sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4dlv | GNP | GTPase HRas |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4dlv | GNP | GTPase HRas | / | 1.000 | |
| 2rgc | GNP | GTPase HRas | / | 0.908 | |
| 4dlx | GNP | GTPase HRas | / | 0.899 | |
| 4dlz | GNP | GTPase HRas | / | 0.868 | |
| 3rs5 | GNP | GTPase HRas | / | 0.849 | |
| 2rgb | GNP | GTPase HRas | / | 0.832 | |
| 3rs0 | GNP | GTPase HRas | / | 0.818 | |
| 2rge | GNP | GTPase HRas | / | 0.817 | |
| 4dlw | GNP | GTPase HRas | / | 0.811 | |
| 3rsl | GNP | GTPase HRas | / | 0.787 | |
| 3v4f | GNP | GTPase HRas | / | 0.768 | |
| 3oiv | GNP | GTPase HRas | / | 0.765 | |
| 3rs7 | GNP | GTPase HRas | / | 0.744 | |
| 3lbn | GNP | GTPase HRas | / | 0.729 | |
| 3k8y | GNP | GTPase HRas | / | 0.699 | |
| 3ddc | GNP | GTPase HRas | / | 0.694 | |
| 2c5l | GTP | GTPase HRas | / | 0.670 | |
| 4l9w | GNP | GTPase HRas | / | 0.665 | |
| 4dls | GNP | GTPase HRas | / | 0.661 | |
| 3l8y | GNP | GTPase HRas | / | 0.660 | |
| 3i3s | GNP | GTPase HRas | / | 0.647 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.645 | |
| 3oiu | GNP | GTPase HRas | / | 0.642 | |
| 4nyi | GNP | GTPase HRas | / | 0.642 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.639 | |
| 3oiw | GNP | GTPase HRas | / | 0.634 | |
| 4dsn | GCP | GTPase KRas | / | 0.632 | |
| 4g0n | GNP | GTPase HRas | / | 0.631 | |
| 5b2z | GNP | GTPase HRas | / | 0.631 | |
| 3kud | GDP | GTPase HRas | / | 0.628 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.627 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.626 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.616 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.615 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.611 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.611 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.610 | |
| 4l9s | GDP | GTPase HRas | / | 0.608 | |
| 4nyj | GNP | GTPase HRas | / | 0.604 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.602 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.600 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.600 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.587 | |
| 4dlt | GNP | GTPase HRas | / | 0.581 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.580 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.580 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.580 | |
| 3lbh | GNP | GTPase HRas | / | 0.579 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.578 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.576 | |
| 4mit | GTP | Rho-related protein racC | / | 0.576 | |
| 3bc1 | GNP | Ras-related protein Rab-27A | / | 0.574 | |
| 3rs4 | GNP | GTPase HRas | / | 0.574 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.573 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.573 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.570 | |
| 4epw | GDP | GTPase KRas | / | 0.567 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.566 | |
| 4tq9 | GDP | GTPase KRas | / | 0.566 | |
| 4l8g | GDP | GTPase KRas | / | 0.565 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.565 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.564 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.560 | |
| 4obe | GDP | GTPase KRas | / | 0.560 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.559 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.559 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.558 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.558 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.557 | |
| 4lv6 | GDP | GTPase KRas | / | 0.557 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.556 | |
| 4ldj | GDP | GTPase KRas | / | 0.554 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.551 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.550 | |
| 4dso | GSP | GTPase KRas | / | 0.550 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.548 | |
| 3wyf | GTP | GTP-binding nuclear protein | / | 0.547 | |
| 4q02 | GDP | GTPase KRas | / | 0.546 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.542 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.542 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.541 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.540 | |
| 4xvq | GNP | GTPase HRas | / | 0.540 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.539 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.539 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.538 | |
| 3tgp | GNP | GTPase HRas | / | 0.537 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.535 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.535 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.534 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.534 | |
| 2rgg | GNP | GTPase HRas | / | 0.534 | |
| 4wa7 | GDP | GTPase KRas | / | 0.534 | |
| 4epx | GDP | GTPase KRas | / | 0.532 | |
| 4ql3 | GDP | GTPase KRas | / | 0.532 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.531 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.531 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.529 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.529 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.528 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.528 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.527 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.527 | |
| 3lbi | GNP | GTPase HRas | / | 0.526 | |
| 4lpk | GDP | GTPase KRas | / | 0.526 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.522 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.521 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.520 | |
| 4xvr | GNP | GTPase HRas | / | 0.520 | |
| 2ce2 | GDP | GTPase HRas | / | 0.519 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.519 | |
| 4q03 | GDP | GTPase KRas | / | 0.518 | |
| 1lfd | GNP | GTPase HRas | / | 0.517 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.517 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.516 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.516 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.515 | |
| 4lrw | GDP | GTPase KRas | / | 0.514 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.513 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.512 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.511 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.509 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.507 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.507 | |
| 2mse | GNP | MHC class I alpha chain | / | 0.505 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.505 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.504 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.504 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.501 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.500 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.500 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.499 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.498 | |
| 1gwn | GTP | Rho-related GTP-binding protein RhoE | / | 0.498 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.498 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.498 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.496 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.494 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.493 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.491 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.491 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.489 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.488 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.486 | |
| 2cl6 | CAG | GTPase HRas | / | 0.485 | |
| 1kph | SAH | Cyclopropane mycolic acid synthase 1 | 2.1.1.79 | 0.484 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.484 | |
| 3gya | COA | GCN5-related N-acetyltransferase | / | 0.483 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.482 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.482 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.482 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.481 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.480 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.480 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.479 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.479 | |
| 3k9l | GNP | GTPase HRas | / | 0.479 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.479 | |
| 4rrb | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.479 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.479 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.478 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.477 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.477 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.477 | |
| 5c4f | UPG | Histo-blood group ABO system transferase | / | 0.477 | |
| 2xau | ADP | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 | 3.6.4.13 | 0.476 | |
| 1b9i | PXG | 3-amino-5-hydroxybenzoate synthase | 4.2.1.144 | 0.475 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.475 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.475 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.475 | |
| 4dsu | GDP | GTPase KRas | / | 0.475 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.475 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.473 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.473 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.473 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.473 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.473 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.473 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.473 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.473 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.472 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.472 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.472 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.471 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.471 | |
| 4uj5 | GNP | Ras-related protein Rab-11A | / | 0.471 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2i0v | 6C3 | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.470 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.470 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.470 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.470 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.470 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.470 | |
| 4uof | DAT | Nucleoside diphosphate kinase | / | 0.470 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.469 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.469 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.468 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.468 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 0.468 | |
| 3sfx | JAN | Uncharacterized protein | / | 0.467 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.467 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.466 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.466 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.465 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.465 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.465 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.464 | |
| 3tkl | GTP | Ras-related protein Rab-1A | / | 0.464 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.463 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.463 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.463 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.463 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.463 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.462 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.461 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.461 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.461 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.461 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.461 | |
| 4ehv | 0SJ | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1z2n | ADP | Inositol-tetrakisphosphate 1-kinase | 2.7.1.134 | 0.460 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.460 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.460 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.460 | |
| 3gy9 | COA | GCN5-related N-acetyltransferase | / | 0.460 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.460 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.460 | |
| 3v49 | PK0 | Androgen receptor | / | 0.460 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.460 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.459 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.459 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 2wn6 | NDP | ADP-ribosyltransferase enzymatic component | / | 0.459 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.459 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.459 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.459 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.459 | |
| 1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.458 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.458 | |
| 2vk8 | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.458 | |
| 3nkt | 1HN | Gentisate 1,2-dioxygenase | / | 0.458 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.458 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.458 | |
| 4ykl | GMP | Aprataxin-like protein | 3 | 0.458 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.457 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.457 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.457 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.457 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.456 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.456 | |
| 4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.456 | |
| 4yvn | EBS | Spore coat protein A | / | 0.456 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.455 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.455 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.455 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.455 | |
| 2xvw | 9NR | Serum albumin | / | 0.455 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.455 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.455 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.455 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.455 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.455 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.454 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.454 | |
| 1z2c | GNP | Rho-related GTP-binding protein RhoC | / | 0.454 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.454 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.454 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.453 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.453 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.453 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.453 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.453 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 3eku | CY9 | Actin-5C | / | 0.452 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
| 5c80 | URI | Uridine phosphorylase | / | 0.452 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.452 | |
| 1a4l | DCF | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1gm8 | SOX | Penicillin G acylase | 3.5.1.11 | 0.451 | |
| 1mbz | IOT | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.451 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.451 | |
| 1ysi | N3B | Bcl-2-like protein 1 | / | 0.451 | |
| 2ada | HPR | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2ji6 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.451 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.451 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 2wu2 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.451 | |
| 2wu2 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.451 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.451 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.451 | |
| 4rrl | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.451 | |
| 1wy7 | SAH | Uncharacterized protein | / | 0.450 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2aa2 | AS4 | Mineralocorticoid receptor | / | 0.450 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.450 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 3gwu | SRE | Na(+):neurotransmitter symporter (Snf family) | / | 0.450 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.450 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.450 | |
| 4fwf | FAD | Lysine-specific histone demethylase 1B | 1 | 0.450 | |
| 4l2x | YL2 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.450 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.450 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.450 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.449 | |
| 1u3q | 272 | Estrogen receptor beta | / | 0.449 | |
| 1wuq | 8GT | GTP cyclohydrolase 1 | / | 0.449 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2c3u | 2TP | Pyruvate synthase | / | 0.449 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 3eks | CY9 | Actin-5C | / | 0.449 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3rga | ILD | Epoxide hydrolase LasB | 5.5.1 | 0.449 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.449 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.448 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.448 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.448 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 3gb4 | D3M | DdmC | / | 0.448 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.448 | |
| 3q1f | YPP | Beta-lactamase | / | 0.448 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.448 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.447 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.447 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.447 | |
| 1n08 | ADP | Riboflavin kinase | 2.7.1.26 | 0.447 | |
| 1n5t | OAL | ActVA 6 protein | / | 0.447 | |
| 1sze | 173 | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.447 | |
| 1wnz | 2VA | Isoleucine--tRNA ligase | 6.1.1.5 | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.447 | |
| 3ipu | O40 | Oxysterols receptor LXR-alpha | / | 0.447 | |
| 3kro | IPE | Geranyl diphosphate synthase large subunit | / | 0.447 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.447 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.447 | |
| 4bqy | FNT | Egl nine homolog 1 | / | 0.447 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.446 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1yf8 | P6C | Beta-galactoside-specific lectin 4 | 3.2.2.22 | 0.446 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.446 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4gur | FAD | Lysine-specific histone demethylase 1B | 1 | 0.446 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.446 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.446 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2g72 | F21 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.445 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.445 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2yxj | N3C | Bcl-2-like protein 1 | / | 0.445 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.445 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4l8u | 9AZ | Serum albumin | / | 0.445 | |
| 4lng | JAN | CaaX farnesyltransferase beta subunit Ram1 | / | 0.445 | |
| 4m2b | UPG | UDP-glucose pyrophosphorylase | / | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4ram | PNM | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.445 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 2f3m | GTD | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.444 | |
| 2r8o | T5X | Transketolase 1 | / | 0.444 | |
| 2rto | IMI | Streptavidin | / | 0.444 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.444 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.444 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.444 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.444 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.444 | |
| 3zfd | ANP | Chromosome-associated kinesin KIF4 | / | 0.444 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.444 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.443 | |
| 1fkx | PRH | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.443 | |
| 2wgg | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.443 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.443 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.443 | |
| 3b9l | AZZ | Serum albumin | / | 0.443 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.443 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 4fx2 | FMN | Flavodoxin | / | 0.443 | |
| 4h5c | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.443 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 5kf1 | COA | Predicted acetyltransferase | / | 0.443 | |
| 1cde | DZF | Phosphoribosylglycinamide formyltransferase | / | 0.442 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 1ga8 | UPF | LgtC | / | 0.442 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.442 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2bxq | IMN | Serum albumin | / | 0.442 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.442 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.442 | |
| 3up0 | D7S | aceDAF-12 | / | 0.442 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4krs | 1SX | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4l4x | NDP | AmphI | / | 0.442 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.442 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.441 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.441 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.441 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.441 | |
| 2aa7 | 1CA | Mineralocorticoid receptor | / | 0.441 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.441 | |
| 2p3q | SAH | Genome polyprotein | / | 0.441 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.441 | |
| 2rtq | IMI | Streptavidin | / | 0.441 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.441 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.441 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.441 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.441 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.441 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.441 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.441 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.441 | |
| 4nu0 | AP5 | Adenylate kinase | / | 0.441 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.441 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.440 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.440 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.440 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.440 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.440 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3n3b | FMN | Protein NrdI | / | 0.440 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.440 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4edz | 0O5 | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.440 |