sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fr0 | SAM | Arsenic methyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4fr0 | SAM | Arsenic methyltransferase | / | 1.000 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.507 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.506 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.499 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.497 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.490 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.485 | |
| 2ibt | NEA | Modification methylase TaqI | 2.1.1.72 | 0.479 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.478 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.478 | |
| 3roc | 29A | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.477 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.477 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.477 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.477 | |
| 1c70 | L75 | Protease | / | 0.476 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.476 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.475 | |
| 5kj6 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.475 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.474 | |
| 3pt9 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.474 | |
| 5je3 | SAH | Methyl transferase | / | 0.474 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.471 | |
| 3f46 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.471 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.470 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 3qv2 | SAH | 5-cytosine DNA methyltransferase | / | 0.469 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.469 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.467 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.467 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.467 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.467 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.466 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.466 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.466 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.466 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.466 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.466 | |
| 5upj | UIN | Gag-Pol polyprotein | / | 0.466 | |
| 1qbu | 846 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.465 | |
| 4qpp | SAH | Protein arginine N-methyltransferase 6 | / | 0.465 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.464 | |
| 5cdt | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.463 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1c6y | MK1 | Protease | / | 0.462 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 1qan | SAH | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.462 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 1qbs | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3abi | NAD | Uncharacterized protein | / | 0.461 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.461 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.461 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.460 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.460 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.460 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 5cdg | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.460 | |
| 5e72 | SAM | N2, N2-dimethylguanosine tRNA methyltransferase | / | 0.460 | |
| 1axe | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.459 | |
| 1rby | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.459 | |
| 3dag | FEG | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.459 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.459 | |
| 1c6x | 3IN | Protease | / | 0.458 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.458 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.458 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.458 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.458 | |
| 3swr | SFG | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.458 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.457 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1hdz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.456 | |
| 1skm | SAH | Modification methylase HhaI | 2.1.1.37 | 0.456 | |
| 2gci | MRR | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.456 | |
| 2nxe | SAM | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.456 | |
| 2qe6 | SAM | Uncharacterized protein | / | 0.456 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.456 | |
| 3f47 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.456 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.456 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.456 | |
| 4hxy | NDP | Plm1 | / | 0.456 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.455 | |
| 2dpm | SAM | Modification methylase DpnIIA | 2.1.1.72 | 0.455 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.455 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.455 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.455 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.455 | |
| 1eby | BEB | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.454 | |
| 1rc0 | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.454 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.454 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.454 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.454 | |
| 4e2b | FMN | Dehydrogenase | / | 0.454 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 4hla | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.454 | |
| 9mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.454 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.453 | |
| 2vht | ATP | NTPase P4 | / | 0.453 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.453 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.453 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4l8u | 9AZ | Serum albumin | / | 0.453 | |
| 4zvm | DM2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.453 | |
| 5epe | SAH | Uncharacterized protein | / | 0.453 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.452 | |
| 1rbz | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.452 | |
| 2vwp | NDP | Glucose 1-dehydrogenase | / | 0.452 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.452 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.452 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.451 | |
| 1w5v | BE3 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2oxt | SAM | Genome polyprotein | / | 0.451 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.451 | |
| 3r7u | X96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.451 | |
| 1aj8 | COA | Citrate synthase | / | 0.450 | |
| 1b6p | PI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.450 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.450 | |
| 1qao | SAM | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.450 | |
| 1qaq | SFG | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.450 | |
| 2rkf | AB1 | Pol protein | / | 0.450 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.450 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.450 | |
| 4gbe | SAH | DNA adenine methylase | 2.1.1.72 | 0.450 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4ylh | YE1 | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase | / | 0.450 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.449 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.449 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.449 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.449 | |
| 2i4u | DJR | Protease | / | 0.449 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2uzv | SS5 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.449 | |
| 2zwv | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.449 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.449 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3o9z | NAD | Lipopolysaccaride biosynthesis protein wbpB | / | 0.449 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.449 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 4c05 | SAH | Protein arginine N-methyltransferase 6 | / | 0.449 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.449 | |
| 1g38 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.448 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.448 | |
| 2xvq | 9DS | Serum albumin | / | 0.448 | |
| 2xye | CXG | Gag-Pol polyprotein | / | 0.448 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.448 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.448 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.448 | |
| 6gsw | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.448 | |
| 1c3e | NHR | Phosphoribosylglycinamide formyltransferase | / | 0.447 | |
| 1eag | A70 | Candidapepsin-2 | 3.4.23.24 | 0.447 | |
| 1gqt | ACP | Ribokinase | / | 0.447 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.447 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.447 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.447 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.447 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2zif | SAM | Methyltransferase | / | 0.447 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.447 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.447 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.447 | |
| 4ein | NOH | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 4hjf | C2E | GGDEF family protein | / | 0.447 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.446 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.446 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.446 | |
| 2b1p | AIZ | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.446 | |
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 0.446 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.446 | |
| 2ohv | NHL | Glutamate racemase | / | 0.446 | |
| 2owu | SAH | Diphthine synthase | / | 0.446 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 2q29 | ACO | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.446 | |
| 2xgo | ZKD | Uncharacterized protein | / | 0.446 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.446 | |
| 3cgo | JNO | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 3hzt | J60 | Calmodulin-like domain protein kinase isoform 3 | / | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.446 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.446 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4cjw | CBJ | Integrase | / | 0.446 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.446 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.446 | |
| 5cds | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1ajv | NMB | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.445 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 3fz1 | B98 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3h65 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.445 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.445 | |
| 3ndx | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.445 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.445 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 1hsh | MK1 | Gag-Pol polyprotein | / | 0.444 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.444 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.444 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.444 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.444 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.444 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.444 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.444 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.444 | |
| 4kwh | NAP | Reductase homolog | / | 0.444 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.444 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 2btr | U73 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2fdd | 385 | Pol protein | / | 0.443 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.443 | |
| 3e8c | G96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3tku | M77 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.443 | |
| 3upj | U03 | Gag-Pol polyprotein | / | 0.443 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.443 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.443 | |
| 5cds | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 6upj | NIU | Gag-Pol polyprotein | / | 0.443 | |
| 7mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.443 | |
| 1eg2 | MTA | Modification methylase RsrI | 2.1.1.72 | 0.442 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 1pyd | TDP | Pyruvate decarboxylase isozyme 1 | / | 0.442 | |
| 2c7q | SAH | Modification methylase HhaI | 2.1.1.37 | 0.442 | |
| 2q55 | MU0 | Protease | / | 0.442 | |
| 2qhc | AB1 | Protease | / | 0.442 | |
| 3ort | AGS | Serine/threonine protein kinase | / | 0.442 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 3up0 | D7S | aceDAF-12 | / | 0.442 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.442 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.442 | |
| 4hdp | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4q1x | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 5hxw | FAD | L-amino acid deaminase | / | 0.442 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.442 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1c6z | ROC | Protease | / | 0.441 | |
| 1pxl | CK4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 1w5x | BE5 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.441 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.441 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3cis | ATP | Universal stress protein Rv2623 | / | 0.441 | |
| 3grr | SAH | Probable ribosomal RNA small subunit methyltransferase A | / | 0.441 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.441 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.441 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
| 3mxd | K53 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.441 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.441 | |
| 3vey | 0H5 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.441 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.441 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.441 | |
| 1c2t | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.440 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.440 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.440 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1g35 | AHF | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1lld | NAD | L-lactate dehydrogenase 2 | 1.1.1.27 | 0.440 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.440 | |
| 2ceo | T44 | Thyroxine-binding globulin | / | 0.440 | |
| 2hs2 | 017 | Protease | / | 0.440 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.440 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3q5d | GDP | Atlastin-1 | 3.6.5 | 0.440 | |
| 3ua3 | SAH | Protein arginine N-methyltransferase 5 | / | 0.440 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.440 | |
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.440 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.440 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.440 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.440 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.440 |