sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5hbs | RTL | Retinol-binding protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5hbs | RTL | Retinol-binding protein 1 | / | 1.000 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.644 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.629 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.580 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.562 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.508 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.505 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.503 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.502 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.501 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.500 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.498 | |
| 3up0 | D7S | aceDAF-12 | / | 0.496 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.494 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.494 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.491 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.491 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.491 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.490 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.490 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.489 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.488 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.488 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.488 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.487 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.482 | |
| 5gcn | COA | HAT A1 | / | 0.482 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.481 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.481 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.478 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.477 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.477 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.475 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.473 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.473 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.473 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.472 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.472 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.472 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.472 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.471 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.471 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.471 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.471 | |
| 2dji | FAD | Pyruvate oxidase | / | 0.470 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.469 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.469 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.468 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.468 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.468 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.467 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.467 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.467 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.467 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.466 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3up3 | XCA | aceDAF-12 | / | 0.466 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.466 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.465 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.465 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.465 | |
| 2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.464 | |
| 4qin | SG8 | Smoothened homolog | / | 0.464 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.463 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.463 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.463 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.463 | |
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 | 0.463 | |
| 1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.462 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.462 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1v5e | FAD | Pyruvate oxidase | / | 0.461 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.461 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.461 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.461 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.461 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.460 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.460 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.459 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.459 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.459 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.458 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.458 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.458 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.458 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.457 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.457 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.457 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.456 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.456 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.456 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.456 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.456 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.456 | |
| 4l8u | 9AZ | Serum albumin | / | 0.456 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.456 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.455 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.455 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.455 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.455 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.455 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.455 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.455 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.454 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.454 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.454 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.453 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1fml | RTL | Retinol dehydratase | / | 0.453 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2jfa | RAL | Estrogen receptor | / | 0.453 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.453 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.453 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.453 | |
| 4a2b | AGS | Cell division protein FtsA | / | 0.453 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.452 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.452 | |
| 1sqv | UHD | Cytochrome b | / | 0.452 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.452 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.452 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.452 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.452 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.452 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.452 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.452 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.451 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.451 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.451 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.451 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.451 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 2p15 | EZT | Estrogen receptor | / | 0.451 | |
| 2vcw | ZZA | Hematopoietic prostaglandin D synthase | / | 0.451 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.451 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.451 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.451 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.451 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.451 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.451 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.450 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.450 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3v49 | PK0 | Androgen receptor | / | 0.450 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.450 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.450 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.450 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.450 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 4v12 | POG | MaoC like domain protein | / | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.449 | |
| 2v1a | FMN | NPH1-1 | / | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.449 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4c2j | COA | 3-ketoacyl-CoA thiolase, mitochondrial | 2.3.1.16 | 0.449 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.449 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.448 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.448 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.448 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 2zoq | 5ID | Mitogen-activated protein kinase 3 | 2.7.11.24 | 0.448 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.448 | |
| 3gb4 | D3M | DdmC | / | 0.448 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.448 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.448 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.448 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.447 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.447 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.447 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.447 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.447 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.447 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.447 | |
| 5doz | NDP | JamJ | / | 0.447 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.446 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.446 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.446 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.446 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.446 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.446 | |
| 2kce | D16 | Thymidylate synthase | / | 0.446 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.446 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.446 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.446 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.446 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.446 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1bi9 | NAD | Retinal dehydrogenase 2 | / | 0.445 | |
| 1ddt | APU | Diphtheria toxin | / | 0.445 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.445 | |
| 1nbh | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.445 | |
| 2cah | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.445 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.445 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.444 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 2bns | MST | Reaction center protein L chain | / | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2bw7 | ECS | Adenylate cyclase | / | 0.444 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.444 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.444 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3nbv | ANP | Ketohexokinase | / | 0.444 | |
| 3sfi | 3SF | HTH-type transcriptional regulator EthR | / | 0.444 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 4dw6 | 0MN | HTH-type transcriptional regulator EthR | / | 0.444 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.443 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.443 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.443 | |
| 2ynf | WHU | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 3cse | N22 | Uncharacterized protein | / | 0.443 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.443 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.443 | |
| 3lla | ACP | Myosin heavy chain kinase A | 2.7.11.7 | 0.443 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.443 | |
| 3stx | BKA | Methylketone synthase I | / | 0.443 | |
| 4jld | ADP | Adenylate kinase | / | 0.443 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.443 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 1e1k | NAP | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.442 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.442 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.442 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.442 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.442 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.442 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.442 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.442 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.441 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.441 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.441 | |
| 1txz | APR | Probable ADP-ribose 1''-phosphate phosphatase YML087W | 3.1.3.84 | 0.441 | |
| 1zdw | FLV | Prenyltransferase | / | 0.441 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.441 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.441 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.441 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.441 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.441 | |
| 3zk6 | H1I | Bcl-2-like protein 1 | / | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4cs0 | ACO | PanD regulatory factor | / | 0.441 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.441 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.441 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4o7u | THF | Thymidylate synthase | / | 0.441 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1qax | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.440 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.440 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.440 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.440 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 |