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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4y35F90Endothiapepsin3.4.23.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4y35F90Endothiapepsin3.4.23.221.000
3pldF90Endothiapepsin3.4.23.220.842
3pllF06Endothiapepsin3.4.23.220.806
4yd7F5NEndothiapepsin3.4.23.220.797
3pwwROCEndothiapepsin3.4.23.220.787
4y3rF06Endothiapepsin3.4.23.220.784
3pmy41LEndothiapepsin3.4.23.220.782
3pm4F5NEndothiapepsin3.4.23.220.763
3pgiF41Endothiapepsin3.4.23.220.724
3t7x4SHEndothiapepsin3.4.23.220.719
3t7p7SPEndothiapepsin3.4.23.220.681
3t6iNC8Endothiapepsin3.4.23.220.667
4y3zF41Endothiapepsin3.4.23.220.667
4y380A9Endothiapepsin3.4.23.220.666
2v00V15Endothiapepsin3.4.23.220.657
3prsRITEndothiapepsin3.4.23.220.649
1e82M90Endothiapepsin3.4.23.220.638
1gvw0EMEndothiapepsin3.4.23.220.634
3psyRB9Endothiapepsin3.4.23.220.631
1e81M91Endothiapepsin3.4.23.220.624
1gvt2ZSEndothiapepsin3.4.23.220.621
1od10QSEndothiapepsin3.4.23.220.619
1ppl1Z7Penicillopepsin-13.4.23.200.610
2webPP4Penicillopepsin-13.4.23.200.610
4zeaIMIEndothiapepsin3.4.23.220.604
1ppkIVVPenicillopepsin-13.4.23.200.601
1e800GQEndothiapepsin3.4.23.220.589
2wedPP6Penicillopepsin-13.4.23.200.588
1bxqPP8Penicillopepsin-13.4.23.200.586
1bxoPP7Penicillopepsin-13.4.23.200.585
1ppm0P1Penicillopepsin-13.4.23.200.583
2jji0QSEndothiapepsin3.4.23.220.579
2jjj0QSEndothiapepsin3.4.23.220.575
2wecPP5Penicillopepsin-13.4.23.200.568
1eagA70Candidapepsin-23.4.23.240.558
1zapA70Candidapepsin-23.4.23.240.551
1qrpHH0Pepsin A-43.4.23.10.540
2zjmF1MBeta-secretase 13.4.23.460.518
3q70RITCandidapepsin-23.4.23.240.514
1lf3EH5Plasmepsin-23.4.23.390.512
2hm1LIQBeta-secretase 13.4.23.460.503
3lpiZ74Beta-secretase 13.4.23.460.496
4ke01R8Beta-secretase 13.4.23.460.487
2weaPP6Penicillopepsin-13.4.23.200.485
3t6iNC9Endothiapepsin3.4.23.220.485
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.484
3nsh957Beta-secretase 13.4.23.460.482
3oqkS52Renin3.4.23.150.482
4i0i957Beta-secretase 13.4.23.460.482
1xddAAYIntegrin alpha-L/0.481
4y4jLNREndothiapepsin3.4.23.220.480
1xs7MMIBeta-secretase 13.4.23.460.479
2qbmCAMCamphor 5-monooxygenase1.14.15.10.479
1lf2R37Plasmepsin-23.4.23.390.478
3tpr5HABeta-secretase 13.4.23.460.478
4y57F63Endothiapepsin3.4.23.220.477
1x2hLPALipoate-protein ligase A6.3.1.200.476
2ohvNHLGlutamate racemase/0.476
2z3uCRRCytochrome P450/0.476
3fwjCAMCamphor 5-monooxygenase1.14.15.10.476
2g226IGRenin3.4.23.150.475
3fwiCAMCamphor 5-monooxygenase1.14.15.10.475
3wrmCAMCamphor 5-monooxygenase1.14.15.10.475
4y3jHICEndothiapepsin3.4.23.220.475
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.474
1psa0ZLPepsin A3.4.23.10.473
1bim0QBRenin3.4.23.150.472
3pi53P5Beta-secretase 13.4.23.460.472
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
2g1s4IGRenin3.4.23.150.471
4bfzZVZPantothenate kinase2.7.1.330.471
1t88CAMCamphor 5-monooxygenase1.14.15.10.470
2zbaZBATrichothecene 3-O-acetyltransferase/0.470
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
1h51FMNPentaerythritol tetranitrate reductase/0.469
1uyuCAMCamphor 5-monooxygenase1.14.15.10.469
1xe65FPPlasmepsin-23.4.23.390.469
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.469
1dz8CAMCamphor 5-monooxygenase1.14.15.10.468
1gebCAMCamphor 5-monooxygenase1.14.15.10.468
4lxk1YTBeta-secretase 13.4.23.460.468
2f3eAXQBeta-secretase 13.4.23.460.467
3lxiCAMCytochrome P450/0.467
1bwlFMNNADPH dehydrogenase 11.6.99.10.466
2dvlFADAcyl-CoA dehydrogenase/0.466
2qboCAMCamphor 5-monooxygenase1.14.15.10.466
3cid318Beta-secretase 13.4.23.460.466
4xr9NADCalS8/0.466
2p4j23IBeta-secretase 13.4.23.460.465
3dv5BAVBeta-secretase 13.4.23.460.465
3fwgCAMCamphor 5-monooxygenase1.14.15.10.465
3tm5SFGUncharacterized protein/0.465
4lxa1YSBeta-secretase 13.4.23.460.465
1dz4CAMCamphor 5-monooxygenase1.14.15.10.464
1fm4DXCMajor pollen allergen Bet v 1-L/0.464
3l63CAMCamphor 5-monooxygenase1.14.15.10.464
4a81DXCMajor pollen allergen Bet v 1-A/0.464
1ppjANYCytochrome b/0.463
1yw8A75Methionine aminopeptidase 2/0.463
2wihP48Cyclin-dependent kinase 22.7.11.220.463
4yqfGDPSeptin-9/0.463
1o76CAMCamphor 5-monooxygenase1.14.15.10.462
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.462
1ftlDNQGlutamate receptor 2/0.461
4bb3KKAIsopenicillin N synthase1.21.3.10.461
1nooCAHCamphor 5-monooxygenase1.14.15.10.460
2cchATPCyclin-dependent kinase 22.7.11.220.460
2ea2F77Methionine aminopeptidase 2/0.460
3cib314Beta-secretase 13.4.23.460.460
3x2eNAIAdenosylhomocysteinase/0.460
4gl4NAIAlcohol dehydrogenase class-3/0.460
1yrdCAMCamphor 5-monooxygenase1.14.15.10.459
2feuCAMCamphor 5-monooxygenase1.14.15.10.459
2g1r3IGRenin3.4.23.150.459
4cp4CAMCamphor 5-monooxygenase1.14.15.10.459
4ek1CAMCamphor 5-monooxygenase1.14.15.10.459
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.458
2zaxCAMCamphor 5-monooxygenase1.14.15.10.458
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.458
1drhNAPDihydrofolate reductase1.5.1.30.457
1g41ADPATP-dependent protease ATPase subunit HslU/0.457
2m56CAMCamphor 5-monooxygenase1.14.15.10.457
3k5fAYHBeta-secretase 13.4.23.460.457
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.457
3vydVYDRenin3.4.23.150.457
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
1towCRZFatty acid-binding protein, adipocyte/0.456
1w6hTITPlasmepsin-23.4.23.390.456
2qblCAMCamphor 5-monooxygenase1.14.15.10.456
3bk2U5PRibonuclease J/0.456
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.456
4djhJDCKappa-type opioid receptor/0.456
1a8rGTPGTP cyclohydrolase 13.5.4.160.455
1m13HYFNuclear receptor subfamily 1 group I member 2/0.455
2a1nCAMCamphor 5-monooxygenase1.14.15.10.455
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.455
2g20L1ARenin3.4.23.150.455
3udq09EBeta-secretase 13.4.23.460.455
3veu0GOBeta-secretase 13.4.23.460.455
4f6w0SSCyclin-dependent kinase 82.7.11.220.455
4l0qNADAlcohol dehydrogenase class-3/0.455
4l3q926Glucokinase2.7.1.20.455
1mczTDPBenzoylformate decarboxylase4.1.1.70.454
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.454
2g1o2IGRenin3.4.23.150.454
2zjwREFCasein kinase II subunit alpha2.7.11.10.454
3k5dXLIBeta-secretase 13.4.23.460.454
3rtnRTNBeta-secretase 13.4.23.460.454
3ts1TYATyrosine--tRNA ligase6.1.1.10.454
3vswR31Renin3.4.23.150.454
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.454
6cp4CAMCamphor 5-monooxygenase1.14.15.10.454
1dyhDZFDihydrofolate reductase1.5.1.30.453
2abbFMNPentaerythritol tetranitrate reductase/0.453
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.453
3rsv3RSBeta-secretase 13.4.23.460.453
4fse0VABeta-secretase 13.4.23.460.453
2bkzSBCCyclin-dependent kinase 22.7.11.220.452
2el0SAHDiphthine synthase/0.452
3p67FMNPentaerythritol tetranitrate reductase/0.452
3v1s0LHStrictosidine synthase4.3.3.20.452
4a862ANMajor pollen allergen Bet v 1-A/0.452
4i8vBHFCytochrome P450 1A11.14.14.10.452
4nbwNADShort-chain dehydrogenase/reductase SDR/0.452
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.451
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.451
1vyrFMNPentaerythritol tetranitrate reductase/0.451
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.451
2cppCAMCamphor 5-monooxygenase1.14.15.10.451
3zxsFADDeoxyribodipyrimidine photolyase-related protein/0.451
4m83ERYOleandomycin glycosyltransferase2.4.10.451
1kh3ANPArgininosuccinate synthase/0.450
1zdfUPGGlycogenin-12.4.1.1860.450
3t64DU3Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.450
4ey6GNTAcetylcholinesterase3.1.1.70.450
4mv8ACPBiotin carboxylase6.3.4.140.450
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1t86CAMCamphor 5-monooxygenase1.14.15.10.449
1yrcCAMCamphor 5-monooxygenase1.14.15.10.449
2g94ZPQBeta-secretase 13.4.23.460.449
2iko7IGRenin3.4.23.150.449
2tysPLTTryptophan synthase beta chain4.2.1.200.449
2v59LZKBiotin carboxylase6.3.4.140.449
3d84NDPDihydrofolate reductase1.5.1.30.449
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3h3qH13Collagen type IV alpha-3-binding protein/0.449
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3k5c0BIBeta-secretase 13.4.23.460.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3owaFADAcyl-CoA dehydrogenase/0.449
3r2fPB0Beta-secretase 13.4.23.460.449
3wrhCAMCamphor 5-monooxygenase1.14.15.10.449
3wrlCAMCamphor 5-monooxygenase1.14.15.10.449
4kkyCAMCamphor 5-monooxygenase1.14.15.10.449
4l4fCAMCamphor 5-monooxygenase1.14.15.10.449
1cqp803Integrin alpha-L/0.448
1gqtACPRibokinase/0.448
1n3rGTPGTP cyclohydrolase 13.5.4.160.448
1rx8FOLDihydrofolate reductase1.5.1.30.448
2zawCAMCamphor 5-monooxygenase1.14.15.10.448
3c34KAIGlutamate receptor ionotropic, kainate 1/0.448
5c1mCLRMu-type opioid receptor/0.448
1rfuADPPyridoxal kinase2.7.1.350.447
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
1t85CAMCamphor 5-monooxygenase1.14.15.10.447
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2b8v3BNBeta-secretase 13.4.23.460.447
2w6qOA5Biotin carboxylase6.3.4.140.447
3cppCAMCamphor 5-monooxygenase1.14.15.10.447
3h03UBPGlutamate receptor 2/0.447
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.447
3qizQI2Botulinum neurotoxin type A3.4.24.690.447
4gd40WSLysine-specific demethylase 4A1.14.110.447
4ips1G4Mycocyclosin synthase1.14.21.90.447
4ipw1G7Mycocyclosin synthase1.14.21.90.447
4lb9EVPSerum albumin/0.447
4mlp2CXCryptochrome-2/0.447
3sn6P0GBeta-2 adrenergic receptor/0.447
1fl2FADAlkyl hydroperoxide reductase subunit F1.8.10.446
1tdrMTXDihydrofolate reductase1.5.1.30.446
1tu8GTXGlutathione S-transferase 22.5.1.180.446
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.446
2vttLZDCyclin-dependent kinase 22.7.11.220.446
3gwfFADCyclohexanone monooxygenase/0.446
3h6vNS6Glutamate receptor 2/0.446
3own3OWRenin3.4.23.150.446
3vyfVYFRenin3.4.23.150.446
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.446
4eh9IRGMitogen-activated protein kinase 14/0.446
4iae1DXAlr2278 protein/0.446
4y93746Tyrosine-protein kinase/0.446
1mrwK57Gag-Pol polyprotein3.4.23.160.445
1rx1NAPDihydrofolate reductase1.5.1.30.445
1vceSAHDiphthine synthase/0.445
2g1n1IGRenin3.4.23.150.445
2qbnCAMCamphor 5-monooxygenase1.14.15.10.445
2wi72KLHeat shock protein HSP 90-alpha/0.445
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.445
3cic316Beta-secretase 13.4.23.460.445
3fp0FP015-O-acetyltransferase/0.445
3fr28CAFatty acid-binding protein, adipocyte/0.445
3fr5I4AFatty acid-binding protein, adipocyte/0.445
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
3k8q22APurine nucleoside phosphorylase2.4.2.10.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
4hy6FJ1Heat shock protein HSP 90-alpha/0.445
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
1touB1VFatty acid-binding protein, adipocyte/0.444
2cv2GSUGlutamate--tRNA ligase6.1.1.170.444
2f3fAXFBeta-secretase 13.4.23.460.444
2v58LZJBiotin carboxylase6.3.4.140.444
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3frkTQPQdtB/0.444
3fwfCAMCamphor 5-monooxygenase1.14.15.10.444
3iocA5DPantothenate synthetase6.3.2.10.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
3mtfA3FActivin receptor type-12.7.11.300.444
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.444
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.444
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.444
4g090VDHistidinol dehydrogenase/0.444
4hnhNAPNAD-dependent epimerase/dehydratase/0.444
4jlm1NNDeoxycytidine kinase2.7.1.740.444
5dhgDGVNociceptin receptor/0.444
1iwjCAMCamphor 5-monooxygenase1.14.15.10.443
1jqdSAHHistamine N-methyltransferase2.1.1.80.443
1rfvADPPyridoxal kinase2.7.1.350.443
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
2ab8MTPAdenosine kinase2.7.1.200.443
2bxmIMNSerum albumin/0.443
2cdaNAPGlucose 1-dehydrogenase/0.443
2cig1DGDihydrofolate reductase1.5.1.30.443
2ea4F79Methionine aminopeptidase 2/0.443
2g247IGRenin3.4.23.150.443
3nmpPYVAbscisic acid receptor PYL2/0.443
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.443
4g3qUD1Bifunctional protein GlmU/0.443
4g95OAGDihydrofolate reductase1.5.1.30.443
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.443
4uyf73BBromodomain-containing protein 2/0.443
1kp3ATPArgininosuccinate synthase6.3.4.50.442
1likADNAdenosine kinase2.7.1.200.442
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.442
1txtCAAHMG-CoA synthase/0.442
2flhZEACytokinin-specific binding protein/0.442
2gjnFMNNitronate monooxygenase1.13.12.160.442
2viyVG3Beta-secretase 13.4.23.460.442
2y882ERPhosphoribosyl isomerase A5.3.1.160.442
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.442
3hl0NADMaleylacetate reductase/0.442
4h9506UDihydrofolate reductase1.5.1.30.442
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.442
1h60STRPentaerythritol tetranitrate reductase/0.441
1iwiCAMCamphor 5-monooxygenase1.14.15.10.441
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2clsGTPRho-related GTP-binding protein Rho6/0.441
2qg4NADUDP-glucose 6-dehydrogenase1.1.1.220.441
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.441
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.441
3e23SAMUncharacterized protein/0.441
3gnvXNZGenome polyprotein2.7.7.480.441
3h3r14HCollagen type IV alpha-3-binding protein/0.441
3ixj586Beta-secretase 13.4.23.460.441
3ojxFMNNADPH--cytochrome P450 reductase/0.441
3pd3A3TThreonine--tRNA ligase6.1.1.30.441
3tk3CPZCytochrome P450 2B41.14.14.10.441
4l4dCAMCamphor 5-monooxygenase1.14.15.10.441
4l4eCAMCamphor 5-monooxygenase1.14.15.10.441
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1n77ATPGlutamate--tRNA ligase6.1.1.170.440
1rj6AZMCarbonic anhydrase 144.2.1.10.440
3dhbC6LN-acyl homoserine lactonase AiiA3.1.1.810.440
3ohf3HFBeta-secretase 13.4.23.460.440
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.440
4a86H35Major pollen allergen Bet v 1-A/0.440
4g3pUD1Bifunctional protein GlmU/0.440
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.440