Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qtqX35Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qtqX35Cyclin-dependent kinase 22.7.11.221.000
3qtxX43Cyclin-dependent kinase 22.7.11.220.735
4ez30S0Cyclin-dependent kinase 22.7.11.220.707
3rk909ZCyclin-dependent kinase 22.7.11.220.705
3rm719ZCyclin-dependent kinase 22.7.11.220.666
3r8zZ63Cyclin-dependent kinase 22.7.11.220.641
1gih1PUCyclin-dependent kinase 22.7.11.220.639
3r9hZ67Cyclin-dependent kinase 22.7.11.220.637
2xmyCDKCyclin-dependent kinase 22.7.11.220.625
3rk507ZCyclin-dependent kinase 22.7.11.220.620
3ral04ZCyclin-dependent kinase 22.7.11.220.613
3sqq99ZCyclin-dependent kinase 22.7.11.220.613
2btrU73Cyclin-dependent kinase 22.7.11.220.610
3qzfX66Cyclin-dependent kinase 22.7.11.220.604
4fx360KCyclin-dependent kinase 22.7.11.220.602
3rk708ZCyclin-dependent kinase 22.7.11.220.601
2xnbY8LCyclin-dependent kinase 22.7.11.220.598
1ke6LS2Cyclin-dependent kinase 22.7.11.220.597
1dm2HMDCyclin-dependent kinase 22.7.11.220.593
1p2a5BNCyclin-dependent kinase 22.7.11.220.592
3rni21ZCyclin-dependent kinase 22.7.11.220.592
3qqkX02Cyclin-dependent kinase 22.7.11.220.587
4fkw62KCyclin-dependent kinase 22.7.11.220.587
3rpv26ZCyclin-dependent kinase 22.7.11.220.586
1oguST8Cyclin-dependent kinase 22.7.11.220.580
3rmf20ZCyclin-dependent kinase 22.7.11.220.580
2wxvWXVCyclin-dependent kinase 22.7.11.220.579
3qtwX3ACyclin-dependent kinase 22.7.11.220.579
4ek610KCyclin-dependent kinase 22.7.11.220.579
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.578
3qzgX67Cyclin-dependent kinase 22.7.11.220.578
1w0xOLOCyclin-dependent kinase 22.7.11.220.577
2bhhRYUCyclin-dependent kinase 22.7.11.220.576
4fkt48KCyclin-dependent kinase 22.7.11.220.576
1ke5LS1Cyclin-dependent kinase 22.7.11.220.575
3qqfX07Cyclin-dependent kinase 22.7.11.220.574
3rjc06ZCyclin-dependent kinase 22.7.11.220.574
1ke9LS5Cyclin-dependent kinase 22.7.11.220.573
1v1k3FPCyclin-dependent kinase 22.7.11.220.572
2r3lSCWCyclin-dependent kinase 22.7.11.220.572
3sw418KCyclin-dependent kinase 22.7.11.220.572
1oiqHDUCyclin-dependent kinase 22.7.11.220.571
3qu0X40Cyclin-dependent kinase 22.7.11.220.568
3qx2X63Cyclin-dependent kinase 22.7.11.220.568
3r7iX9ICyclin-dependent kinase 22.7.11.220.568
3r9dX6BCyclin-dependent kinase 22.7.11.220.568
4bgh3I6Cyclin-dependent kinase 22.7.11.220.568
4fkg4CKCyclin-dependent kinase 22.7.11.220.568
1fvt106Cyclin-dependent kinase 22.7.11.220.567
1h1r6CPCyclin-dependent kinase 22.7.11.220.567
3qxoX65Cyclin-dependent kinase 22.7.11.220.567
1h1s4SPCyclin-dependent kinase 22.7.11.220.566
4erwSTUCyclin-dependent kinase 22.7.11.220.566
3raiX85Cyclin-dependent kinase 22.7.11.220.565
3rak03ZCyclin-dependent kinase 22.7.11.220.565
3r73X87Cyclin-dependent kinase 22.7.11.220.564
1vyzN5BCyclin-dependent kinase 22.7.11.220.563
3r28XA0Cyclin-dependent kinase 22.7.11.220.563
3qwkX62Cyclin-dependent kinase 22.7.11.220.562
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.561
4fko20KCyclin-dependent kinase 22.7.11.220.560
1di8DTQCyclin-dependent kinase 22.7.11.220.559
2wpa889Cyclin-dependent kinase 22.7.11.220.558
3qtuX44Cyclin-dependent kinase 22.7.11.220.558
3qwjX6ACyclin-dependent kinase 22.7.11.220.558
3fz1B98Cyclin-dependent kinase 22.7.11.220.557
4fkq42KCyclin-dependent kinase 22.7.11.220.557
1pyePM1Cyclin-dependent kinase 22.7.11.220.556
3py0SU9Cyclin-dependent kinase 22.7.11.220.556
3s1h56ZCyclin-dependent kinase 22.7.11.220.556
2r3kSCQCyclin-dependent kinase 22.7.11.220.555
2b55D31Cyclin-dependent kinase 22.7.11.220.554
4acm7YGCyclin-dependent kinase 22.7.11.220.554
2w1hL0FCyclin-dependent kinase 22.7.11.220.553
4nj32KDCyclin-dependent kinase 22.7.11.220.553
1ke7LS3Cyclin-dependent kinase 22.7.11.220.552
1ke8LS4Cyclin-dependent kinase 22.7.11.220.552
3s0o50ZCyclin-dependent kinase 22.7.11.220.550
2uzlC94Cyclin-dependent kinase 22.7.11.220.549
3ig7EFPCyclin-dependent kinase 22.7.11.220.549
3r6xX84Cyclin-dependent kinase 22.7.11.220.549
3r7uX96Cyclin-dependent kinase 22.7.11.220.548
1h0w207Cyclin-dependent kinase 22.7.11.220.547
2w06FRVCyclin-dependent kinase 22.7.11.220.547
3iggEFQCyclin-dependent kinase 22.7.11.220.547
1pxmCK5Cyclin-dependent kinase 22.7.11.220.546
2r3iSCFCyclin-dependent kinase 22.7.11.220.545
2r3r6SCCyclin-dependent kinase 22.7.11.220.545
3ql8X01Cyclin-dependent kinase 22.7.11.220.545
2c6tDT5Cyclin-dependent kinase 22.7.11.220.544
3unk0BYCyclin-dependent kinase 22.7.11.220.544
2b52D42Cyclin-dependent kinase 22.7.11.220.543
1y8yCT7Cyclin-dependent kinase 22.7.11.220.542
3rkb12ZCyclin-dependent kinase 22.7.11.220.541
2i40BLZCyclin-dependent kinase 22.7.11.220.540
1pxkCK3Cyclin-dependent kinase 22.7.11.220.539
1urwI1PCyclin-dependent kinase 22.7.11.220.539
3r1qX75Cyclin-dependent kinase 22.7.11.220.539
4fkr45KCyclin-dependent kinase 22.7.11.220.539
1ykr628Cyclin-dependent kinase 22.7.11.220.538
3qtrX36Cyclin-dependent kinase 22.7.11.220.538
3rpo24ZCyclin-dependent kinase 22.7.11.220.538
2r3p3SCCyclin-dependent kinase 22.7.11.220.537
2vv9IM9Cyclin-dependent kinase 22.7.11.220.537
3r7eX88Cyclin-dependent kinase 22.7.11.220.537
3wblPDYCyclin-dependent kinase 22.7.11.220.537
4kd11QKCyclin-dependent kinase 22.7.11.220.537
3r1sX73Cyclin-dependent kinase 22.7.11.220.536
4eomATPCyclin-dependent kinase 22.7.11.220.536
4fki09KCyclin-dependent kinase 22.7.11.220.536
1pkdUCNCyclin-dependent kinase 22.7.11.220.535
2c6iDT1Cyclin-dependent kinase 22.7.11.220.535
2btsU32Cyclin-dependent kinase 22.7.11.220.534
2j9mPY8Cyclin-dependent kinase 22.7.11.220.534
4fkpLS5Cyclin-dependent kinase 22.7.11.220.534
4qmpDKISerine/threonine-protein kinase 242.7.11.10.534
3qziX72Cyclin-dependent kinase 22.7.11.220.533
3rm618ZCyclin-dependent kinase 22.7.11.220.533
3qqhX0ACyclin-dependent kinase 22.7.11.220.532
3qzhX69Cyclin-dependent kinase 22.7.11.220.532
3rpy27ZCyclin-dependent kinase 22.7.11.220.532
4ii5ADPCyclin-dependent kinase 22.7.11.220.532
3s2pPMUCyclin-dependent kinase 22.7.11.220.531
2uzoC62Cyclin-dependent kinase 22.7.11.220.529
3bhtMFRCyclin-dependent kinase 22.7.11.220.529
3rzb02ZCyclin-dependent kinase 22.7.11.220.529
3s00Z60Cyclin-dependent kinase 22.7.11.220.529
3qruX19Cyclin-dependent kinase 22.7.11.220.528
2fvdLIACyclin-dependent kinase 22.7.11.220.527
2iw84SPCyclin-dependent kinase 22.7.11.220.526
3ti1B49Cyclin-dependent kinase 22.7.11.220.526
4fkj11KCyclin-dependent kinase 22.7.11.220.526
2iw94SPCyclin-dependent kinase 22.7.11.220.525
3ddqRRCCyclin-dependent kinase 22.7.11.220.525
2r3o2SCCyclin-dependent kinase 22.7.11.220.524
3qtzX42Cyclin-dependent kinase 22.7.11.220.524
4eor4SPCyclin-dependent kinase 22.7.11.220.524
1gij2PUCyclin-dependent kinase 22.7.11.220.523
2x1nX1NCyclin-dependent kinase 22.7.11.220.523
3uli1N3Cyclin-dependent kinase 22.7.11.220.523
1g5sI17Cyclin-dependent kinase 22.7.11.220.519
2uzdC85Cyclin-dependent kinase 22.7.11.220.519
3roy22ZCyclin-dependent kinase 22.7.11.220.517
3unj0BXCyclin-dependent kinase 22.7.11.220.517
4bcpT3CCyclin-dependent kinase 22.7.11.220.517
3pj8404Cyclin-dependent kinase 22.7.11.220.516
3r8vZ62Cyclin-dependent kinase 22.7.11.220.516
3tnwF18Cyclin-dependent kinase 22.7.11.220.516
2bheBRYCyclin-dependent kinase 22.7.11.220.515
3ddpRC8Cyclin-dependent kinase 22.7.11.220.515
1oi9N20Cyclin-dependent kinase 22.7.11.220.514
2wihP48Cyclin-dependent kinase 22.7.11.220.514
4eos1ROCyclin-dependent kinase 22.7.11.220.514
2r64740Cyclin-dependent kinase 22.7.11.220.513
4eok4SPCyclin-dependent kinase 22.7.11.220.513
4eop1ROCyclin-dependent kinase 22.7.11.220.513
2cchATPCyclin-dependent kinase 22.7.11.220.511
2b54D05Cyclin-dependent kinase 22.7.11.220.510
2c69CT8Cyclin-dependent kinase 22.7.11.220.510
2w17I19Cyclin-dependent kinase 22.7.11.220.510
3pxyJWSCyclin-dependent kinase 22.7.11.220.509
3r7vZ02Cyclin-dependent kinase 22.7.11.220.509
4lyn1YGCyclin-dependent kinase 22.7.11.220.509
1vyw292Cyclin-dependent kinase 22.7.11.220.508
3ezrEZRCyclin-dependent kinase 22.7.11.220.508
3r71X86Cyclin-dependent kinase 22.7.11.220.508
1ckpPVBCyclin-dependent kinase 22.7.11.220.507
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.507
1r78FMDCyclin-dependent kinase 22.7.11.220.506
2r3gSC9Cyclin-dependent kinase 22.7.11.220.505
3qqlX03Cyclin-dependent kinase 22.7.11.220.505
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.503
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.503
1e9hINRCyclin-dependent kinase 22.7.11.220.502
1fvv107Cyclin-dependent kinase 22.7.11.220.502
1gii1PUCyclin-dependent kinase 22.7.11.220.502
2c6o4SPCyclin-dependent kinase 22.7.11.220.502
2r3fSC8Cyclin-dependent kinase 22.7.11.220.502
2r3mSCXCyclin-dependent kinase 22.7.11.220.502
2vu3LZECyclin-dependent kinase 22.7.11.220.502
1gy3ATPCyclin-dependent kinase 22.7.11.220.501
1h0vUN4Cyclin-dependent kinase 22.7.11.220.501
1oiuN76Cyclin-dependent kinase 22.7.11.220.501
1w8cN69Cyclin-dependent kinase 22.7.11.220.501
2c5nCK8Cyclin-dependent kinase 22.7.11.220.498
3dogNNNCyclin-dependent kinase 22.7.11.220.497
3r9nZ68Cyclin-dependent kinase 22.7.11.220.497
3rpr25ZCyclin-dependent kinase 22.7.11.220.497
4bcnT9NCyclin-dependent kinase 22.7.11.220.497
1oiyN41Cyclin-dependent kinase 22.7.11.220.494
3lfnA27Cyclin-dependent kinase 22.7.11.220.493
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.493
1e1xNW1Cyclin-dependent kinase 22.7.11.220.492
2r3jSCJCyclin-dependent kinase 22.7.11.220.492
2vtsLZCCyclin-dependent kinase 22.7.11.220.492
1b39ATPCyclin-dependent kinase 22.7.11.220.491
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.491
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.491
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.490
1h1pCMGCyclin-dependent kinase 22.7.11.220.489
3ggfGVDSerine/threonine-protein kinase 26/0.489
3r8lZ30Cyclin-dependent kinase 22.7.11.220.488
4eon1ROCyclin-dependent kinase 22.7.11.220.488
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.488
4eoi1ROCyclin-dependent kinase 22.7.11.220.487
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.486
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.485
3r8uZ31Cyclin-dependent kinase 22.7.11.220.485
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.484
3lfsA07Cyclin-dependent kinase 22.7.11.220.482
3r9oZ71Cyclin-dependent kinase 22.7.11.220.481
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.481
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.481
3rahO1ZCyclin-dependent kinase 22.7.11.220.480
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.479
3qtsX46Cyclin-dependent kinase 22.7.11.220.479
3a7jADPSerine/threonine-protein kinase 242.7.11.10.478
5aniES4Cyclin-dependent kinase 22.7.11.220.476
2wipP49Cyclin-dependent kinase 22.7.11.220.475
4lopSB4Mitogen-activated protein kinase 14/0.475
2duv371Cyclin-dependent kinase 22.7.11.220.474
3tiz3TICyclin-dependent kinase 22.7.11.220.474
2c4g514Cyclin-dependent kinase 22.7.11.220.473
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.473
2c6mDT5Cyclin-dependent kinase 22.7.11.220.472
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.472
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.472
4ivd15TTyrosine-protein kinase JAK1/0.472
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.471
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.471
1unlRRCCyclin-dependent-like kinase 52.7.11.10.468
4eol1ROCyclin-dependent kinase 22.7.11.220.468
3qrtX14Cyclin-dependent kinase 22.7.11.220.467
4dgo0JWCasein kinase II subunit alpha2.7.11.10.467
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.467
1h1q2A6Cyclin-dependent kinase 22.7.11.220.466
2eufLQQCyclin-dependent kinase 62.7.11.220.466
2uzeC95Cyclin-dependent kinase 22.7.11.220.466
4qmzB49Serine/threonine-protein kinase 242.7.11.10.466
2c6lDT4Cyclin-dependent kinase 22.7.11.220.465
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.465
4qmySTUSerine/threonine-protein kinase 242.7.11.10.464
3gubGUBDeath-associated protein kinase 12.7.11.10.463
4e4m0NHTyrosine-protein kinase JAK2/0.463
1pxpCK8Cyclin-dependent kinase 22.7.11.220.462
2xikJ60Serine/threonine-protein kinase 252.7.11.10.462
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.462
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.462
1e1vCMGCyclin-dependent kinase 22.7.11.220.461
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.461
1ungALHCyclin-dependent-like kinase 52.7.11.10.461
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.460
3sheI85MAP kinase-activated protein kinase 32.7.11.10.460
4cfnJYMCyclin-dependent kinase 22.7.11.220.460
1v0oINRCell division control protein 2 homolog2.7.11.220.459
2b53D23Cyclin-dependent kinase 22.7.11.220.459
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.459
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.459
1gz8MBPCyclin-dependent kinase 22.7.11.220.458
3gu5ANPDeath-associated protein kinase 12.7.11.10.458
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.458
4qmlANPSerine/threonine-protein kinase 242.7.11.10.458
1bwsNDPGDP-L-fucose synthase/0.457
1me6IVSPlasmepsin-23.4.23.390.457
1xjdSTUProtein kinase C theta type2.7.11.130.457
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.457
2bkzSBCCyclin-dependent kinase 22.7.11.220.457
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.457
4btjATPTau-tubulin kinase 12.7.11.10.456
4ez50RSCyclin-dependent kinase 62.7.11.220.455
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.455
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.455
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.455
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.453
2f2cAP9Cyclin-dependent kinase 62.7.11.220.453
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
1rx8NAPDihydrofolate reductase1.5.1.30.452
3efwAK8Aurora kinase A2.7.11.10.452
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.452
3zep1NXTyrosine-protein kinase JAK32.7.10.20.452
5e8wSTUTGF-beta receptor type-12.7.11.300.452
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.451
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4wboANWRhodopsin kinase/0.451
1unhIXMCyclin-dependent-like kinase 52.7.11.10.450
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.450
3c50ADPRhodopsin kinase/0.450
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.449
2wotZZGTGF-beta receptor type-12.7.11.300.448
4fkv61KCyclin-dependent kinase 22.7.11.220.448
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.447
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2pvnP63Casein kinase II subunit alpha2.7.11.10.446
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.446
4ivc1J6Tyrosine-protein kinase JAK1/0.446
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.445
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.445
3c4zADPRhodopsin kinase/0.445
3mdmFJZCholesterol 24-hydroxylase/0.445
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.445
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.444
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.444
2yi7BZ8Heat shock protein HSP 90-alpha/0.444
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3t8oATPRhodopsin kinase/0.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.443
4bcoT6QCyclin-dependent kinase 22.7.11.220.443
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.443
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.443
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.443
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2ekaSAHDiphthine synthase/0.442
2hog710Serine/threonine-protein kinase Chk12.7.11.10.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
3a60STURibosomal protein S6 kinase beta-12.7.11.10.441
3a7hATPSerine/threonine-protein kinase 242.7.11.10.441
3p8zSAHGenome polyprotein2.1.1.560.441
4loqSB4Mitogen-activated protein kinase 14/0.441
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.440
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.440