sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 1.000 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.669 | |
| 2xk6 | EQH | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.655 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.613 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.606 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.600 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.590 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.586 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.581 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.573 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.552 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.545 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.539 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.532 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.531 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.524 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.507 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.505 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.498 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.496 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.495 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.495 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.494 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.494 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.493 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.493 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.493 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.492 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.492 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.490 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.490 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.489 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.488 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.486 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.485 | |
| 2xno | ED8 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.485 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.485 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.483 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.483 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.482 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.482 | |
| 2w5a | ADP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.482 | |
| 3up3 | XCA | aceDAF-12 | / | 0.482 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.482 | |
| 5dp2 | NAP | CurF | / | 0.482 | |
| 2qhx | FE1 | Pteridine reductase 1 | 1.5.1.33 | 0.481 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.481 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.479 | |
| 3cqu | CQU | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.478 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.478 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.477 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.477 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.476 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.476 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.475 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.474 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.474 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.473 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.473 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.472 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.471 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.470 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.470 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.470 | |
| 4b6l | 9ZP | Serine/threonine-protein kinase PLK3 | 2.7.11.21 | 0.470 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.470 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.469 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.468 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.467 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.466 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.465 | |
| 2xvw | 9NR | Serum albumin | / | 0.465 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 4n4t | 2GV | Tankyrase-1 | 2.4.2.30 | 0.465 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.465 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.464 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.464 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.464 | |
| 3zra | ORB | Progesterone receptor | / | 0.464 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.463 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.463 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.462 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.462 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.462 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.462 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.462 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.462 | |
| 2bxo | OPB | Serum albumin | / | 0.461 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.461 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.461 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.461 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.461 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.461 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.461 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.461 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.460 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1syn | F89 | Thymidylate synthase | / | 0.460 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.460 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.460 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.459 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.459 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.459 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.458 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.458 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.458 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.458 | |
| 1e1l | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.457 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.457 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.457 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.457 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.457 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.457 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.456 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.456 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.456 | |
| 3arv | SAU | Chitinase A | / | 0.456 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.456 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.456 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.456 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.455 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.455 | |
| 4djw | 0KP | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.455 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.455 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.455 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1e7w | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.454 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.454 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.454 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.454 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.454 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.454 | |
| 3fzt | 4JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.454 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.454 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4lb2 | DM5 | Serum albumin | / | 0.454 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.454 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.454 | |
| 5doz | NDP | JamJ | / | 0.454 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.453 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.453 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 3b9l | AZZ | Serum albumin | / | 0.453 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.453 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.452 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.452 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.452 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3p9t | TCL | Repressor | / | 0.452 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.452 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.452 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.452 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.452 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.451 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.451 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.451 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.451 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.451 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.451 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4nbb | 9CA | Terminal oxygenase component of carbazole | / | 0.451 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.451 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 2bxq | IMN | Serum albumin | / | 0.450 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.450 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.450 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.450 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.450 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.449 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2bxm | IMN | Serum albumin | / | 0.449 | |
| 2jav | 5Z5 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3gb4 | D3M | DdmC | / | 0.449 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.449 | |
| 3up0 | D7S | aceDAF-12 | / | 0.449 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.448 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2vdv | SAM | tRNA (guanine-N(7)-)-methyltransferase | / | 0.448 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.448 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.448 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.448 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.447 | |
| 2od7 | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.447 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.447 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.447 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.447 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.447 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.447 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.447 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.447 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.446 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.446 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.446 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.446 | |
| 4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.446 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.446 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.445 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.445 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.445 | |
| 2xvv | 9DN | Serum albumin | / | 0.445 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.445 | |
| 3f88 | 3HT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.444 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1hk5 | T44 | Serum albumin | / | 0.444 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.444 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.444 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.444 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.444 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.444 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.443 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.443 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.443 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.443 | |
| 3hqd | ANP | Kinesin-like protein KIF11 | / | 0.443 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.443 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.443 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.443 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.442 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.442 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.442 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.442 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.442 | |
| 3htj | ET | EbrA repressor | / | 0.442 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.442 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.442 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.441 | |
| 1qzz | SAM | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.441 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.441 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.441 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.441 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.441 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.440 | |
| 1t57 | FMN | Conserved protein | / | 0.440 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.440 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.440 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.440 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.440 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3zk6 | H1I | Bcl-2-like protein 1 | / | 0.440 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.440 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4qmw | KS1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.440 |