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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3r6xX84Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3r6xX84Cyclin-dependent kinase 22.7.11.221.000
3qxoX65Cyclin-dependent kinase 22.7.11.220.775
3roy22ZCyclin-dependent kinase 22.7.11.220.729
3raiX85Cyclin-dependent kinase 22.7.11.220.724
3r1qX75Cyclin-dependent kinase 22.7.11.220.700
3rm719ZCyclin-dependent kinase 22.7.11.220.692
3r28XA0Cyclin-dependent kinase 22.7.11.220.689
3qwkX62Cyclin-dependent kinase 22.7.11.220.648
3qx2X63Cyclin-dependent kinase 22.7.11.220.644
3r7vZ02Cyclin-dependent kinase 22.7.11.220.636
1ckpPVBCyclin-dependent kinase 22.7.11.220.619
4fki09KCyclin-dependent kinase 22.7.11.220.619
3r73X87Cyclin-dependent kinase 22.7.11.220.618
4ez30S0Cyclin-dependent kinase 22.7.11.220.608
3qzgX67Cyclin-dependent kinase 22.7.11.220.606
3qqfX07Cyclin-dependent kinase 22.7.11.220.604
3qwjX6ACyclin-dependent kinase 22.7.11.220.604
1v1k3FPCyclin-dependent kinase 22.7.11.220.599
3s0o50ZCyclin-dependent kinase 22.7.11.220.597
2btrU73Cyclin-dependent kinase 22.7.11.220.595
3lfnA27Cyclin-dependent kinase 22.7.11.220.595
3qzhX69Cyclin-dependent kinase 22.7.11.220.595
4ek610KCyclin-dependent kinase 22.7.11.220.595
3sqq99ZCyclin-dependent kinase 22.7.11.220.594
4lyn1YGCyclin-dependent kinase 22.7.11.220.593
3iggEFQCyclin-dependent kinase 22.7.11.220.590
3qu0X40Cyclin-dependent kinase 22.7.11.220.589
3qtzX42Cyclin-dependent kinase 22.7.11.220.585
1ke6LS2Cyclin-dependent kinase 22.7.11.220.584
1pxmCK5Cyclin-dependent kinase 22.7.11.220.583
3r1sX73Cyclin-dependent kinase 22.7.11.220.583
3ddpRC8Cyclin-dependent kinase 22.7.11.220.580
3rpo24ZCyclin-dependent kinase 22.7.11.220.580
1g5sI17Cyclin-dependent kinase 22.7.11.220.579
3r8lZ30Cyclin-dependent kinase 22.7.11.220.579
3r7eX88Cyclin-dependent kinase 22.7.11.220.578
2r64740Cyclin-dependent kinase 22.7.11.220.577
3qqkX02Cyclin-dependent kinase 22.7.11.220.577
3rni21ZCyclin-dependent kinase 22.7.11.220.574
3rm618ZCyclin-dependent kinase 22.7.11.220.568
3s2pPMUCyclin-dependent kinase 22.7.11.220.568
3r9dX6BCyclin-dependent kinase 22.7.11.220.567
1p2a5BNCyclin-dependent kinase 22.7.11.220.566
3rjc06ZCyclin-dependent kinase 22.7.11.220.566
1ke9LS5Cyclin-dependent kinase 22.7.11.220.564
1vyzN5BCyclin-dependent kinase 22.7.11.220.564
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.564
1pxkCK3Cyclin-dependent kinase 22.7.11.220.563
3ezrEZRCyclin-dependent kinase 22.7.11.220.562
1fvt106Cyclin-dependent kinase 22.7.11.220.560
3qtxX43Cyclin-dependent kinase 22.7.11.220.560
3unk0BYCyclin-dependent kinase 22.7.11.220.560
4fkj11KCyclin-dependent kinase 22.7.11.220.560
2btsU32Cyclin-dependent kinase 22.7.11.220.559
3rpv26ZCyclin-dependent kinase 22.7.11.220.559
4fkq42KCyclin-dependent kinase 22.7.11.220.559
1oiqHDUCyclin-dependent kinase 22.7.11.220.558
3qtuX44Cyclin-dependent kinase 22.7.11.220.558
3ti1B49Cyclin-dependent kinase 22.7.11.220.558
1gih1PUCyclin-dependent kinase 22.7.11.220.556
3ddqRRCCyclin-dependent kinase 22.7.11.220.553
1h1r6CPCyclin-dependent kinase 22.7.11.220.552
3qruX19Cyclin-dependent kinase 22.7.11.220.548
3r9hZ67Cyclin-dependent kinase 22.7.11.220.548
3rk909ZCyclin-dependent kinase 22.7.11.220.548
4eor4SPCyclin-dependent kinase 22.7.11.220.548
3r1yX76Cyclin-dependent kinase 22.7.11.220.547
3r7iX9ICyclin-dependent kinase 22.7.11.220.547
1h0w207Cyclin-dependent kinase 22.7.11.220.545
1h1s4SPCyclin-dependent kinase 22.7.11.220.545
1oguST8Cyclin-dependent kinase 22.7.11.220.545
1vyw292Cyclin-dependent kinase 22.7.11.220.545
3s00Z60Cyclin-dependent kinase 22.7.11.220.544
4fkpLS5Cyclin-dependent kinase 22.7.11.220.544
1oi9N20Cyclin-dependent kinase 22.7.11.220.543
3rk708ZCyclin-dependent kinase 22.7.11.220.543
3s1h56ZCyclin-dependent kinase 22.7.11.220.543
4fkr45KCyclin-dependent kinase 22.7.11.220.543
2b55D31Cyclin-dependent kinase 22.7.11.220.542
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.542
2iw94SPCyclin-dependent kinase 22.7.11.220.542
2uzoC62Cyclin-dependent kinase 22.7.11.220.542
3lfsA07Cyclin-dependent kinase 22.7.11.220.540
2duv371Cyclin-dependent kinase 22.7.11.220.539
2r3lSCWCyclin-dependent kinase 22.7.11.220.539
2w06FRVCyclin-dependent kinase 22.7.11.220.539
1di8DTQCyclin-dependent kinase 22.7.11.220.537
1w0xOLOCyclin-dependent kinase 22.7.11.220.536
2vthLZ2Cyclin-dependent kinase 22.7.11.220.536
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.536
3rk507ZCyclin-dependent kinase 22.7.11.220.536
5aniES4Cyclin-dependent kinase 22.7.11.220.536
1gii1PUCyclin-dependent kinase 22.7.11.220.535
3ig7EFPCyclin-dependent kinase 22.7.11.220.534
3ql8X01Cyclin-dependent kinase 22.7.11.220.534
3r8pZ46Cyclin-dependent kinase 22.7.11.220.533
3unj0BXCyclin-dependent kinase 22.7.11.220.533
1urwI1PCyclin-dependent kinase 22.7.11.220.532
2r3kSCQCyclin-dependent kinase 22.7.11.220.532
1ke5LS1Cyclin-dependent kinase 22.7.11.220.531
4fkg4CKCyclin-dependent kinase 22.7.11.220.531
1ke7LS3Cyclin-dependent kinase 22.7.11.220.530
2a4lRRCCyclin-dependent kinase 22.7.11.220.530
2iw84SPCyclin-dependent kinase 22.7.11.220.530
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.530
2w1hL0FCyclin-dependent kinase 22.7.11.220.529
2xmyCDKCyclin-dependent kinase 22.7.11.220.529
1ke8LS4Cyclin-dependent kinase 22.7.11.220.528
1w8cN69Cyclin-dependent kinase 22.7.11.220.528
3r7uX96Cyclin-dependent kinase 22.7.11.220.528
3rak03ZCyclin-dependent kinase 22.7.11.220.528
3ral04ZCyclin-dependent kinase 22.7.11.220.528
4bcpT3CCyclin-dependent kinase 22.7.11.220.527
1h0vUN4Cyclin-dependent kinase 22.7.11.220.526
2b52D42Cyclin-dependent kinase 22.7.11.220.526
1ykr628Cyclin-dependent kinase 22.7.11.220.525
4kd11QKCyclin-dependent kinase 22.7.11.220.525
1b39ATPCyclin-dependent kinase 22.7.11.220.524
1oiuN76Cyclin-dependent kinase 22.7.11.220.524
1r78FMDCyclin-dependent kinase 22.7.11.220.524
4eos1ROCyclin-dependent kinase 22.7.11.220.523
2c4g514Cyclin-dependent kinase 22.7.11.220.522
4eon1ROCyclin-dependent kinase 22.7.11.220.522
1oitHDTCyclin-dependent kinase 22.7.11.220.521
3qqhX0ACyclin-dependent kinase 22.7.11.220.521
3rkb12ZCyclin-dependent kinase 22.7.11.220.521
3tiz3TICyclin-dependent kinase 22.7.11.220.521
2bhhRYUCyclin-dependent kinase 22.7.11.220.520
2r3o2SCCyclin-dependent kinase 22.7.11.220.520
2w05FRTCyclin-dependent kinase 22.7.11.220.520
4bgh3I6Cyclin-dependent kinase 22.7.11.220.520
1h1pCMGCyclin-dependent kinase 22.7.11.220.517
3r8uZ31Cyclin-dependent kinase 22.7.11.220.517
2c69CT8Cyclin-dependent kinase 22.7.11.220.516
4bcmT7ZCyclin-dependent kinase 22.7.11.220.516
3wblPDYCyclin-dependent kinase 22.7.11.220.515
2uznC96Cyclin-dependent kinase 22.7.11.220.514
3qtqX35Cyclin-dependent kinase 22.7.11.220.514
2r3p3SCCyclin-dependent kinase 22.7.11.220.513
3qziX72Cyclin-dependent kinase 22.7.11.220.513
4eomATPCyclin-dependent kinase 22.7.11.220.513
3qrtX14Cyclin-dependent kinase 22.7.11.220.512
4fkt48KCyclin-dependent kinase 22.7.11.220.512
1pxoCK7Cyclin-dependent kinase 22.7.11.220.511
4acm7YGCyclin-dependent kinase 22.7.11.220.511
3sw418KCyclin-dependent kinase 22.7.11.220.510
1oiyN41Cyclin-dependent kinase 22.7.11.220.508
2r3gSC9Cyclin-dependent kinase 22.7.11.220.508
2i40BLZCyclin-dependent kinase 22.7.11.220.507
2r3r6SCCyclin-dependent kinase 22.7.11.220.507
3py0SU9Cyclin-dependent kinase 22.7.11.220.507
3rpy27ZCyclin-dependent kinase 22.7.11.220.507
2vtsLZCCyclin-dependent kinase 22.7.11.220.506
3qx4X4BCyclin-dependent kinase 22.7.11.220.505
2wpa889Cyclin-dependent kinase 22.7.11.220.504
3qqlX03Cyclin-dependent kinase 22.7.11.220.504
4eol1ROCyclin-dependent kinase 22.7.11.220.504
3bhtMFRCyclin-dependent kinase 22.7.11.220.503
3rmf20ZCyclin-dependent kinase 22.7.11.220.503
1e1xNW1Cyclin-dependent kinase 22.7.11.220.502
1pkdUCNCyclin-dependent kinase 22.7.11.220.502
1pyePM1Cyclin-dependent kinase 22.7.11.220.502
3pj8404Cyclin-dependent kinase 22.7.11.220.502
3qtrX36Cyclin-dependent kinase 22.7.11.220.502
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.501
2c5nCK8Cyclin-dependent kinase 22.7.11.220.500
3rpr25ZCyclin-dependent kinase 22.7.11.220.500
4bcnT9NCyclin-dependent kinase 22.7.11.220.500
1e9hINRCyclin-dependent kinase 22.7.11.220.499
1gij2PUCyclin-dependent kinase 22.7.11.220.499
2vv9IM9Cyclin-dependent kinase 22.7.11.220.499
1dm2HMDCyclin-dependent kinase 22.7.11.220.498
4eok4SPCyclin-dependent kinase 22.7.11.220.498
4fko20KCyclin-dependent kinase 22.7.11.220.498
2exmZIPCyclin-dependent kinase 22.7.11.220.497
1unlRRCCyclin-dependent-like kinase 52.7.11.10.496
2b54D05Cyclin-dependent kinase 22.7.11.220.496
2r3iSCFCyclin-dependent kinase 22.7.11.220.496
3pxyJWSCyclin-dependent kinase 22.7.11.220.496
4fks46KCyclin-dependent kinase 22.7.11.220.496
1e1vCMGCyclin-dependent kinase 22.7.11.220.495
1h1q2A6Cyclin-dependent kinase 22.7.11.220.495
2c6tDT5Cyclin-dependent kinase 22.7.11.220.495
2j9mPY8Cyclin-dependent kinase 22.7.11.220.495
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.495
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
3qzfX66Cyclin-dependent kinase 22.7.11.220.493
3r8zZ63Cyclin-dependent kinase 22.7.11.220.492
2x1nX1NCyclin-dependent kinase 22.7.11.220.491
3fz1B98Cyclin-dependent kinase 22.7.11.220.491
4bcoT6QCyclin-dependent kinase 22.7.11.220.491
3rzb02ZCyclin-dependent kinase 22.7.11.220.490
4fkv61KCyclin-dependent kinase 22.7.11.220.490
1oirHDYCyclin-dependent kinase 22.7.11.220.487
2c6iDT1Cyclin-dependent kinase 22.7.11.220.487
2c6mDT5Cyclin-dependent kinase 22.7.11.220.487
3qtwX3ACyclin-dependent kinase 22.7.11.220.487
4cfnJYMCyclin-dependent kinase 22.7.11.220.487
2cchATPCyclin-dependent kinase 22.7.11.220.486
4qmpDKISerine/threonine-protein kinase 242.7.11.10.486
3tnwF18Cyclin-dependent kinase 22.7.11.220.485
4fx360KCyclin-dependent kinase 22.7.11.220.485
2wxvWXVCyclin-dependent kinase 22.7.11.220.484
4eop1ROCyclin-dependent kinase 22.7.11.220.484
1pxpCK8Cyclin-dependent kinase 22.7.11.220.483
3dogNNNCyclin-dependent kinase 22.7.11.220.483
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.483
1gz8MBPCyclin-dependent kinase 22.7.11.220.482
2c6lDT4Cyclin-dependent kinase 22.7.11.220.481
4nj32KDCyclin-dependent kinase 22.7.11.220.481
2vttLZDCyclin-dependent kinase 22.7.11.220.480
3sw719KCyclin-dependent kinase 22.7.11.220.480
3uli1N3Cyclin-dependent kinase 22.7.11.220.479
3ggfGVDSerine/threonine-protein kinase 26/0.478
4eoi1ROCyclin-dependent kinase 22.7.11.220.478
2w17I19Cyclin-dependent kinase 22.7.11.220.477
4fkw62KCyclin-dependent kinase 22.7.11.220.477
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.476
1aq1STUCyclin-dependent kinase 22.7.11.220.475
2uzlC94Cyclin-dependent kinase 22.7.11.220.475
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.473
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.473
2c6o4SPCyclin-dependent kinase 22.7.11.220.472
2wotZZGTGF-beta receptor type-12.7.11.300.472
1b38ATPCyclin-dependent kinase 22.7.11.220.471
2xnbY8LCyclin-dependent kinase 22.7.11.220.471
3r9nZ68Cyclin-dependent kinase 22.7.11.220.471
4bcqTJFCyclin-dependent kinase 22.7.11.220.471
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.471
2c5yMTWCyclin-dependent kinase 22.7.11.220.470
2uzdC85Cyclin-dependent kinase 22.7.11.220.470
3r9oZ71Cyclin-dependent kinase 22.7.11.220.468
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.468
1qmzATPCyclin-dependent kinase 22.7.11.220.467
2bheBRYCyclin-dependent kinase 22.7.11.220.467
1gy3ATPCyclin-dependent kinase 22.7.11.220.465
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.463
2r3fSC8Cyclin-dependent kinase 22.7.11.220.462
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.461
1y8yCT7Cyclin-dependent kinase 22.7.11.220.458
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.458
1finATPCyclin-dependent kinase 22.7.11.220.456
2wihP48Cyclin-dependent kinase 22.7.11.220.456
3qtsX46Cyclin-dependent kinase 22.7.11.220.456
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.456
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.456
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4fv9E71Mitogen-activated protein kinase 12.7.11.240.455
2r3mSCXCyclin-dependent kinase 22.7.11.220.454
3nup3NUCyclin-dependent kinase 62.7.11.220.454
3sheI85MAP kinase-activated protein kinase 32.7.11.10.454
2uzeC95Cyclin-dependent kinase 22.7.11.220.452
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.452
2uzbC75Cyclin-dependent kinase 22.7.11.220.450
2vtqLZACyclin-dependent kinase 22.7.11.220.449
4fv8E63Mitogen-activated protein kinase 12.7.11.240.449
2b7aIZATyrosine-protein kinase JAK2/0.448
3t8oATPRhodopsin kinase/0.447
2eufLQQCyclin-dependent kinase 62.7.11.220.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.446
4dgo0JWCasein kinase II subunit alpha2.7.11.10.446
2csnCKICasein kinase I homolog 12.7.11.10.445
1v0oINRCell division control protein 2 homolog2.7.11.220.444
3nwxKVSGag-Pol polyprotein3.4.23.160.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1v0pPVBCell division control protein 2 homolog2.7.11.220.443
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.443
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.442
4ogrADNCyclin-dependent kinase 92.7.11.220.442
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.442
1xjdSTUProtein kinase C theta type2.7.11.130.441
2pvnP63Casein kinase II subunit alpha2.7.11.10.441
2bkzSBCCyclin-dependent kinase 22.7.11.220.440
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.440