sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 1.000 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.671 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.598 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.589 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.589 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.567 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.558 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.544 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.525 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.524 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.510 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.503 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.498 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.484 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.483 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.483 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.481 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.480 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.477 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.477 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.477 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.476 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.476 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.476 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.475 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.475 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.473 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.473 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.472 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.472 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.472 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.469 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.468 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.467 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.467 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.467 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.467 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.467 | |
| 3v2u | ATP | Protein GAL3 | / | 0.467 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.466 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.466 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.466 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.466 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.465 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.465 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.465 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.464 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.464 | |
| 1yvf | PH7 | Polyprotein | / | 0.464 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.464 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.464 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.464 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.464 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.464 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 2ohv | NHL | Glutamate racemase | / | 0.463 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.463 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.463 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.463 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.462 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.462 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.462 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.462 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.461 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.461 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.461 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.460 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.460 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.460 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.460 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4e2b | FMN | Dehydrogenase | / | 0.460 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.459 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.459 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.458 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.458 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.458 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.458 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.458 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.458 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.457 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.457 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.457 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.457 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.456 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.456 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 4jic | FMN | GTN Reductase | / | 0.456 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.455 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.455 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.455 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.455 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.455 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.455 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.455 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.455 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.454 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.454 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.453 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.453 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.453 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.452 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.452 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.452 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.451 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.451 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.451 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.451 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1kfc | IPL | Tryptophan synthase alpha chain | / | 0.450 | |
| 1ppj | ANY | Cytochrome b | / | 0.450 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.450 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.450 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.450 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.450 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.450 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.450 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.450 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.450 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.449 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.449 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.449 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.449 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4iae | 1DX | Alr2278 protein | / | 0.449 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.448 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.448 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.448 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.448 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.448 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.448 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.448 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.447 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.447 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.447 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.447 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.447 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.447 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.447 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.447 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.447 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.447 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.446 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.446 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.446 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.446 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.446 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.446 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.446 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.446 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.446 | |
| 4rnv | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.446 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.445 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.445 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.445 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.445 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4mkh | AP5 | Adenylate kinase | / | 0.445 | |
| 4o7u | THF | Thymidylate synthase | / | 0.445 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.445 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.444 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.444 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.444 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.444 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.444 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.444 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.444 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.443 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.443 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.443 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3eks | CY9 | Actin-5C | / | 0.443 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.443 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.443 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.442 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.442 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.442 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.442 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.442 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.442 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.442 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.442 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.441 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.441 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.441 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.441 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.441 | |
| 5a3b | APR | SIR2 family protein | / | 0.441 | |
| 1e2n | RCA | Thymidine kinase | / | 0.440 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.440 | |
| 2az3 | CDP | Nucleoside diphosphate kinase | / | 0.440 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.440 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.440 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.440 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.440 |