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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3frdDHFDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3frdDHFDihydrofolate reductase1.5.1.31.000
3fywXCFDihydrofolate reductase1.5.1.30.702
3fraI2HDihydrofolate reductase1.5.1.30.633
3freTOPDihydrofolate reductase1.5.1.30.629
3frfXCFDihydrofolate reductase1.5.1.30.626
4fgh0U6Dihydrofolate reductase1.5.1.30.618
3srqQ19Dihydrofolate reductase1.5.1.30.600
3fy9XCFDihydrofolate reductase1.5.1.30.599
3jw5TOPDihydrofolate reductase/0.592
4xe606UDihydrofolate reductase1.5.1.30.591
1vj3TABDihydrofolate reductase1.5.1.30.582
3m08RARDihydrofolate reductase1.5.1.30.578
2w3vTOPDihydrofolate reductase/0.570
2zzaFOLDihydrofolate reductase/0.569
3dfrMTXDihydrofolate reductase1.5.1.30.569
3fy8XCFDihydrofolate reductase1.5.1.30.569
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.564
3sh25DRDihydrofolate reductase1.5.1.30.562
3ia4MTXDihydrofolate reductase/0.560
3srrQ20Dihydrofolate reductase1.5.1.30.556
3td8D2RDihydrofolate reductase1.5.1.30.556
4ele31IDihydrofolate reductase/0.556
3jwcEKBDihydrofolate reductase/0.554
3srwQ27Dihydrofolate reductase1.5.1.30.554
2fziDH3Dihydrofolate reductase1.5.1.30.552
3eel53TUncharacterized protein/0.551
3fyvXCFDihydrofolate reductase1.5.1.30.549
3jw3TOPDihydrofolate reductase/0.548
3jwm5WBDihydrofolate reductase/0.548
1dajMOTDihydrofolate reductase1.5.1.30.547
3fl8RARDihydrofolate reductase/0.547
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.547
2fzhDH1Dihydrofolate reductase1.5.1.30.546
3sa16DRDihydrofolate reductase/0.546
1diuBDMDihydrofolate reductase1.5.1.30.545
2w9gTOPDihydrofolate reductase1.5.1.30.545
1cd2FOLDihydrofolate reductase1.5.1.30.540
3cseN22Uncharacterized protein/0.539
1rx3MTXDihydrofolate reductase1.5.1.30.538
1dg5TOPDihydrofolate reductase1.5.1.30.537
4elf35IDihydrofolate reductase/0.537
3ix9MTXDihydrofolate reductase1.5.1.30.533
3sruQ26Dihydrofolate reductase1.5.1.30.532
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.531
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.531
4ixeIXEDihydrofolate reductase1.5.1.30.531
3eek53SUncharacterized protein/0.530
3qlzQLZUncharacterized protein/0.530
4h9814QUncharacterized protein/0.530
3qlxQLRUncharacterized protein/0.529
3tqbFOLDihydrofolate reductase/0.528
1ddsMTXDihydrofolate reductase1.5.1.30.527
3eej53RUncharacterized protein/0.527
4elg52JDihydrofolate reductase/0.526
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.525
4elb34SDihydrofolate reductase/0.524
3cd2MTXDihydrofolate reductase1.5.1.30.519
4h9614QDihydrofolate reductase1.5.1.30.519
3eem53VUncharacterized protein/0.518
4nx6FOLDihydrofolate reductase1.5.1.30.518
1drbMTXDihydrofolate reductase1.5.1.30.517
4p66MTXDihydrofolate reductase/0.517
1jolFFODihydrofolate reductase1.5.1.30.516
4nx7FOLDihydrofolate reductase1.5.1.30.515
1df7MTXDihydrofolate reductase1.5.1.30.512
3datMTXDihydrofolate reductase/0.512
3qls55VDihydrofolate reductase1.5.1.30.512
4elh53IDihydrofolate reductase/0.511
4elb34RDihydrofolate reductase/0.510
3tq9MTXDihydrofolate reductase/0.509
4m2xTMQDihydrofolate reductase1.5.1.30.509
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.508
1m7aMQUDihydrofolate reductase1.5.1.30.507
3sgy06WDihydrofolate reductase1.5.1.30.504
3qlrQLRDihydrofolate reductase1.5.1.30.503
3i8aN22Dihydrofolate reductase1.5.1.30.502
1klkPMDDihydrofolate reductase1.5.1.30.501
3qly55VUncharacterized protein/0.498
3srsM23Dihydrofolate reductase1.5.1.30.497
4x5gFOLDihydrofolate reductase1.5.1.30.497
1zrzBI1Protein kinase C iota type2.7.11.130.496
3sai9DRDihydrofolate reductase/0.496
4kjjFOLDihydrofolate reductase1.5.1.30.494
1disBDMDihydrofolate reductase1.5.1.30.493
3sa27DRDihydrofolate reductase/0.493
1jomFFODihydrofolate reductase1.5.1.30.492
1rf7DHFDihydrofolate reductase1.5.1.30.492
1tdrMTXDihydrofolate reductase1.5.1.30.492
2qk8MTXDihydrofolate reductase/0.492
4h9753SDihydrofolate reductase1.5.1.30.492
1dg7WRBDihydrofolate reductase1.5.1.30.490
3qlwN22Dihydrofolate reductase1.5.1.30.489
1re7FOLDihydrofolate reductase1.5.1.30.488
2cd2FOLDihydrofolate reductase1.5.1.30.488
3dauMTXDihydrofolate reductase1.5.1.30.487
1ly3COGDihydrofolate reductase1.5.1.30.485
1m13HYFNuclear receptor subfamily 1 group I member 2/0.485
2nnhREACytochrome P450 2C8/0.483
4g8zTOPDihydrofolate reductase1.5.1.30.483
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.482
1rc4DDFDihydrofolate reductase1.5.1.30.480
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.480
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.479
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.479
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.477
4ixfIXFDihydrofolate reductase1.5.1.30.477
1ddrMTXDihydrofolate reductase1.5.1.30.476
3m09RARDihydrofolate reductase1.5.1.30.476
5hi6MTXDihydrofolate reductase/0.476
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.475
1aoeGW3Dihydrofolate reductase1.5.1.30.474
4hgt15GCasein kinase I isoform delta2.7.11.10.474
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.474
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.473
4h9506UDihydrofolate reductase1.5.1.30.473
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.473
1dyjDDFDihydrofolate reductase1.5.1.30.472
2harOCCVitamin D3 receptor/0.472
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.472
4b7sQLECytochrome P450 monooxygenase PikC/0.472
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.472
4x5fFOLDihydrofolate reductase1.5.1.30.472
4ixgIXGDihydrofolate reductase1.5.1.30.471
1ly4COQDihydrofolate reductase1.5.1.30.470
3d80Q22Dihydrofolate reductase1.5.1.30.469
1eupASD6-deoxyerythronolide B hydroxylase/0.468
3meeT27Gag-Pol polyprotein2.7.7.490.468
4v12POGMaoC like domain protein/0.468
2fwyH64Heat shock protein HSP 90-alpha/0.467
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
3l3rOAGDihydrofolate reductase1.5.1.30.467
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.467
4tuvCPZCytochrome P450 1191.140.467
1bygSTUTyrosine-protein kinase CSK/0.466
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.466
1iwjCAMCamphor 5-monooxygenase1.14.15.10.466
3a0iAJIGlucokinase2.7.1.20.466
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.466
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1kzjCB3Thymidylate synthase/0.465
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.465
2znnS44Peroxisome proliferator-activated receptor alpha/0.465
3fl9TOPDihydrofolate reductase/0.465
3lu8IQXSerum albumin/0.465
3sqyQ11Dihydrofolate reductase1.5.1.30.465
4nb6444Nuclear receptor ROR-gamma/0.465
2bxmIMNSerum albumin/0.464
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
2of4979Tyrosine-protein kinase Lck2.7.10.20.464
3nr4PYVAbscisic acid receptor PYL2/0.464
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.464
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.464
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.464
1hfqMOTDihydrofolate reductase1.5.1.30.463
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.463
3d7kD7KBenzaldehyde lyase/0.463
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.463
1uymPU3Heat shock protein HSP 90-beta/0.462
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.462
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1db1VDXVitamin D3 receptor/0.461
2jn3JN3Fatty acid-binding protein, liver/0.461
2q5g1FAPeroxisome proliferator-activated receptor delta/0.461
3gc9B45Mitogen-activated protein kinase 112.7.11.240.461
3tk3CPZCytochrome P450 2B41.14.14.10.461
3vt65YIVitamin D3 receptor/0.461
4uymVOR14-alpha sterol demethylase Cyp51B/0.461
2cppCAMCamphor 5-monooxygenase1.14.15.10.460
2vf0F89Thymidylate synthase/0.460
4eevL1XHepatocyte growth factor receptor2.7.10.10.460
1dz6CAMCamphor 5-monooxygenase1.14.15.10.459
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2c7xNRBCytochrome P450 monooxygenase PikC/0.459
2vn0TDZCytochrome P450 2C8/0.459
3koo24DBifunctional epoxide hydrolase 23.3.2.100.459
3s79ASDAromatase1.14.14.140.459
3vt7VDXVitamin D3 receptor/0.459
1rb3MTXDihydrofolate reductase1.5.1.30.458
2hw2RFPRifampin ADP-ribosyl transferase/0.458
3kpzZNEVitamin D3 receptor/0.458
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.458
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4ia1BIVVitamin D3 receptor A/0.458
4ia3BIVVitamin D3 receptor A/0.458
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.458
4lch1WNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.458
4m6l21VDihydrofolate reductase1.5.1.30.458
5cshATPCasein kinase II subunit alpha2.7.11.10.458
1osvCHCBile acid receptor/0.457
2x6dX6DAurora kinase A2.7.11.10.457
4f640S8Fibroblast growth factor receptor 1/0.457
4fhi0S4Vitamin D3 receptor A/0.457
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.457
1knuYPAPeroxisome proliferator-activated receptor gamma/0.456
1tlcF89Thymidylate synthase/0.456
1xqcAEJEstrogen receptor/0.456
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
2vzmNRBCytochrome P450 monooxygenase PikC/0.456
2yncYNCGlycylpeptide N-tetradecanoyltransferase/0.456
3mnrSD1Heat shock protein HSP 90-alpha/0.456
3zuxTCHTransporter/0.456
4bb3KKAIsopenicillin N synthase1.21.3.10.456
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.456
1dz8CAMCamphor 5-monooxygenase1.14.15.10.455
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.455
2c6hPXICytochrome P450 monooxygenase PikC/0.455
3mdvCL6Cholesterol 24-hydroxylase/0.455
4fz60VGTyrosine-protein kinase SYK2.7.10.20.455
4g1z0VPVitamin D3 receptor A/0.455
4kbyC2EStimulator of interferon genes protein/0.455
4mlhVO2Glucokinase2.7.1.20.455
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.455
4z34ON7Lysophosphatidic acid receptor 1/0.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1s0zEB1Vitamin D3 receptor/0.454
1uzwCDHIsopenicillin N synthase1.21.3.10.454
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2bxe1FLSerum albumin/0.454
2vwx7X4Ephrin type-B receptor 42.7.10.10.454
3mdmFJZCholesterol 24-hydroxylase/0.454
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.454
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.454
4fyn0VETyrosine-protein kinase SYK2.7.10.20.454
4ruoBIVVitamin D3 receptor A/0.454
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.453
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.453
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.453
3h1vTK1Glucokinase2.7.1.20.453
3irxUDRGag-Pol polyprotein2.7.7.490.453
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.453
3qm4PN0Cytochrome P450 2D6/0.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
3v9v21LPeroxisome proliferator-activated receptor gamma/0.453
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.453
4iah1DXAlr2278 protein/0.453
4jlk1NODeoxycytidine kinase2.7.1.740.453
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.452
1pjkANPCasein kinase II subunit alpha2.7.11.10.452
1txiTX5Vitamin D3 receptor/0.452
1zeoC01Peroxisome proliferator-activated receptor gamma/0.452
2pmdGNPTranslation initiation factor 2 subunit gamma/0.452
2vg7NNIGag-Pol polyprotein2.7.7.490.452
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
2ze2T27Gag-Pol polyprotein2.7.7.490.452
3gbuATPUncharacterized sugar kinase PH14592.7.10.452
3pe6ZYHMonoglyceride lipase/0.452
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.452
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.452
3uzcT4EAdenosine receptor A2a/0.452
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.451
1s19MC9Vitamin D3 receptor/0.451
1v7aFRCAdenosine deaminase3.5.4.40.451
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2hasC3OVitamin D3 receptor/0.451
2hb7O1CVitamin D3 receptor/0.451
2hcdBIVVitamin D3 receptor A/0.451
2j4z626Aurora kinase A2.7.11.10.451
2j7t274Serine/threonine-protein kinase 102.7.11.10.451
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.451
3fwjCAMCamphor 5-monooxygenase1.14.15.10.451
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3ictCOACoenzyme A disulfide reductase/0.451
3inwJZBHeat shock protein HSP 90-alpha/0.451
3oafOAGDihydrofolate reductase1.5.1.30.451
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.451
3t2kFADSulfide-quinone reductase/0.451
3tdaPN0Cytochrome P450 2D6/0.451
3vs3VSETyrosine-protein kinase HCK2.7.10.20.451
3vtdTKDVitamin D3 receptor/0.451
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.451
4fhh0U3Vitamin D3 receptor A/0.451
5e8xSTUTGF-beta receptor type-12.7.11.300.451
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1iyzNDPProbable quinone oxidoreductase/0.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.450
3at4CCKCasein kinase II subunit alpha2.7.11.10.450
4cd2FOLDihydrofolate reductase1.5.1.30.450
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
5itzLOCTubulin beta-2B chain/0.450
3rfmCFFAdenosine receptor A2a/0.450
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1oc1ASVIsopenicillin N synthase1.21.3.10.449
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.449
1uyfPU1Heat shock protein HSP 90-alpha/0.449
1zys199Serine/threonine-protein kinase Chk12.7.11.10.449
2qblCAMCamphor 5-monooxygenase1.14.15.10.449
3icsCOACoenzyme A disulfide reductase/0.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
3stxBKAMethylketone synthase I/0.449
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4gk3L87Ephrin type-A receptor 32.7.10.10.449
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.449
4i3wNADAldehyde dehydrogenase (NAD+)/0.449
4j6cSTRCytochrome P450 monooxygenase/0.449
4l8u9AZSerum albumin/0.449
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1rkgVD1Vitamin D3 receptor/0.448
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.448
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2qe4JJ3Estrogen receptor/0.448
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.448
2xw7NDPDihydrofolate reductase/0.448
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.448
3cbsR12Cellular retinoic acid-binding protein 2/0.448
3deiRXBCaspase-33.4.22.560.448
3ghwGHWDihydrofolate reductase1.5.1.30.448
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.448
3megT27Gag-Pol polyprotein2.7.7.490.448
3opdHIEHeat shock protein 83/0.448
3w5rLOAVitamin D3 receptor/0.448
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.448
4b7dQLECytochrome P450 monooxygenase PikC/0.448
4gmy0X5Tyrosine-protein kinase JAK2/0.448
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.448
1culFOKAdenylate cyclase type 2/0.447
1culFOKAdenylate cyclase type 5/0.447
1pl8NADSorbitol dehydrogenase1.1.1.140.447
1rkhVD2Vitamin D3 receptor/0.447
1zhwHC2Oxysterol-binding protein homolog 4/0.447
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.447
2hamC33Vitamin D3 receptor/0.447
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.447
2vcmM11Isopenicillin N synthase1.21.3.10.447
2wsaMYAGlycylpeptide N-tetradecanoyltransferase/0.447
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.447
3ft8MOJHeat shock protein HSP 90-alpha/0.447
3l0lHC3Nuclear receptor ROR-gamma/0.447
3mqe416Prostaglandin G/H synthase 21.14.99.10.447
3o0iP54Heat shock protein HSP 90-alpha/0.447
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.447
3wd7COAAcridone synthase/0.447
3zk5Z18Cytochrome P450 monooxygenase PikC/0.447
4b8zNAPGDP-L-fucose synthase1.1.1.2710.447
4c2zMYAGlycylpeptide N-tetradecanoyltransferase 1/0.447
4fgg0U5Dihydrofolate reductase1.5.1.30.447
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.447
4r20AERCytochrome P450 family 17 polypeptide 2/0.447
1e26GPBDihydrofolate reductase1.5.1.30.446
1l2jETCEstrogen receptor beta/0.446
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1rg7MTXDihydrofolate reductase1.5.1.30.446
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.446
2o4jVD4Vitamin D3 receptor/0.446
3fwiCAMCamphor 5-monooxygenase1.14.15.10.446
3gkjHC3Niemann-Pick C1 protein/0.446
3icrCOACoenzyme A disulfide reductase/0.446
3inxJZCHeat shock protein HSP 90-alpha/0.446
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.446
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
3vt8YI3Vitamin D3 receptor/0.446
3w0gW07Vitamin D3 receptor/0.446
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4ia2BIVVitamin D3 receptor A/0.446
4jbtASDCytochrome P450 monooxygenase/0.446
4nk92K5Fibroblast growth factor receptor 1/0.446
4nka2K7Fibroblast growth factor receptor 1/0.446
1bifAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.445
1draMTXDihydrofolate reductase1.5.1.30.445
1fmlRTLRetinol dehydratase/0.445
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.445
1hncGDNGlutathione S-transferase Mu 22.5.1.180.445
1ie8KH1Vitamin D3 receptor/0.445
1ndzFR5Adenosine deaminase3.5.4.40.445
1o5rFR9Adenosine deaminase3.5.4.40.445
1ysx4EBSerum albumin/0.445
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.445
2m56CAMCamphor 5-monooxygenase1.14.15.10.445
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
3d7tSTUTyrosine-protein kinase CSK/0.445
3w5tLHPVitamin D3 receptor/0.445
3zuyTCHTransporter/0.445
4gk2L66Ephrin type-A receptor 32.7.10.10.445
4m7vRARDihydrofolate reductase/0.445
4ubsDIFPentalenic acid synthase1.14.15.110.445
1jioDEB6-deoxyerythronolide B hydroxylase/0.444
1lwlDSOCamphor 5-monooxygenase1.14.15.10.444
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1pkfEPDEpothilone C/D epoxidase1.140.444
2bbqPFGThymidylate synthase/0.444
2eb3ANPEpidermal growth factor receptor2.7.10.10.444
2hc4VDXVitamin D3 receptor A/0.444
2jedLG8Protein kinase C theta type2.7.11.130.444
2wi72KLHeat shock protein HSP 90-alpha/0.444
2y30SM8Putative repressor SimReg2/0.444
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.444
2znpK55Peroxisome proliferator-activated receptor delta/0.444
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
3ctj320Hepatocyte growth factor receptor2.7.10.10.444
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3tqhNDPQuinone oxidoreductase/0.444
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.444
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4ib4ERM5-hydroxytryptamine receptor 2B/0.444
4lxhC1EAlpha/beta hydrolase fold/0.444
4nxvGDPMitochondrial dynamics protein MID51/0.444
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1phgMYTCamphor 5-monooxygenase1.14.15.10.443
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.443
1xddAAYIntegrin alpha-L/0.443
1yrcCAMCamphor 5-monooxygenase1.14.15.10.443
2fszOHTEstrogen receptor beta/0.443
2fzjDH3Dihydrofolate reductase1.5.1.30.443
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.443
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.443
3w0jT08Vitamin D3 receptor/0.443
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.443
4nr42LKCREB-binding protein/0.443
5c8yACPTubulin tyrosine ligase/0.443
1k6pXN3Gag-Pol polyprotein3.4.23.160.442
1lhvNOGSex hormone-binding globulin/0.442
1qoqIGPTryptophan synthase alpha chain/0.442
1uyePU9Heat shock protein HSP 90-alpha/0.442
1w2xRCPAcetyl-CoA carboxylase/0.442
1ykdCMPAdenylate cyclase/0.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2cig1DGDihydrofolate reductase1.5.1.30.442
2w3wVG9Dihydrofolate reductase/0.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.442
3pxkPXKFocal adhesion kinase 12.7.10.20.442
3qj5022Alcohol dehydrogenase class-31.1.1.10.442
3vt45YIVitamin D3 receptor/0.442
3wowANPCasein kinase II subunit alpha2.7.11.10.442
4c68NHWGlycylpeptide N-tetradecanoyltransferase/0.442
4dgo0JWCasein kinase II subunit alpha2.7.11.10.442
4i2q1BTGag-Pol polyprotein2.7.7.490.442
4kbk1QGCasein kinase I isoform delta2.7.11.10.442
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.442
4l9q9TPSerum albumin/0.442
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.442
4wkqIREEpidermal growth factor receptor2.7.10.10.442
4k5y1Q5Corticotropin-releasing factor receptor 1/0.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1felFENRetinol-binding protein 4/0.441
2ca0PXICytochrome P450 monooxygenase PikC/0.441
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.441
2zlaVDBVitamin D3 receptor/0.441
3cv9VDXVitamin D3 dihydroxylase/0.441
3dhoB2MStreptogramin A acetyltransferase2.3.10.441
3fc152PMitogen-activated protein kinase 14/0.441
3h1jSMACytochrome b/0.441
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3uteFADUDP-galactopyranose mutase/0.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.441
3vtcTK3Vitamin D3 receptor/0.441
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.441
4dymIYZActivin receptor type-12.7.11.300.441
4ko0JLJGag-Pol polyprotein2.7.7.490.441
5cp4CAMCamphor 5-monooxygenase1.14.15.10.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
1aj8COACitrate synthase/0.440
1iwiCAMCamphor 5-monooxygenase1.14.15.10.440
1jipKTN6-deoxyerythronolide B hydroxylase/0.440
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.440
1rd7FOLDihydrofolate reductase1.5.1.30.440
1synF89Thymidylate synthase/0.440
1upw444Oxysterols receptor LXR-beta/0.440
1uyhPU0Heat shock protein HSP 90-alpha/0.440
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.440
3a783EVVitamin D3 receptor/0.440
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3dxjNE6DNA-directed RNA polymerase subunit beta/0.440
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.440
3h0a9RARetinoic acid receptor RXR-alpha/0.440
3ih0ANPUncharacterized sugar kinase PH14592.7.10.440
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.440
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.440
3vt5YI2Vitamin D3 receptor/0.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4i8vBHFCytochrome P450 1A11.14.14.10.440
4jbqVX6Aurora kinase A2.7.11.10.440
4lcf1WLUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.440
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
5cdsPFBAlcohol dehydrogenase E chain1.1.1.10.440
6cp4CAMCamphor 5-monooxygenase1.14.15.10.440