sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3t4l | ZEA | Histidine kinase 4 | 2.7.13.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3t4l | ZEA | Histidine kinase 4 | 2.7.13.3 | 1.000 | |
| 3t4q | ZEA | Histidine kinase 4 | 2.7.13.3 | 0.810 | |
| 3t4k | EMU | Histidine kinase 4 | 2.7.13.3 | 0.678 | |
| 3t4s | H35 | Histidine kinase 4 | 2.7.13.3 | 0.497 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.492 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.487 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.487 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.484 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.482 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.481 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.481 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.480 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.479 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.478 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.477 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.476 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.476 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.476 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.476 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.476 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.475 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.475 | |
| 1sxj | ADP | Replication factor C subunit 5 | / | 0.474 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.474 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.474 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.474 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.474 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.474 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.473 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.473 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.472 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.472 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 4fk1 | FAD | Putative thioredoxin reductase | / | 0.472 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.471 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.470 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.470 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.470 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.469 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.469 | |
| 2yir | YIR | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.468 | |
| 3gob | HXX | DdmC | / | 0.468 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.468 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.468 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.467 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.467 | |
| 4bdg | P3J | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.467 | |
| 1cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.466 | |
| 4i09 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.466 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.466 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 3eya | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.465 | |
| 3iaf | TPP | Benzaldehyde lyase | / | 0.465 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 1efp | FAD | Electron transfer flavoprotein subunit alpha | / | 0.464 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 3q0u | LL3 | HTH-type transcriptional regulator EthR | / | 0.464 | |
| 3ryp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.464 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.464 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.464 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.463 | |
| 3ppo | DCK | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.463 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.463 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.463 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.462 | |
| 2onm | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.462 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.462 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.462 | |
| 3o8g | O8G | HTH-type transcriptional regulator EthR | / | 0.462 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.462 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.461 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 2x8e | X8E | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 2yww | ATP | Aspartate carbamoyltransferase regulatory chain | / | 0.461 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.461 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.461 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.461 | |
| 3m6g | ATP | Actin, alpha skeletal muscle | / | 0.461 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.461 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.461 | |
| 4dw6 | 0MN | HTH-type transcriptional regulator EthR | / | 0.461 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.461 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.460 | |
| 1sn5 | T3 | Transthyretin | / | 0.460 | |
| 1z1f | STL | Resveratrol synthase | / | 0.460 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.460 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.460 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.460 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.460 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.460 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.459 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.459 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.459 | |
| 4a9t | A9T | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.459 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 4hxy | NDP | Plm1 | / | 0.459 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.459 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3wy0 | COA | Uncharacterized protein | / | 0.458 | |
| 4c59 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.458 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2ci0 | 1CM | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.457 | |
| 2e9p | 77A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.457 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 4ho2 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.457 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.457 | |
| 4pl8 | ATP | Actin, alpha skeletal muscle | / | 0.457 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.456 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.456 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.456 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.456 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.456 | |
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 | 0.456 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.456 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.455 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.455 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.455 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.455 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.455 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.454 | |
| 1qg0 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.454 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.454 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.454 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.454 | |
| 4ft8 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.454 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.453 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.453 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.453 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.453 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.452 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.452 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.452 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.452 | |
| 1fml | RTL | Retinol dehydratase | / | 0.451 | |
| 1gaq | FAD | Ferredoxin | / | 0.451 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1sx4 | ADP | 60 kDa chaperonin | / | 0.451 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.451 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.451 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.451 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.451 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.451 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.450 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.450 | |
| 1r2j | FAD | FkbI | / | 0.450 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.450 | |
| 1zuc | T98 | Progesterone receptor | / | 0.450 | |
| 2gzw | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.450 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.450 | |
| 2vk4 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.450 | |
| 2ydj | YDJ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.450 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.450 | |
| 3nf7 | CIW | Gag-Pol polyprotein | / | 0.450 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.450 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.450 | |
| 4hzf | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.450 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.450 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.450 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1kqg | HQO | Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit | / | 0.449 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.449 | |
| 1ruo | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.449 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.449 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.449 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.449 | |
| 3g1m | RF3 | HTH-type transcriptional regulator EthR | / | 0.449 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.449 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.449 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.449 | |
| 3kc3 | MK2 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.449 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1 | / | 0.449 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1-binding protein 1 | / | 0.449 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.449 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.448 | |
| 2a1u | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.448 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.448 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.448 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.448 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3rk1 | ATP | N-type ATP pyrophosphatase superfamily | / | 0.448 | |
| 4aql | TXC | Guanine deaminase | 3.5.4.3 | 0.448 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.448 | |
| 1g6c | TZP | Thiamine-phosphate synthase | / | 0.447 | |
| 1r31 | MEV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 3qud | N3F | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.447 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.447 | |
| 4e03 | ADP | Plasmid partitioning protein ParF | / | 0.447 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.447 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.447 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.447 | |
| 4ros | APR | Malate dehydrogenase | / | 0.447 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 5dib | NAD | Betaine-aldehyde dehydrogenase | / | 0.447 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.447 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.446 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.446 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.446 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.446 | |
| 2pv7 | NAD | T-protein | 1.3.1.12 | 0.446 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.446 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.446 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.446 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.446 | |
| 3lff | Z83 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3o8h | O8H | HTH-type transcriptional regulator EthR | / | 0.446 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.446 | |
| 3tk0 | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.446 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.446 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4bgq | 38R | Cyclin-dependent kinase-like 5 | 2.7.11.22 | 0.446 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.446 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4iae | 1DX | Alr2278 protein | / | 0.446 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.446 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.446 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.445 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.445 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3ete | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.445 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.445 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.445 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.445 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4k42 | ADP | Actin, alpha skeletal muscle | / | 0.445 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.445 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.444 | |
| 1pxm | CK5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3f46 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.444 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.444 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.444 | |
| 3t2v | KKJ | Peptidoglycan recognition protein 1 | / | 0.444 | |
| 3uvp | 048 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3w4k | 3LD | D-amino-acid oxidase | 1.4.3.3 | 0.444 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.444 | |
| 4aic | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.444 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.444 | |
| 4lb2 | DM5 | Serum albumin | / | 0.444 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.443 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.443 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3nta | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.443 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.443 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3sso | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.443 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.443 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1f20 | NAP | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.442 | |
| 1hld | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.442 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.442 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.442 | |
| 1yin | CM3 | Estrogen receptor | / | 0.442 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2pe0 | 39Z | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.442 | |
| 3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.442 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4aw1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.442 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.442 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.442 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.441 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.441 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2igy | A2T | Plasmepsin 2 | / | 0.441 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 2q5o | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.441 | |
| 3cx8 | GSP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.441 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.441 | |
| 3nlb | 5BE | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.441 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.441 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.441 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.441 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.441 | |
| 4r8h | SP1 | cAMP-activated global transcriptional regulator CRP | / | 0.441 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.441 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.440 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1tu3 | GNP | Ras-related protein Rab-5A | / | 0.440 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.440 | |
| 1zdw | FLV | Prenyltransferase | / | 0.440 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.440 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2oj9 | BMI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.440 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2ydk | YDK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.440 | |
| 3qai | XNN | Ketohexokinase | / | 0.440 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.440 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.440 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 | |
| 4mcb | 21W | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.440 |