sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gb4 | D3M | DdmC |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3gb4 | D3M | DdmC | / | 1.000 | |
| 3gl2 | D3M | DdmC | / | 0.556 | |
| 3gts | D3M | DdmC | / | 0.546 | |
| 3gob | HXX | DdmC | / | 0.505 | |
| 2ejz | SAH | Diphthine synthase | / | 0.497 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.495 | |
| 5dp2 | NAP | CurF | / | 0.491 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.490 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.488 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.487 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.485 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.483 | |
| 1zdw | FLV | Prenyltransferase | / | 0.483 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.482 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.481 | |
| 1g28 | FMN | PHY3 | / | 0.481 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.480 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.478 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.477 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.476 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.475 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.475 | |
| 2jlc | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.473 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.473 | |
| 3up3 | XCA | aceDAF-12 | / | 0.473 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.473 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.472 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.471 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.469 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.469 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.469 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.467 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.467 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.466 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.466 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.465 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.465 | |
| 4l8u | 9AZ | Serum albumin | / | 0.465 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.464 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.464 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.463 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.463 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.463 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 3b9l | AZZ | Serum albumin | / | 0.462 | |
| 4u7w | NDP | MxaA | / | 0.462 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.461 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.461 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.461 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.461 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.461 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.461 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.460 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.460 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.460 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.460 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.460 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.459 | |
| 5esd | TDP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.459 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.458 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.458 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.458 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.458 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.457 | |
| 2emu | SAH | Diphthine synthase | / | 0.457 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.457 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.457 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.457 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.457 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 1hk5 | T44 | Serum albumin | / | 0.456 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.456 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.456 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.455 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.455 | |
| 1u0h | ONM | Adenylate cyclase type 2 | / | 0.455 | |
| 1u0h | ONM | Adenylate cyclase type 5 | / | 0.455 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 3zuy | TCH | Transporter | / | 0.455 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.455 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.455 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.454 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.454 | |
| 2xvv | 9DN | Serum albumin | / | 0.454 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.454 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.454 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.453 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.453 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.453 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.453 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.452 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.451 | |
| 1gqt | ACP | Ribokinase | / | 0.451 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.451 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.451 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.451 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.451 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3lit | E15 | Protease | / | 0.451 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.451 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1r2j | FAD | FkbI | / | 0.450 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.450 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.450 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.450 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.449 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.449 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.449 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.449 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.449 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.449 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.449 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.449 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.449 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.448 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.448 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.448 | |
| 2xvw | 9NR | Serum albumin | / | 0.448 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.448 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4oal | 245 | Cytokinin dehydrogenase 4 | / | 0.448 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.448 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.447 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.447 | |
| 3b3f | SAH | Histone-arginine methyltransferase CARM1 | / | 0.447 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.447 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.446 | |
| 2owu | SAH | Diphthine synthase | / | 0.446 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4iah | 1DX | Alr2278 protein | / | 0.446 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.446 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.446 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.445 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.445 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.445 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.445 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2p6k | SAH | Diphthine synthase | / | 0.445 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.445 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.445 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.445 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.445 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.445 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.445 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1krv | 147 | Galactoside O-acetyltransferase | 2.3.1.18 | 0.444 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.444 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.444 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.444 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.444 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.444 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.444 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.444 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.444 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.444 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.444 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.444 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.443 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.443 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.443 | |
| 2eeq | SAH | Diphthine synthase | / | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.443 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.443 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.443 | |
| 1c6y | MK1 | Protease | / | 0.442 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.442 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.442 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.442 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.442 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.442 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.442 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.442 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.442 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.442 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2e8q | SAH | Diphthine synthase | / | 0.441 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.441 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.441 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.441 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.441 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.441 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.441 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.441 | |
| 4dpl | NAP | Malonyl-CoA reductase | 1.2.1.75 | 0.441 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.441 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4tlx | FDA | KtzI | / | 0.441 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.441 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.441 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.441 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.440 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1s36 | CEI | Obelin | / | 0.440 | |
| 1syn | F89 | Thymidylate synthase | / | 0.440 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 2eld | SAH | Diphthine synthase | / | 0.440 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.440 | |
| 2gpj | FAD | Siderophore-interacting protein | / | 0.440 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.440 | |
| 2huv | SAH | Diphthine synthase | / | 0.440 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.440 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.440 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.440 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.440 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.440 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.440 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.440 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4phl | PIL | Phosphodiesterase | / | 0.440 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.440 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.440 |