sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4dls | GNP | GTPase HRas |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4dls | GNP | GTPase HRas | / | 1.000 | |
| 3rs7 | GNP | GTPase HRas | / | 0.854 | |
| 2rgb | GNP | GTPase HRas | / | 0.779 | |
| 4dlz | GNP | GTPase HRas | / | 0.764 | |
| 4dlx | GNP | GTPase HRas | / | 0.732 | |
| 3rsl | GNP | GTPase HRas | / | 0.702 | |
| 3rs5 | GNP | GTPase HRas | / | 0.699 | |
| 2rgc | GNP | GTPase HRas | / | 0.698 | |
| 4g0n | GNP | GTPase HRas | / | 0.690 | |
| 4dlv | GNP | GTPase HRas | / | 0.682 | |
| 4l9w | GNP | GTPase HRas | / | 0.678 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.678 | |
| 3rs0 | GNP | GTPase HRas | / | 0.676 | |
| 3l8y | GNP | GTPase HRas | / | 0.674 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.674 | |
| 2rge | GNP | GTPase HRas | / | 0.672 | |
| 3rs4 | GNP | GTPase HRas | / | 0.669 | |
| 4dsn | GCP | GTPase KRas | / | 0.666 | |
| 2c5l | GTP | GTPase HRas | / | 0.665 | |
| 3lbn | GNP | GTPase HRas | / | 0.665 | |
| 3oiw | GNP | GTPase HRas | / | 0.660 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.652 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.640 | |
| 3v4f | GNP | GTPase HRas | / | 0.640 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.639 | |
| 3i3s | GNP | GTPase HRas | / | 0.635 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.635 | |
| 5b2z | GNP | GTPase HRas | / | 0.635 | |
| 3lbi | GNP | GTPase HRas | / | 0.634 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.630 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.630 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.629 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.625 | |
| 4lv6 | GDP | GTPase KRas | / | 0.622 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.622 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.619 | |
| 3kud | GDP | GTPase HRas | / | 0.619 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.619 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.618 | |
| 4dlt | GNP | GTPase HRas | / | 0.616 | |
| 4nyj | GNP | GTPase HRas | / | 0.616 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.615 | |
| 3oiu | GNP | GTPase HRas | / | 0.613 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.612 | |
| 3lbh | GNP | GTPase HRas | / | 0.610 | |
| 4tq9 | GDP | GTPase KRas | / | 0.609 | |
| 4nyi | GNP | GTPase HRas | / | 0.608 | |
| 4obe | GDP | GTPase KRas | / | 0.608 | |
| 4mit | GTP | Rho-related protein racC | / | 0.607 | |
| 3ddc | GNP | GTPase HRas | / | 0.606 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.603 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.602 | |
| 4dlw | GNP | GTPase HRas | / | 0.598 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.596 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.595 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.593 | |
| 2ce2 | GDP | GTPase HRas | / | 0.587 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.587 | |
| 4dso | GSP | GTPase KRas | / | 0.587 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.586 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.582 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.580 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.580 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.579 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.579 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.579 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.579 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.578 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.576 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.575 | |
| 3wyf | GTP | GTP-binding nuclear protein | / | 0.575 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.574 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.574 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.573 | |
| 4l8g | GDP | GTPase KRas | / | 0.571 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.569 | |
| 4lpk | GDP | GTPase KRas | / | 0.564 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.562 | |
| 3k8y | GNP | GTPase HRas | / | 0.561 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.560 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.559 | |
| 4q02 | GDP | GTPase KRas | / | 0.559 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.558 | |
| 4ql3 | GDP | GTPase KRas | / | 0.558 | |
| 4ldj | GDP | GTPase KRas | / | 0.556 | |
| 4wa7 | GDP | GTPase KRas | / | 0.556 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.552 | |
| 4epw | GDP | GTPase KRas | / | 0.552 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.551 | |
| 4epx | GDP | GTPase KRas | / | 0.550 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.549 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.549 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.548 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.547 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.547 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.546 | |
| 4l9s | GDP | GTPase HRas | / | 0.545 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.545 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.540 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.538 | |
| 4q03 | GDP | GTPase KRas | / | 0.538 | |
| 4lrw | GDP | GTPase KRas | / | 0.537 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.536 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.534 | |
| 2zet | GTP | Ras-related protein Rab-27B | / | 0.533 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.533 | |
| 2rgg | GNP | GTPase HRas | / | 0.532 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.530 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.528 | |
| 3tgp | GNP | GTPase HRas | / | 0.528 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.525 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.525 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.523 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.520 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.519 | |
| 3oiv | GNP | GTPase HRas | / | 0.517 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.516 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.515 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.514 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.511 | |
| 4xvq | GNP | GTPase HRas | / | 0.510 | |
| 4uj5 | GNP | Ras-related protein Rab-11A | / | 0.509 | |
| 4xvr | GNP | GTPase HRas | / | 0.508 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.506 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.505 | |
| 3k9l | GNP | GTPase HRas | / | 0.505 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.505 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.503 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.502 | |
| 1z2c | GNP | Rho-related GTP-binding protein RhoC | / | 0.502 | |
| 1lfd | GNP | GTPase HRas | / | 0.500 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.497 | |
| 2mse | GNP | MHC class I alpha chain | / | 0.495 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.494 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.494 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.492 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.492 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.491 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.486 | |
| 1tu3 | GNP | Ras-related protein Rab-5A | / | 0.486 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.486 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.486 | |
| 2cl6 | CAG | GTPase HRas | / | 0.484 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.483 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.483 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.482 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.479 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.479 | |
| 1gwn | GTP | Rho-related GTP-binding protein RhoE | / | 0.478 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.478 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.477 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.475 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.475 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.474 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.474 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.474 | |
| 3b9l | AZZ | Serum albumin | / | 0.472 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.472 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 2cls | GTP | Rho-related GTP-binding protein Rho6 | / | 0.470 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.470 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.470 | |
| 1uad | GNP | Ras-related protein Ral-A | / | 0.469 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.469 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.469 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.469 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.468 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.468 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.468 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.467 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.467 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.466 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.466 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.466 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.466 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.466 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.465 | |
| 1g7v | PAI | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.464 | |
| 2d4h | 5GP | Guanylate-binding protein 1 | / | 0.464 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.463 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2xvw | 9NR | Serum albumin | / | 0.462 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.462 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.461 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.461 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.460 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.460 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.460 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.460 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 2xvv | 9DN | Serum albumin | / | 0.459 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.459 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.459 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.458 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.457 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.457 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.457 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.457 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.457 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.457 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.457 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.456 | |
| 2xk6 | EQH | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.456 | |
| 4bqw | QNM | Egl nine homolog 1 | / | 0.456 | |
| 4bs4 | A64 | Tankyrase-2 | 2.4.2.30 | 0.456 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.455 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.455 | |
| 4rx6 | ATP | Nitrogen regulatory PII-like protein | / | 0.455 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.454 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.454 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.454 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.454 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.454 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.454 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.454 | |
| 3tl1 | JRO | Putative polyketide cyclase | / | 0.454 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.454 | |
| 4ytn | FD8 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.454 | |
| 4ytn | FD8 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | / | 0.454 | |
| 4ytn | FD8 | Succinate dehydrogenase cytochrome b560 | / | 0.454 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.453 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.453 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.453 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.453 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.453 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.453 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.453 | |
| 2bxq | IMN | Serum albumin | / | 0.452 | |
| 2ido | TMP | DNA polymerase III subunit epsilon | 2.7.7.7 | 0.452 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.452 | |
| 4rel | KMP | Glycosyltransferase | / | 0.452 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.452 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 2b1z | 17M | Estrogen receptor | / | 0.451 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.451 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.451 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3t8v | BTJ | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 4j3l | AJ5 | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.451 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.450 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.450 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.450 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.450 | |
| 4mzu | TYD | WxcM-like protein | / | 0.450 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.449 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.449 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.449 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4bux | F35 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.449 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.449 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.449 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.448 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.448 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.448 | |
| 4j7g | TRH | PCZA361.3 | / | 0.448 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 2rtd | BTN | Streptavidin | / | 0.447 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.447 | |
| 4phl | PIL | Phosphodiesterase | / | 0.447 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.446 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.446 | |
| 4c05 | SAH | Protein arginine N-methyltransferase 6 | / | 0.446 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4gus | FAD | Lysine-specific histone demethylase 1B | 1 | 0.446 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.446 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.445 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 2hvd | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.445 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.445 | |
| 1aqi | SAH | Modification methylase TaqI | 2.1.1.72 | 0.444 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.444 | |
| 1mx0 | ANP | Type 2 DNA topoisomerase 6 subunit B | / | 0.444 | |
| 1pw6 | FRB | Interleukin-2 | / | 0.444 | |
| 1q63 | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.444 | |
| 2eg5 | SAH | 7-methylxanthosine synthase 1 | / | 0.444 | |
| 2i0v | 6C3 | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.444 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.444 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.444 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.444 | |
| 4lng | JAN | CaaX farnesyltransferase beta subunit Ram1 | / | 0.444 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.444 | |
| 1a4l | DCF | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1lwx | AZD | Nucleoside diphosphate kinase, cytosolic | 2.7.4.6 | 0.443 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.443 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.443 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.443 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.443 | |
| 4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.443 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.442 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.442 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.442 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.442 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.442 | |
| 4avu | LDR | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.442 | |
| 4lb2 | DM5 | Serum albumin | / | 0.442 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.442 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.442 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.441 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2e7z | MGD | Acetylene hydratase | / | 0.441 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.441 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.441 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.441 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.441 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.441 | |
| 2ylo | TES | Androgen receptor | / | 0.441 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.441 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4b1f | KRH | Glutamate racemase | / | 0.441 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.441 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.441 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.440 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.440 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.440 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 3sfx | JAN | Uncharacterized protein | / | 0.440 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.440 | |
| 4j21 | AJ6 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.440 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.440 |