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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rni21ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rni21ZCyclin-dependent kinase 22.7.11.221.000
1pxmCK5Cyclin-dependent kinase 22.7.11.220.643
4ek610KCyclin-dependent kinase 22.7.11.220.640
1gih1PUCyclin-dependent kinase 22.7.11.220.624
3rjc06ZCyclin-dependent kinase 22.7.11.220.621
4fkt48KCyclin-dependent kinase 22.7.11.220.612
3rk708ZCyclin-dependent kinase 22.7.11.220.611
3lfqA28Cyclin-dependent kinase 22.7.11.220.610
3lfnA27Cyclin-dependent kinase 22.7.11.220.606
3rk909ZCyclin-dependent kinase 22.7.11.220.603
3rpv26ZCyclin-dependent kinase 22.7.11.220.601
2a0cCK9Cyclin-dependent kinase 22.7.11.220.591
2btrU73Cyclin-dependent kinase 22.7.11.220.590
2r3lSCWCyclin-dependent kinase 22.7.11.220.589
3qu0X40Cyclin-dependent kinase 22.7.11.220.589
4fkg4CKCyclin-dependent kinase 22.7.11.220.589
4fki09KCyclin-dependent kinase 22.7.11.220.588
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.583
3qtxX43Cyclin-dependent kinase 22.7.11.220.583
4ek816KCyclin-dependent kinase 22.7.11.220.583
4fkv61KCyclin-dependent kinase 22.7.11.220.583
3sqq99ZCyclin-dependent kinase 22.7.11.220.582
3r1yX76Cyclin-dependent kinase 22.7.11.220.581
1ykr628Cyclin-dependent kinase 22.7.11.220.579
3qtzX42Cyclin-dependent kinase 22.7.11.220.579
3rmf20ZCyclin-dependent kinase 22.7.11.220.579
1g5sI17Cyclin-dependent kinase 22.7.11.220.578
3qtrX36Cyclin-dependent kinase 22.7.11.220.578
3r9dX6BCyclin-dependent kinase 22.7.11.220.573
4fkw62KCyclin-dependent kinase 22.7.11.220.573
3r8lZ30Cyclin-dependent kinase 22.7.11.220.572
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.571
1w0xOLOCyclin-dependent kinase 22.7.11.220.570
1y91CT9Cyclin-dependent kinase 22.7.11.220.570
3rpo24ZCyclin-dependent kinase 22.7.11.220.570
2b52D42Cyclin-dependent kinase 22.7.11.220.569
1gii1PUCyclin-dependent kinase 22.7.11.220.568
2c6o4SPCyclin-dependent kinase 22.7.11.220.568
4acm7YGCyclin-dependent kinase 22.7.11.220.568
3rak03ZCyclin-dependent kinase 22.7.11.220.567
4fkpLS5Cyclin-dependent kinase 22.7.11.220.567
3py0SU9Cyclin-dependent kinase 22.7.11.220.566
3qxoX65Cyclin-dependent kinase 22.7.11.220.566
1v1k3FPCyclin-dependent kinase 22.7.11.220.565
3rk507ZCyclin-dependent kinase 22.7.11.220.565
1oitHDTCyclin-dependent kinase 22.7.11.220.564
1ke9LS5Cyclin-dependent kinase 22.7.11.220.563
4fkj11KCyclin-dependent kinase 22.7.11.220.563
4fks46KCyclin-dependent kinase 22.7.11.220.562
1ckpPVBCyclin-dependent kinase 22.7.11.220.561
1gij2PUCyclin-dependent kinase 22.7.11.220.561
1p2a5BNCyclin-dependent kinase 22.7.11.220.561
2w1hL0FCyclin-dependent kinase 22.7.11.220.561
2uzoC62Cyclin-dependent kinase 22.7.11.220.560
2xmyCDKCyclin-dependent kinase 22.7.11.220.560
1urwI1PCyclin-dependent kinase 22.7.11.220.558
2w06FRVCyclin-dependent kinase 22.7.11.220.557
2vv9IM9Cyclin-dependent kinase 22.7.11.220.556
3s1h56ZCyclin-dependent kinase 22.7.11.220.556
4fkr45KCyclin-dependent kinase 22.7.11.220.556
1ke6LS2Cyclin-dependent kinase 22.7.11.220.555
2vthLZ2Cyclin-dependent kinase 22.7.11.220.555
1pxoCK7Cyclin-dependent kinase 22.7.11.220.553
1aq1STUCyclin-dependent kinase 22.7.11.220.552
3qqkX02Cyclin-dependent kinase 22.7.11.220.552
3s2pPMUCyclin-dependent kinase 22.7.11.220.552
4ez30S0Cyclin-dependent kinase 22.7.11.220.552
1ke5LS1Cyclin-dependent kinase 22.7.11.220.551
1oirHDYCyclin-dependent kinase 22.7.11.220.551
3qtuX44Cyclin-dependent kinase 22.7.11.220.551
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.550
2a4lRRCCyclin-dependent kinase 22.7.11.220.549
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.549
2bhhRYUCyclin-dependent kinase 22.7.11.220.548
3iggEFQCyclin-dependent kinase 22.7.11.220.548
3r73X87Cyclin-dependent kinase 22.7.11.220.548
3rm719ZCyclin-dependent kinase 22.7.11.220.548
3unk0BYCyclin-dependent kinase 22.7.11.220.548
3pj8404Cyclin-dependent kinase 22.7.11.220.547
4bgh3I6Cyclin-dependent kinase 22.7.11.220.547
3ral04ZCyclin-dependent kinase 22.7.11.220.546
3rkb12ZCyclin-dependent kinase 22.7.11.220.546
4fkq42KCyclin-dependent kinase 22.7.11.220.546
2btsU32Cyclin-dependent kinase 22.7.11.220.545
1h1r6CPCyclin-dependent kinase 22.7.11.220.544
2b55D31Cyclin-dependent kinase 22.7.11.220.544
1h1s4SPCyclin-dependent kinase 22.7.11.220.543
1pxlCK4Cyclin-dependent kinase 22.7.11.220.543
3qzgX67Cyclin-dependent kinase 22.7.11.220.543
3sw418KCyclin-dependent kinase 22.7.11.220.542
1ke7LS3Cyclin-dependent kinase 22.7.11.220.541
1pyePM1Cyclin-dependent kinase 22.7.11.220.540
3lfsA07Cyclin-dependent kinase 22.7.11.220.540
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.539
3r7iX9ICyclin-dependent kinase 22.7.11.220.539
3r9hZ67Cyclin-dependent kinase 22.7.11.220.539
3ti1B49Cyclin-dependent kinase 22.7.11.220.539
3ezvEZVCyclin-dependent kinase 22.7.11.220.538
4fko20KCyclin-dependent kinase 22.7.11.220.538
2r3kSCQCyclin-dependent kinase 22.7.11.220.537
3fz1B98Cyclin-dependent kinase 22.7.11.220.537
2uznC96Cyclin-dependent kinase 22.7.11.220.536
3ig7EFPCyclin-dependent kinase 22.7.11.220.536
4nj32KDCyclin-dependent kinase 22.7.11.220.536
3r6xX84Cyclin-dependent kinase 22.7.11.220.535
3s0o50ZCyclin-dependent kinase 22.7.11.220.535
2w17I19Cyclin-dependent kinase 22.7.11.220.534
3ddpRC8Cyclin-dependent kinase 22.7.11.220.533
3rm618ZCyclin-dependent kinase 22.7.11.220.533
3qwjX6ACyclin-dependent kinase 22.7.11.220.532
3r7yZ04Cyclin-dependent kinase 22.7.11.220.531
2r3jSCJCyclin-dependent kinase 22.7.11.220.528
1vyzN5BCyclin-dependent kinase 22.7.11.220.527
4eon1ROCyclin-dependent kinase 22.7.11.220.527
2r3p3SCCyclin-dependent kinase 22.7.11.220.526
3r7uX96Cyclin-dependent kinase 22.7.11.220.526
3sw719KCyclin-dependent kinase 22.7.11.220.526
1di8DTQCyclin-dependent kinase 22.7.11.220.525
1dm2HMDCyclin-dependent kinase 22.7.11.220.525
1oguST8Cyclin-dependent kinase 22.7.11.220.524
2vtrLZBCyclin-dependent kinase 22.7.11.220.524
2vttLZDCyclin-dependent kinase 22.7.11.220.524
2r64740Cyclin-dependent kinase 22.7.11.220.523
2x1nX1NCyclin-dependent kinase 22.7.11.220.523
3qrtX14Cyclin-dependent kinase 22.7.11.220.523
4eor4SPCyclin-dependent kinase 22.7.11.220.522
2iw94SPCyclin-dependent kinase 22.7.11.220.521
3r8vZ62Cyclin-dependent kinase 22.7.11.220.521
2r3iSCFCyclin-dependent kinase 22.7.11.220.520
3r83Z14Cyclin-dependent kinase 22.7.11.220.520
3r9oZ71Cyclin-dependent kinase 22.7.11.220.520
3qqlX03Cyclin-dependent kinase 22.7.11.220.519
2duv371Cyclin-dependent kinase 22.7.11.220.518
3r71X86Cyclin-dependent kinase 22.7.11.220.518
3roy22ZCyclin-dependent kinase 22.7.11.220.518
3pxyJWSCyclin-dependent kinase 22.7.11.220.517
3qqfX07Cyclin-dependent kinase 22.7.11.220.517
3ddqRRCCyclin-dependent kinase 22.7.11.220.516
1w8cN69Cyclin-dependent kinase 22.7.11.220.515
3r1sX73Cyclin-dependent kinase 22.7.11.220.515
2r3r6SCCyclin-dependent kinase 22.7.11.220.514
3qzhX69Cyclin-dependent kinase 22.7.11.220.514
2iw84SPCyclin-dependent kinase 22.7.11.220.513
2vtsLZCCyclin-dependent kinase 22.7.11.220.513
3uli1N3Cyclin-dependent kinase 22.7.11.220.512
2fvdLIACyclin-dependent kinase 22.7.11.220.511
3qqhX0ACyclin-dependent kinase 22.7.11.220.511
4fklCK2Cyclin-dependent kinase 22.7.11.220.511
2b53D23Cyclin-dependent kinase 22.7.11.220.510
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.510
1oi9N20Cyclin-dependent kinase 22.7.11.220.509
3bhtMFRCyclin-dependent kinase 22.7.11.220.509
1b38ATPCyclin-dependent kinase 22.7.11.220.508
1h0w207Cyclin-dependent kinase 22.7.11.220.508
1vyw292Cyclin-dependent kinase 22.7.11.220.508
1pxpCK8Cyclin-dependent kinase 22.7.11.220.507
3ezrEZRCyclin-dependent kinase 22.7.11.220.507
3r8pZ46Cyclin-dependent kinase 22.7.11.220.507
4fx360KCyclin-dependent kinase 22.7.11.220.506
1fvt106Cyclin-dependent kinase 22.7.11.220.505
2c6tDT5Cyclin-dependent kinase 22.7.11.220.505
3qtqX35Cyclin-dependent kinase 22.7.11.220.505
2uzbC75Cyclin-dependent kinase 22.7.11.220.504
2uzdC85Cyclin-dependent kinase 22.7.11.220.504
3r7vZ02Cyclin-dependent kinase 22.7.11.220.504
3unj0BXCyclin-dependent kinase 22.7.11.220.504
1y8yCT7Cyclin-dependent kinase 22.7.11.220.503
2j9mPY8Cyclin-dependent kinase 22.7.11.220.503
3ql8X01Cyclin-dependent kinase 22.7.11.220.503
1e1xNW1Cyclin-dependent kinase 22.7.11.220.501
1ke8LS4Cyclin-dependent kinase 22.7.11.220.501
1pxkCK3Cyclin-dependent kinase 22.7.11.220.501
3qwkX62Cyclin-dependent kinase 22.7.11.220.501
2c6iDT1Cyclin-dependent kinase 22.7.11.220.500
1fvv107Cyclin-dependent kinase 22.7.11.220.499
1oiyN41Cyclin-dependent kinase 22.7.11.220.499
1pkdUCNCyclin-dependent kinase 22.7.11.220.499
4lyn1YGCyclin-dependent kinase 22.7.11.220.499
2c6kDT2Cyclin-dependent kinase 22.7.11.220.498
2r3mSCXCyclin-dependent kinase 22.7.11.220.498
2ds11CDCyclin-dependent kinase 22.7.11.220.497
2uzeC95Cyclin-dependent kinase 22.7.11.220.497
3qruX19Cyclin-dependent kinase 22.7.11.220.497
3r8zZ63Cyclin-dependent kinase 22.7.11.220.496
3sheI85MAP kinase-activated protein kinase 32.7.11.10.496
2c5yMTWCyclin-dependent kinase 22.7.11.220.495
2wihP48Cyclin-dependent kinase 22.7.11.220.495
1oiqHDUCyclin-dependent kinase 22.7.11.220.494
4bcoT6QCyclin-dependent kinase 22.7.11.220.494
1r78FMDCyclin-dependent kinase 22.7.11.220.493
2i40BLZCyclin-dependent kinase 22.7.11.220.493
1e9hINRCyclin-dependent kinase 22.7.11.220.492
1oiuN76Cyclin-dependent kinase 22.7.11.220.492
3r1qX75Cyclin-dependent kinase 22.7.11.220.492
4eok4SPCyclin-dependent kinase 22.7.11.220.492
2uzlC94Cyclin-dependent kinase 22.7.11.220.491
2vu3LZECyclin-dependent kinase 22.7.11.220.491
2xnbY8LCyclin-dependent kinase 22.7.11.220.491
1unlRRCCyclin-dependent-like kinase 52.7.11.10.490
2c5nCK8Cyclin-dependent kinase 22.7.11.220.490
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.490
3wblPDYCyclin-dependent kinase 22.7.11.220.490
3raiX85Cyclin-dependent kinase 22.7.11.220.489
5aniES4Cyclin-dependent kinase 22.7.11.220.489
3r7eX88Cyclin-dependent kinase 22.7.11.220.488
1b39ATPCyclin-dependent kinase 22.7.11.220.487
2c6lDT4Cyclin-dependent kinase 22.7.11.220.486
3r28XA0Cyclin-dependent kinase 22.7.11.220.486
3dogNNNCyclin-dependent kinase 22.7.11.220.485
3tnwF18Cyclin-dependent kinase 22.7.11.220.485
4qmpDKISerine/threonine-protein kinase 242.7.11.10.485
2pvnP63Casein kinase II subunit alpha2.7.11.10.484
4bcpT3CCyclin-dependent kinase 22.7.11.220.484
1h1q2A6Cyclin-dependent kinase 22.7.11.220.483
3rpy27ZCyclin-dependent kinase 22.7.11.220.483
4eomATPCyclin-dependent kinase 22.7.11.220.483
2wxvWXVCyclin-dependent kinase 22.7.11.220.482
1hckATPCyclin-dependent kinase 22.7.11.220.480
2b54D05Cyclin-dependent kinase 22.7.11.220.480
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.480
2wpa889Cyclin-dependent kinase 22.7.11.220.480
3nynSGVG protein-coupled receptor kinase 62.7.11.160.480
4dgo0JWCasein kinase II subunit alpha2.7.11.10.480
1eh4IC1Casein kinase I homolog 12.7.11.10.479
2exmZIPCyclin-dependent kinase 22.7.11.220.479
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.479
3qziX72Cyclin-dependent kinase 22.7.11.220.479
4ii5ADPCyclin-dependent kinase 22.7.11.220.478
2wotZZGTGF-beta receptor type-12.7.11.300.477
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.477
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.476
4bcmT7ZCyclin-dependent kinase 22.7.11.220.476
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.476
1xjdSTUProtein kinase C theta type2.7.11.130.475
2cchATPCyclin-dependent kinase 22.7.11.220.475
2eufLQQCyclin-dependent kinase 62.7.11.220.475
3qx4X4BCyclin-dependent kinase 22.7.11.220.475
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.474
3tiz3TICyclin-dependent kinase 22.7.11.220.474
4eos1ROCyclin-dependent kinase 22.7.11.220.474
2r3o2SCCyclin-dependent kinase 22.7.11.220.473
4kd11QKCyclin-dependent kinase 22.7.11.220.472
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.471
2r3gSC9Cyclin-dependent kinase 22.7.11.220.471
3qtwX3ACyclin-dependent kinase 22.7.11.220.471
3r9nZ68Cyclin-dependent kinase 22.7.11.220.471
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.471
3my5RFZCyclin-dependent kinase 22.7.11.220.470
3zh8C58Protein kinase C iota type2.7.11.130.470
1vjy460TGF-beta receptor type-12.7.11.300.469
2c6mDT5Cyclin-dependent kinase 22.7.11.220.469
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.469
1h0vUN4Cyclin-dependent kinase 22.7.11.220.468
1v0pPVBCell division control protein 2 homolog2.7.11.220.468
4cfnJYMCyclin-dependent kinase 22.7.11.220.468
2pvlP55Casein kinase II subunit alpha2.7.11.10.467
3gubGUBDeath-associated protein kinase 12.7.11.10.467
4aua4AUCyclin-dependent kinase 62.7.11.220.467
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.467
1h1pCMGCyclin-dependent kinase 22.7.11.220.466
3be9P04Casein kinase II subunit alpha2.7.11.10.466
3ggfGVDSerine/threonine-protein kinase 26/0.466
4dgnLU2Casein kinase II subunit alpha2.7.11.10.466
3rahO1ZCyclin-dependent kinase 22.7.11.220.463
4bcnT9NCyclin-dependent kinase 22.7.11.220.462
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.462
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.461
4anmWULCasein kinase II subunit alpha2.7.11.10.461
2f2cAP9Cyclin-dependent kinase 62.7.11.220.460
2xikJ60Serine/threonine-protein kinase 252.7.11.10.460
3qx2X63Cyclin-dependent kinase 22.7.11.220.460
2vtqLZACyclin-dependent kinase 22.7.11.220.459
3gxlQIGTGF-beta receptor type-12.7.11.300.458
4eop1ROCyclin-dependent kinase 22.7.11.220.458
1v0oINRCell division control protein 2 homolog2.7.11.220.457
2pvhP19Casein kinase II subunit alpha2.7.11.10.457
3hmm855TGF-beta receptor type-12.7.11.300.457
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.457
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.457
3i60E86Mitogen-activated protein kinase 12.7.11.240.456
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.456
4fv9E71Mitogen-activated protein kinase 12.7.11.240.456
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.454
4qmzB49Serine/threonine-protein kinase 242.7.11.10.454
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.453
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.453
1m2pHNACasein kinase II subunit alpha2.7.11.10.452
4i22IREEpidermal growth factor receptor2.7.10.10.452
3eljGS7Mitogen-activated protein kinase 82.7.11.240.451
3rzb02ZCyclin-dependent kinase 22.7.11.220.451
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
2r3fSC8Cyclin-dependent kinase 22.7.11.220.449
2y9qANPMitogen-activated protein kinase 12.7.11.240.449
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4bcqTJFCyclin-dependent kinase 22.7.11.220.448
4bgg844Activin receptor type-12.7.11.300.448
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.447
1py5PY1TGF-beta receptor type-12.7.11.300.447
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.447
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.447
3mtlFEFCyclin-dependent kinase 162.7.11.220.447
3mvl38PMitogen-activated protein kinase 14/0.447
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.446
4btjADPTau-tubulin kinase 12.7.11.10.445
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.445
1xo2FSECyclin-dependent kinase 62.7.11.220.444
2bkzSBCCyclin-dependent kinase 22.7.11.220.444
3a7jADPSerine/threonine-protein kinase 242.7.11.10.444
3nieANPMitogen-activated protein kinase/0.444
1om1IQACasein kinase II subunit alpha2.7.11.10.443
2hog710Serine/threonine-protein kinase Chk12.7.11.10.443
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fv6E57Mitogen-activated protein kinase 12.7.11.240.443
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.443
1qmzATPCyclin-dependent kinase 22.7.11.220.442
2dwbANPAurora kinase A2.7.11.10.442
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.442
3cgfJNFMitogen-activated protein kinase 102.7.11.240.441
3r8uZ31Cyclin-dependent kinase 22.7.11.220.441
4eoi1ROCyclin-dependent kinase 22.7.11.220.441
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.441
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
1pxjCK2Cyclin-dependent kinase 22.7.11.220.440
2c4g514Cyclin-dependent kinase 22.7.11.220.440
2c69CT8Cyclin-dependent kinase 22.7.11.220.440
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.440
3qqgX06Cyclin-dependent kinase 22.7.11.220.440
4lopSB4Mitogen-activated protein kinase 14/0.440
5cshATPCasein kinase II subunit alpha2.7.11.10.440