sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1onf | FAD | Glutathione reductase | 1.8.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 1onf | FAD | Glutathione reductase | 1.8.1.7 | 1.240 | |
| 3dk4 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.917 | |
| 1zx9 | FAD | Mercuric reductase | 1.16.1.1 | 0.915 | |
| 3dk8 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.909 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.907 | |
| 3grs | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.906 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.892 | |
| 1gre | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.891 | |
| 1grh | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.889 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.876 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.871 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.870 | |
| 3dh9 | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.863 | |
| 3djg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.863 | |
| 1zk7 | FAD | Mercuric reductase | 1.16.1.1 | 0.861 | |
| 1grg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.854 | |
| 1gsn | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.854 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.849 | |
| 4gr1 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.848 | |
| 1geu | FAD | Glutathione reductase | 1.8.1.7 | 0.844 | |
| 1gra | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.837 | |
| 1ger | FAD | Glutathione reductase | 1.8.1.7 | 0.833 | |
| 4b1b | FAD | Thioredoxin reductase | 1.8.1.9 | 0.832 | |
| 3lad | FAD | Dihydrolipoyl dehydrogenase | / | 0.818 | |
| 2nvk | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.814 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.814 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.810 | |
| 1bwc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.808 | |
| 1get | FAD | Glutathione reductase | 1.8.1.7 | 0.807 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.806 | |
| 3sqp | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.804 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.803 | |
| 1k4q | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.802 | |
| 3dgz | FAD | Thioredoxin reductase 2, mitochondrial | 1.8.1.9 | 0.802 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.800 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.800 | |
| 1zmd | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.797 | |
| 3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.797 | |
| 2qae | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.791 | |
| 3rnm | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.789 | |
| 1feb | FAD | Trypanothione reductase | 1.8.1.12 | 0.787 | |
| 2eq7 | FAD | Dihydrolipoyl dehydrogenase | / | 0.783 | |
| 1ges | FAD | Glutathione reductase | 1.8.1.7 | 0.782 | |
| 2v6o | FAD | Thioredoxin glutathione reductase | / | 0.782 | |
| 4kpr | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.780 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.776 | |
| 1gxf | FAD | Trypanothione reductase | 1.8.1.12 | 0.773 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.766 | |
| 1jeh | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.765 | |
| 2wp5 | FAD | Trypanothione reductase | / | 0.764 | |
| 1lpf | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.761 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.759 | |
| 1ebd | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.758 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.754 | |
| 2a8x | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.753 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.751 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.751 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.748 | |
| 1lvl | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.748 | |
| 1fec | FAD | Trypanothione reductase | 1.8.1.12 | 0.746 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.746 | |
| 2eq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.745 | |
| 2eq8 | FAD | Dihydrolipoyl dehydrogenase | / | 0.743 | |
| 3ic9 | FAD | Putative dihydrolipoamide dehydrogenase | / | 0.739 | |
| 4nev | FAD | Trypanothione reductase | / | 0.739 | |
| 1f8r | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.738 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.738 | |
| 1reo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.737 | |
| 3cnt | FAD | Polyamine oxidase FMS1 | / | 0.736 | |
| 2c3c | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.734 | |
| 2f5z | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.734 | |
| 2jk6 | FAD | Trypanothione reductase | / | 0.734 | |
| 1zmc | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.733 | |
| 3oz2 | FAD | Digeranylgeranylglycerophospholipid reductase | / | 0.732 | |
| 2c3d | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.731 | |
| 2wow | FAD | Trypanothione reductase | / | 0.731 | |
| 2yqu | FAD | Dihydrolipoyl dehydrogenase | / | 0.731 | |
| 4j56 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.731 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.730 | |
| 4hb9 | FAD | Uncharacterized protein | / | 0.729 | |
| 1fea | FAD | Trypanothione reductase | 1.8.1.12 | 0.728 | |
| 5j60 | FAD | Thioredoxin reductase | / | 0.726 | |
| 3urh | FAD | Dihydrolipoyl dehydrogenase | / | 0.724 | |
| 3lzx | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.723 | |
| 1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.722 | |
| 4jq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.722 | |
| 1tdn | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.720 | |
| 2r9z | FAD | Glutathione amide reductase | / | 0.720 | |
| 1bzl | FAD | Trypanothione reductase | 1.8.1.12 | 0.719 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.719 | |
| 4fwf | FAD | Lysine-specific histone demethylase 1B | 1 | 0.719 | |
| 2qa1 | FAD | PgaE | / | 0.717 | |
| 1h6v | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.715 | |
| 3oc4 | FAD | Oxidoreductase, pyridine nucleotide-disulfide family | / | 0.715 | |
| 1kif | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.714 | |
| 4j36 | FAD | Kynurenine 3-monooxygenase | / | 0.713 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.712 | |
| 3qfb | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.710 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.710 | |
| 1tdo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.708 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.705 | |
| 4opc | FDA | Conserved Archaeal protein | / | 0.703 | |
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.702 | |
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.702 | |
| 5l3d | FAD | Lysine-specific histone demethylase 1A | 1 | 0.702 | |
| 1y56 | FAD | 382aa long hypothetical sarcosine oxidase | / | 0.701 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.700 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.700 | |
| 1mo9 | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.698 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.698 | |
| 4cnk | FAD | L-amino acid oxidase | / | 0.697 | |
| 2cfy | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.696 | |
| 3fmw | FAD | Oxygenase | / | 0.696 | |
| 3ka7 | FAD | Putative oxidoreductase | / | 0.696 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.694 | |
| 3lov | FAD | Protoporphyrinogen oxidase | / | 0.694 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.694 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.694 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.694 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.692 | |
| 2b9x | FAD | Putative aminooxidase | / | 0.692 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.692 | |
| 4xwz | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.691 | |
| 1nhr | FAD | NADH peroxidase | 1.11.1.1 | 0.690 | |
| 1nhs | FAD | NADH peroxidase | 1.11.1.1 | 0.690 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.690 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.690 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.689 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.688 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.688 | |
| 3cox | FAD | Cholesterol oxidase | 1.1.3.6 | 0.687 | |
| 4hj6 | FMN | LOV protein | / | 0.687 | |
| 2bab | FAD | Putative aminooxidase | / | 0.686 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.686 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.685 | |
| 3alj | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.685 | |
| 5g3s | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.684 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.683 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.683 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.683 | |
| 2yg6 | FAD | Putrescine oxidase | / | 0.683 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.683 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.683 | |
| 2y48 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.682 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.682 | |
| 4g73 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.682 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.681 | |
| 1mok | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.680 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.680 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.679 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.679 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.679 | |
| 2xdo | FAD | TetX family tetracycline inactivation enzyme | / | 0.678 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.678 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.677 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.676 | |
| 2w0h | FAD | Trypanothione reductase | / | 0.675 | |
| 4gut | FAD | Lysine-specific histone demethylase 1B | 1 | 0.673 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.673 | |
| 1npx | FAD | NADH peroxidase | 1.11.1.1 | 0.672 | |
| 4cy8 | FDA | 2-hydroxybiphenyl-3-monooxygenase | / | 0.672 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.672 | |
| 1gte | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.671 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.671 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.670 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.670 | |
| 4emw | FAD | Coenzyme A disulfide reductase | / | 0.670 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.669 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.668 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.668 | |
| 2jb1 | FAD | L-amino acid oxidase | / | 0.668 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.668 | |
| 3all | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.666 | |
| 4x4j | FAD | Putative oxygenase | / | 0.666 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.665 | |
| 1tdf | FAD | Thioredoxin reductase | 1.8.1.9 | 0.665 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.664 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.664 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.664 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.663 | |
| 4h4v | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.663 | |
| 1k0j | FAD | p-hydroxybenzoate hydroxylase | / | 0.662 | |
| 4cbq | FAD | Thioredoxin reductase | / | 0.662 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.662 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.662 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.662 | |
| 4opt | FDA | Conserved Archaeal protein | / | 0.662 | |
| 4rsl | FAD | Fructosyl peptide oxidase | / | 0.662 | |
| 3atq | FDA | Conserved Archaeal protein | / | 0.661 | |
| 3we0 | FAD | Lysine 2-monooxygenase | / | 0.661 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.660 | |
| 2jae | FAD | L-amino acid oxidase | / | 0.660 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.660 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.659 | |
| 4jnq | FDA | Thioredoxin reductase | / | 0.659 | |
| 2cdu | FAD | NADH oxidase | / | 0.658 | |
| 3ad9 | FAD | Subunit beta of sarcosine oxidase | / | 0.658 | |
| 4j33 | FAD | Kynurenine 3-monooxygenase | / | 0.658 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.657 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.657 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.657 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.657 | |
| 4gcm | FAD | Thioredoxin reductase | 1.8.1.9 | 0.657 | |
| 1fl2 | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.656 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.656 | |
| 1m6i | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.656 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.656 | |
| 2xyo | FAD | TetX family tetracycline inactivation enzyme | / | 0.656 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.656 | |
| 5fs8 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.656 | |
| 3kpf | FAD | Polyamine oxidase | 1.5.3.14 | 0.655 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.655 | |
| 1tde | FAD | Thioredoxin reductase | 1.8.1.9 | 0.654 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.654 | |
| 4guu | FA9 | Lysine-specific histone demethylase 1B | 1 | 0.654 | |
| 4k5r | FAD | Oxygenase | / | 0.654 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.654 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.653 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.653 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.653 | |
| 1ve9 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.652 | |
| 2jb2 | FAD | L-amino acid oxidase | / | 0.652 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.652 | |
| 4jn9 | FAD | DepH | / | 0.652 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.651 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.651 | |
| 1ng3 | FAD | Glycine oxidase | 1.4.3.19 | 0.650 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.650 | |
| 4j31 | FAD | Kynurenine 3-monooxygenase | / | 0.650 |