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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h2p FAD 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.240
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.170
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.154
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.125
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.118
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.067
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.987
4bjz FADProbable salicylate monooxygenase / 0.923
4k5r FADOxygenase / 0.919
4bk3 FADProbable salicylate monooxygenase / 0.890
4bk2 FADProbable salicylate monooxygenase / 0.884
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.844
4k2x FADPolyketide oxygenase/hydroxylase / 0.838
5buk FADFADH2-dependent halogenase / 0.831
4j2w FADKynurenine 3-monooxygenase / 0.825
4j34 FADKynurenine 3-monooxygenase / 0.824
3rp8 FADFAD-dependent urate hydroxylase / 0.819
2qa1 FADPgaE / 0.813
4j33 FADKynurenine 3-monooxygenase / 0.808
4j36 FADKynurenine 3-monooxygenase / 0.808
2xdo FADTetX family tetracycline inactivation enzyme / 0.802
4j31 FADKynurenine 3-monooxygenase / 0.798
1k0j FADp-hydroxybenzoate hydroxylase / 0.789
4hb9 FADUncharacterized protein / 0.789
4icy FADPgaE / 0.788
2qa2 FADPolyketide oxygenase CabE / 0.785
3ept FDAPutative FAD-monooxygenase / 0.780
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.779
1d7l RFLp-hydroxybenzoate hydroxylase / 0.775
1ng3 FADGlycine oxidase 1.4.3.19 0.764
4opg FDAConserved Archaeal protein / 0.763
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.761
4a6n FADTetX family tetracycline inactivation enzyme / 0.760
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.758
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.755
4x4j FADPutative oxygenase / 0.752
2hqm FADGlutathione reductase 1.8.1.7 0.748
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.748
5dbj FADFADH2-dependent halogenase PltA / 0.748
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.747
3lad FADDihydrolipoyl dehydrogenase / 0.747
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.746
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.743
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.741
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.740
2bab FADPutative aminooxidase / 0.739
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.739
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.738
3fmw FADOxygenase / 0.736
4j57 FADThioredoxin reductase 2 1.8.1.9 0.736
4opd FDAConserved Archaeal protein / 0.736
2eq6 FADDihydrolipoyl dehydrogenase / 0.735
1k0l FADp-hydroxybenzoate hydroxylase / 0.734
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.734
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.730
4opi FDAConserved Archaeal protein / 0.730
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.727
3nix FADFlavoprotein/dehydrogenase / 0.726
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
4nte FADDepH / 0.723
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.722
4opt FDAConserved Archaeal protein / 0.721
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.720
2eq8 FADDihydrolipoyl dehydrogenase / 0.720
2eq9 FADDihydrolipoyl dehydrogenase / 0.720
4opc FDAConserved Archaeal protein / 0.720
4opl FDAConserved Archaeal protein / 0.720
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.719
2tpr FADTrypanothione reductase 1.8.1.12 0.719
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.718
2rab FADGlutathione amide reductase / 0.718
1ryi FADGlycine oxidase 1.4.3.19 0.717
2eq7 FADDihydrolipoyl dehydrogenase / 0.717
3atr FDAConserved Archaeal protein / 0.717
4jq9 FADDihydrolipoyl dehydrogenase / 0.717
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.716
1zx9 FADMercuric reductase 1.16.1.1 0.716
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.716
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.714
1feb FADTrypanothione reductase 1.8.1.12 0.713
2wba FADTrypanothione reductase 1.8.1.12 0.713
2zbw FADFerredoxin--NADP reductase / 0.713
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.713
1trb FADThioredoxin reductase 1.8.1.9 0.712
3k4n FADPyranose 2-oxidase / 0.712
4jnq FDAThioredoxin reductase / 0.710
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.709
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.709
1fea FADTrypanothione reductase 1.8.1.12 0.708
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.708
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.707
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.707
1get FADGlutathione reductase 1.8.1.7 0.706
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.706
3atq FDAConserved Archaeal protein / 0.706
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.705
2jk6 FADTrypanothione reductase / 0.705
4ntc FADThioredoxin reductase gliT / 0.705
4ntd FADThioredoxin reductase / 0.705
4jn9 FADDepH / 0.704
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.703
2q0k FADThioredoxin reductase 1.8.1.9 0.703
3axb FADPutative oxidoreductase / 0.703
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.703
3fbs FADOxidoreductase / 0.703
3urh FADDihydrolipoyl dehydrogenase / 0.700
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.699
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.698
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.698
1rsg FADPolyamine oxidase FMS1 / 0.697
4opu FDAConserved Archaeal protein / 0.697
4ysh FADGlycine oxidase / 0.697
1fec FADTrypanothione reductase 1.8.1.12 0.696
1geu FADGlutathione reductase 1.8.1.7 0.696
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.696
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
4fwe FADLysine-specific histone demethylase 1B 1 0.695
2wp5 FADTrypanothione reductase / 0.694
3cnt FADPolyamine oxidase FMS1 / 0.694
3icr FADCoenzyme A disulfide reductase / 0.694
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.693
4gcm FADThioredoxin reductase 1.8.1.9 0.693
1f8w FADNADH peroxidase 1.11.1.1 0.692
2ign FADPyranose 2-oxidase / 0.691
2yqu FADDihydrolipoyl dehydrogenase / 0.691
3cox FADCholesterol oxidase 1.1.3.6 0.691
3lsh FADPyranose 2-oxidase / 0.691
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.691
1zk7 FADMercuric reductase 1.16.1.1 0.689
4cbq FADThioredoxin reductase / 0.689
1h83 FADPolyamine oxidase 1.5.3.14 0.688
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.688
2npx FADNADH peroxidase 1.11.1.1 0.687
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.686
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.686
4mok FADPyranose 2-oxidase / 0.686
1ges FADGlutathione reductase 1.8.1.7 0.685
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.685
3pl8 FADPyranose 2-oxidase / 0.685
1bzl FADTrypanothione reductase 1.8.1.12 0.684
2rgh FADAlpha-Glycerophosphate Oxidase / 0.684
3cge FADCoenzyme A disulfide reductase / 0.683
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.683
3p9u FADTetX family tetracycline inactivation enzyme / 0.683
4dsh FDAUncharacterized protein / 0.683
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.682
2igo FADPyranose 2-oxidase / 0.682
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.682
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.680
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.680
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.680
4a99 FADTetX family tetracycline inactivation enzyme / 0.680
4gut FADLysine-specific histone demethylase 1B 1 0.680
4nev FADTrypanothione reductase / 0.680
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.680
3ics FADCoenzyme A disulfide reductase / 0.679
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.679
4gdp FADPolyamine oxidase FMS1 / 0.679
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.678
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.678
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.678
3lsi FADPyranose 2-oxidase / 0.678
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.678
1ger FADGlutathione reductase 1.8.1.7 0.677
1nhq FADNADH peroxidase 1.11.1.1 0.677
3cgd FADCoenzyme A disulfide reductase / 0.677
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.677
3vqr FADPutative oxidoreductase / 0.677
4hsu FADLysine-specific histone demethylase 1B 1 0.677
1q1w FADPutidaredoxin reductase 1.18.1.5 0.676
4fk1 FADPutative thioredoxin reductase / 0.676
4guu FA9Lysine-specific histone demethylase 1B 1 0.676
4fwj FADLysine-specific histone demethylase 1B 1 0.675
4i58 FADCyclohexylamine Oxidase / 0.675
2v6o FADThioredoxin glutathione reductase / 0.674
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.673
1pdh FASp-hydroxybenzoate hydroxylase / 0.673
2r9z FADGlutathione amide reductase / 0.673
3kpf FADPolyamine oxidase 1.5.3.14 0.673
4fwf FADLysine-specific histone demethylase 1B 1 0.673
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.673
4up3 FADThioredoxin reductase / 0.673
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.672
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.671
2yg5 FADPutrescine oxidase / 0.671
4dna FADProbable glutathione reductase / 0.671
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.670
5hxw FADL-amino acid deaminase / 0.669
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
2q7v FADThioredoxin reductase / 0.667
3cn8 FADPolyamine oxidase FMS1 / 0.667
3k4c FADPyranose 2-oxidase / 0.667
3lsm SFDPyranose 2-oxidase / 0.667
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.667
3v76 FDAUncharacterized protein / 0.667
3if9 FADGlycine oxidase 1.4.3.19 0.666
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.665
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.665
1cl0 FADThioredoxin reductase 1.8.1.9 0.664
1h81 FADPolyamine oxidase 1.5.3.14 0.664
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.664
3cty FADProbable thioredoxin reductase / 0.664
3gsi FADDimethylglycine oxidase 1.5.3.10 0.664
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.664
4j56 FADThioredoxin reductase 2 1.8.1.9 0.664
4kuk RBFPutative blue-light photoreceptor / 0.664
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.664
2wow FADTrypanothione reductase / 0.663
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.662
2y48 FADLysine-specific histone demethylase 1A 1 0.662
2yg3 FADPutrescine oxidase / 0.662
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
4guv FADTetX family tetracycline inactivation enzyme / 0.662
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.662
2x8g FADThioredoxin glutathione reductase / 0.661
3d72 FADVivid PAS protein VVD / 0.661
3zdn FADMonoamine oxidase N 1.4.3.4 0.661
4ccq FADThioredoxin reductase / 0.661
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.661
1q1r FADPutidaredoxin reductase 1.18.1.5 0.660
3bi5 FADPolyamine oxidase FMS1 / 0.660
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.660
1gxf FADTrypanothione reductase 1.8.1.12 0.659
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.659
3bi2 FADPolyamine oxidase FMS1 / 0.659
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.659
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.658
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.658
1ng4 FADGlycine oxidase 1.4.3.19 0.658
1nhp FADNADH peroxidase 1.11.1.1 0.658
2cdu FADNADH oxidase / 0.658
3cnd FADPolyamine oxidase FMS1 / 0.658
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.658
4gus FADLysine-specific histone demethylase 1B 1 0.658
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.657
4ccr FADThioredoxin reductase / 0.657
4ech FADPolyamine oxidase FMS1 / 0.657
1xpq FADPolyamine oxidase FMS1 / 0.656
4c5o FADPutative monooxygenase / 0.656
1tyt FADTrypanothione reductase 1.8.1.12 0.654
2b9w FADPutative aminooxidase / 0.654
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.653
3ict FADCoenzyme A disulfide reductase / 0.653
3ka7 FADPutative oxidoreductase / 0.653
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.653
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.652
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.652
1phh FADp-hydroxybenzoate hydroxylase / 0.651
1tdo FADL-amino-acid oxidase 1.4.3.2 0.651
1z6l FADPolyamine oxidase FMS1 / 0.651
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.651
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.651
2vvl FADMonoamine oxidase N 1.4.3.4 0.650
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.650