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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3r8uZ31Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3r8uZ31Cyclin-dependent kinase 22.7.11.221.000
3qx2X63Cyclin-dependent kinase 22.7.11.220.623
1h0w207Cyclin-dependent kinase 22.7.11.220.613
3rm719ZCyclin-dependent kinase 22.7.11.220.613
2c6mDT5Cyclin-dependent kinase 22.7.11.220.611
3r8vZ62Cyclin-dependent kinase 22.7.11.220.610
3r1qX75Cyclin-dependent kinase 22.7.11.220.609
3r28XA0Cyclin-dependent kinase 22.7.11.220.604
3rpr25ZCyclin-dependent kinase 22.7.11.220.597
3r71X86Cyclin-dependent kinase 22.7.11.220.595
3r73X87Cyclin-dependent kinase 22.7.11.220.592
4kd11QKCyclin-dependent kinase 22.7.11.220.586
4ez30S0Cyclin-dependent kinase 22.7.11.220.584
1y8yCT7Cyclin-dependent kinase 22.7.11.220.579
3rk909ZCyclin-dependent kinase 22.7.11.220.579
3r9hZ67Cyclin-dependent kinase 22.7.11.220.577
3r9nZ68Cyclin-dependent kinase 22.7.11.220.573
2c6iDT1Cyclin-dependent kinase 22.7.11.220.571
2r3gSC9Cyclin-dependent kinase 22.7.11.220.571
1w8cN69Cyclin-dependent kinase 22.7.11.220.570
3iggEFQCyclin-dependent kinase 22.7.11.220.569
2c69CT8Cyclin-dependent kinase 22.7.11.220.567
3rpo24ZCyclin-dependent kinase 22.7.11.220.565
3qzhX69Cyclin-dependent kinase 22.7.11.220.564
3r6xX84Cyclin-dependent kinase 22.7.11.220.563
3s00Z60Cyclin-dependent kinase 22.7.11.220.562
1oiyN41Cyclin-dependent kinase 22.7.11.220.559
2r3iSCFCyclin-dependent kinase 22.7.11.220.555
3r1sX73Cyclin-dependent kinase 22.7.11.220.555
3qziX72Cyclin-dependent kinase 22.7.11.220.554
3s0o50ZCyclin-dependent kinase 22.7.11.220.554
3roy22ZCyclin-dependent kinase 22.7.11.220.552
3rpv26ZCyclin-dependent kinase 22.7.11.220.552
1h0vUN4Cyclin-dependent kinase 22.7.11.220.550
3my5RFZCyclin-dependent kinase 22.7.11.220.549
3qwkX62Cyclin-dependent kinase 22.7.11.220.549
3rahO1ZCyclin-dependent kinase 22.7.11.220.549
2btrU73Cyclin-dependent kinase 22.7.11.220.547
2r3fSC8Cyclin-dependent kinase 22.7.11.220.547
2r3r6SCCyclin-dependent kinase 22.7.11.220.547
3qqkX02Cyclin-dependent kinase 22.7.11.220.547
1e1xNW1Cyclin-dependent kinase 22.7.11.220.546
1v1k3FPCyclin-dependent kinase 22.7.11.220.546
2w06FRVCyclin-dependent kinase 22.7.11.220.545
3ezrEZRCyclin-dependent kinase 22.7.11.220.545
4eor4SPCyclin-dependent kinase 22.7.11.220.545
5aniES4Cyclin-dependent kinase 22.7.11.220.545
3qtsX46Cyclin-dependent kinase 22.7.11.220.544
3r83Z14Cyclin-dependent kinase 22.7.11.220.542
4fkj11KCyclin-dependent kinase 22.7.11.220.542
3raiX85Cyclin-dependent kinase 22.7.11.220.541
4fkq42KCyclin-dependent kinase 22.7.11.220.540
3qu0X40Cyclin-dependent kinase 22.7.11.220.539
3qzgX67Cyclin-dependent kinase 22.7.11.220.539
2c6kDT2Cyclin-dependent kinase 22.7.11.220.538
3qqlX03Cyclin-dependent kinase 22.7.11.220.538
2r64740Cyclin-dependent kinase 22.7.11.220.536
3lfnA27Cyclin-dependent kinase 22.7.11.220.536
3qtuX44Cyclin-dependent kinase 22.7.11.220.536
1pxmCK5Cyclin-dependent kinase 22.7.11.220.535
4fkg4CKCyclin-dependent kinase 22.7.11.220.535
1urwI1PCyclin-dependent kinase 22.7.11.220.534
2c68CT6Cyclin-dependent kinase 22.7.11.220.533
2c6o4SPCyclin-dependent kinase 22.7.11.220.533
3r9dX6BCyclin-dependent kinase 22.7.11.220.533
1ke6LS2Cyclin-dependent kinase 22.7.11.220.532
3qwjX6ACyclin-dependent kinase 22.7.11.220.532
1vyzN5BCyclin-dependent kinase 22.7.11.220.531
2fvdLIACyclin-dependent kinase 22.7.11.220.531
3rkb12ZCyclin-dependent kinase 22.7.11.220.531
3ddpRC8Cyclin-dependent kinase 22.7.11.220.529
3r7vZ02Cyclin-dependent kinase 22.7.11.220.529
3rm618ZCyclin-dependent kinase 22.7.11.220.529
3qqfX07Cyclin-dependent kinase 22.7.11.220.528
3pj8404Cyclin-dependent kinase 22.7.11.220.527
2vtsLZCCyclin-dependent kinase 22.7.11.220.526
1ke5LS1Cyclin-dependent kinase 22.7.11.220.525
1oguST8Cyclin-dependent kinase 22.7.11.220.525
2r3o2SCCyclin-dependent kinase 22.7.11.220.525
4fklCK2Cyclin-dependent kinase 22.7.11.220.525
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.524
3qtxX43Cyclin-dependent kinase 22.7.11.220.524
3s2pPMUCyclin-dependent kinase 22.7.11.220.524
3lfqA28Cyclin-dependent kinase 22.7.11.220.523
4fkr45KCyclin-dependent kinase 22.7.11.220.523
4lyn1YGCyclin-dependent kinase 22.7.11.220.523
1w0xOLOCyclin-dependent kinase 22.7.11.220.522
1ykr628Cyclin-dependent kinase 22.7.11.220.520
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.520
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.519
2c4g514Cyclin-dependent kinase 22.7.11.220.518
2uzoC62Cyclin-dependent kinase 22.7.11.220.517
3qxoX65Cyclin-dependent kinase 22.7.11.220.517
3r1yX76Cyclin-dependent kinase 22.7.11.220.517
3qruX19Cyclin-dependent kinase 22.7.11.220.516
4fkw62KCyclin-dependent kinase 22.7.11.220.516
2btsU32Cyclin-dependent kinase 22.7.11.220.513
2iw84SPCyclin-dependent kinase 22.7.11.220.513
2a0cCK9Cyclin-dependent kinase 22.7.11.220.511
2b55D31Cyclin-dependent kinase 22.7.11.220.511
3r8lZ30Cyclin-dependent kinase 22.7.11.220.511
1h1r6CPCyclin-dependent kinase 22.7.11.220.510
2b52D42Cyclin-dependent kinase 22.7.11.220.510
3sqq99ZCyclin-dependent kinase 22.7.11.220.510
2r3lSCWCyclin-dependent kinase 22.7.11.220.509
3ral04ZCyclin-dependent kinase 22.7.11.220.509
1vyw292Cyclin-dependent kinase 22.7.11.220.508
3dogNNNCyclin-dependent kinase 22.7.11.220.508
3unk0BYCyclin-dependent kinase 22.7.11.220.508
1g5sI17Cyclin-dependent kinase 22.7.11.220.507
2c6lDT4Cyclin-dependent kinase 22.7.11.220.507
3r8pZ46Cyclin-dependent kinase 22.7.11.220.507
2iw94SPCyclin-dependent kinase 22.7.11.220.506
3ezvEZVCyclin-dependent kinase 22.7.11.220.506
3qtqX35Cyclin-dependent kinase 22.7.11.220.505
3rjc06ZCyclin-dependent kinase 22.7.11.220.505
3tnwF18Cyclin-dependent kinase 22.7.11.220.505
4fkpLS5Cyclin-dependent kinase 22.7.11.220.505
2vu3LZECyclin-dependent kinase 22.7.11.220.504
2vv9IM9Cyclin-dependent kinase 22.7.11.220.504
3rni21ZCyclin-dependent kinase 22.7.11.220.504
1gij2PUCyclin-dependent kinase 22.7.11.220.503
4bgh3I6Cyclin-dependent kinase 22.7.11.220.503
4eol1ROCyclin-dependent kinase 22.7.11.220.502
1oitHDTCyclin-dependent kinase 22.7.11.220.501
2vthLZ2Cyclin-dependent kinase 22.7.11.220.500
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.500
1gih1PUCyclin-dependent kinase 22.7.11.220.499
1oi9N20Cyclin-dependent kinase 22.7.11.220.499
2a4lRRCCyclin-dependent kinase 22.7.11.220.499
2duv371Cyclin-dependent kinase 22.7.11.220.499
4ek610KCyclin-dependent kinase 22.7.11.220.499
4fki09KCyclin-dependent kinase 22.7.11.220.499
4fko20KCyclin-dependent kinase 22.7.11.220.499
1h1s4SPCyclin-dependent kinase 22.7.11.220.498
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.498
3r7yZ04Cyclin-dependent kinase 22.7.11.220.498
4eomATPCyclin-dependent kinase 22.7.11.220.498
3ig7EFPCyclin-dependent kinase 22.7.11.220.496
3qtrX36Cyclin-dependent kinase 22.7.11.220.496
3rk507ZCyclin-dependent kinase 22.7.11.220.496
3rk708ZCyclin-dependent kinase 22.7.11.220.496
4acm7YGCyclin-dependent kinase 22.7.11.220.496
1gz8MBPCyclin-dependent kinase 22.7.11.220.495
1ke7LS3Cyclin-dependent kinase 22.7.11.220.494
3wblPDYCyclin-dependent kinase 22.7.11.220.494
4bcnT9NCyclin-dependent kinase 22.7.11.220.494
1b38ATPCyclin-dependent kinase 22.7.11.220.493
3r7eX88Cyclin-dependent kinase 22.7.11.220.493
4bcmT7ZCyclin-dependent kinase 22.7.11.220.493
2exmZIPCyclin-dependent kinase 22.7.11.220.492
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.492
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.492
3qrtX14Cyclin-dependent kinase 22.7.11.220.492
2r3p3SCCyclin-dependent kinase 22.7.11.220.491
1e1vCMGCyclin-dependent kinase 22.7.11.220.490
1pkdUCNCyclin-dependent kinase 22.7.11.220.490
3r8zZ63Cyclin-dependent kinase 22.7.11.220.490
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.489
1pxlCK4Cyclin-dependent kinase 22.7.11.220.488
4bcqTJFCyclin-dependent kinase 22.7.11.220.488
3r7uX96Cyclin-dependent kinase 22.7.11.220.487
3rak03ZCyclin-dependent kinase 22.7.11.220.487
3s1h56ZCyclin-dependent kinase 22.7.11.220.487
4eoi1ROCyclin-dependent kinase 22.7.11.220.487
1oiqHDUCyclin-dependent kinase 22.7.11.220.486
2w17I19Cyclin-dependent kinase 22.7.11.220.486
2i40BLZCyclin-dependent kinase 22.7.11.220.484
2vttLZDCyclin-dependent kinase 22.7.11.220.484
3sw418KCyclin-dependent kinase 22.7.11.220.484
1fvt106Cyclin-dependent kinase 22.7.11.220.483
1p2a5BNCyclin-dependent kinase 22.7.11.220.483
4eos1ROCyclin-dependent kinase 22.7.11.220.483
3r7iX9ICyclin-dependent kinase 22.7.11.220.482
1h1pCMGCyclin-dependent kinase 22.7.11.220.481
2uznC96Cyclin-dependent kinase 22.7.11.220.481
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.480
4fx360KCyclin-dependent kinase 22.7.11.220.480
2vtqLZACyclin-dependent kinase 22.7.11.220.479
3qqhX0ACyclin-dependent kinase 22.7.11.220.479
1e9hINRCyclin-dependent kinase 22.7.11.220.477
1ke9LS5Cyclin-dependent kinase 22.7.11.220.477
1di8DTQCyclin-dependent kinase 22.7.11.220.476
3rpy27ZCyclin-dependent kinase 22.7.11.220.476
5e8ySTUTGF-beta receptor type-22.7.11.300.476
4cfnJYMCyclin-dependent kinase 22.7.11.220.475
4qmpDKISerine/threonine-protein kinase 242.7.11.10.475
2cchATPCyclin-dependent kinase 22.7.11.220.474
3sw719KCyclin-dependent kinase 22.7.11.220.474
3rmf20ZCyclin-dependent kinase 22.7.11.220.473
4fkt48KCyclin-dependent kinase 22.7.11.220.473
1pxkCK3Cyclin-dependent kinase 22.7.11.220.472
3fz1B98Cyclin-dependent kinase 22.7.11.220.472
2b54D05Cyclin-dependent kinase 22.7.11.220.471
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.470
1ckpPVBCyclin-dependent kinase 22.7.11.220.467
1r78FMDCyclin-dependent kinase 22.7.11.220.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
1y91CT9Cyclin-dependent kinase 22.7.11.220.464
2c5yMTWCyclin-dependent kinase 22.7.11.220.464
4bcpT3CCyclin-dependent kinase 22.7.11.220.464
4fkv61KCyclin-dependent kinase 22.7.11.220.463
4k8aK8AFocal adhesion kinase 12.7.10.20.463
1gii1PUCyclin-dependent kinase 22.7.11.220.462
1hckATPCyclin-dependent kinase 22.7.11.220.462
4btjATPTau-tubulin kinase 12.7.11.10.462
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.462
4fks46KCyclin-dependent kinase 22.7.11.220.462
1fvv107Cyclin-dependent kinase 22.7.11.220.461
1h1q2A6Cyclin-dependent kinase 22.7.11.220.461
2r3kSCQCyclin-dependent kinase 22.7.11.220.461
3qtzX42Cyclin-dependent kinase 22.7.11.220.461
4ek816KCyclin-dependent kinase 22.7.11.220.461
2w1hL0FCyclin-dependent kinase 22.7.11.220.460
3ql8X01Cyclin-dependent kinase 22.7.11.220.460
1oiuN76Cyclin-dependent kinase 22.7.11.220.459
1pyePM1Cyclin-dependent kinase 22.7.11.220.459
1unlRRCCyclin-dependent-like kinase 52.7.11.10.459
3ddqRRCCyclin-dependent kinase 22.7.11.220.459
1b39ATPCyclin-dependent kinase 22.7.11.220.458
4eon1ROCyclin-dependent kinase 22.7.11.220.458
2c6tDT5Cyclin-dependent kinase 22.7.11.220.457
2xngA0HAurora kinase A2.7.11.10.457
3oom507Activin receptor type-12.7.11.300.457
3py0SU9Cyclin-dependent kinase 22.7.11.220.457
4eok4SPCyclin-dependent kinase 22.7.11.220.457
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.456
3lfsA07Cyclin-dependent kinase 22.7.11.220.456
3unj0BXCyclin-dependent kinase 22.7.11.220.456
1gy3ATPCyclin-dependent kinase 22.7.11.220.455
1pxpCK8Cyclin-dependent kinase 22.7.11.220.455
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.455
2uzlC94Cyclin-dependent kinase 22.7.11.220.455
3ti1B49Cyclin-dependent kinase 22.7.11.220.454
1qmzATPCyclin-dependent kinase 22.7.11.220.453
2c5nCK8Cyclin-dependent kinase 22.7.11.220.453
4k771Q4Tyrosine-protein kinase JAK1/0.453
1finATPCyclin-dependent kinase 22.7.11.220.452
1ke8LS4Cyclin-dependent kinase 22.7.11.220.452
1oirHDYCyclin-dependent kinase 22.7.11.220.452
1pxoCK7Cyclin-dependent kinase 22.7.11.220.452
2wotZZGTGF-beta receptor type-12.7.11.300.452
2x1nX1NCyclin-dependent kinase 22.7.11.220.452
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.452
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.452
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.452
4btjADPTau-tubulin kinase 12.7.11.10.452
3tiz3TICyclin-dependent kinase 22.7.11.220.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
4yswFADXanthine dehydrogenase/oxidase/0.450
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
1v0pPVBCell division control protein 2 homolog2.7.11.220.449
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.449
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.449
2xnbY8LCyclin-dependent kinase 22.7.11.220.448
2j9mPY8Cyclin-dependent kinase 22.7.11.220.447
2r3mSCXCyclin-dependent kinase 22.7.11.220.447
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.447
3qzfX66Cyclin-dependent kinase 22.7.11.220.447
3sheI85MAP kinase-activated protein kinase 32.7.11.10.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
3uli1N3Cyclin-dependent kinase 22.7.11.220.447
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.447
2b7aIZATyrosine-protein kinase JAK2/0.446
2izuP01Casein kinase I isoform gamma-32.7.11.10.446
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.446
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.446
4ivb1J5Tyrosine-protein kinase JAK1/0.446
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.445
2uzdC85Cyclin-dependent kinase 22.7.11.220.445
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.445
3pxyJWSCyclin-dependent kinase 22.7.11.220.445
4c4jX21Dual specificity protein kinase TTK2.7.12.10.445
4qmlANPSerine/threonine-protein kinase 242.7.11.10.445
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2cciATPCyclin-dependent kinase 22.7.11.220.444
2csnCKICasein kinase I homolog 12.7.11.10.444
2vd5BI8Myotonin-protein kinase2.7.11.10.444
2wihP48Cyclin-dependent kinase 22.7.11.220.444
2wpa889Cyclin-dependent kinase 22.7.11.220.444
3qtwX3ACyclin-dependent kinase 22.7.11.220.444
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.444
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.444
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.444
4ii5ADPCyclin-dependent kinase 22.7.11.220.444
4ogrADNCyclin-dependent kinase 92.7.11.220.444
2j0m4STFocal adhesion kinase 12.7.10.20.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
3qx4X4BCyclin-dependent kinase 22.7.11.220.443
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.443
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.442
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2j0lANPFocal adhesion kinase 12.7.10.20.441
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.441
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.441
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.440
2ds11CDCyclin-dependent kinase 22.7.11.220.440
4g170VNCasein kinase I isoform gamma-32.7.11.10.440
5drdATPAurora kinase A2.7.11.10.440