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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j56 FAD Thioredoxin reductase 2 1.8.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4j56 FADThioredoxin reductase 2 1.8.1.9 1.296
4j57 FADThioredoxin reductase 2 1.8.1.9 1.077
2hqm FADGlutathione reductase 1.8.1.7 1.031
1ges FADGlutathione reductase 1.8.1.7 0.990
1ger FADGlutathione reductase 1.8.1.7 0.973
4b1b FADThioredoxin reductase 1.8.1.9 0.961
2v6o FADThioredoxin glutathione reductase / 0.959
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.955
2x8g FADThioredoxin glutathione reductase / 0.955
2jk6 FADTrypanothione reductase / 0.953
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.953
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.950
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.948
2x8h FADThioredoxin glutathione reductase / 0.947
4nev FADTrypanothione reductase / 0.946
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.944
2r9z FADGlutathione amide reductase / 0.942
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.938
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.928
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.925
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.922
2eq7 FADDihydrolipoyl dehydrogenase / 0.921
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.915
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.913
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.910
2wba FADTrypanothione reductase 1.8.1.12 0.909
1get FADGlutathione reductase 1.8.1.7 0.902
1bzl FADTrypanothione reductase 1.8.1.12 0.901
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.900
1zx9 FADMercuric reductase 1.16.1.1 0.898
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.897
2tpr FADTrypanothione reductase 1.8.1.12 0.894
2yqu FADDihydrolipoyl dehydrogenase / 0.889
2eq6 FADDihydrolipoyl dehydrogenase / 0.884
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.881
1geu FADGlutathione reductase 1.8.1.7 0.879
4la1 FADThioredoxin glutathione reductase / 0.868
3urh FADDihydrolipoyl dehydrogenase / 0.867
4jq9 FADDihydrolipoyl dehydrogenase / 0.867
2wow FADTrypanothione reductase / 0.865
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.864
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.863
1tyt FADTrypanothione reductase 1.8.1.12 0.860
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.859
1typ FADTrypanothione reductase 1.8.1.12 0.854
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.854
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.851
1gxf FADTrypanothione reductase 1.8.1.12 0.849
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.849
1feb FADTrypanothione reductase 1.8.1.12 0.848
1fea FADTrypanothione reductase 1.8.1.12 0.845
4dna FADProbable glutathione reductase / 0.844
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.841
1fec FADTrypanothione reductase 1.8.1.12 0.837
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.833
2eq8 FADDihydrolipoyl dehydrogenase / 0.830
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.830
2w0h FADTrypanothione reductase / 0.829
1zk7 FADMercuric reductase 1.16.1.1 0.823
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.822
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.820
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.818
2wp5 FADTrypanothione reductase / 0.818
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.810
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.809
2qa1 FADPgaE / 0.806
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.806
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.804
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.803
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.801
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.800
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.798
4k2x FADPolyketide oxygenase/hydroxylase / 0.797
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.788
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.785
2rab FADGlutathione amide reductase / 0.785
4nte FADDepH / 0.785
1tde FADThioredoxin reductase 1.8.1.9 0.782
3lad FADDihydrolipoyl dehydrogenase / 0.782
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.781
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.779
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.774
3cty FADProbable thioredoxin reductase / 0.773
4bk2 FADProbable salicylate monooxygenase / 0.770
2eq9 FADDihydrolipoyl dehydrogenase / 0.768
4j34 FADKynurenine 3-monooxygenase / 0.768
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.767
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.764
1ojt FADDihydrolipoyl dehydrogenase / 0.763
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.763
1nhs FADNADH peroxidase 1.11.1.1 0.761
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.759
4opi FDAConserved Archaeal protein / 0.759
4j31 FADKynurenine 3-monooxygenase / 0.757
3icr FADCoenzyme A disulfide reductase / 0.756
1b4v FADCholesterol oxidase 1.1.3.6 0.754
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.754
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.754
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.753
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.753
4u2t FADCholesterol oxidase 1.1.3.6 0.753
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.752
1trb FADThioredoxin reductase 1.8.1.9 0.752
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.752
3cnj FADCholesterol oxidase 1.1.3.6 0.752
4jnq FDAThioredoxin reductase / 0.752
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.751
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.748
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.748
2npx FADNADH peroxidase 1.11.1.1 0.747
1nhr FADNADH peroxidase 1.11.1.1 0.745
2zbw FADFerredoxin--NADP reductase / 0.745
4cnk FADL-amino acid oxidase / 0.745
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.744
3atq FDAConserved Archaeal protein / 0.743
3fbs FADOxidoreductase / 0.742
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.741
4a6n FADTetX family tetracycline inactivation enzyme / 0.741
4j36 FADKynurenine 3-monooxygenase / 0.741
4rek FADCholesterol oxidase 1.1.3.6 0.740
4j33 FADKynurenine 3-monooxygenase / 0.739
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.738
1pdh FASp-hydroxybenzoate hydroxylase / 0.737
2yg4 FADPutrescine oxidase / 0.737
3gyi FADCholesterol oxidase 1.1.3.6 0.737
4dsh FDAUncharacterized protein / 0.737
4u2s FDACholesterol oxidase 1.1.3.6 0.736
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.734
1ijh FADCholesterol oxidase 1.1.3.6 0.733
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.733
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.733
3gyj FADCholesterol oxidase 1.1.3.6 0.732
3itj FADThioredoxin reductase 1 1.8.1.9 0.732
1onf FADGlutathione reductase 1.8.1.7 0.731
4bk3 FADProbable salicylate monooxygenase / 0.731
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.731
4opl FDAConserved Archaeal protein / 0.728
4opt FDAConserved Archaeal protein / 0.728
4opu FDAConserved Archaeal protein / 0.728
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.727
4opg FDAConserved Archaeal protein / 0.727
3rha FDAPutrescine oxidase / 0.726
4j2w FADKynurenine 3-monooxygenase / 0.725
1nhp FADNADH peroxidase 1.11.1.1 0.723
2q0k FADThioredoxin reductase 1.8.1.9 0.723
4ynt FDAGlucose oxidase, putative / 0.723
2cvj FADThioredoxin reductase related protein / 0.722
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.722
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.721
1n1p FADCholesterol oxidase 1.1.3.6 0.721
1n4v FADCholesterol oxidase 1.1.3.6 0.721
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.721
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.721
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.720
4fwf FADLysine-specific histone demethylase 1B 1 0.720
3b6d FAECholesterol oxidase 1.1.3.6 0.719
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.719
4cnj FADL-amino acid oxidase / 0.719
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.718
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.718
4up3 FADThioredoxin reductase / 0.717
1joa FADNADH peroxidase 1.11.1.1 0.716
3r9u FADThioredoxin reductase / 0.715
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.715
2ywl FADThioredoxin reductase related protein / 0.714
5dbj FADFADH2-dependent halogenase PltA / 0.714
4mih FADPyranose 2-oxidase 1.1.3.10 0.713
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.713
4a5l FADThioredoxin reductase / 0.712
4a99 FADTetX family tetracycline inactivation enzyme / 0.712
4fwe FADLysine-specific histone demethylase 1B 1 0.712
4x4j FADPutative oxygenase / 0.712
2b9x FADPutative aminooxidase / 0.711
3cgd FADCoenzyme A disulfide reductase / 0.711
3nix FADFlavoprotein/dehydrogenase / 0.711
2b9w FADPutative aminooxidase / 0.710
4gut FADLysine-specific histone demethylase 1B 1 0.710
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.709
1n4u FAECholesterol oxidase 1.1.3.6 0.708
1npx FADNADH peroxidase 1.11.1.1 0.708
2gr3 FADFerredoxin reductase / 0.708
3ict FADCoenzyme A disulfide reductase / 0.708
4xwr FADCholesterol oxidase 1.1.3.6 0.708
1b8s FADCholesterol oxidase 1.1.3.6 0.707
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.707
2gew FADCholesterol oxidase 1.1.3.6 0.707
1mxt FAECholesterol oxidase 1.1.3.6 0.706
1n4w FADCholesterol oxidase 1.1.3.6 0.706
4xxg FADCholesterol oxidase 1.1.3.6 0.706
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.706
3cge FADCoenzyme A disulfide reductase / 0.705
5buk FADFADH2-dependent halogenase / 0.705
1nhq FADNADH peroxidase 1.11.1.1 0.704
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.704
4hsu FADLysine-specific histone demethylase 1B 1 0.704
3ish FADThioredoxin reductase 1.8.1.9 0.703
4bjz FADProbable salicylate monooxygenase / 0.703
4gur FADLysine-specific histone demethylase 1B 1 0.703
2yg7 FADPutrescine oxidase / 0.702
4gcm FADThioredoxin reductase 1.8.1.9 0.702
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.701
2yg3 FADPutrescine oxidase / 0.701
4jn9 FADDepH / 0.701
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.701
1cc2 FADCholesterol oxidase 1.1.3.6 0.700
1tdf FADThioredoxin reductase 1.8.1.9 0.700
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.697
3atr FDAConserved Archaeal protein / 0.696
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.696
2gr0 FADFerredoxin reductase / 0.695
4ccq FADThioredoxin reductase / 0.695
2vq7 FADPutative flavin-containing monooxygenase / 0.694
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.694
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.694
1rsg FADPolyamine oxidase FMS1 / 0.693
2q7v FADThioredoxin reductase / 0.693
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.693
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.693
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.692
4ccr FADThioredoxin reductase / 0.691
4u2l SFDCholesterol oxidase 1.1.3.6 0.691
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.689
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4ntc FADThioredoxin reductase gliT / 0.689
2gqw FADFerredoxin reductase / 0.688
3f8d FADNADH oxidase/thioredoxin reductase / 0.688
3cgc FADCoenzyme A disulfide reductase / 0.687
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.687
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.686
2whd FADThioredoxin reductase / 0.686
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.685
2xvi FADPutative flavin-containing monooxygenase / 0.685
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.685
1k0l FADp-hydroxybenzoate hydroxylase / 0.684
5j60 FADThioredoxin reductase / 0.684
2ba9 FADPutative aminooxidase / 0.683
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.683
1cbo FADCholesterol oxidase 1.1.3.6 0.682
2xvf FADPutative flavin-containing monooxygenase / 0.682
3t37 FADPyridoxine 4-oxidase / 0.682
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.681
2yg5 FADPutrescine oxidase / 0.680
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.680
3cgb FADCoenzyme A disulfide reductase / 0.679
3cox FADCholesterol oxidase 1.1.3.6 0.679
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
1d7y FADFerredoxin reductase / 0.677
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.677
3ukf FDAUDP-galactopyranose mutase / 0.677
4gus FADLysine-specific histone demethylase 1B 1 0.677
4yry FADGlutamate synthase, beta subunit / 0.677
1f8w FADNADH peroxidase 1.11.1.1 0.675
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.675
2x3n FADProbable FAD-dependent monooxygenase / 0.675
3ada NADSubunit alpha of sarocosine oxidase / 0.675
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.675
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.674
1pkv RBFRiboflavin synthase 2.5.1.9 0.674
1q1r FADPutidaredoxin reductase 1.18.1.5 0.674
2gqf FADUncharacterized protein HI_0933 / 0.674
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.674
3ad9 NADSubunit alpha of sarocosine oxidase / 0.674
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.674
2xlp FADPutative flavin-containing monooxygenase / 0.673
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.673
2b9y FADPutative aminooxidase / 0.672
4guu FA9Lysine-specific histone demethylase 1B 1 0.672
2xdo FADTetX family tetracycline inactivation enzyme / 0.671
4fwj FADLysine-specific histone demethylase 1B 1 0.671
4ntd FADThioredoxin reductase / 0.671
2q0l FADThioredoxin reductase 1.8.1.9 0.670
4hb9 FADUncharacterized protein / 0.669
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.668
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.668
3ka7 FADPutative oxidoreductase / 0.668
2igo FADPyranose 2-oxidase / 0.666
2jb1 FADL-amino acid oxidase / 0.666
2jae FADL-amino acid oxidase / 0.665
2qa2 FADPolyketide oxygenase CabE / 0.664
3axb FADPutative oxidoreductase / 0.664
3bg7 FADPyranose 2-oxidase / 0.664
4dsg FADUncharacterized protein / 0.664
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.664
4usr FADMonooxygenase / 0.664
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.663
2yg6 FADPutrescine oxidase / 0.662
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.662
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.662
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.661
3he3 FADUDP-galactopyranose mutase / 0.660
3qvp FADGlucose oxidase 1.1.3.4 0.660
4qi5 FADCellobiose dehydrogenase / 0.660
4cbq FADThioredoxin reductase / 0.659
4guv FADTetX family tetracycline inactivation enzyme / 0.659
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.658
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.657
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.657
4aox FADSteroid monooxygenase / 0.657
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.657
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.656
2bac FADPutative aminooxidase / 0.656
4z24 FADPutative GMC-type oxidoreductase R135 1 0.656
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
3d8x FADThioredoxin reductase 1 1.8.1.9 0.655
3k30 ADPHistamine dehydrogenase / 0.655
3vqr FADPutative oxidoreductase / 0.655
3zdn FADMonoamine oxidase N 1.4.3.4 0.655
4u8k FDAUDP-galactopyranose mutase / 0.655
1cf3 FADGlucose oxidase 1.1.3.4 0.654
4rsl FADFructosyl peptide oxidase / 0.654
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.653
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.652
1z6l FADPolyamine oxidase FMS1 / 0.652
4i58 FADCyclohexylamine Oxidase / 0.652
1tdo FADL-amino-acid oxidase 1.4.3.2 0.651
2dw4 FADLysine-specific histone demethylase 1A 1 0.651
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.651
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.651
3uth FDAUDP-galactopyranose mutase / 0.651
5cho FADFlavin reductase / 0.651
1gpe FADGlucose oxidase 1.1.3.4 0.650
3hdy FDAUDP-galactopyranose mutase / 0.650