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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pxpCK8Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pxpCK8Cyclin-dependent kinase 22.7.11.221.000
1gii1PUCyclin-dependent kinase 22.7.11.220.594
2r3jSCJCyclin-dependent kinase 22.7.11.220.584
3r8lZ30Cyclin-dependent kinase 22.7.11.220.576
2xmyCDKCyclin-dependent kinase 22.7.11.220.575
1pxlCK4Cyclin-dependent kinase 22.7.11.220.572
4fkt48KCyclin-dependent kinase 22.7.11.220.566
3sw719KCyclin-dependent kinase 22.7.11.220.564
2vthLZ2Cyclin-dependent kinase 22.7.11.220.560
2bheBRYCyclin-dependent kinase 22.7.11.220.557
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.557
3qxoX65Cyclin-dependent kinase 22.7.11.220.553
3qzgX67Cyclin-dependent kinase 22.7.11.220.552
4ek610KCyclin-dependent kinase 22.7.11.220.552
1oitHDTCyclin-dependent kinase 22.7.11.220.551
2a0cCK9Cyclin-dependent kinase 22.7.11.220.551
2uzoC62Cyclin-dependent kinase 22.7.11.220.551
4fko20KCyclin-dependent kinase 22.7.11.220.550
3pxyJWSCyclin-dependent kinase 22.7.11.220.549
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.546
3fz1B98Cyclin-dependent kinase 22.7.11.220.543
4fkq42KCyclin-dependent kinase 22.7.11.220.543
3rkb12ZCyclin-dependent kinase 22.7.11.220.542
4bgh3I6Cyclin-dependent kinase 22.7.11.220.541
2c6o4SPCyclin-dependent kinase 22.7.11.220.540
2btsU32Cyclin-dependent kinase 22.7.11.220.539
2btrU73Cyclin-dependent kinase 22.7.11.220.536
3lfqA28Cyclin-dependent kinase 22.7.11.220.536
1ke5LS1Cyclin-dependent kinase 22.7.11.220.531
1ykr628Cyclin-dependent kinase 22.7.11.220.530
2w1hL0FCyclin-dependent kinase 22.7.11.220.530
3ezvEZVCyclin-dependent kinase 22.7.11.220.530
3lfnA27Cyclin-dependent kinase 22.7.11.220.530
3qqlX03Cyclin-dependent kinase 22.7.11.220.530
3r1yX76Cyclin-dependent kinase 22.7.11.220.529
2r3iSCFCyclin-dependent kinase 22.7.11.220.528
3iggEFQCyclin-dependent kinase 22.7.11.220.526
1p2a5BNCyclin-dependent kinase 22.7.11.220.525
3rk507ZCyclin-dependent kinase 22.7.11.220.525
1oirHDYCyclin-dependent kinase 22.7.11.220.523
2vv9IM9Cyclin-dependent kinase 22.7.11.220.523
3s2pPMUCyclin-dependent kinase 22.7.11.220.523
1w0xOLOCyclin-dependent kinase 22.7.11.220.522
4fki09KCyclin-dependent kinase 22.7.11.220.521
4fks46KCyclin-dependent kinase 22.7.11.220.521
4ek816KCyclin-dependent kinase 22.7.11.220.520
3rk708ZCyclin-dependent kinase 22.7.11.220.519
1pxoCK7Cyclin-dependent kinase 22.7.11.220.518
2c6iDT1Cyclin-dependent kinase 22.7.11.220.518
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.518
3qqhX0ACyclin-dependent kinase 22.7.11.220.518
4fkpLS5Cyclin-dependent kinase 22.7.11.220.518
2c6lDT4Cyclin-dependent kinase 22.7.11.220.517
1pxmCK5Cyclin-dependent kinase 22.7.11.220.516
2w17I19Cyclin-dependent kinase 22.7.11.220.516
3sw418KCyclin-dependent kinase 22.7.11.220.516
2c5yMTWCyclin-dependent kinase 22.7.11.220.515
4acm7YGCyclin-dependent kinase 22.7.11.220.515
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.514
3qqgX06Cyclin-dependent kinase 22.7.11.220.514
3rni21ZCyclin-dependent kinase 22.7.11.220.514
3wblPDYCyclin-dependent kinase 22.7.11.220.514
1y91CT9Cyclin-dependent kinase 22.7.11.220.513
3rak03ZCyclin-dependent kinase 22.7.11.220.513
3s1h56ZCyclin-dependent kinase 22.7.11.220.513
2r3lSCWCyclin-dependent kinase 22.7.11.220.512
3lfsA07Cyclin-dependent kinase 22.7.11.220.512
3qtuX44Cyclin-dependent kinase 22.7.11.220.512
2r3p3SCCyclin-dependent kinase 22.7.11.220.510
4fkv61KCyclin-dependent kinase 22.7.11.220.510
2j9mPY8Cyclin-dependent kinase 22.7.11.220.509
1g5sI17Cyclin-dependent kinase 22.7.11.220.507
2b53D23Cyclin-dependent kinase 22.7.11.220.507
4fkr45KCyclin-dependent kinase 22.7.11.220.507
1w8cN69Cyclin-dependent kinase 22.7.11.220.506
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.506
2r3r6SCCyclin-dependent kinase 22.7.11.220.505
3rm719ZCyclin-dependent kinase 22.7.11.220.505
3rmf20ZCyclin-dependent kinase 22.7.11.220.505
3r7yZ04Cyclin-dependent kinase 22.7.11.220.504
4fkj11KCyclin-dependent kinase 22.7.11.220.504
2r3kSCQCyclin-dependent kinase 22.7.11.220.503
3ral04ZCyclin-dependent kinase 22.7.11.220.503
1vyzN5BCyclin-dependent kinase 22.7.11.220.501
2w06FRVCyclin-dependent kinase 22.7.11.220.500
4fkg4CKCyclin-dependent kinase 22.7.11.220.497
2r64740Cyclin-dependent kinase 22.7.11.220.496
3rpy27ZCyclin-dependent kinase 22.7.11.220.496
1hckATPCyclin-dependent kinase 22.7.11.220.493
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.493
1pxkCK3Cyclin-dependent kinase 22.7.11.220.490
2r3mSCXCyclin-dependent kinase 22.7.11.220.490
2vu3LZECyclin-dependent kinase 22.7.11.220.490
2w05FRTCyclin-dependent kinase 22.7.11.220.490
3be9P04Casein kinase II subunit alpha2.7.11.10.490
1gih1PUCyclin-dependent kinase 22.7.11.220.489
3rpv26ZCyclin-dependent kinase 22.7.11.220.489
3unk0BYCyclin-dependent kinase 22.7.11.220.489
4dgnLU2Casein kinase II subunit alpha2.7.11.10.489
3r83Z14Cyclin-dependent kinase 22.7.11.220.488
1y8yCT7Cyclin-dependent kinase 22.7.11.220.487
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.487
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
3raiX85Cyclin-dependent kinase 22.7.11.220.487
3qtxX43Cyclin-dependent kinase 22.7.11.220.486
3qu0X40Cyclin-dependent kinase 22.7.11.220.486
3r7vZ02Cyclin-dependent kinase 22.7.11.220.486
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.486
1h1s4SPCyclin-dependent kinase 22.7.11.220.485
1urwI1PCyclin-dependent kinase 22.7.11.220.485
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.485
3r7uX96Cyclin-dependent kinase 22.7.11.220.485
1b38ATPCyclin-dependent kinase 22.7.11.220.484
1ke6LS2Cyclin-dependent kinase 22.7.11.220.484
2pvlP55Casein kinase II subunit alpha2.7.11.10.484
3qtrX36Cyclin-dependent kinase 22.7.11.220.484
2x1nX1NCyclin-dependent kinase 22.7.11.220.483
3r9dX6BCyclin-dependent kinase 22.7.11.220.483
2r3fSC8Cyclin-dependent kinase 22.7.11.220.482
3qwjX6ACyclin-dependent kinase 22.7.11.220.482
1b39ATPCyclin-dependent kinase 22.7.11.220.481
1v1k3FPCyclin-dependent kinase 22.7.11.220.481
4fklCK2Cyclin-dependent kinase 22.7.11.220.481
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.481
3pe2E1BCasein kinase II subunit alpha2.7.11.10.480
3qqkX02Cyclin-dependent kinase 22.7.11.220.480
3qruX19Cyclin-dependent kinase 22.7.11.220.480
5dpvSKEAurora kinase A2.7.11.10.480
1aq1STUCyclin-dependent kinase 22.7.11.220.479
1fvt106Cyclin-dependent kinase 22.7.11.220.479
2fvdLIACyclin-dependent kinase 22.7.11.220.479
2vttLZDCyclin-dependent kinase 22.7.11.220.479
4ez30S0Cyclin-dependent kinase 22.7.11.220.479
3at4CCKCasein kinase II subunit alpha2.7.11.10.478
3r8pZ46Cyclin-dependent kinase 22.7.11.220.478
4dgmAGICasein kinase II subunit alpha2.7.11.10.478
1ke7LS3Cyclin-dependent kinase 22.7.11.220.477
2c6kDT2Cyclin-dependent kinase 22.7.11.220.477
3qtzX42Cyclin-dependent kinase 22.7.11.220.477
3r9nZ68Cyclin-dependent kinase 22.7.11.220.477
3sheI85MAP kinase-activated protein kinase 32.7.11.10.476
4fkw62KCyclin-dependent kinase 22.7.11.220.476
2a4lRRCCyclin-dependent kinase 22.7.11.220.475
2pvhP19Casein kinase II subunit alpha2.7.11.10.475
3rk909ZCyclin-dependent kinase 22.7.11.220.475
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.475
1oguST8Cyclin-dependent kinase 22.7.11.220.474
3ezrEZRCyclin-dependent kinase 22.7.11.220.474
2duv371Cyclin-dependent kinase 22.7.11.220.473
1ke9LS5Cyclin-dependent kinase 22.7.11.220.472
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.472
3ql8X01Cyclin-dependent kinase 22.7.11.220.472
3unj0BXCyclin-dependent kinase 22.7.11.220.472
4bgg844Activin receptor type-12.7.11.300.472
1fvv107Cyclin-dependent kinase 22.7.11.220.471
3sqq99ZCyclin-dependent kinase 22.7.11.220.471
1ke8LS4Cyclin-dependent kinase 22.7.11.220.470
3qxpX64Cyclin-dependent kinase 22.7.11.220.470
3rahO1ZCyclin-dependent kinase 22.7.11.220.470
3ti1B49Cyclin-dependent kinase 22.7.11.220.470
2uzlC94Cyclin-dependent kinase 22.7.11.220.469
2uznC96Cyclin-dependent kinase 22.7.11.220.469
3le62BZCyclin-dependent kinase 22.7.11.220.469
3r8vZ62Cyclin-dependent kinase 22.7.11.220.469
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.468
1oiyN41Cyclin-dependent kinase 22.7.11.220.467
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2c6tDT5Cyclin-dependent kinase 22.7.11.220.466
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.466
3rjc06ZCyclin-dependent kinase 22.7.11.220.466
1dm2HMDCyclin-dependent kinase 22.7.11.220.465
3i60E86Mitogen-activated protein kinase 12.7.11.240.465
3s0o50ZCyclin-dependent kinase 22.7.11.220.465
5dt0SKEAurora kinase A2.7.11.10.465
2pvnP63Casein kinase II subunit alpha2.7.11.10.464
2r3q5SCCyclin-dependent kinase 22.7.11.220.464
2uzeC95Cyclin-dependent kinase 22.7.11.220.464
3my5RFZCyclin-dependent kinase 22.7.11.220.464
3r7iX9ICyclin-dependent kinase 22.7.11.220.464
4btjATPTau-tubulin kinase 12.7.11.10.464
1di8DTQCyclin-dependent kinase 22.7.11.220.463
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.463
2uzbC75Cyclin-dependent kinase 22.7.11.220.463
2vtqLZACyclin-dependent kinase 22.7.11.220.462
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.462
4kd11QKCyclin-dependent kinase 22.7.11.220.462
5dr6SKEAurora kinase A2.7.11.10.462
2b55D31Cyclin-dependent kinase 22.7.11.220.461
3dogNNNCyclin-dependent kinase 22.7.11.220.461
3r28XA0Cyclin-dependent kinase 22.7.11.220.461
4bcmT7ZCyclin-dependent kinase 22.7.11.220.461
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.461
4ii5ADPCyclin-dependent kinase 22.7.11.220.461
2iw84SPCyclin-dependent kinase 22.7.11.220.460
3ggfGVDSerine/threonine-protein kinase 26/0.460
3qzhX69Cyclin-dependent kinase 22.7.11.220.460
3r6xX84Cyclin-dependent kinase 22.7.11.220.460
3roy22ZCyclin-dependent kinase 22.7.11.220.460
4hvi19STyrosine-protein kinase JAK32.7.10.20.460
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.460
2vtrLZBCyclin-dependent kinase 22.7.11.220.459
3mtfA3FActivin receptor type-12.7.11.300.459
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.459
4fv6E57Mitogen-activated protein kinase 12.7.11.240.459
4jboWPHAurora kinase A2.7.11.10.459
5dr9SKEAurora kinase A2.7.11.10.459
2exmZIPCyclin-dependent kinase 22.7.11.220.458
2xnbY8LCyclin-dependent kinase 22.7.11.220.458
3ig7EFPCyclin-dependent kinase 22.7.11.220.458
3nieANPMitogen-activated protein kinase/0.458
3py0SU9Cyclin-dependent kinase 22.7.11.220.458
4anmWULCasein kinase II subunit alpha2.7.11.10.458
4o0wADNAurora kinase A2.7.11.10.458
5dosATPAurora kinase A2.7.11.10.458
2eufLQQCyclin-dependent kinase 62.7.11.220.457
3rpo24ZCyclin-dependent kinase 22.7.11.220.457
4aua4AUCyclin-dependent kinase 62.7.11.220.457
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.457
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.456
2zjwREFCasein kinase II subunit alpha2.7.11.10.456
3nynSGVG protein-coupled receptor kinase 62.7.11.160.456
3r73X87Cyclin-dependent kinase 22.7.11.220.456
4btjADPTau-tubulin kinase 12.7.11.10.456
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.456
1ckpPVBCyclin-dependent kinase 22.7.11.220.455
1gij2PUCyclin-dependent kinase 22.7.11.220.455
3r9hZ67Cyclin-dependent kinase 22.7.11.220.455
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.454
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.454
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.454
1om1IQACasein kinase II subunit alpha2.7.11.10.453
1pyePM1Cyclin-dependent kinase 22.7.11.220.453
2r3o2SCCyclin-dependent kinase 22.7.11.220.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
1h0w207Cyclin-dependent kinase 22.7.11.220.452
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
3axwTIDCasein kinase II subunit alpha2.7.11.10.452
4ez50RSCyclin-dependent kinase 62.7.11.220.452
1e1xNW1Cyclin-dependent kinase 22.7.11.220.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.451
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.451
3r1qX75Cyclin-dependent kinase 22.7.11.220.451
2c69CT8Cyclin-dependent kinase 22.7.11.220.450
2pvmP29Casein kinase II subunit alpha2.7.11.10.450
3q9xEMOCasein kinase II subunit alpha2.7.11.10.450
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.450
3uli1N3Cyclin-dependent kinase 22.7.11.220.450
1eh4IC1Casein kinase I homolog 12.7.11.10.449
1finATPCyclin-dependent kinase 22.7.11.220.449
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.449
3ddpRC8Cyclin-dependent kinase 22.7.11.220.449
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.449
3qx4X4BCyclin-dependent kinase 22.7.11.220.449
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.449
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.449
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.448
1pkdUCNCyclin-dependent kinase 22.7.11.220.448
3lltANPProtein serine/threonine kinase-1/0.448
3r9oZ71Cyclin-dependent kinase 22.7.11.220.448
4eor4SPCyclin-dependent kinase 22.7.11.220.448
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.448
1h1r6CPCyclin-dependent kinase 22.7.11.220.447
1m2pHNACasein kinase II subunit alpha2.7.11.10.447
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1v0pPVBCell division control protein 2 homolog2.7.11.220.446
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.446
2bhhRYUCyclin-dependent kinase 22.7.11.220.446
3qqfX07Cyclin-dependent kinase 22.7.11.220.446
4eomATPCyclin-dependent kinase 22.7.11.220.446
1h1pCMGCyclin-dependent kinase 22.7.11.220.445
2xikJ60Serine/threonine-protein kinase 252.7.11.10.445
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.445
3nux3NVCyclin-dependent kinase 62.7.11.220.445
4eok4SPCyclin-dependent kinase 22.7.11.220.445
4fx360KCyclin-dependent kinase 22.7.11.220.445
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.444
1xjdSTUProtein kinase C theta type2.7.11.130.444
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.444
2hog710Serine/threonine-protein kinase Chk12.7.11.10.444
2i40BLZCyclin-dependent kinase 22.7.11.220.444
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.444
3efwAK8Aurora kinase A2.7.11.10.444
3qtwX3ACyclin-dependent kinase 22.7.11.220.444
3tnwF18Cyclin-dependent kinase 22.7.11.220.444
2uzdC85Cyclin-dependent kinase 22.7.11.220.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
3rm618ZCyclin-dependent kinase 22.7.11.220.443
4eos1ROCyclin-dependent kinase 22.7.11.220.443
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
2b52D42Cyclin-dependent kinase 22.7.11.220.442
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.442
4lyn1YGCyclin-dependent kinase 22.7.11.220.442
1oiqHDUCyclin-dependent kinase 22.7.11.220.441
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.441
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.441
1e9hINRCyclin-dependent kinase 22.7.11.220.440
2ckeIQUDeath-associated protein kinase 2/0.440
2fxdDR7Pol polyprotein/0.440
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440