sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 1.000 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.596 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.591 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.581 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.579 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.577 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.559 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.559 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.558 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.552 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.543 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.540 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.536 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.535 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.534 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.534 | |
| 4qec | NAP | ElxO | / | 0.534 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.532 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.528 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.519 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.519 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.519 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.519 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.518 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.517 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.515 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.509 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.508 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.507 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.506 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.505 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.505 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.503 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.502 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.502 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.501 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.498 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.496 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.495 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.495 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.495 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.495 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.494 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.494 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.494 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.493 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.492 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.492 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.491 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.490 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.489 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.489 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.488 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.488 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.488 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.488 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.487 | |
| 4u7w | NDP | MxaA | / | 0.486 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.485 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.484 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.483 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.483 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.483 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.483 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.482 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.482 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.482 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.482 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.481 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.481 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.480 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.480 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.480 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.480 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.479 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.479 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.479 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.478 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.478 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.477 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.476 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.475 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.474 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.474 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.474 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.474 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.474 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.474 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.473 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.472 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.472 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.471 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.471 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.470 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.470 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.469 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.469 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.468 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.467 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.467 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.466 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.466 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.465 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.465 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.465 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.464 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.464 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.464 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.463 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.463 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.463 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.463 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.463 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.462 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.462 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.462 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.462 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.462 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.461 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.461 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.460 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.460 | |
| 4l4x | NDP | AmphI | / | 0.460 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.460 | |
| 3a3g | DLZ | Lumazine protein | / | 0.459 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.458 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.458 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.458 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.458 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.458 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.458 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.457 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.457 | |
| 2xfi | XFI | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.457 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.456 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.456 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.456 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.456 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.456 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.455 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.455 | |
| 1gd1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.455 | |
| 2ejz | SAH | Diphthine synthase | / | 0.455 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.454 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.454 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.454 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.454 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.453 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.453 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.453 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.453 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.453 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.452 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.452 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.452 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.452 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.452 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.452 | |
| 4y0k | NAP | AntE | / | 0.452 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.451 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.451 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.451 | |
| 4kwh | NAP | Reductase homolog | / | 0.451 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.450 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.450 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.450 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.450 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.450 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.450 | |
| 3b9l | AZZ | Serum albumin | / | 0.450 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.450 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.450 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.450 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.450 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.450 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.450 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.449 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.449 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.449 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.449 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.449 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.449 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.449 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.449 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.448 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.448 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.448 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.447 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.447 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.446 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.446 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.446 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.446 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 4dja | FAD | (6-4) photolyase | / | 0.446 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.446 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1tys | DHF | Thymidylate synthase | / | 0.445 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.445 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 4uun | NAI | L-lactate dehydrogenase | / | 0.445 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.445 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.445 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1gqt | ACP | Ribokinase | / | 0.444 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.444 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.444 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.444 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.444 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.444 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.444 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.444 | |
| 4p63 | NAD | Probable deoxyhypusine synthase | 2.5.1.46 | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.443 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.443 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.443 | |
| 3eks | CY9 | Actin-5C | / | 0.443 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.443 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.443 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.443 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.442 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.442 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.442 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.442 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.442 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.441 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.441 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.441 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.441 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.441 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.441 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.440 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.440 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.440 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.440 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.440 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.440 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.440 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.440 |