxin--NADP reductase 1.18.1.2 0.663
4hj4 FMNLOV protein / 0.663
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.662
1rz1 FADPhenol 2-hydroxylase component B / 0.662
1yrx FMNAppA protein / 0.662
2gr0 FADFerredoxin reductase / 0.662
3da1 FADGlycerol-3-phosphate dehydrogenase / 0.662
3p82 FMNPentaerythritol tetranitrate reductase / 0.662
4mo2 FDAUDP-galactopyranose mutase / 0.662
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
3mpi FADGlutaryl-CoA dehydrogenase 1.3.99.32 0.661
4tm3 FADKtzI / 0.661
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.660
1n4v FADCholesterol oxidase 1.1.3.6 0.660
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.660
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.660
2dvl FADAcyl-CoA dehydrogenase / 0.660
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.660
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.660
3cn8 FADPolyamine oxidase FMS1 / 0.660
3is2 FADVivid PAS protein VVD / 0.660
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.660
3ukk FDAUDP-galactopyranose mutase / 0.660
4ccq FADThioredoxin reductase / 0.660
4em4 FADCoenzyme A disulfide reductase / 0.660
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.660
2gew FADCholesterol oxidase 1.1.3.6 0.659
1y56 ATPUncharacterized protein / 0.658
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.658
4cw5 FMNDfnA / 0.658
4fwf FADLysine-specific histone demethylase 1B 1 0.658
4j34 FADKynurenine 3-monooxygenase / 0.658
4j57 FADThioredoxin reductase 2 1.8.1.9 0.658
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.657
1y9d FADPyruvate oxidase 1.2.3.3 0.657
2hko FADLysine-specific histone demethylase 1A 1 0.657
3bg7 FADPyranose 2-oxidase / 0.657
3cnj FADCholesterol oxidase 1.1.3.6 0.657
4wuj FMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy / 0.657
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
2b9y FADPutative aminooxidase / 0.656
4u2s FDACholesterol oxidase 1.1.3.6 0.656
4u8l FDAUDP-galactopyranose mutase / 0.656
1d7l RFLp-hydroxybenzoate hydroxylase / 0.655
1n1p FADCholesterol oxidase 1.1.3.6 0.655
2o06 MTASpermidine synthase 2.5.1.16 0.655
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.655
4em3 FADCoenzyme A disulfide reductase / 0.655
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.654
3fbs FADOxidoreductase / 0.654
3nmu SAMFibrillarin-like rRNA/tRNA 2'-O-methyltransferase / 0.654
1kqb FMNOxygen-insensitive NAD(P)H nitroreductase / 0.653
1mxt FAECholesterol oxidase 1.1.3.6 0.653
1nhq FADNADH peroxidase 1.11.1.1 0.653
2gj3 FADNitrogen fixation regulatory protein 2.7.13.3 0.653
3d72 FADVivid PAS protein VVD / 0.653
3uth FDAUDP-galactopyranose mutase / 0.653
4a99 FADTetX family tetracycline inactivation enzyme / 0.653
4b69 FADL-ornithine N(5)-monooxygenase / 0.653
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.652
3hj9 FMNUncharacterized protein / 0.652
4irn FADAnaB / 0.652
4la1 FADThioredoxin glutathione reductase / 0.652
1n9l FMNPutative blue light receptor / 0.651
1nhr FADNADH peroxidase 1.11.1.1 0.651
1xpq FADPolyamine oxidase FMS1 / 0.651
3bi5 FADPolyamine oxidase FMS1 / 0.651
4q71 FADBifunctional protein PutA / 0.651
4u8n FDAUDP-galactopyranose mutase / 0.651
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.650
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650
2vyq FADFerredoxin--NADP reductase 1.18.1.2 0.650
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.650
3ept FDAPutative FAD-monooxygenase / 0.650
3gwz SAHMitomycin biosynthesis 6-O-methyltransferase / 0.650
3ukf FDAUDP-galactopyranose mutase / 0.650
4wx1 FDAUDP-galactopyranose mutase / 0.650
4ykf NAIAlkyl hydroperoxide reductase subunit F 1.8.1 0.650