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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c68CT6Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c68CT6Cyclin-dependent kinase 22.7.11.221.000
1w8cN69Cyclin-dependent kinase 22.7.11.220.698
3rahO1ZCyclin-dependent kinase 22.7.11.220.633
2c69CT8Cyclin-dependent kinase 22.7.11.220.623
3r9nZ68Cyclin-dependent kinase 22.7.11.220.576
2c6mDT5Cyclin-dependent kinase 22.7.11.220.571
3r8uZ31Cyclin-dependent kinase 22.7.11.220.567
2r3fSC8Cyclin-dependent kinase 22.7.11.220.566
2r3gSC9Cyclin-dependent kinase 22.7.11.220.562
2c6o4SPCyclin-dependent kinase 22.7.11.220.560
4fklCK2Cyclin-dependent kinase 22.7.11.220.558
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.551
3r71X86Cyclin-dependent kinase 22.7.11.220.549
3r8vZ62Cyclin-dependent kinase 22.7.11.220.548
2a0cCK9Cyclin-dependent kinase 22.7.11.220.546
4kd11QKCyclin-dependent kinase 22.7.11.220.544
3lfsA07Cyclin-dependent kinase 22.7.11.220.543
3r7yZ04Cyclin-dependent kinase 22.7.11.220.542
3pj8404Cyclin-dependent kinase 22.7.11.220.540
3qx2X63Cyclin-dependent kinase 22.7.11.220.538
2r3r6SCCyclin-dependent kinase 22.7.11.220.533
3r83Z14Cyclin-dependent kinase 22.7.11.220.533
1v1k3FPCyclin-dependent kinase 22.7.11.220.530
2exmZIPCyclin-dependent kinase 22.7.11.220.530
3qwjX6ACyclin-dependent kinase 22.7.11.220.529
3rm618ZCyclin-dependent kinase 22.7.11.220.526
1gz8MBPCyclin-dependent kinase 22.7.11.220.525
1oiyN41Cyclin-dependent kinase 22.7.11.220.525
3rpo24ZCyclin-dependent kinase 22.7.11.220.523
3r73X87Cyclin-dependent kinase 22.7.11.220.522
2r3mSCXCyclin-dependent kinase 22.7.11.220.521
2a4lRRCCyclin-dependent kinase 22.7.11.220.520
2r3p3SCCyclin-dependent kinase 22.7.11.220.520
2b55D31Cyclin-dependent kinase 22.7.11.220.519
2w06FRVCyclin-dependent kinase 22.7.11.220.519
2c6iDT1Cyclin-dependent kinase 22.7.11.220.518
3qqlX03Cyclin-dependent kinase 22.7.11.220.518
3raiX85Cyclin-dependent kinase 22.7.11.220.518
3lfqA28Cyclin-dependent kinase 22.7.11.220.516
3lfnA27Cyclin-dependent kinase 22.7.11.220.515
3qtsX46Cyclin-dependent kinase 22.7.11.220.514
1h0w207Cyclin-dependent kinase 22.7.11.220.513
2c6lDT4Cyclin-dependent kinase 22.7.11.220.513
3r8pZ46Cyclin-dependent kinase 22.7.11.220.512
1p2a5BNCyclin-dependent kinase 22.7.11.220.511
2btsU32Cyclin-dependent kinase 22.7.11.220.511
2r3iSCFCyclin-dependent kinase 22.7.11.220.511
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.511
3r7uX96Cyclin-dependent kinase 22.7.11.220.511
2w05FRTCyclin-dependent kinase 22.7.11.220.509
1h0vUN4Cyclin-dependent kinase 22.7.11.220.508
3rpr25ZCyclin-dependent kinase 22.7.11.220.507
3rm719ZCyclin-dependent kinase 22.7.11.220.506
3iggEFQCyclin-dependent kinase 22.7.11.220.505
3r7iX9ICyclin-dependent kinase 22.7.11.220.504
3sqq99ZCyclin-dependent kinase 22.7.11.220.503
3ezrEZRCyclin-dependent kinase 22.7.11.220.502
3qruX19Cyclin-dependent kinase 22.7.11.220.500
3qxpX64Cyclin-dependent kinase 22.7.11.220.499
3r1sX73Cyclin-dependent kinase 22.7.11.220.498
2fvdLIACyclin-dependent kinase 22.7.11.220.497
3roy22ZCyclin-dependent kinase 22.7.11.220.497
3my5RFZCyclin-dependent kinase 22.7.11.220.495
3qzhX69Cyclin-dependent kinase 22.7.11.220.495
3qtuX44Cyclin-dependent kinase 22.7.11.220.493
2c6kDT2Cyclin-dependent kinase 22.7.11.220.492
2r3kSCQCyclin-dependent kinase 22.7.11.220.492
3qqkX02Cyclin-dependent kinase 22.7.11.220.492
3qzgX67Cyclin-dependent kinase 22.7.11.220.491
3r7vZ02Cyclin-dependent kinase 22.7.11.220.491
3rni21ZCyclin-dependent kinase 22.7.11.220.491
4bgh3I6Cyclin-dependent kinase 22.7.11.220.489
4lyn1YGCyclin-dependent kinase 22.7.11.220.489
2r3o2SCCyclin-dependent kinase 22.7.11.220.488
4btjADPTau-tubulin kinase 12.7.11.10.488
1e1xNW1Cyclin-dependent kinase 22.7.11.220.487
4fkq42KCyclin-dependent kinase 22.7.11.220.486
3qxoX65Cyclin-dependent kinase 22.7.11.220.484
2wpa889Cyclin-dependent kinase 22.7.11.220.483
3qrtX14Cyclin-dependent kinase 22.7.11.220.483
3qziX72Cyclin-dependent kinase 22.7.11.220.483
3ral04ZCyclin-dependent kinase 22.7.11.220.483
1di8DTQCyclin-dependent kinase 22.7.11.220.482
2b53D23Cyclin-dependent kinase 22.7.11.220.482
3dogNNNCyclin-dependent kinase 22.7.11.220.482
1ke6LS2Cyclin-dependent kinase 22.7.11.220.481
1w0xOLOCyclin-dependent kinase 22.7.11.220.480
2c4g514Cyclin-dependent kinase 22.7.11.220.480
2w1hL0FCyclin-dependent kinase 22.7.11.220.480
3qqfX07Cyclin-dependent kinase 22.7.11.220.480
3qtzX42Cyclin-dependent kinase 22.7.11.220.480
2vtsLZCCyclin-dependent kinase 22.7.11.220.479
2iw84SPCyclin-dependent kinase 22.7.11.220.478
4ek816KCyclin-dependent kinase 22.7.11.220.478
5aniES4Cyclin-dependent kinase 22.7.11.220.478
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.477
3qtrX36Cyclin-dependent kinase 22.7.11.220.476
3r28XA0Cyclin-dependent kinase 22.7.11.220.476
3r6xX84Cyclin-dependent kinase 22.7.11.220.476
3tiz3TICyclin-dependent kinase 22.7.11.220.476
3r1yX76Cyclin-dependent kinase 22.7.11.220.475
4bcnT9NCyclin-dependent kinase 22.7.11.220.475
1oi9N20Cyclin-dependent kinase 22.7.11.220.474
1oirHDYCyclin-dependent kinase 22.7.11.220.474
2uzoC62Cyclin-dependent kinase 22.7.11.220.474
3r7eX88Cyclin-dependent kinase 22.7.11.220.474
3rk909ZCyclin-dependent kinase 22.7.11.220.474
4eol1ROCyclin-dependent kinase 22.7.11.220.474
4fkpLS5Cyclin-dependent kinase 22.7.11.220.474
4eor4SPCyclin-dependent kinase 22.7.11.220.473
4fkr45KCyclin-dependent kinase 22.7.11.220.473
2r64740Cyclin-dependent kinase 22.7.11.220.472
3qyw6PBMitogen-activated protein kinase 12.7.11.240.472
1vyw292Cyclin-dependent kinase 22.7.11.220.471
2vttLZDCyclin-dependent kinase 22.7.11.220.471
3r8lZ30Cyclin-dependent kinase 22.7.11.220.471
1h1r6CPCyclin-dependent kinase 22.7.11.220.470
3rpv26ZCyclin-dependent kinase 22.7.11.220.469
1ke7LS3Cyclin-dependent kinase 22.7.11.220.468
1oitHDTCyclin-dependent kinase 22.7.11.220.468
3s1h56ZCyclin-dependent kinase 22.7.11.220.468
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.468
1e9hINRCyclin-dependent kinase 22.7.11.220.467
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.467
2r3q5SCCyclin-dependent kinase 22.7.11.220.467
3ig7EFPCyclin-dependent kinase 22.7.11.220.467
3nieANPMitogen-activated protein kinase/0.467
3r9hZ67Cyclin-dependent kinase 22.7.11.220.467
3rak03ZCyclin-dependent kinase 22.7.11.220.467
3le62BZCyclin-dependent kinase 22.7.11.220.466
4bcoT6QCyclin-dependent kinase 22.7.11.220.465
4fkv61KCyclin-dependent kinase 22.7.11.220.465
4acm7YGCyclin-dependent kinase 22.7.11.220.464
1oguST8Cyclin-dependent kinase 22.7.11.220.463
1r78FMDCyclin-dependent kinase 22.7.11.220.463
1y8yCT7Cyclin-dependent kinase 22.7.11.220.463
3r9dX6BCyclin-dependent kinase 22.7.11.220.463
1h1q2A6Cyclin-dependent kinase 22.7.11.220.462
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.461
1pxjCK2Cyclin-dependent kinase 22.7.11.220.461
3ddpRC8Cyclin-dependent kinase 22.7.11.220.461
3s0o50ZCyclin-dependent kinase 22.7.11.220.461
1pxmCK5Cyclin-dependent kinase 22.7.11.220.460
2b54D05Cyclin-dependent kinase 22.7.11.220.460
2vu3LZECyclin-dependent kinase 22.7.11.220.460
3iok1P6Tyrosine-protein kinase JAK2/0.460
4bcpT3CCyclin-dependent kinase 22.7.11.220.460
1oiuN76Cyclin-dependent kinase 22.7.11.220.459
2iw94SPCyclin-dependent kinase 22.7.11.220.459
1b38ATPCyclin-dependent kinase 22.7.11.220.458
1pxlCK4Cyclin-dependent kinase 22.7.11.220.458
2j0lANPFocal adhesion kinase 12.7.10.20.458
4btjATPTau-tubulin kinase 12.7.11.10.458
2b52D42Cyclin-dependent kinase 22.7.11.220.457
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.457
3rmf20ZCyclin-dependent kinase 22.7.11.220.457
3s2pPMUCyclin-dependent kinase 22.7.11.220.457
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.457
4eon1ROCyclin-dependent kinase 22.7.11.220.457
4fkj11KCyclin-dependent kinase 22.7.11.220.457
4fv9E71Mitogen-activated protein kinase 12.7.11.240.457
4jrnANPRhoptry kinase family protein/0.457
4yswFADXanthine dehydrogenase/oxidase/0.457
3ddqRRCCyclin-dependent kinase 22.7.11.220.456
4erwSTUCyclin-dependent kinase 22.7.11.220.455
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.455
1aq1STUCyclin-dependent kinase 22.7.11.220.454
1gii1PUCyclin-dependent kinase 22.7.11.220.454
1ykr628Cyclin-dependent kinase 22.7.11.220.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
2wihP48Cyclin-dependent kinase 22.7.11.220.454
3ql8X01Cyclin-dependent kinase 22.7.11.220.454
4ivb1J5Tyrosine-protein kinase JAK1/0.454
2r3lSCWCyclin-dependent kinase 22.7.11.220.453
3qx4X4BCyclin-dependent kinase 22.7.11.220.453
3r1qX75Cyclin-dependent kinase 22.7.11.220.453
3s00Z60Cyclin-dependent kinase 22.7.11.220.453
4eok4SPCyclin-dependent kinase 22.7.11.220.453
4h3qANPMitogen-activated protein kinase 12.7.11.240.453
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1ke9LS5Cyclin-dependent kinase 22.7.11.220.452
2ds11CDCyclin-dependent kinase 22.7.11.220.452
2xa4AZ5Tyrosine-protein kinase JAK2/0.452
2zjwREFCasein kinase II subunit alpha2.7.11.10.452
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.452
3rkb12ZCyclin-dependent kinase 22.7.11.220.452
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.452
4fob0USALK tyrosine kinase receptor2.7.10.10.452
3pe2E1BCasein kinase II subunit alpha2.7.11.10.451
3rk507ZCyclin-dependent kinase 22.7.11.220.451
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.451
4zohFADPutative oxidoreductase FAD-binding subunit/0.451
5e8ySTUTGF-beta receptor type-22.7.11.300.451
2duv371Cyclin-dependent kinase 22.7.11.220.450
3uli1N3Cyclin-dependent kinase 22.7.11.220.450
3wblPDYCyclin-dependent kinase 22.7.11.220.450
3zh8C58Protein kinase C iota type2.7.11.130.450
1h1s4SPCyclin-dependent kinase 22.7.11.220.449
2p33J07Mitogen-activated protein kinase 102.7.11.240.449
2uxoTACHTH-type transcriptional regulator TtgR/0.449
3ormAGSSerine/threonine protein kinase/0.449
3rjc06ZCyclin-dependent kinase 22.7.11.220.449
4fki09KCyclin-dependent kinase 22.7.11.220.449
1unlRRCCyclin-dependent-like kinase 52.7.11.10.447
1y91CT9Cyclin-dependent kinase 22.7.11.220.447
2uznC96Cyclin-dependent kinase 22.7.11.220.447
3at4CCKCasein kinase II subunit alpha2.7.11.10.447
3qwkX62Cyclin-dependent kinase 22.7.11.220.447
4bcqTJFCyclin-dependent kinase 22.7.11.220.447
4fkw62KCyclin-dependent kinase 22.7.11.220.447
5e8wSTUTGF-beta receptor type-12.7.11.300.447
3r8zZ63Cyclin-dependent kinase 22.7.11.220.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
4ii5ADPCyclin-dependent kinase 22.7.11.220.446
1gih1PUCyclin-dependent kinase 22.7.11.220.445
2c5yMTWCyclin-dependent kinase 22.7.11.220.445
3qtwX3ACyclin-dependent kinase 22.7.11.220.445
3sw418KCyclin-dependent kinase 22.7.11.220.445
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.445
2bhhRYUCyclin-dependent kinase 22.7.11.220.444
1pxpCK8Cyclin-dependent kinase 22.7.11.220.443
2cchATPCyclin-dependent kinase 22.7.11.220.443
2pwlACPFibroblast growth factor receptor 2/0.443
2x1nX1NCyclin-dependent kinase 22.7.11.220.443
3pxyJWSCyclin-dependent kinase 22.7.11.220.443
3rvg17PTyrosine-protein kinase JAK2/0.443
3sheI85MAP kinase-activated protein kinase 32.7.11.10.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bcmT7ZCyclin-dependent kinase 22.7.11.220.443
4cfnJYMCyclin-dependent kinase 22.7.11.220.443
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.443
4fx360KCyclin-dependent kinase 22.7.11.220.443
1oiqHDUCyclin-dependent kinase 22.7.11.220.442
3eljGS7Mitogen-activated protein kinase 82.7.11.240.442
3hmm855TGF-beta receptor type-12.7.11.300.442
3nga3NGCasein kinase II subunit alpha2.7.11.10.442
3qqhX0ACyclin-dependent kinase 22.7.11.220.442
4c4jX21Dual specificity protein kinase TTK2.7.12.10.442
1h1pCMGCyclin-dependent kinase 22.7.11.220.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2c3qGTXGlutathione S-transferase theta-12.5.1.180.441
2vv9IM9Cyclin-dependent kinase 22.7.11.220.441
2xngA0HAurora kinase A2.7.11.10.441
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3qtxX43Cyclin-dependent kinase 22.7.11.220.441
3tz3B36Acetyl-CoA carboxylase/0.441
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4fkt48KCyclin-dependent kinase 22.7.11.220.441
4gub0Y4Casein kinase II subunit alpha2.7.11.10.441
4hge15VTyrosine-protein kinase JAK2/0.441
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.441
2ckeIQUDeath-associated protein kinase 2/0.440
2r3jSCJCyclin-dependent kinase 22.7.11.220.440
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
3q43D66M1 family aminopeptidase3.4.110.440
4eos1ROCyclin-dependent kinase 22.7.11.220.440
4fv6E57Mitogen-activated protein kinase 12.7.11.240.440