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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bra FAD [F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.522
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.393
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.223
4a99 FADTetX family tetracycline inactivation enzyme / 0.864
4hb9 FADUncharacterized protein / 0.799
3ihg FADAklavinone 12-hydroxylase RdmE / 0.792
4bk2 FADProbable salicylate monooxygenase / 0.789
2r0c FADPutative FAD-monooxygenase / 0.779
2bab FADPutative aminooxidase / 0.778
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.776
2xdo FADTetX family tetracycline inactivation enzyme / 0.775
3cgb FADCoenzyme A disulfide reductase / 0.771
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.770
2b9x FADPutative aminooxidase / 0.768
3nlc FADUncharacterized protein / 0.766
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.760
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.759
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.757
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.756
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.754
2b9y FADPutative aminooxidase / 0.752
2gv8 FADThiol-specific monooxygenase 1.14.13 0.752
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.752
2yqu FADDihydrolipoyl dehydrogenase / 0.750
4j2w FADKynurenine 3-monooxygenase / 0.750
1zx9 FADMercuric reductase 1.16.1.1 0.749
3ict FADCoenzyme A disulfide reductase / 0.747
4dna FADProbable glutathione reductase / 0.746
2eq6 FADDihydrolipoyl dehydrogenase / 0.742
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.742
2b9w FADPutative aminooxidase / 0.741
4x4j FADPutative oxygenase / 0.741
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.739
2eq8 FADDihydrolipoyl dehydrogenase / 0.738
2ba9 FADPutative aminooxidase / 0.737
4tm1 FDAKtzI / 0.737
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.735
1bzl FADTrypanothione reductase 1.8.1.12 0.734
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.734
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.734
4bk3 FADProbable salicylate monooxygenase / 0.732
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.730
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.726
3cgd FADCoenzyme A disulfide reductase / 0.724
4cnk FADL-amino acid oxidase / 0.722
2yg5 FADPutrescine oxidase / 0.721
4nte FADDepH / 0.721
4qi4 FADCellobiose dehydrogenase / 0.721
4u2l SFDCholesterol oxidase 1.1.3.6 0.721
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.721
4eep FMNPhototropin-2 2.7.11.1 0.720
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.719
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.718
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.718
4nzh FADL-ornithine N(5)-monooxygenase / 0.718
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.717
2q7v FADThioredoxin reductase / 0.717
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.717
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.715
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.714
1k0l FADp-hydroxybenzoate hydroxylase / 0.714
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.714
2q0l FADThioredoxin reductase 1.8.1.9 0.714
2rab FADGlutathione amide reductase / 0.714
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.713
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.713
4opc FDAConserved Archaeal protein / 0.713
2eq7 FADDihydrolipoyl dehydrogenase / 0.712
3cgc FADCoenzyme A disulfide reductase / 0.712
4k2x FADPolyketide oxygenase/hydroxylase / 0.712
1h83 FADPolyamine oxidase 1.5.3.14 0.711
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.711
4mo2 FDAUDP-galactopyranose mutase / 0.710
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.709
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.708
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.707
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.706
2w0h FADTrypanothione reductase / 0.706
4ap3 FADSteroid monooxygenase / 0.706
4bjz FADProbable salicylate monooxygenase / 0.706
4ees FMNPhototropin-2 2.7.11.1 0.706
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.705
3atq FDAConserved Archaeal protein / 0.705
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.705
3f8d FADNADH oxidase/thioredoxin reductase / 0.704
4gcm FADThioredoxin reductase 1.8.1.9 0.704
4nev FADTrypanothione reductase / 0.704
1feb FADTrypanothione reductase 1.8.1.12 0.703
2e1m FADL-glutamate oxidase / 0.703
1gvh FADFlavohemoprotein / 0.702
1ojt FADDihydrolipoyl dehydrogenase / 0.702
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.701
3k30 ADPHistamine dehydrogenase / 0.701
3rp8 FADFAD-dependent urate hydroxylase / 0.701
1cc2 FADCholesterol oxidase 1.1.3.6 0.700
2eq7 NADDihydrolipoyl dehydrogenase / 0.700
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.700
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.700
3r9u FADThioredoxin reductase / 0.699
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.698
3rha FDAPutrescine oxidase / 0.698
1typ FADTrypanothione reductase 1.8.1.12 0.697
2bn4 FADNADPH--cytochrome P450 reductase / 0.697
3lov FADProtoporphyrinogen oxidase / 0.697
4ap1 FADSteroid monooxygenase / 0.697
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.697
4opd FDAConserved Archaeal protein / 0.697
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.695
1f8w FADNADH peroxidase 1.11.1.1 0.695
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.695
2wba FADTrypanothione reductase 1.8.1.12 0.695
2gvc FADThiol-specific monooxygenase 1.14.13 0.694
3h5n ATPMccB protein / 0.694
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.693
2x8h FADThioredoxin glutathione reductase / 0.693
4h6r FDAProline dehydrogenase / 0.693
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.692
4yac NAIC alpha-dehydrogenase / 0.692
4aos FADSteroid monooxygenase / 0.691
4aox FADSteroid monooxygenase / 0.691
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.690
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.690
4j34 FADKynurenine 3-monooxygenase / 0.690
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4opi FDAConserved Archaeal protein / 0.689
2tpr FADTrypanothione reductase 1.8.1.12 0.688
4jq9 FADDihydrolipoyl dehydrogenase / 0.688
4yv2 S4MSpermidine synthase, putative / 0.688
1gpe FADGlucose oxidase 1.1.3.4 0.687
1qh0 FADFerredoxin--NADP reductase 1.18.1.2 0.687
3cnd FADPolyamine oxidase FMS1 / 0.687
1gal FADGlucose oxidase 1.1.3.4 0.686
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
4eet FMNPhototropin-2 2.7.11.1 0.686
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.686
4ynt FDAGlucose oxidase, putative / 0.686
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.686
1nhs FADNADH peroxidase 1.11.1.1 0.685
2iid FADL-amino-acid oxidase 1.4.3.2 0.685
3cox FADCholesterol oxidase 1.1.3.6 0.685
3fg2 FADPutative rubredoxin reductase / 0.685
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.685
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.684
2yg3 FADPutrescine oxidase / 0.684
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.684
4jn9 FADDepH / 0.684
1f8r FADL-amino-acid oxidase 1.4.3.2 0.683
3qvp FADGlucose oxidase 1.1.3.4 0.683
1cf3 FADGlucose oxidase 1.1.3.4 0.682
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.682
3ada NADSubunit alpha of sarocosine oxidase / 0.682
3gwf FADCyclohexanone monooxygenase / 0.682
4mok FADPyranose 2-oxidase / 0.682
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.681
5cku FADL-ornithine N(5)-monooxygenase / 0.681
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.680
1f3p FADFerredoxin reductase / 0.680
1nhr FADNADH peroxidase 1.11.1.1 0.680
4usr FADMonooxygenase / 0.680
1ges FADGlutathione reductase 1.8.1.7 0.679
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.679
2v7g NADUrocanate hydratase 4.2.1.49 0.679
3cn8 FADPolyamine oxidase FMS1 / 0.677
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.676
2x3n FADProbable FAD-dependent monooxygenase / 0.676
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.675
2ign FADPyranose 2-oxidase / 0.675
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
4j56 FADThioredoxin reductase 2 1.8.1.9 0.675
1d7l RFLp-hydroxybenzoate hydroxylase / 0.674
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.674
1fec FADTrypanothione reductase 1.8.1.12 0.673
1zk7 FADMercuric reductase 1.16.1.1 0.673
2pd8 FADVivid PAS protein VVD / 0.673
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.673
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.672
4gur FADLysine-specific histone demethylase 1B 1 0.672
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.672
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.671
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.671
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.671
1ger FADGlutathione reductase 1.8.1.7 0.669
3jsk AHZThiamine thiazole synthase / 0.669
4opl FDAConserved Archaeal protein / 0.669
5buk FADFADH2-dependent halogenase / 0.669
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.668
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.668
2r6h FADNa(+)-translocating NADH-quinone reductase subunit F / 0.668
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.668
3ad9 NADSubunit alpha of sarocosine oxidase / 0.668
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.668
3qvr FADGlucose oxidase 1.1.3.4 0.668
4eqs FADCoenzyme A disulfide reductase / 0.668
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.667
4eqx FADCoenzyme A disulfide reductase / 0.667
4hj4 FMNLOV protein / 0.667
4rdi ATPtRNA threonylcarbamoyladenosine dehydratase 6.1 0.667
4tm0 FADKtzI / 0.667
5dbj FADFADH2-dependent halogenase PltA / 0.667
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.666
3kkj FADRenalase / 0.666
3t14 FADSulfide-quinone reductase / 0.666
4x9n FADUncharacterized protein MG039 homolog / 0.666
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.666
1fnd FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.665
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
1tyt FADTrypanothione reductase 1.8.1.12 0.665
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.665
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.665
3p9u FADTetX family tetracycline inactivation enzyme / 0.665
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
1npx FADNADH peroxidase 1.11.1.1 0.664
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.664
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.664
3k4c FADPyranose 2-oxidase / 0.664
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.664
1qgy FADFerredoxin--NADP reductase 1.18.1.2 0.663
4j36 FADKynurenine 3-monooxygenase / 0.663
4z26 FADPutative GMC-type oxidoreductase R135 1 0.663
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.662
3utg FDAUDP-galactopyranose mutase / 0.661
4opg FDAConserved Archaeal protein / 0.661
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.660
2vq7 FADPutative flavin-containing monooxygenase / 0.660
2vqb FADPutative flavin-containing monooxygenase / 0.660
3icr FADCoenzyme A disulfide reductase / 0.660
2fkn NADUrocanate hydratase 4.2.1.49 0.659
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.659
4tm4 FDAKtzI / 0.659
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.658
2r9z FADGlutathione amide reductase / 0.658
2yg7 FADPutrescine oxidase / 0.658
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.658
3ics FADCoenzyme A disulfide reductase / 0.658
4emw FADCoenzyme A disulfide reductase / 0.658
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.658
3atr FDAConserved Archaeal protein / 0.657
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
3p7n FMNLight-activated DNA-binding protein EL222 / 0.657
2v6o FADThioredoxin glutathione reductase / 0.656
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.656
4j33 FADKynurenine 3-monooxygenase / 0.656
4x9m FADUncharacterized protein MG039 homolog / 0.656
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.655
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.655
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.654
1q1r FADPutidaredoxin reductase 1.18.1.5 0.654
2cvj FADThioredoxin reductase related protein / 0.654
2npx FADNADH peroxidase 1.11.1.1 0.654
4qi5 FADCellobiose dehydrogenase / 0.654
4xr9 NADCalS8 / 0.654
1yqz FADCoenzyme A disulfide reductase / 0.653
2igo FADPyranose 2-oxidase / 0.653
2xlp FADPutative flavin-containing monooxygenase / 0.652
3e23 SAMUncharacterized protein / 0.652
3f8p NADNADH oxidase/thioredoxin reductase / 0.652
3f8r NAPNADH oxidase/thioredoxin reductase / 0.652
3hdy FADUDP-galactopyranose mutase / 0.652
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.652
1tez HDFDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.651
1z3c SA8mRNA cap guanine-N7 methyltransferase 2.1.1.56 0.651
2yg4 FADPutrescine oxidase / 0.651
2yg6 FADPutrescine oxidase / 0.651
3dme FADPutative conserved exported protein / 0.651
4gus FADLysine-specific histone demethylase 1B 1 0.651
4ntd FADThioredoxin reductase / 0.651
4r3a RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.651
1nhp FADNADH peroxidase 1.11.1.1 0.650
3qft FADNADPH--cytochrome P450 reductase / 0.650
5hsa FASAlcohol oxidase 1 1.1.3.13 0.650