sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4pd6 | URI | Nucleoside permease |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4pd6 | URI | Nucleoside permease | / | 1.000 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.544 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.503 | |
| 1osv | CHC | Bile acid receptor | / | 0.496 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.493 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.491 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.489 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.484 | |
| 4pda | CTN | Nucleoside permease | / | 0.481 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.480 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.477 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.477 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.475 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.475 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.473 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.473 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.473 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.473 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.472 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.472 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.471 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.470 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.469 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.469 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.469 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.469 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.469 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.469 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.468 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.468 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.467 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.467 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.467 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.467 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.467 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.467 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.466 | |
| 2xb5 | I7T | Tetracycline repressor protein class D | / | 0.466 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.466 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.466 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.466 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.466 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.465 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.465 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.465 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.464 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.464 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.464 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.463 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.463 | |
| 4j4b | NAI | Uncharacterized protein | / | 0.463 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.462 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.462 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.462 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.462 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.461 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.461 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.461 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.461 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.461 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.461 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.460 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.460 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.460 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.460 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.460 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.460 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.459 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.459 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2y3s | TIR | TamL | / | 0.459 | |
| 3lu8 | IQX | Serum albumin | / | 0.459 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.459 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.458 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.457 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.457 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.457 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.456 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.456 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.456 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.456 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2xsz | ATP | RuvB-like 2 | 3.6.4.12 | 0.456 | |
| 3b20 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.456 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.456 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.455 | |
| 2oxt | SAM | Genome polyprotein | / | 0.455 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.455 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.455 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.455 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.455 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.455 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.454 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.454 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.454 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.454 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.454 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4l9q | 9TP | Serum albumin | / | 0.454 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.454 | |
| 4rw4 | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.454 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.453 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.453 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.453 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.453 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.453 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.453 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.453 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.453 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.452 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.452 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.452 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3nbp | JGZ | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.452 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.452 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4fxf | ATP | Pyruvate kinase PKM | 2.7.1.40 | 0.452 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.452 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.451 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.451 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.451 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.451 | |
| 5doz | NDP | JamJ | / | 0.451 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.450 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.450 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.450 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1eio | GCH | Gastrotropin | / | 0.449 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.449 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.449 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.449 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.449 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 2wq6 | FAD | RE11660p | / | 0.449 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.449 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.449 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.449 | |
| 4pd5 | GEO | Nucleoside permease | / | 0.449 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.449 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.449 | |
| 1cbo | FAD | Cholesterol oxidase | 1.1.3.6 | 0.448 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.448 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2k62 | ITL | Fatty acid-binding protein, liver | / | 0.448 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.448 | |
| 3mec | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.448 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.448 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4l8u | 9AZ | Serum albumin | / | 0.448 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.448 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.447 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.447 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.447 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.447 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.447 | |
| 3tij | URI | Nucleoside permease | / | 0.447 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.447 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.447 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.447 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.447 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.446 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.446 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.446 | |
| 1q0q | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.446 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.446 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.446 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.446 | |
| 3k9v | CPS | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | / | 0.446 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.446 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.446 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.446 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.446 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.446 | |
| 4n6b | COA | Uncharacterized protein | / | 0.446 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
| 4rek | FAD | Cholesterol oxidase | 1.1.3.6 | 0.446 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.446 | |
| 5a3b | APR | SIR2 family protein | / | 0.446 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.445 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.445 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.445 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.445 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.445 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.445 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.445 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.445 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.445 | |
| 4cta | ATP | CinA-like protein | / | 0.445 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.445 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.445 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.445 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.445 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.445 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.445 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.445 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.444 | |
| 1ep4 | S11 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.444 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.444 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.444 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.444 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.444 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.444 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.444 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3i0s | RT7 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.444 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.444 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.443 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.443 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.443 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.443 | |
| 2pwr | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.443 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.443 | |
| 3sa3 | 23X | Protease | / | 0.443 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.443 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.443 | |
| 3w2o | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.443 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.443 | |
| 4nu6 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.443 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.443 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.442 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.442 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2y3r | TRK | TamL | / | 0.442 | |
| 2ycr | HCW | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.442 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.442 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.442 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.442 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.442 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.442 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.442 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.441 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.441 | |
| 1qbr | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1sn5 | T3 | Transthyretin | / | 0.441 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.441 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.441 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.441 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.441 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4lgh | 0JN | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4u2s | FDA | Cholesterol oxidase | 1.1.3.6 | 0.441 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.441 | |
| 5a3c | NAD | SIR2 family protein | / | 0.441 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.441 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.440 | |
| 1pp9 | SMA | Cytochrome b | / | 0.440 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.440 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.440 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.440 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.440 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.440 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.440 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.440 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.440 | |
| 3ete | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.440 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.440 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.440 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.440 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.440 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.440 | |
| 4pb1 | RBV | Nucleoside permease | / | 0.440 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.440 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |