sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kvu | ACO | Fluoroacetyl-CoA thioesterase | 3.1.2.29 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3kvu | ACO | Fluoroacetyl-CoA thioesterase | 3.1.2.29 | 1.000 | |
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 0.500 | |
| 1u30 | GOX | Pancreatic alpha-amylase | / | 0.496 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.495 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.490 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.485 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.484 | |
| 5aaj | HSC | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.484 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 3up0 | D7S | aceDAF-12 | / | 0.481 | |
| 5dbv | COA | Aldehyde Dehydrogenase | / | 0.481 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.480 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.479 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.478 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.477 | |
| 2ix5 | CAA | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.476 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.475 | |
| 4o7u | THF | Thymidylate synthase | / | 0.475 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.475 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1buc | CAA | Acyl-CoA dehydrogenase, short-chain specific | 1.3.8.1 | 0.472 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.472 | |
| 2e9z | UTP | Genome polyprotein | / | 0.471 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.470 | |
| 3bej | MUF | Bile acid receptor | / | 0.470 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.470 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.470 | |
| 1h0w | 207 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.469 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.469 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.469 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.468 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.468 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.467 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.467 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.467 | |
| 4c6u | TLG | 3-oxoacyl-ACP synthase | / | 0.466 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.465 | |
| 2hgs | ADP | Glutathione synthetase | 6.3.2.3 | 0.465 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.465 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.465 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.464 | |
| 2imk | GTX | AGAP009194-PA | / | 0.464 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.464 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3ruq | ADP | Chaperonin | / | 0.464 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.464 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1nbu | PH2 | Dihydroneopterin aldolase | / | 0.463 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.463 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.462 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.462 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.462 | |
| 4n4w | SNT | Smoothened homolog | / | 0.462 | |
| 2avi | BTN | Avidin | / | 0.461 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.461 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.460 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.460 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.460 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.460 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.460 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.460 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.460 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.459 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.459 | |
| 3mfu | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.459 | |
| 3ruv | ANP | Chaperonin | / | 0.459 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.459 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.458 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.458 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.458 | |
| 4ajb | TAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.458 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.458 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.458 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.458 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.458 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.458 | |
| 1e1m | NAP | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.457 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.457 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.457 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.457 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.457 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.457 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4eoi | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.456 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.456 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.456 | |
| 4ivb | 1J5 | Tyrosine-protein kinase JAK1 | / | 0.456 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.455 | |
| 1kt4 | RTL | Retinol-binding protein 4 | / | 0.455 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.455 | |
| 3cbg | SAH | O-methyltransferase | / | 0.455 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.455 | |
| 3q0j | CAA | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.455 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.455 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.455 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.455 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.455 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.454 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.454 | |
| 2rtr | IMI | Streptavidin | / | 0.454 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 3ukr | CKH | Actin-related protein 3 | / | 0.454 | |
| 3ukr | CKH | Actin-related protein 2 | / | 0.454 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.454 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.454 | |
| 4xsr | UPG | Alr3699 protein | / | 0.454 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1egc | CO8 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.453 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.453 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.453 | |
| 3saz | 043 | Malate synthase G | / | 0.453 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3zxs | DLZ | Deoxyribodipyrimidine photolyase-related protein | / | 0.453 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1jqi | CAA | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.452 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.452 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.452 | |
| 2f2u | M77 | Rho-associated protein kinase 2 | 2.7.11.1 | 0.452 | |
| 2fvd | LIA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2rki | TT1 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.452 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.452 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.452 | |
| 3nrc | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4fox | UMP | Thymidylate synthase ThyA | / | 0.452 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.452 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4k8a | K8A | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.452 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 5dib | NAD | Betaine-aldehyde dehydrogenase | / | 0.452 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.451 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.451 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.451 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.451 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.451 | |
| 1qvn | FRI | Interleukin-2 | / | 0.451 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.451 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.451 | |
| 2ojj | 82A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.451 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 3vqh | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.451 | |
| 3x2w | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 4c5b | ADP | D-alanine--D-alanine ligase B | 6.3.2.4 | 0.451 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.451 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.450 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.450 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.450 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3up3 | XCA | aceDAF-12 | / | 0.450 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.450 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.450 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.449 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.449 | |
| 1ivh | COS | Isovaleryl-CoA dehydrogenase, mitochondrial | 1.3.8.4 | 0.449 | |
| 1ngd | ADP | Heat shock cognate 71 kDa protein | / | 0.449 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.449 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.449 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.449 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.449 | |
| 3bhr | THG | Thymidylate synthase | / | 0.449 | |
| 3k14 | 535 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.449 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4fkp | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4iaf | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 4l1f | COS | Acyl-CoA dehydrogenase domain protein | / | 0.449 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.449 | |
| 5k0t | 415 | Methionine--tRNA ligase | / | 0.449 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.448 | |
| 2hvd | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.448 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.448 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.448 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.448 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.447 | |
| 1fdo | MGD | Formate dehydrogenase H | 1.1.99.33 | 0.447 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.447 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.447 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.447 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.447 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.447 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.447 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.447 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.446 | |
| 1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.446 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.446 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2a3i | C0R | Mineralocorticoid receptor | / | 0.446 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.446 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.446 | |
| 2xvv | 9DN | Serum albumin | / | 0.446 | |
| 2xvw | 9NR | Serum albumin | / | 0.446 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.446 | |
| 3dol | GWI | Pol protein | / | 0.446 | |
| 4die | C5P | Cytidylate kinase | / | 0.446 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.446 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.446 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.445 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1rx0 | 2MC | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.445 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.445 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.445 | |
| 2cjp | VPR | Epoxide hydrolase | / | 0.445 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.445 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.445 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.445 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4hzp | COA | Conserved hypthetical protein | / | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4pd6 | URI | Nucleoside permease | / | 0.445 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.445 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.444 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.444 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.444 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2o2y | TCL | Enoyl-ACP reductase | / | 0.444 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.444 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.444 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.444 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.444 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.444 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.444 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.444 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.444 | |
| 4bqu | CLR | Japanin | / | 0.444 | |
| 4ctj | SAM | Genome polyprotein | / | 0.444 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.444 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.444 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 5l7d | CLR | Smoothened homolog | / | 0.444 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.443 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.443 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.443 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.443 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.443 | |
| 1upa | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.443 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.443 | |
| 2uyw | BTN | Avd protein | / | 0.443 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.443 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.443 | |
| 3r7c | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.443 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.443 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.443 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.443 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.443 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.443 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4uck | SAM | Large structural protein | / | 0.443 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1c3e | NHR | Phosphoribosylglycinamide formyltransferase | / | 0.442 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1pvd | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.442 | |
| 1u4g | HPI | Elastase | 3.4.24.26 | 0.442 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.442 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.442 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.442 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2xir | 00J | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.442 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.442 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3tlh | 3TL | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.442 | |
| 4eon | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.441 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 2e16 | SAH | Diphthine synthase | / | 0.441 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.441 | |
| 3di6 | PDZ | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.441 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.441 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 4abk | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.441 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.441 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.441 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.441 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4mzu | COA | WxcM-like protein | / | 0.441 | |
| 4nbb | 9CA | Terminal oxygenase component of carbazole | / | 0.441 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 1lqu | NDP | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.440 | |
| 1vyz | N5B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.440 | |
| 2acw | UPG | Glycosyltransferase | / | 0.440 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.440 | |
| 2j7p | GNP | Signal recognition particle protein | / | 0.440 | |
| 2j7p | GNP | Signal recognition particle receptor FtsY | / | 0.440 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.440 | |
| 3iif | APR | Core histone macro-H2A.1 | / | 0.440 | |
| 3lf0 | ATP | Nitrogen regulatory protein P-II | / | 0.440 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.440 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3os3 | 3OS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.440 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.440 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 4gt3 | ATP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.440 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4rd2 | GNP | Translation initiation factor 2 subunit gamma | / | 0.440 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.440 |