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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1typ FAD Trypanothione reductase 1.8.1.12

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1typ FADTrypanothione reductase 1.8.1.12 1.369
1tyt FADTrypanothione reductase 1.8.1.12 1.203
2wba FADTrypanothione reductase 1.8.1.12 1.171
1bzl FADTrypanothione reductase 1.8.1.12 1.168
1fec FADTrypanothione reductase 1.8.1.12 1.153
2tpr FADTrypanothione reductase 1.8.1.12 1.151
1feb FADTrypanothione reductase 1.8.1.12 1.149
4nev FADTrypanothione reductase / 1.130
1fea FADTrypanothione reductase 1.8.1.12 1.110
2wow FADTrypanothione reductase / 1.096
2jk6 FADTrypanothione reductase / 1.068
1ger FADGlutathione reductase 1.8.1.7 1.054
2wp5 FADTrypanothione reductase / 1.041
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.038
2hqm FADGlutathione reductase 1.8.1.7 1.034
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.017
1ges FADGlutathione reductase 1.8.1.7 1.010
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 1.003
2x8g FADThioredoxin glutathione reductase / 1.001
2w0h FADTrypanothione reductase / 1.000
2x8h FADThioredoxin glutathione reductase / 0.996
4dna FADProbable glutathione reductase / 0.992
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.991
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.990
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.985
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.973
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.973
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.970
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.966
1gxf FADTrypanothione reductase 1.8.1.12 0.960
2v6o FADThioredoxin glutathione reductase / 0.957
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.957
2r9z FADGlutathione amide reductase / 0.953
1geu FADGlutathione reductase 1.8.1.7 0.943
4j57 FADThioredoxin reductase 2 1.8.1.9 0.943
1get FADGlutathione reductase 1.8.1.7 0.939
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.938
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.931
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.930
2yqu FADDihydrolipoyl dehydrogenase / 0.917
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.916
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.915
2eq7 FADDihydrolipoyl dehydrogenase / 0.909
4b1b FADThioredoxin reductase 1.8.1.9 0.906
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.902
4la1 FADThioredoxin glutathione reductase / 0.901
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.894
1zx9 FADMercuric reductase 1.16.1.1 0.894
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.890
2eq6 FADDihydrolipoyl dehydrogenase / 0.887
1zk7 FADMercuric reductase 1.16.1.1 0.886
2eq8 FADDihydrolipoyl dehydrogenase / 0.879
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.878
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.877
2eq9 FADDihydrolipoyl dehydrogenase / 0.876
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.875
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.871
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.865
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.865
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.859
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.857
4j56 FADThioredoxin reductase 2 1.8.1.9 0.854
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.854
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.851
3urh FADDihydrolipoyl dehydrogenase / 0.850
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.849
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.841
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.839
3icr FADCoenzyme A disulfide reductase / 0.837
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.836
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.835
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.829
2rab FADGlutathione amide reductase / 0.827
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.822
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.820
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.818
3lad FADDihydrolipoyl dehydrogenase / 0.803
1tdf FADThioredoxin reductase 1.8.1.9 0.801
1tde FADThioredoxin reductase 1.8.1.9 0.800
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.799
1b4v FADCholesterol oxidase 1.1.3.6 0.798
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.793
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.789
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.786
1ojt FADDihydrolipoyl dehydrogenase / 0.786
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.785
1trb FADThioredoxin reductase 1.8.1.9 0.782
2whd FADThioredoxin reductase / 0.781
4ccr FADThioredoxin reductase / 0.781
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.781
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.780
1nhq FADNADH peroxidase 1.11.1.1 0.777
2qa1 FADPgaE / 0.772
4rek FADCholesterol oxidase 1.1.3.6 0.772
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.770
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.763
3cty FADProbable thioredoxin reductase / 0.760
1n4u FAECholesterol oxidase 1.1.3.6 0.759
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.758
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.757
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.755
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.753
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.752
1onf FADGlutathione reductase 1.8.1.7 0.751
3atq FDAConserved Archaeal protein / 0.751
1npx FADNADH peroxidase 1.11.1.1 0.750
1nhr FADNADH peroxidase 1.11.1.1 0.749
3ict FADCoenzyme A disulfide reductase / 0.748
4a6n FADTetX family tetracycline inactivation enzyme / 0.748
4j31 FADKynurenine 3-monooxygenase / 0.746
4jq9 FADDihydrolipoyl dehydrogenase / 0.745
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.744
3cnj FADCholesterol oxidase 1.1.3.6 0.743
4fwe FADLysine-specific histone demethylase 1B 1 0.743
1cc2 FADCholesterol oxidase 1.1.3.6 0.741
1mxt FAECholesterol oxidase 1.1.3.6 0.741
1nhs FADNADH peroxidase 1.11.1.1 0.741
4j36 FADKynurenine 3-monooxygenase / 0.741
4nte FADDepH / 0.741
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.740
3gyj FADCholesterol oxidase 1.1.3.6 0.740
4j33 FADKynurenine 3-monooxygenase / 0.740
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.740
4xxg FADCholesterol oxidase 1.1.3.6 0.740
4opg FDAConserved Archaeal protein / 0.739
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.738
4jn9 FADDepH / 0.738
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.737
3cgc FADCoenzyme A disulfide reductase / 0.737
3itj FADThioredoxin reductase 1 1.8.1.9 0.737
1cbo FADCholesterol oxidase 1.1.3.6 0.736
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.736
4u2t FADCholesterol oxidase 1.1.3.6 0.735
1joa FADNADH peroxidase 1.11.1.1 0.734
4opt FDAConserved Archaeal protein / 0.734
1f8w FADNADH peroxidase 1.11.1.1 0.733
3fbs FADOxidoreductase / 0.731
4jnq FDAThioredoxin reductase / 0.731
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.729
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.729
4j2w FADKynurenine 3-monooxygenase / 0.729
4k2x FADPolyketide oxygenase/hydroxylase / 0.729
4j34 FADKynurenine 3-monooxygenase / 0.728
3cgb FADCoenzyme A disulfide reductase / 0.727
3atr FDAConserved Archaeal protein / 0.726
3gyi FADCholesterol oxidase 1.1.3.6 0.725
4bk3 FADProbable salicylate monooxygenase / 0.725
4cnk FADL-amino acid oxidase / 0.720
3r9u FADThioredoxin reductase / 0.719
4opu FDAConserved Archaeal protein / 0.719
1qo8 FADFumarate reductase flavoprotein subunit / 0.717
2igo FADPyranose 2-oxidase / 0.716
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.716
3bg7 FADPyranose 2-oxidase / 0.716
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.716
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.715
4ccq FADThioredoxin reductase / 0.714
2xdo FADTetX family tetracycline inactivation enzyme / 0.709
4a99 FADTetX family tetracycline inactivation enzyme / 0.709
4opl FDAConserved Archaeal protein / 0.709
4cbq FADThioredoxin reductase / 0.708
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.708
4up3 FADThioredoxin reductase / 0.707
4ynt FDAGlucose oxidase, putative / 0.707
4cnj FADL-amino acid oxidase / 0.706
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.706
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.705
4hb9 FADUncharacterized protein / 0.705
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.705
2gqf FADUncharacterized protein HI_0933 / 0.704
3f8d FADNADH oxidase/thioredoxin reductase / 0.704
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.704
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.704
5dbj FADFADH2-dependent halogenase PltA / 0.703
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.702
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.702
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.702
4k5r FADOxygenase / 0.702
4u2s FDACholesterol oxidase 1.1.3.6 0.702
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.702
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.701
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.700
4opi FDAConserved Archaeal protein / 0.700
1cl0 FADThioredoxin reductase 1.8.1.9 0.699
1pkv RBFRiboflavin synthase 2.5.1.9 0.699
3rp8 FADFAD-dependent urate hydroxylase / 0.699
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.698
4gcm FADThioredoxin reductase 1.8.1.9 0.698
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.698
5j60 FADThioredoxin reductase / 0.698
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.697
4bk2 FADProbable salicylate monooxygenase / 0.697
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.697
4mih FADPyranose 2-oxidase 1.1.3.10 0.697
2gqw FADFerredoxin reductase / 0.696
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.695
4a65 FADThioredoxin reductase / 0.695
3v76 FDAUncharacterized protein / 0.694
4bjz FADProbable salicylate monooxygenase / 0.694
2e1m FADL-glutamate oxidase / 0.693
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.691
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.690
3ka7 FADPutative oxidoreductase / 0.690
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.690
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.689
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.689
2yg3 FADPutrescine oxidase / 0.688
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.688
3cgd FADCoenzyme A disulfide reductase / 0.686
4ntd FADThioredoxin reductase / 0.686
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.685
2q7v FADThioredoxin reductase / 0.684
3d8x FADThioredoxin reductase 1 1.8.1.9 0.684
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.683
2cdu FADNADH oxidase / 0.682
1q1r FADPutidaredoxin reductase 1.18.1.5 0.681
2zbw FADFerredoxin--NADP reductase / 0.680
3axb FADPutative oxidoreductase / 0.680
2hko FADLysine-specific histone demethylase 1A 1 0.679
2yg4 FADPutrescine oxidase / 0.679
4rsl FADFructosyl peptide oxidase / 0.679
2npx FADNADH peroxidase 1.11.1.1 0.678
2ed4 FAD4-hydroxyphenylacetate 3-monooxygenase reductase component 1.5.1.36 0.677
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.675
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.674
1rz0 FADPhenol 2-hydroxylase component B / 0.672
4gur FADLysine-specific histone demethylase 1B 1 0.672
4guu FA9Lysine-specific histone demethylase 1B 1 0.672
5cho FADFlavin reductase / 0.672
3ihg FADAklavinone 12-hydroxylase RdmE / 0.671
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.670
3sz0 FADSulfide-quinone reductase / 0.669
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.669
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.669
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.669
1d7y FADFerredoxin reductase / 0.668
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.668
4icy FADPgaE / 0.668
2x3n FADProbable FAD-dependent monooxygenase / 0.667
3bi5 FADPolyamine oxidase FMS1 / 0.667
1rsg FADPolyamine oxidase FMS1 / 0.666
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.666
4fwf FADLysine-specific histone demethylase 1B 1 0.666
4l82 FMNUncharacterized protein / 0.666
3cge FADCoenzyme A disulfide reductase / 0.665
4tm1 FDAKtzI / 0.664
1q1w FADPutidaredoxin reductase 1.18.1.5 0.663
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.663
2dw4 FADLysine-specific histone demethylase 1A 1 0.662
4fwj FADLysine-specific histone demethylase 1B 1 0.662
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.661
2gr3 FADFerredoxin reductase / 0.661
3k4c FADPyranose 2-oxidase / 0.661
4a5l FADThioredoxin reductase / 0.661
4gus FADLysine-specific histone demethylase 1B 1 0.661
2yg5 FADPutrescine oxidase / 0.660
2yg7 FADPutrescine oxidase / 0.660
1rz1 FADPhenol 2-hydroxylase component B / 0.659
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.659
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.657
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
3k4n FADPyranose 2-oxidase / 0.657
2b9w FADPutative aminooxidase / 0.656
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.655
2h94 FADLysine-specific histone demethylase 1A 1 0.655
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.655
3rha FDAPutrescine oxidase / 0.655
4yry FADGlutamate synthase, beta subunit / 0.655
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.654
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.654
4b64 FADL-ornithine N(5)-monooxygenase / 0.654
2vq7 FADPutative flavin-containing monooxygenase / 0.653
2yg6 FADPutrescine oxidase / 0.653
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.652
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.652
1b8s FADCholesterol oxidase 1.1.3.6 0.651
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.651
3cox FADCholesterol oxidase 1.1.3.6 0.651
3hji FADVivid PAS protein VVD / 0.651
2bac FADPutative aminooxidase / 0.650
2fzm FADBifunctional protein PutA 1.5.5.2 0.650
2q0k FADThioredoxin reductase 1.8.1.9 0.650
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.650