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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eon1ROCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4eon1ROCyclin-dependent kinase 22.7.11.221.000
1h1r6CPCyclin-dependent kinase 22.7.11.220.590
1h1s4SPCyclin-dependent kinase 22.7.11.220.570
4fki09KCyclin-dependent kinase 22.7.11.220.559
2w1hL0FCyclin-dependent kinase 22.7.11.220.549
1g5sI17Cyclin-dependent kinase 22.7.11.220.546
1oitHDTCyclin-dependent kinase 22.7.11.220.545
3lfqA28Cyclin-dependent kinase 22.7.11.220.545
4fkpLS5Cyclin-dependent kinase 22.7.11.220.545
1aq1STUCyclin-dependent kinase 22.7.11.220.544
3rk708ZCyclin-dependent kinase 22.7.11.220.544
3rni21ZCyclin-dependent kinase 22.7.11.220.541
3lfnA27Cyclin-dependent kinase 22.7.11.220.540
2w05FRTCyclin-dependent kinase 22.7.11.220.537
3qu0X40Cyclin-dependent kinase 22.7.11.220.537
4acm7YGCyclin-dependent kinase 22.7.11.220.537
4eor4SPCyclin-dependent kinase 22.7.11.220.536
4ek816KCyclin-dependent kinase 22.7.11.220.535
2btrU73Cyclin-dependent kinase 22.7.11.220.533
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.533
3ddqRRCCyclin-dependent kinase 22.7.11.220.533
4fkj11KCyclin-dependent kinase 22.7.11.220.533
2b52D42Cyclin-dependent kinase 22.7.11.220.532
3pj8404Cyclin-dependent kinase 22.7.11.220.532
1e1xNW1Cyclin-dependent kinase 22.7.11.220.531
2btsU32Cyclin-dependent kinase 22.7.11.220.531
2iw94SPCyclin-dependent kinase 22.7.11.220.530
3iggEFQCyclin-dependent kinase 22.7.11.220.530
3r9dX6BCyclin-dependent kinase 22.7.11.220.527
4eos1ROCyclin-dependent kinase 22.7.11.220.527
1ke7LS3Cyclin-dependent kinase 22.7.11.220.526
3sqq99ZCyclin-dependent kinase 22.7.11.220.526
4eoi1ROCyclin-dependent kinase 22.7.11.220.526
1di8DTQCyclin-dependent kinase 22.7.11.220.525
3rk909ZCyclin-dependent kinase 22.7.11.220.525
4bcpT3CCyclin-dependent kinase 22.7.11.220.525
1oguST8Cyclin-dependent kinase 22.7.11.220.524
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.523
2wotZZGTGF-beta receptor type-12.7.11.300.523
4bgh3I6Cyclin-dependent kinase 22.7.11.220.523
1oirHDYCyclin-dependent kinase 22.7.11.220.521
4fkt48KCyclin-dependent kinase 22.7.11.220.521
1h1q2A6Cyclin-dependent kinase 22.7.11.220.520
3rjc06ZCyclin-dependent kinase 22.7.11.220.520
1gih1PUCyclin-dependent kinase 22.7.11.220.517
1ke6LS2Cyclin-dependent kinase 22.7.11.220.517
2iw84SPCyclin-dependent kinase 22.7.11.220.517
1b38ATPCyclin-dependent kinase 22.7.11.220.516
1pxmCK5Cyclin-dependent kinase 22.7.11.220.516
3qzgX67Cyclin-dependent kinase 22.7.11.220.516
1ke5LS1Cyclin-dependent kinase 22.7.11.220.515
1w0xOLOCyclin-dependent kinase 22.7.11.220.514
3r8vZ62Cyclin-dependent kinase 22.7.11.220.512
2c5nCK8Cyclin-dependent kinase 22.7.11.220.511
3rpo24ZCyclin-dependent kinase 22.7.11.220.511
3s0o50ZCyclin-dependent kinase 22.7.11.220.511
3unk0BYCyclin-dependent kinase 22.7.11.220.511
4ez30S0Cyclin-dependent kinase 22.7.11.220.511
2c6o4SPCyclin-dependent kinase 22.7.11.220.510
2uzeC95Cyclin-dependent kinase 22.7.11.220.510
2w06FRVCyclin-dependent kinase 22.7.11.220.510
4fkv61KCyclin-dependent kinase 22.7.11.220.510
2duv371Cyclin-dependent kinase 22.7.11.220.509
3qwjX6ACyclin-dependent kinase 22.7.11.220.508
3r1yX76Cyclin-dependent kinase 22.7.11.220.508
1h1pCMGCyclin-dependent kinase 22.7.11.220.507
2x1nX1NCyclin-dependent kinase 22.7.11.220.507
3r83Z14Cyclin-dependent kinase 22.7.11.220.507
4bcoT6QCyclin-dependent kinase 22.7.11.220.507
1ckpPVBCyclin-dependent kinase 22.7.11.220.506
4eop1ROCyclin-dependent kinase 22.7.11.220.506
2a4lRRCCyclin-dependent kinase 22.7.11.220.505
4fkg4CKCyclin-dependent kinase 22.7.11.220.505
4fkq42KCyclin-dependent kinase 22.7.11.220.505
1e9hINRCyclin-dependent kinase 22.7.11.220.504
1oiuN76Cyclin-dependent kinase 22.7.11.220.504
1pyePM1Cyclin-dependent kinase 22.7.11.220.504
1urwI1PCyclin-dependent kinase 22.7.11.220.504
1w8cN69Cyclin-dependent kinase 22.7.11.220.504
2vv9IM9Cyclin-dependent kinase 22.7.11.220.504
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.501
3rk507ZCyclin-dependent kinase 22.7.11.220.501
3rm618ZCyclin-dependent kinase 22.7.11.220.500
1eh4IC1Casein kinase I homolog 12.7.11.10.499
1h0w207Cyclin-dependent kinase 22.7.11.220.498
1pxoCK7Cyclin-dependent kinase 22.7.11.220.498
2a0cCK9Cyclin-dependent kinase 22.7.11.220.498
3pxyJWSCyclin-dependent kinase 22.7.11.220.498
1xjdSTUProtein kinase C theta type2.7.11.130.497
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.497
3dogNNNCyclin-dependent kinase 22.7.11.220.497
3qtzX42Cyclin-dependent kinase 22.7.11.220.497
4anmWULCasein kinase II subunit alpha2.7.11.10.497
1hckATPCyclin-dependent kinase 22.7.11.220.495
1vyzN5BCyclin-dependent kinase 22.7.11.220.495
2b55D31Cyclin-dependent kinase 22.7.11.220.495
3s1h56ZCyclin-dependent kinase 22.7.11.220.495
1p2a5BNCyclin-dependent kinase 22.7.11.220.493
1qmzATPCyclin-dependent kinase 22.7.11.220.493
2uznC96Cyclin-dependent kinase 22.7.11.220.493
3s2pPMUCyclin-dependent kinase 22.7.11.220.493
4fkw62KCyclin-dependent kinase 22.7.11.220.492
1v1k3FPCyclin-dependent kinase 22.7.11.220.491
3rpv26ZCyclin-dependent kinase 22.7.11.220.491
2b7aIZATyrosine-protein kinase JAK2/0.490
3r6xX84Cyclin-dependent kinase 22.7.11.220.490
1gii1PUCyclin-dependent kinase 22.7.11.220.489
3bhtMFRCyclin-dependent kinase 22.7.11.220.489
3py0SU9Cyclin-dependent kinase 22.7.11.220.489
3sheI85MAP kinase-activated protein kinase 32.7.11.10.489
1ke9LS5Cyclin-dependent kinase 22.7.11.220.488
3r8lZ30Cyclin-dependent kinase 22.7.11.220.488
4eok4SPCyclin-dependent kinase 22.7.11.220.488
3qqkX02Cyclin-dependent kinase 22.7.11.220.487
3qtrX36Cyclin-dependent kinase 22.7.11.220.487
4fks46KCyclin-dependent kinase 22.7.11.220.487
1vjy460TGF-beta receptor type-12.7.11.300.486
2vttLZDCyclin-dependent kinase 22.7.11.220.486
3qtuX44Cyclin-dependent kinase 22.7.11.220.486
3rak03ZCyclin-dependent kinase 22.7.11.220.486
4ek610KCyclin-dependent kinase 22.7.11.220.486
1b39ATPCyclin-dependent kinase 22.7.11.220.485
3qqhX0ACyclin-dependent kinase 22.7.11.220.485
4dgmAGICasein kinase II subunit alpha2.7.11.10.485
3ddpRC8Cyclin-dependent kinase 22.7.11.220.484
3sw418KCyclin-dependent kinase 22.7.11.220.484
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.484
3r9hZ67Cyclin-dependent kinase 22.7.11.220.483
2r3kSCQCyclin-dependent kinase 22.7.11.220.482
3gubGUBDeath-associated protein kinase 12.7.11.10.482
4dgo0JWCasein kinase II subunit alpha2.7.11.10.482
4fkr45KCyclin-dependent kinase 22.7.11.220.482
4fx360KCyclin-dependent kinase 22.7.11.220.482
3qzhX69Cyclin-dependent kinase 22.7.11.220.481
4lyn1YGCyclin-dependent kinase 22.7.11.220.481
1ykr628Cyclin-dependent kinase 22.7.11.220.480
2xmyCDKCyclin-dependent kinase 22.7.11.220.480
3qqlX03Cyclin-dependent kinase 22.7.11.220.480
3r73X87Cyclin-dependent kinase 22.7.11.220.480
1oi9N20Cyclin-dependent kinase 22.7.11.220.479
1pxlCK4Cyclin-dependent kinase 22.7.11.220.479
2r3lSCWCyclin-dependent kinase 22.7.11.220.479
4dgnLU2Casein kinase II subunit alpha2.7.11.10.479
1vyw292Cyclin-dependent kinase 22.7.11.220.478
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.478
2r3jSCJCyclin-dependent kinase 22.7.11.220.477
3my5RFZCyclin-dependent kinase 22.7.11.220.477
3ql8X01Cyclin-dependent kinase 22.7.11.220.477
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
3mtfA3FActivin receptor type-12.7.11.300.476
3rm719ZCyclin-dependent kinase 22.7.11.220.476
4fklCK2Cyclin-dependent kinase 22.7.11.220.476
1pxkCK3Cyclin-dependent kinase 22.7.11.220.475
1unlRRCCyclin-dependent-like kinase 52.7.11.10.475
1y91CT9Cyclin-dependent kinase 22.7.11.220.475
2eufLQQCyclin-dependent kinase 62.7.11.220.475
3rmf20ZCyclin-dependent kinase 22.7.11.220.475
2exmZIPCyclin-dependent kinase 22.7.11.220.474
2vthLZ2Cyclin-dependent kinase 22.7.11.220.474
3qxoX65Cyclin-dependent kinase 22.7.11.220.474
3r7yZ04Cyclin-dependent kinase 22.7.11.220.474
4eol1ROCyclin-dependent kinase 22.7.11.220.474
4bcmT7ZCyclin-dependent kinase 22.7.11.220.473
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
2cchATPCyclin-dependent kinase 22.7.11.220.472
2uzoC62Cyclin-dependent kinase 22.7.11.220.472
2w17I19Cyclin-dependent kinase 22.7.11.220.472
3unj0BXCyclin-dependent kinase 22.7.11.220.472
1ke8LS4Cyclin-dependent kinase 22.7.11.220.471
3qtxX43Cyclin-dependent kinase 22.7.11.220.471
3r1sX73Cyclin-dependent kinase 22.7.11.220.471
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.471
4i22IREEpidermal growth factor receptor2.7.10.10.471
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.471
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
3ig7EFPCyclin-dependent kinase 22.7.11.220.469
1h0vUN4Cyclin-dependent kinase 22.7.11.220.468
2r3gSC9Cyclin-dependent kinase 22.7.11.220.468
2xnbY8LCyclin-dependent kinase 22.7.11.220.468
3fz1B98Cyclin-dependent kinase 22.7.11.220.468
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.468
1oiyN41Cyclin-dependent kinase 22.7.11.220.467
2vtsLZCCyclin-dependent kinase 22.7.11.220.467
4jboWPHAurora kinase A2.7.11.10.467
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.466
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.465
3vquO22Dual specificity protein kinase TTK2.7.12.10.465
1py5PY1TGF-beta receptor type-12.7.11.300.464
2r64740Cyclin-dependent kinase 22.7.11.220.464
2vtqLZACyclin-dependent kinase 22.7.11.220.464
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.464
3nynSGVG protein-coupled receptor kinase 62.7.11.160.464
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.464
1gij2PUCyclin-dependent kinase 22.7.11.220.463
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.463
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.463
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3roy22ZCyclin-dependent kinase 22.7.11.220.463
3uli1N3Cyclin-dependent kinase 22.7.11.220.463
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.463
4bcnT9NCyclin-dependent kinase 22.7.11.220.463
3hmm855TGF-beta receptor type-12.7.11.300.462
3r8pZ46Cyclin-dependent kinase 22.7.11.220.462
2wouZZFTGF-beta receptor type-12.7.11.300.461
3raiX85Cyclin-dependent kinase 22.7.11.220.461
3qwkX62Cyclin-dependent kinase 22.7.11.220.459
1pkdUCNCyclin-dependent kinase 22.7.11.220.458
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.458
3eyhIZATyrosine-protein kinase JAK1/0.458
3ezvEZVCyclin-dependent kinase 22.7.11.220.458
3r7vZ02Cyclin-dependent kinase 22.7.11.220.458
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.458
4ii5ADPCyclin-dependent kinase 22.7.11.220.458
1fvt106Cyclin-dependent kinase 22.7.11.220.457
2pvhP19Casein kinase II subunit alpha2.7.11.10.457
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.457
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.457
3r7uX96Cyclin-dependent kinase 22.7.11.220.457
4cfnJYMCyclin-dependent kinase 22.7.11.220.457
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.457
2wpa889Cyclin-dependent kinase 22.7.11.220.456
3lfsA07Cyclin-dependent kinase 22.7.11.220.456
3ral04ZCyclin-dependent kinase 22.7.11.220.456
3be9P04Casein kinase II subunit alpha2.7.11.10.455
3ezrEZRCyclin-dependent kinase 22.7.11.220.455
3qx2X63Cyclin-dependent kinase 22.7.11.220.455
3r71X86Cyclin-dependent kinase 22.7.11.220.455
3r9oZ71Cyclin-dependent kinase 22.7.11.220.455
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.455
4qmpDKISerine/threonine-protein kinase 242.7.11.10.455
1r78FMDCyclin-dependent kinase 22.7.11.220.454
3sw719KCyclin-dependent kinase 22.7.11.220.454
4ez50RSCyclin-dependent kinase 62.7.11.220.454
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.454
1pxpCK8Cyclin-dependent kinase 22.7.11.220.453
2c5yMTWCyclin-dependent kinase 22.7.11.220.453
4kd11QKCyclin-dependent kinase 22.7.11.220.453
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.453
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.452
3ti1B49Cyclin-dependent kinase 22.7.11.220.452
4fv6E57Mitogen-activated protein kinase 12.7.11.240.452
5aniES4Cyclin-dependent kinase 22.7.11.220.452
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.451
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
4bgg844Activin receptor type-12.7.11.300.451
4nj32KDCyclin-dependent kinase 22.7.11.220.451
2r3iSCFCyclin-dependent kinase 22.7.11.220.450
2uzdC85Cyclin-dependent kinase 22.7.11.220.450
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.450
3gxlQIGTGF-beta receptor type-12.7.11.300.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4hge15VTyrosine-protein kinase JAK2/0.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
4wsqKSAAP2-associated protein kinase 12.7.11.10.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.449
2b53D23Cyclin-dependent kinase 22.7.11.220.449
2ds11CDCyclin-dependent kinase 22.7.11.220.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.449
3qruX19Cyclin-dependent kinase 22.7.11.220.449
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
1dawANPCasein kinase II subunit alpha2.7.11.10.448
4bcqTJFCyclin-dependent kinase 22.7.11.220.448
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.448
1fvv107Cyclin-dependent kinase 22.7.11.220.447
2i40BLZCyclin-dependent kinase 22.7.11.220.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.447
2j9mPY8Cyclin-dependent kinase 22.7.11.220.446
3r1qX75Cyclin-dependent kinase 22.7.11.220.446
4c02TAKActivin receptor type-12.7.11.300.446
4fv9E71Mitogen-activated protein kinase 12.7.11.240.446
1m2pHNACasein kinase II subunit alpha2.7.11.10.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
2pvnP63Casein kinase II subunit alpha2.7.11.10.445
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.445
3qqfX07Cyclin-dependent kinase 22.7.11.220.445
4k6z1Q3Tyrosine-protein kinase JAK1/0.445
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
3eljGS7Mitogen-activated protein kinase 82.7.11.240.444
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.444
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.443
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3at4CCKCasein kinase II subunit alpha2.7.11.10.443
3rahO1ZCyclin-dependent kinase 22.7.11.220.443
5dt3ATPAurora kinase A2.7.11.10.443
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.442
3ggfGVDSerine/threonine-protein kinase 26/0.442
3lltANPProtein serine/threonine kinase-1/0.442
3lq5SLQCyclin-dependent kinase 92.7.11.220.442
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.442
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
4ivc1J6Tyrosine-protein kinase JAK1/0.441
2xikJ60Serine/threonine-protein kinase 252.7.11.10.440
2y9qANPMitogen-activated protein kinase 12.7.11.240.440
4e4m0NHTyrosine-protein kinase JAK2/0.440
4hgt15GCasein kinase I isoform delta2.7.11.10.440
4i3zADPCyclin-dependent kinase 22.7.11.220.440
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.440