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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lyn1YGCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4lyn1YGCyclin-dependent kinase 22.7.11.221.000
4fki09KCyclin-dependent kinase 22.7.11.220.685
2r64740Cyclin-dependent kinase 22.7.11.220.624
3lfsA07Cyclin-dependent kinase 22.7.11.220.619
3qwjX6ACyclin-dependent kinase 22.7.11.220.616
2duv371Cyclin-dependent kinase 22.7.11.220.612
3roy22ZCyclin-dependent kinase 22.7.11.220.603
3lfnA27Cyclin-dependent kinase 22.7.11.220.601
3rk909ZCyclin-dependent kinase 22.7.11.220.601
1pxoCK7Cyclin-dependent kinase 22.7.11.220.597
3qu0X40Cyclin-dependent kinase 22.7.11.220.596
3r1yX76Cyclin-dependent kinase 22.7.11.220.595
1ke6LS2Cyclin-dependent kinase 22.7.11.220.593
2a0cCK9Cyclin-dependent kinase 22.7.11.220.588
2xmyCDKCyclin-dependent kinase 22.7.11.220.588
1v1k3FPCyclin-dependent kinase 22.7.11.220.585
1w0xOLOCyclin-dependent kinase 22.7.11.220.585
3iggEFQCyclin-dependent kinase 22.7.11.220.584
3rpo24ZCyclin-dependent kinase 22.7.11.220.583
1ke5LS1Cyclin-dependent kinase 22.7.11.220.582
3qxoX65Cyclin-dependent kinase 22.7.11.220.581
2btrU73Cyclin-dependent kinase 22.7.11.220.579
2btsU32Cyclin-dependent kinase 22.7.11.220.578
4fkj11KCyclin-dependent kinase 22.7.11.220.578
3r6xX84Cyclin-dependent kinase 22.7.11.220.577
4ez30S0Cyclin-dependent kinase 22.7.11.220.575
1ckpPVBCyclin-dependent kinase 22.7.11.220.573
1h1r6CPCyclin-dependent kinase 22.7.11.220.573
3rk708ZCyclin-dependent kinase 22.7.11.220.573
3s2pPMUCyclin-dependent kinase 22.7.11.220.572
3qx2X63Cyclin-dependent kinase 22.7.11.220.571
4fkq42KCyclin-dependent kinase 22.7.11.220.571
1h0w207Cyclin-dependent kinase 22.7.11.220.570
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.567
2a4lRRCCyclin-dependent kinase 22.7.11.220.566
3r73X87Cyclin-dependent kinase 22.7.11.220.565
3rm719ZCyclin-dependent kinase 22.7.11.220.565
3sqq99ZCyclin-dependent kinase 22.7.11.220.565
1gih1PUCyclin-dependent kinase 22.7.11.220.564
1pxmCK5Cyclin-dependent kinase 22.7.11.220.564
3lfqA28Cyclin-dependent kinase 22.7.11.220.563
4ek610KCyclin-dependent kinase 22.7.11.220.562
1ke7LS3Cyclin-dependent kinase 22.7.11.220.561
3ezrEZRCyclin-dependent kinase 22.7.11.220.560
3rpv26ZCyclin-dependent kinase 22.7.11.220.560
4fkpLS5Cyclin-dependent kinase 22.7.11.220.560
1w8cN69Cyclin-dependent kinase 22.7.11.220.559
3r7yZ04Cyclin-dependent kinase 22.7.11.220.559
3qzgX67Cyclin-dependent kinase 22.7.11.220.558
3r1qX75Cyclin-dependent kinase 22.7.11.220.558
3ddqRRCCyclin-dependent kinase 22.7.11.220.557
3rm618ZCyclin-dependent kinase 22.7.11.220.557
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.556
1di8DTQCyclin-dependent kinase 22.7.11.220.555
2b52D42Cyclin-dependent kinase 22.7.11.220.555
3qqkX02Cyclin-dependent kinase 22.7.11.220.555
1g5sI17Cyclin-dependent kinase 22.7.11.220.554
3r1sX73Cyclin-dependent kinase 22.7.11.220.554
1oguST8Cyclin-dependent kinase 22.7.11.220.553
3ezvEZVCyclin-dependent kinase 22.7.11.220.553
1p2a5BNCyclin-dependent kinase 22.7.11.220.552
2r3kSCQCyclin-dependent kinase 22.7.11.220.552
2w06FRVCyclin-dependent kinase 22.7.11.220.552
3ddpRC8Cyclin-dependent kinase 22.7.11.220.552
3fz1B98Cyclin-dependent kinase 22.7.11.220.552
3qqfX07Cyclin-dependent kinase 22.7.11.220.552
2uzoC62Cyclin-dependent kinase 22.7.11.220.550
3qzhX69Cyclin-dependent kinase 22.7.11.220.550
4acm7YGCyclin-dependent kinase 22.7.11.220.549
1b38ATPCyclin-dependent kinase 22.7.11.220.548
1vyw292Cyclin-dependent kinase 22.7.11.220.547
1oitHDTCyclin-dependent kinase 22.7.11.220.543
2c6o4SPCyclin-dependent kinase 22.7.11.220.542
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.542
1ykr628Cyclin-dependent kinase 22.7.11.220.541
3qruX19Cyclin-dependent kinase 22.7.11.220.541
1ke8LS4Cyclin-dependent kinase 22.7.11.220.540
4ek816KCyclin-dependent kinase 22.7.11.220.540
1oiqHDUCyclin-dependent kinase 22.7.11.220.539
1gii1PUCyclin-dependent kinase 22.7.11.220.538
3r7uX96Cyclin-dependent kinase 22.7.11.220.538
4fkt48KCyclin-dependent kinase 22.7.11.220.538
3rk507ZCyclin-dependent kinase 22.7.11.220.537
3rni21ZCyclin-dependent kinase 22.7.11.220.537
4eon1ROCyclin-dependent kinase 22.7.11.220.537
3qtuX44Cyclin-dependent kinase 22.7.11.220.536
4bgh3I6Cyclin-dependent kinase 22.7.11.220.536
1e1xNW1Cyclin-dependent kinase 22.7.11.220.535
1r78FMDCyclin-dependent kinase 22.7.11.220.534
2b55D31Cyclin-dependent kinase 22.7.11.220.534
2r3lSCWCyclin-dependent kinase 22.7.11.220.534
1e9hINRCyclin-dependent kinase 22.7.11.220.533
2iw94SPCyclin-dependent kinase 22.7.11.220.533
3r28XA0Cyclin-dependent kinase 22.7.11.220.531
3unk0BYCyclin-dependent kinase 22.7.11.220.531
4fkg4CKCyclin-dependent kinase 22.7.11.220.530
4fkv61KCyclin-dependent kinase 22.7.11.220.529
1oi9N20Cyclin-dependent kinase 22.7.11.220.528
2r3mSCXCyclin-dependent kinase 22.7.11.220.527
2vthLZ2Cyclin-dependent kinase 22.7.11.220.527
4fks46KCyclin-dependent kinase 22.7.11.220.526
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.525
2vv9IM9Cyclin-dependent kinase 22.7.11.220.525
3r8lZ30Cyclin-dependent kinase 22.7.11.220.525
3rjc06ZCyclin-dependent kinase 22.7.11.220.525
3r71X86Cyclin-dependent kinase 22.7.11.220.524
1b39ATPCyclin-dependent kinase 22.7.11.220.523
3r9dX6BCyclin-dependent kinase 22.7.11.220.523
3ti1B49Cyclin-dependent kinase 22.7.11.220.523
4bcoT6QCyclin-dependent kinase 22.7.11.220.523
1hckATPCyclin-dependent kinase 22.7.11.220.522
3ig7EFPCyclin-dependent kinase 22.7.11.220.522
3sw418KCyclin-dependent kinase 22.7.11.220.522
3r83Z14Cyclin-dependent kinase 22.7.11.220.521
1vyzN5BCyclin-dependent kinase 22.7.11.220.520
2wpa889Cyclin-dependent kinase 22.7.11.220.520
1pxlCK4Cyclin-dependent kinase 22.7.11.220.519
3qtxX43Cyclin-dependent kinase 22.7.11.220.519
3qwkX62Cyclin-dependent kinase 22.7.11.220.519
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.518
2vtsLZCCyclin-dependent kinase 22.7.11.220.518
3r7vZ02Cyclin-dependent kinase 22.7.11.220.518
3s1h56ZCyclin-dependent kinase 22.7.11.220.518
3tnwF18Cyclin-dependent kinase 22.7.11.220.518
3qqhX0ACyclin-dependent kinase 22.7.11.220.517
5aniES4Cyclin-dependent kinase 22.7.11.220.517
1oiuN76Cyclin-dependent kinase 22.7.11.220.516
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.516
4bcmT7ZCyclin-dependent kinase 22.7.11.220.516
4bcpT3CCyclin-dependent kinase 22.7.11.220.516
4erwSTUCyclin-dependent kinase 22.7.11.220.516
1pyePM1Cyclin-dependent kinase 22.7.11.220.515
3ral04ZCyclin-dependent kinase 22.7.11.220.515
3rmf20ZCyclin-dependent kinase 22.7.11.220.515
2w1hL0FCyclin-dependent kinase 22.7.11.220.514
3r7eX88Cyclin-dependent kinase 22.7.11.220.514
3s0o50ZCyclin-dependent kinase 22.7.11.220.514
4fklCK2Cyclin-dependent kinase 22.7.11.220.514
1h1s4SPCyclin-dependent kinase 22.7.11.220.513
3r7iX9ICyclin-dependent kinase 22.7.11.220.513
3qtzX42Cyclin-dependent kinase 22.7.11.220.512
3r8vZ62Cyclin-dependent kinase 22.7.11.220.511
3rak03ZCyclin-dependent kinase 22.7.11.220.511
4nj32KDCyclin-dependent kinase 22.7.11.220.511
1oiyN41Cyclin-dependent kinase 22.7.11.220.510
2c6tDT5Cyclin-dependent kinase 22.7.11.220.510
4eok4SPCyclin-dependent kinase 22.7.11.220.510
4fkr45KCyclin-dependent kinase 22.7.11.220.510
1fvt106Cyclin-dependent kinase 22.7.11.220.508
2c5yMTWCyclin-dependent kinase 22.7.11.220.508
1urwI1PCyclin-dependent kinase 22.7.11.220.507
2j9mPY8Cyclin-dependent kinase 22.7.11.220.507
3rkb12ZCyclin-dependent kinase 22.7.11.220.507
1y91CT9Cyclin-dependent kinase 22.7.11.220.506
3qtrX36Cyclin-dependent kinase 22.7.11.220.506
3qx4X4BCyclin-dependent kinase 22.7.11.220.506
4cfnJYMCyclin-dependent kinase 22.7.11.220.506
1h1q2A6Cyclin-dependent kinase 22.7.11.220.505
3tiz3TICyclin-dependent kinase 22.7.11.220.505
1pxkCK3Cyclin-dependent kinase 22.7.11.220.504
2iw84SPCyclin-dependent kinase 22.7.11.220.504
2r3p3SCCyclin-dependent kinase 22.7.11.220.504
3sw719KCyclin-dependent kinase 22.7.11.220.504
1ke9LS5Cyclin-dependent kinase 22.7.11.220.503
3rahO1ZCyclin-dependent kinase 22.7.11.220.502
4eor4SPCyclin-dependent kinase 22.7.11.220.502
1unlRRCCyclin-dependent-like kinase 52.7.11.10.501
2uznC96Cyclin-dependent kinase 22.7.11.220.501
1pxpCK8Cyclin-dependent kinase 22.7.11.220.500
2b54D05Cyclin-dependent kinase 22.7.11.220.500
2vu3LZECyclin-dependent kinase 22.7.11.220.500
2r3jSCJCyclin-dependent kinase 22.7.11.220.499
1h0vUN4Cyclin-dependent kinase 22.7.11.220.497
4fx360KCyclin-dependent kinase 22.7.11.220.496
2exmZIPCyclin-dependent kinase 22.7.11.220.495
3raiX85Cyclin-dependent kinase 22.7.11.220.495
1h1pCMGCyclin-dependent kinase 22.7.11.220.494
2cchATPCyclin-dependent kinase 22.7.11.220.494
2fvdLIACyclin-dependent kinase 22.7.11.220.493
2r3iSCFCyclin-dependent kinase 22.7.11.220.493
3pj8404Cyclin-dependent kinase 22.7.11.220.492
3pxyJWSCyclin-dependent kinase 22.7.11.220.491
2bhhRYUCyclin-dependent kinase 22.7.11.220.490
2c6iDT1Cyclin-dependent kinase 22.7.11.220.490
2r3gSC9Cyclin-dependent kinase 22.7.11.220.490
2vtqLZACyclin-dependent kinase 22.7.11.220.490
3rpy27ZCyclin-dependent kinase 22.7.11.220.490
3qziX72Cyclin-dependent kinase 22.7.11.220.488
2vttLZDCyclin-dependent kinase 22.7.11.220.487
2bheBRYCyclin-dependent kinase 22.7.11.220.486
2c69CT8Cyclin-dependent kinase 22.7.11.220.486
3qxpX64Cyclin-dependent kinase 22.7.11.220.483
2c4g514Cyclin-dependent kinase 22.7.11.220.482
2pvnP63Casein kinase II subunit alpha2.7.11.10.481
3ql8X01Cyclin-dependent kinase 22.7.11.220.480
3uli1N3Cyclin-dependent kinase 22.7.11.220.480
2csnCKICasein kinase I homolog 12.7.11.10.479
3nup3NUCyclin-dependent kinase 62.7.11.220.479
3nynSGVG protein-coupled receptor kinase 62.7.11.160.479
3qqlX03Cyclin-dependent kinase 22.7.11.220.478
1finATPCyclin-dependent kinase 22.7.11.220.477
1oirHDYCyclin-dependent kinase 22.7.11.220.477
4bcnT9NCyclin-dependent kinase 22.7.11.220.477
3qrtX14Cyclin-dependent kinase 22.7.11.220.476
2r3r6SCCyclin-dependent kinase 22.7.11.220.475
3bhtMFRCyclin-dependent kinase 22.7.11.220.475
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.475
4fkw62KCyclin-dependent kinase 22.7.11.220.475
4kd11QKCyclin-dependent kinase 22.7.11.220.475
4eomATPCyclin-dependent kinase 22.7.11.220.474
1dm2HMDCyclin-dependent kinase 22.7.11.220.473
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.473
2wouZZFTGF-beta receptor type-12.7.11.300.473
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.472
2w17I19Cyclin-dependent kinase 22.7.11.220.472
3ggfGVDSerine/threonine-protein kinase 26/0.471
3qzfX66Cyclin-dependent kinase 22.7.11.220.471
3rzb02ZCyclin-dependent kinase 22.7.11.220.471
4eol1ROCyclin-dependent kinase 22.7.11.220.471
3my5RFZCyclin-dependent kinase 22.7.11.220.470
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.470
4eos1ROCyclin-dependent kinase 22.7.11.220.469
4bcqTJFCyclin-dependent kinase 22.7.11.220.468
1aq1STUCyclin-dependent kinase 22.7.11.220.467
2eufLQQCyclin-dependent kinase 62.7.11.220.467
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.467
2y9qANPMitogen-activated protein kinase 12.7.11.240.467
4ogrADNCyclin-dependent kinase 92.7.11.220.467
2r3o2SCCyclin-dependent kinase 22.7.11.220.466
3r8pZ46Cyclin-dependent kinase 22.7.11.220.466
4fko20KCyclin-dependent kinase 22.7.11.220.466
5dr6SKEAurora kinase A2.7.11.10.466
1qmzATPCyclin-dependent kinase 22.7.11.220.465
2c6mDT5Cyclin-dependent kinase 22.7.11.220.465
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.465
2x1nX1NCyclin-dependent kinase 22.7.11.220.465
3r8uZ31Cyclin-dependent kinase 22.7.11.220.465
3r9oZ71Cyclin-dependent kinase 22.7.11.220.465
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.465
2i40BLZCyclin-dependent kinase 22.7.11.220.464
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.464
2uzeC95Cyclin-dependent kinase 22.7.11.220.464
3dogNNNCyclin-dependent kinase 22.7.11.220.464
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.464
2pvlP55Casein kinase II subunit alpha2.7.11.10.463
2r3fSC8Cyclin-dependent kinase 22.7.11.220.463
1py5PY1TGF-beta receptor type-12.7.11.300.462
2c5nCK8Cyclin-dependent kinase 22.7.11.220.462
2f2cAP9Cyclin-dependent kinase 62.7.11.220.462
4jrnANPRhoptry kinase family protein/0.462
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
4ii5ADPCyclin-dependent kinase 22.7.11.220.461
1gz8MBPCyclin-dependent kinase 22.7.11.220.460
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.460
3py0SU9Cyclin-dependent kinase 22.7.11.220.460
3r9hZ67Cyclin-dependent kinase 22.7.11.220.460
2uzdC85Cyclin-dependent kinase 22.7.11.220.459
4hgt15GCasein kinase I isoform delta2.7.11.10.459
3r9nZ68Cyclin-dependent kinase 22.7.11.220.458
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.457
3qtqX35Cyclin-dependent kinase 22.7.11.220.456
3sheI85MAP kinase-activated protein kinase 32.7.11.10.456
1gij2PUCyclin-dependent kinase 22.7.11.220.455
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2uzbC75Cyclin-dependent kinase 22.7.11.220.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2wotZZGTGF-beta receptor type-12.7.11.300.454
3qtwX3ACyclin-dependent kinase 22.7.11.220.454
3unj0BXCyclin-dependent kinase 22.7.11.220.454
3wblPDYCyclin-dependent kinase 22.7.11.220.454
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.454
4jajXU1Aurora kinase A2.7.11.10.454
1pxjCK2Cyclin-dependent kinase 22.7.11.220.453
2c6kDT2Cyclin-dependent kinase 22.7.11.220.453
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.453
4dgo0JWCasein kinase II subunit alpha2.7.11.10.453
4eop1ROCyclin-dependent kinase 22.7.11.220.453
1vjy460TGF-beta receptor type-12.7.11.300.452
2c6lDT4Cyclin-dependent kinase 22.7.11.220.451
2uzlC94Cyclin-dependent kinase 22.7.11.220.450
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.449
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.449
3r8zZ63Cyclin-dependent kinase 22.7.11.220.447
2c68CT6Cyclin-dependent kinase 22.7.11.220.446
3rpr25ZCyclin-dependent kinase 22.7.11.220.446
4eooATPCyclin-dependent kinase 22.7.11.220.446
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.446
1e1vCMGCyclin-dependent kinase 22.7.11.220.445
1unhIXMCyclin-dependent-like kinase 52.7.11.10.445
2bkzSBCCyclin-dependent kinase 22.7.11.220.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
4ic7ANPMitogen-activated protein kinase 72.7.11.240.445
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.444
3qqgX06Cyclin-dependent kinase 22.7.11.220.444
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4ei40Q2Tyrosine-protein kinase JAK1/0.443
4fv9E71Mitogen-activated protein kinase 12.7.11.240.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.442
1gy3ATPCyclin-dependent kinase 22.7.11.220.441
2b53D23Cyclin-dependent kinase 22.7.11.220.441
3lq5SLQCyclin-dependent kinase 92.7.11.220.441
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.441
5dr9SKEAurora kinase A2.7.11.10.441
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.440
4aua4AUCyclin-dependent kinase 62.7.11.220.440