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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tlx FDA KtzI

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4tlx FDAKtzI / 1.288
4tm1 FDAKtzI / 1.262
4tm4 FDAKtzI / 1.258
4tlz FADKtzI / 1.050
4tm0 FADKtzI / 1.002
4tm3 FADKtzI / 0.945
4b65 FADL-ornithine N(5)-monooxygenase / 0.925
4b63 FADL-ornithine N(5)-monooxygenase / 0.916
5cku FADL-ornithine N(5)-monooxygenase / 0.914
4b68 FADL-ornithine N(5)-monooxygenase / 0.902
4b64 FADL-ornithine N(5)-monooxygenase / 0.873
4b66 FADL-ornithine N(5)-monooxygenase / 0.843
4b69 FADL-ornithine N(5)-monooxygenase / 0.836
4nzh FADL-ornithine N(5)-monooxygenase / 0.827
3s5w FADL-ornithine N(5)-monooxygenase / 0.820
4b67 FADL-ornithine N(5)-monooxygenase / 0.809
2xvf FADPutative flavin-containing monooxygenase / 0.793
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.788
4jq9 FADDihydrolipoyl dehydrogenase / 0.782
4cnk FADL-amino acid oxidase / 0.765
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.762
4hb9 FADUncharacterized protein / 0.761
4x4j FADPutative oxygenase / 0.758
2vqb FADPutative flavin-containing monooxygenase / 0.744
4k2x FADPolyketide oxygenase/hydroxylase / 0.744
1b8s FADCholesterol oxidase 1.1.3.6 0.741
1pdh FASp-hydroxybenzoate hydroxylase / 0.739
3kkj FADRenalase / 0.739
3k4c FADPyranose 2-oxidase / 0.738
3pl8 FADPyranose 2-oxidase / 0.737
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.735
4a99 FADTetX family tetracycline inactivation enzyme / 0.734
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.733
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.733
4mo2 FDAUDP-galactopyranose mutase / 0.730
2xve FADPutative flavin-containing monooxygenase / 0.729
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
4mok FADPyranose 2-oxidase / 0.728
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.726
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.725
2vq7 FADPutative flavin-containing monooxygenase / 0.725
4cnj FADL-amino acid oxidase / 0.725
4k5r FADOxygenase / 0.724
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.723
1k0l FADp-hydroxybenzoate hydroxylase / 0.722
2eq6 FADDihydrolipoyl dehydrogenase / 0.722
3nlc FADUncharacterized protein / 0.722
3lsi FADPyranose 2-oxidase / 0.720
4u2t FADCholesterol oxidase 1.1.3.6 0.719
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.718
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.717
3ada NADSubunit alpha of sarocosine oxidase / 0.716
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.714
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.714
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.713
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.712
4xxg FADCholesterol oxidase 1.1.3.6 0.712
3ict FADCoenzyme A disulfide reductase / 0.711
2gew FADCholesterol oxidase 1.1.3.6 0.710
3cox FADCholesterol oxidase 1.1.3.6 0.710
3t2y FADSulfide-quinone reductase / 0.710
1ijh FADCholesterol oxidase 1.1.3.6 0.709
4guv FADTetX family tetracycline inactivation enzyme / 0.709
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
3k30 ADPHistamine dehydrogenase / 0.708
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.707
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.706
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.706
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.706
3p9u FADTetX family tetracycline inactivation enzyme / 0.706
4fwj FADLysine-specific histone demethylase 1B 1 0.706
3lsm SFDPyranose 2-oxidase / 0.705
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.704
1mxt FAECholesterol oxidase 1.1.3.6 0.704
4rek FADCholesterol oxidase 1.1.3.6 0.704
4u2l SFDCholesterol oxidase 1.1.3.6 0.704
4xwr FADCholesterol oxidase 1.1.3.6 0.704
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.703
3bg7 FADPyranose 2-oxidase / 0.703
3cty FADProbable thioredoxin reductase / 0.703
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.703
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.702
1nhr FADNADH peroxidase 1.11.1.1 0.702
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.702
2o07 MTASpermidine synthase 2.5.1.16 0.702
3ad9 NADSubunit alpha of sarocosine oxidase / 0.702
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.702
1gal FADGlucose oxidase 1.1.3.4 0.701
1n1p FADCholesterol oxidase 1.1.3.6 0.701
1n4w FADCholesterol oxidase 1.1.3.6 0.701
3gyi FADCholesterol oxidase 1.1.3.6 0.701
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.700
3lsh FADPyranose 2-oxidase / 0.699
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.698
2xlr FADPutative flavin-containing monooxygenase / 0.698
2yg6 FADPutrescine oxidase / 0.698
4wx1 FDAUDP-galactopyranose mutase / 0.698
1n4u FAECholesterol oxidase 1.1.3.6 0.697
3t2k FADSulfide-quinone reductase / 0.697
4em3 FADCoenzyme A disulfide reductase / 0.697
3utg FDAUDP-galactopyranose mutase / 0.696
1ryi FADGlycine oxidase 1.4.3.19 0.695
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.695
3gsi FADDimethylglycine oxidase 1.5.3.10 0.695
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.694
3ics FADCoenzyme A disulfide reductase / 0.694
3qvr FADGlucose oxidase 1.1.3.4 0.694
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.693
2hmv ADPKtr system potassium uptake protein A / 0.693
2xvi FADPutative flavin-containing monooxygenase / 0.693
2npx FADNADH peroxidase 1.11.1.1 0.692
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
2q7v FADThioredoxin reductase / 0.691
4qi4 FADCellobiose dehydrogenase / 0.690
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.689
2gvc FADThiol-specific monooxygenase 1.14.13 0.689
2xvh FADPutative flavin-containing monooxygenase / 0.689
3uka FADUDP-galactopyranose mutase / 0.689
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.688
2dw4 FADLysine-specific histone demethylase 1A 1 0.688
2e1m FADL-glutamate oxidase / 0.688
2gv8 FADThiol-specific monooxygenase 1.14.13 0.687
2yg3 FADPutrescine oxidase / 0.687
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.687
1n4v FADCholesterol oxidase 1.1.3.6 0.686
2ih2 NEAModification methylase TaqI 2.1.1.72 0.686
2r0c FADPutative FAD-monooxygenase / 0.686
4ynt FDAGlucose oxidase, putative / 0.686
1cc2 FADCholesterol oxidase 1.1.3.6 0.685
1geu FADGlutathione reductase 1.8.1.7 0.685
1nhq FADNADH peroxidase 1.11.1.1 0.685
4bk3 FADProbable salicylate monooxygenase / 0.685
4dna FADProbable glutathione reductase / 0.685
4i58 FADCyclohexylamine Oxidase / 0.685
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.685
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.684
3b6d FAECholesterol oxidase 1.1.3.6 0.684
3cgd FADCoenzyme A disulfide reductase / 0.684
4b1b FADThioredoxin reductase 1.8.1.9 0.684
2yg7 FADPutrescine oxidase / 0.683
3q9t FAYUncharacterized protein / 0.683
2rab FADGlutathione amide reductase / 0.682
2rgh FADAlpha-Glycerophosphate Oxidase / 0.682
3cnj FADCholesterol oxidase 1.1.3.6 0.682
4u2s FDACholesterol oxidase 1.1.3.6 0.682
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
2q0l FADThioredoxin reductase 1.8.1.9 0.681
3mht SAHModification methylase HhaI 2.1.1.37 0.681
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.681
2uyh SAHModification methylase HhaI 2.1.1.37 0.680
3gyj FADCholesterol oxidase 1.1.3.6 0.680
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.680
2xls FADPutative flavin-containing monooxygenase / 0.678
3rha FDAPutrescine oxidase / 0.678
1ges FADGlutathione reductase 1.8.1.7 0.677
3gwd FADCyclohexanone monooxygenase / 0.677
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.676
3ish FADThioredoxin reductase 1.8.1.9 0.676
3rw9 DSHSpermidine synthase 2.5.1.16 0.676
4dsg FADUncharacterized protein / 0.676
4em4 FADCoenzyme A disulfide reductase / 0.676
4la1 FADThioredoxin glutathione reductase / 0.676
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.676
5j60 FADThioredoxin reductase / 0.676
1tdo FADL-amino-acid oxidase 1.4.3.2 0.675
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.675
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.675
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.674
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.674
3ka7 FADPutative oxidoreductase / 0.673
1f8s FADL-amino-acid oxidase 1.4.3.2 0.672
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
1zk7 FADMercuric reductase 1.16.1.1 0.671
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
3icr FADCoenzyme A disulfide reductase / 0.671
3sz0 FADSulfide-quinone reductase / 0.671
2np6 NEAModification methylase TaqI 2.1.1.72 0.670
4ntd FADThioredoxin reductase / 0.670
4yac NAIC alpha-dehydrogenase / 0.670
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
1npx FADNADH peroxidase 1.11.1.1 0.669
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.669
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.669
2eq9 FADDihydrolipoyl dehydrogenase / 0.669
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.669
3lad FADDihydrolipoyl dehydrogenase / 0.669
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.669
4u8l FDAUDP-galactopyranose mutase / 0.669
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.668
4qi7 FADCellobiose dehydrogenase / 0.668
3gwf FADCyclohexanone monooxygenase / 0.667
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.666
2yg5 FADPutrescine oxidase / 0.666
3kpk FADSulfide-quinone reductase / 0.666
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.665
1nhp FADNADH peroxidase 1.11.1.1 0.665
1skm SAHModification methylase HhaI 2.1.1.37 0.665
2ba9 FADPutative aminooxidase / 0.665
2igo FADPyranose 2-oxidase / 0.665
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.665
3we0 FADLysine 2-monooxygenase / 0.665
4c04 SFGProtein arginine N-methyltransferase 6 / 0.665
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.664
1z6l FADPolyamine oxidase FMS1 / 0.663
2c7q SAHModification methylase HhaI 2.1.1.37 0.663
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.663
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.663
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.663
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.662
5hsa FASAlcohol oxidase 1 1.1.3.13 0.662
9mht SAHModification methylase HhaI 2.1.1.37 0.662
1cbo FADCholesterol oxidase 1.1.3.6 0.661
2cdu ADPNADH oxidase / 0.661
3bi5 FADPolyamine oxidase FMS1 / 0.661
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
3qow SAMHistone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.661
4aox FADSteroid monooxygenase / 0.661
4c5o FADPutative monooxygenase / 0.661
1d7y FADFerredoxin reductase / 0.660
1yqz FADCoenzyme A disulfide reductase / 0.660
3dme FADPutative conserved exported protein / 0.660
5l3d FADLysine-specific histone demethylase 1A 1 0.660
1ger FADGlutathione reductase 1.8.1.7 0.659
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.659
2yxl SFG450aa long hypothetical fmu protein / 0.659
3h5n ATPMccB protein / 0.659
2x8h FADThioredoxin glutathione reductase / 0.658
3a25 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.658
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.658
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.658
4e2x SAHMethyltransferase / 0.658
4fk1 FADPutative thioredoxin reductase / 0.658
3jsk AHZThiamine thiazole synthase / 0.657
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.657
3uth FDAUDP-galactopyranose mutase / 0.657
4bk2 FADProbable salicylate monooxygenase / 0.657
4guu FA9Lysine-specific histone demethylase 1B 1 0.657
1qo8 FADFumarate reductase flavoprotein subunit / 0.656
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
2plw SAMRibosomal RNA methyltransferase, putative / 0.656
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
4fp9 SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.656
5hhf FDAUDP-galactopyranose mutase / 0.656
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.654
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.654
3bi2 FADPolyamine oxidase FMS1 / 0.654
3c3y SAHO-methyltransferase / 0.654
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.654
3syi FADSulfide-quinone reductase / 0.654
4fzv SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.654
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.654
7mht SAHModification methylase HhaI 2.1.1.37 0.654
1f8w FADNADH peroxidase 1.11.1.1 0.653
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.653
3rp8 FADFAD-dependent urate hydroxylase / 0.653
4j31 FADKynurenine 3-monooxygenase / 0.653
1get FADGlutathione reductase 1.8.1.7 0.652
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
4j36 FADKynurenine 3-monooxygenase / 0.652
4m37 SAHProtein arginine N-methyltransferase 7 2.1.1 0.652
4ysh FADGlycine oxidase / 0.652
1eg2 MTAModification methylase RsrI 2.1.1.72 0.651
4usr FADMonooxygenase / 0.651
3bgv SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.650
4ap1 FADSteroid monooxygenase / 0.650
4gdc FADUDP-galactopyranose mutase / 0.650
4qi5 FADCellobiose dehydrogenase / 0.650