sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3wzn | BTN | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3wzn | BTN | Streptavidin | / | 1.000 | |
| 1swt | BTN | Streptavidin | / | 0.728 | |
| 4bx7 | B4F | Streptavidin | / | 0.606 | |
| 2rtp | IMI | Streptavidin | / | 0.578 | |
| 2izh | BTN | Streptavidin | / | 0.574 | |
| 2izg | BTN | Streptavidin | / | 0.573 | |
| 2izl | IMI | Streptavidin | / | 0.567 | |
| 2rtq | IMI | Streptavidin | / | 0.564 | |
| 2rtr | IMI | Streptavidin | / | 0.561 | |
| 1stp | BTN | Streptavidin | / | 0.560 | |
| 3ry2 | BTN | Streptavidin | / | 0.559 | |
| 2rte | BTN | Streptavidin | / | 0.558 | |
| 2rtg | BTN | Streptavidin | / | 0.557 | |
| 1srg | MHB | Streptavidin | / | 0.556 | |
| 2rtd | BTN | Streptavidin | / | 0.556 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.553 | |
| 1sri | DMB | Streptavidin | / | 0.551 | |
| 1i9h | BNI | Streptavidin | / | 0.550 | |
| 1srh | MOB | Streptavidin | / | 0.550 | |
| 2rti | GLL | Streptavidin | / | 0.548 | |
| 1mk5 | BTN | Streptavidin | / | 0.547 | |
| 2rtf | BTN | Streptavidin | / | 0.545 | |
| 1srj | NAB | Streptavidin | / | 0.542 | |
| 2rto | IMI | Streptavidin | / | 0.538 | |
| 1lcw | SHM | Streptavidin | / | 0.537 | |
| 1srf | MTB | Streptavidin | / | 0.537 | |
| 1sre | HAB | Streptavidin | / | 0.531 | |
| 2uz2 | BTN | Avd protein | / | 0.531 | |
| 4dne | DTB | Streptavidin | / | 0.531 | |
| 4gda | BTN | Streptavidin | / | 0.531 | |
| 2rtn | IMI | Streptavidin | / | 0.523 | |
| 2avi | BTN | Avidin | / | 0.519 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.519 | |
| 1mep | BTN | Streptavidin | / | 0.517 | |
| 1luq | BTN | Streptavidin | / | 0.516 | |
| 2rtk | GLL | Streptavidin | / | 0.514 | |
| 2y3f | BTN | Streptavidin | / | 0.514 | |
| 1df8 | BTN | Streptavidin | / | 0.512 | |
| 2izf | BTN | Streptavidin | / | 0.508 | |
| 4z28 | BTN | Hoefavidin | / | 0.508 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.507 | |
| 1rxh | BNI | Streptavidin | / | 0.505 | |
| 2izk | GLL | Streptavidin | / | 0.505 | |
| 3vgw | NVZ | Avidin | / | 0.503 | |
| 1lcz | BH7 | Streptavidin | / | 0.501 | |
| 1swe | BTN | Streptavidin | / | 0.499 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.498 | |
| 2c4i | BTN | Avidin | / | 0.497 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.496 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.496 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.493 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.493 | |
| 1avd | BTN | Avidin | / | 0.492 | |
| 2uyw | BTN | Avd protein | / | 0.492 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.491 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.490 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.489 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.488 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
| 3wyq | BTN | Streptavidin | / | 0.486 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.485 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.484 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 1swn | BTN | Streptavidin | / | 0.480 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.480 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.479 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.479 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.478 | |
| 1swp | BTQ | Streptavidin | / | 0.478 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2izj | BTN | Streptavidin | / | 0.477 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.477 | |
| 4bqu | CLR | Japanin | / | 0.477 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.476 | |
| 1swp | BTN | Streptavidin | / | 0.476 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.476 | |
| 2rtm | IMI | Streptavidin | / | 0.476 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.476 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.475 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.474 | |
| 4aox | FAD | Steroid monooxygenase | / | 0.474 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.472 | |
| 1n43 | BTN | Streptavidin | / | 0.471 | |
| 2izi | BTN | Streptavidin | / | 0.471 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 4q4k | FMN | Uncharacterized protein | / | 0.470 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.469 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4bj8 | BTN | Avidin | / | 0.469 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.468 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3vhi | VHI | Avidin | / | 0.467 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.467 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.467 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.466 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.466 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.466 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.466 | |
| 4yvb | BTN | Streptavidin | / | 0.466 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.465 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.465 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.464 | |
| 2kce | D16 | Thymidylate synthase | / | 0.464 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.463 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.462 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.462 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.462 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.462 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 5d9j | 0N8 | Polymerase acidic protein | / | 0.461 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.461 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.460 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.459 | |
| 2zsc | BTN | Tamavidin2 | / | 0.459 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.458 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.458 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1lqa | NDP | Protein tas | / | 0.457 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.457 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.457 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.457 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.456 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.456 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.456 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.456 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.456 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.454 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.454 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 1nc9 | IMI | Streptavidin | / | 0.453 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.453 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.453 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.453 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.453 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.453 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 4pd6 | URI | Nucleoside permease | / | 0.453 | |
| 4phl | PIL | Phosphodiesterase | / | 0.453 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.452 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.452 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2a5c | 8DA | Avidin | / | 0.451 | |
| 2qhx | FE1 | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.451 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.451 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.451 | |
| 4awg | CI3 | Polymerase acidic protein | / | 0.451 | |
| 1axw | MTX | Thymidylate synthase | / | 0.450 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.450 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.450 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.450 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.449 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.449 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.449 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.449 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.448 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.448 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.448 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.448 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.447 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 1i75 | NOJ | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.447 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.447 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.447 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.447 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.447 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.447 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.447 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1fml | RTL | Retinol dehydratase | / | 0.446 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.446 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.446 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.446 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.446 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.445 | |
| 2e95 | B75 | Geranylgeranyl pyrophosphate synthase | / | 0.445 | |
| 4j7g | TRH | PCZA361.3 | / | 0.445 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.445 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.444 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.444 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.444 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.444 | |
| 5fx2 | FMN | Flavodoxin | / | 0.444 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.443 | |
| 3rm8 | RM8 | Acidic mammalian chitinase | 3.2.1.14 | 0.443 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4lwb | QJ8 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.443 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.442 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.442 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.442 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.442 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.441 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2qcx | PF1 | Aminopyrimidine aminohydrolase | / | 0.441 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.441 | |
| 2zwa | SAH | tRNA wybutosine-synthesizing protein 4 | 2.1.1.290 | 0.441 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.441 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.441 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.441 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.440 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1mdt | APU | Diphtheria toxin | / | 0.440 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4l4x | NDP | AmphI | / | 0.440 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.440 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.440 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.440 |